Article
Behavioral Sciences
Heather R. Dial, Eduardo Europa, Stephanie M. Grasso, Maria Luisa Mandelli, Kristin M. Schaffer, H. Isabel Hubbard, Lisa D. Wauters, Lindsey Wineholt, Stephen M. Wilson, Maria Luisa Gorno-Tempini, Maya L. Henry
Summary: Semantic variant primary progressive aphasia (svPPA) is a neurodegenerative disorder characterized by a loss of semantic knowledge and anterior temporal lobe atrophy. Treatment for anomia in svPPA has been shown to improve naming and generalization of trained and untrained items. Structural integrity of the inferior parietal cortex and hippocampus is associated with better post-treatment naming accuracy. Further research is needed to explore the neural mechanisms underlying treatment response in svPPA.
Article
Geriatrics & Gerontology
Laura E. M. Wisse, Molly B. Ungrady, Ranjit Ittyerah, Sydney A. Lim, Paul A. Yushkevich, David A. Wolk, David J. Irwin, Sandhitsu R. Das, Murray Grossman
Summary: In patients with svPPA, early atrophy in the left anterior temporal lobe, especially the perirhinal cortex, has been reported. By using high-resolution T2-MRI, researchers were able to examine the fine-grained medial temporal lobe (MTL) subregional measurements, providing new insights into atrophy patterns and disease progression in svPPA. Cross-sectional and longitudinal studies comparing svPPA, Alzheimer's disease (AD), and healthy controls showed significant volume loss in specific subregions of the MTL in svPPA patients and suggest that MTL subregional measures could be valuable markers for tracking disease progression in svPPA.
NEUROBIOLOGY OF AGING
(2021)
Article
Clinical Neurology
Eun-Joo Kim, So Young Moon, Hee-Jin Kim, Na-Yeon Jung, Sun Min Lee, Young Eun Kim
Summary: We present a case of right-predominant semantic variant primary progressive aphasia in a patient with the p.Asp40Gly variant of ANXA11. This is the first report of frontotemporal dementia without clinical and electrophysiological evidence of amyotrophic lateral sclerosis associated with a known pathogenic variant of ANXA11.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Behavioral Sciences
Evgenii Kalenkovich, Anna Shestakova, Nina Kazanina
Summary: The study aimed to empirically investigate sentence comprehension, constructing two different types of sentence structures in Russian and finding that listeners tend to track the sentence structure more in line with the lexico-semantic model rather than the hierarchical syntactic model.
Article
Medicine, General & Internal
Min Jeong Kwon, Subin Lee, Jieun Park, Sungman Jo, Ji Won Han, Dae Jong Oh, Jun-Young Lee, Joon Hyuk Park, Jae Hyoung Kim, Ki Woong Kim
Summary: Texture analysis may be an important neuroimaging marker for early detection of svPPA and differentiation from AD.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Review
Clinical Neurology
Siddharth Ramanan, Muireann Irish, Karalyn Patterson, James B. Rowe, Maria Luisa Gorno-Tempini, Matthew A. Lambon Ralph
Summary: In this article, a new clinico-anatomical model is proposed to explore the role of left temporoparietal degeneration in non-linguistic cognitive deficits in logopenic variant primary progressive aphasia. By considering research on non-linguistic dysfunction, the authors suggest that the degeneration of temporal/inferior parietal cortices and connected regions can explain a significant portion of multidimensional cognitive features.
Article
Audiology & Speech-Language Pathology
Shannon M. Sheppard, Erin L. Meier, Kevin T. Kim, Bonnie L. Breining, Lynsey M. Keator, Bohao Tang, Brian S. Caffo, Argye E. Hillis
Summary: This study compared sentence comprehension abilities in acute and chronic stage left hemisphere stroke patients, identifying factors related to the severity of damage to Broca's area, supramarginal gyrus, and superior longitudinal fasciculus. The results suggest that intact Broca's area may support syntactic processing after functional reorganization when temporoparietal regions are damaged.
