Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 413, Issue -, Pages 92-99Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2013.09.036
Keywords
N-halamine; Polystyrene; 5-Allylbarbituric acid; Controllable fabrication; Bactericidal
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Funding
- National Natural Science Foundation of China [21304044, 31160332, 21263009]
- National Natural Science Foundation of Jilin Province [201115011]
- Program of Higher-level Talents of Inner Mongolia University [30105-125136]
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N-halamine-based antibacterial polystyrene nanoparticles with different particle size ranged from 91.5 nm to 562.5 nm were facilely fabricated by surfactant-free emulsion polymerization with 5-allyl-barbituric acid served as N-halamine precursor. Effect of experimental parameters such as monomer concentration, initiator concentration, and ionic strength on particle size was investigated systematically. N-halamine-based antibacterial polystyrene nanoparticles showed enhanced antibacterial activity against both Gram-positive species Staphylococcus aureus and Gram-negative species Pseudomonas aeruginosa compared with bulk powder N-halamine. Biocidal activity of N-halamine-based antibacterial polystyrene nanoparticles can be tailored effectively by tuning particle size. Stability and bactericidal activity of N-halamine-based antibacterial polystyrene nanoparticles was detected as a function of extending period. (C) 2013 Elsevier Inc. All rights reserved.
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