BRAIN AND LANGUAGE
(2022)
Article
Psychology, Multidisciplinary
Sladjana Lukic, Abigail E. Licata, Elizabeth Weis, Rian Bogley, Buddhika Ratnasiri, Ariane E. Welch, Leighton B. N. Hinkley, Z. Miller, Adolfo M. Garcia, John F. Houde, Srikantan S. Nagarajan, Maria Luisa Gorno-Tempini, Valentina Borghesani
Summary: In this study, we investigated error patterns in an auditory verb generation task to differentiate the three variants of PPA. The results showed that each PPA variant had distinct error types, indicating the breakdown of different neurocognitive mechanisms.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Nuria Montagut, Sergi Borrego-Ecija, Magdalena Castellvi, Immaculada Rico, Ramon Rene, Mircea Balasa, Albert Llado, Raquel Sanchez-Valle
Summary: The study found that errorless learning speech therapy can improve naming ability in patients with svPPA, but the improvement diminishes progressively after therapy ends, with no improvement found in comprehension tasks.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Maria Serpente, Laura Ghezzi, Chiara Fenoglio, Francesca R. Buccellato, Giorgio G. Fumagalli, Emanuela Rotondo, Marina Arcaro, Andrea Arighi, Daniela Galimberti
Summary: The study investigates the expression profile of circulating miRNAs in different variants of Primary Progressive Aphasia (PPA). The results show a specific miRNA expression profile in semantic variant of PPA that could differentiate it from other PPA variants. The target genes of these miRNAs are involved in pathways relevant to the pathogenesis of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Niloofar Akhavan, Christina Sen, Carolyn Baker, Noelle Abbott, Michelle Gravier, Tracy Love
Summary: This study investigated the real-time auditory sentence processing of neurologically unimpaired listeners and individuals with aphasia. The presence of biased lexical cues was found to affect the lexical encoding and syntactic retrieval process of unimpaired listeners, but only influenced syntactic re-activation for individuals with aphasia.
Article
Immunology
Niels Hansen, Winfried Stoecker, Jens Wiltfang, Claudia Bartels, Kristin Rentzsch, Caroline Bouter
Summary: This study reports a case of svPPA associated with anti-glial fibrillary acid protein (GFAP) antibodies, expanding the clinical spectrum of svPPA and anti-GFAP-antibody related disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Christos Salis, Nadine Martin, Laura Reinert
Summary: The study investigated semantic plausibility and syntactic complexity on immediate sentence recall in latent and anomic aphasia individuals. While accuracy did not differentiate performance between latent aphasia and neurotypical controls, real-time speech measures did show differences. There was some evidence that semantic plausibility and syntactic complexity influenced recall performance, but there were no interactions between the two.
Article
Neurosciences
Aida Suarez-Gonzalez, Sharon A. Savage, Nathalie Bier, Maya L. Henry, Regina Jokel, Lyndsey Nickels, Cathleen Taylor-Rubin
Summary: The article provides an overview of interventions to support language in people with semantic variant primary progressive aphasia (svPPA) over the last two decades and offers recommendations for future clinical practice. It concludes that an integrative framework of treatment and care is the best practice for svPPA, combining rehabilitation interventions, compensatory approaches, education, and support within the context of dementia.
Article
Clinical Neurology
Jing Xu, Yanmin Xia, Meng Meng, Fang Liu, Ping Che, Yanxin Zhang, Ying Wang, Li Cai, Wen Qin, Nan Zhang
Summary: This study presents a large svPPA-affected family with the MAPT P301L mutation, providing insights into the underlying pathology and pathophysiological processes in svPPA caused by tauopathies.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Kristin M. Schaffer, Lisa Wauters, Karinne Berstis, Stephanie M. Grasso, Maya L. Henry
Summary: This study investigates the effectiveness of modified Video Implemented Script Training for Aphasia (VISTA) on an individual with primary progressive aphasia and hearing loss. The results show positive outcomes in script production accuracy, speech intelligibility, and other measurements, with the effects maintained during follow-up assessments.
NEUROPSYCHOLOGICAL REHABILITATION
(2022)
Article
Neurosciences
Heather R. Dial, G. Nike Gnanateja, Rachel S. Tessmer, Maria Luisa Gorno-Tempini, Bharath Chandrasekaran, Maya L. Henry
Summary: lvPPA, a form of primary progressive aphasia, is characterized by impaired phonological processing and deficits in comprehension. Recent research suggests that individuals with lvPPA show increased cortical tracking of the speech envelope in theta oscillations, indicating a heightened reliance on acoustic cues during speech encoding. This neural signature may reflect inefficient encoding of bottom-up speech cues due to dysfunction in the temporoparietal cortex.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Audiology & Speech-Language Pathology
Katarina L. Haley, Adam Jacks, Jordan Jarrett, Taylor Ray, Kevin T. Cunningham, Maria Luisa Gorno-Tempini, Maya L. Henry
Summary: Differentiating between nonfluent/agrammatic and logopenic variants of primary progressive aphasia based on speech articulation and prosody metrics for apraxia of speech is challenging. However, measures of average syllable duration in connected speech samples have shown promise as useful diagnostic tools for this purpose, indicating potential for automation and application in clinical practice.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2021)
Article
Audiology & Speech-Language Pathology
Kristin M. Schaffer, William S. Evans, Christina D. Dutcher, Christina Philburn, Maya L. Henry
Summary: This study investigated a novel intervention combining speech-language treatment with counseling for an individual with nonfluent/agrammatic PPA, showing that this approach is feasible and beneficial for improving speech-language production and psychosocial functioning in individuals with this type of aphasia.
AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2021)
Article
Clinical Neurology
Stephen M. Wilson, Jillian L. Entrup, Sarah M. Schneck, Caitlin F. Onuscheck, Deborah F. Levy, Maysaa Rahman, Emma Willey, Marianne Casilio, Melodie Yen, Alexandra C. Brito, Wayneho Kam, L. Taylor Davis, Michael de Riesthal, Howard S. Kirshner
Summary: Most individuals with aphasia after stroke recover to some extent in the first year, and the recovery process is partially dependent on lesion location and extent. This study aims to provide a comprehensive description of patterns of recovery from aphasia in the first year after stroke. It found that lesion location and extent, as well as different language domains, have an impact on aphasia recovery.
Article
Rehabilitation
A. Volkmer, J. Cartwright, L. Ruggero, A. Beales, J. Gallee, S. Grasso, M. Henry, R. Jokel, J. Kindell, R. Khayum, M. Pozzebon, E. Rochon, C. Taylor-Rubin, R. Townsend, F. Walker, S. Beeke, D. Hersh
Summary: This study aims to establish the philosophy of expert practice and a set of best practice principles when working with PPA patients.
DISABILITY AND REHABILITATION
(2023)
Review
Behavioral Sciences
Anna Kasdan, Andrea N. Burgess, Fabrizio Pizzagalli, Alyssa Scartozzi, Alexander Chern, Sonja A. Kotz, Stephen M. Wilson, Reyna L. Gordon
Summary: This study conducted a systematic review and meta-analysis of functional magnetic resonance imaging studies on the processing of musical rhythms in neurotypical adults. The findings suggest that musical rhythm is represented in a bilateral cortico-subcortical network, involving multiple sensory and motor regions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Daniel Kim, Sarah Diehl, Michael de Riesthal, Kris Tjaden, Stephen M. Wilson, Daniel O. Claassen, Antje S. Mefferd
Summary: Comparing two data-driven approaches for subgrouping HD patients, researchers found 50% to 78% overlap between the subgroup decisions. Overall strangeness and speech rate are important factors for grouping decisions in both approaches. Voice abnormalities also contribute to grouping decisions in one approach.
Article
Clinical Neurology
E. Diachek, V. L. Morgan, S. M. Wilson
Summary: This study compared two adaptive language mapping paradigms with the currently recommended standard paradigms. The results showed that the adaptive semantic paradigm performed best in terms of lateralization, extent of activation in frontal and temporal regions, and overall satisfactory language maps. The adaptive phonological paradigm identified phonological encoding regions that were not detected by other paradigms.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Behavioral Sciences
Heather R. Dial, Eduardo Europa, Stephanie M. Grasso, Maria Luisa Mandelli, Kristin M. Schaffer, H. Isabel Hubbard, Lisa D. Wauters, Lindsey Wineholt, Stephen M. Wilson, Maria Luisa Gorno-Tempini, Maya L. Henry
Summary: Semantic variant primary progressive aphasia (svPPA) is a neurodegenerative disorder characterized by a loss of semantic knowledge and anterior temporal lobe atrophy. Treatment for anomia in svPPA has been shown to improve naming and generalization of trained and untrained items. Structural integrity of the inferior parietal cortex and hippocampus is associated with better post-treatment naming accuracy. Further research is needed to explore the neural mechanisms underlying treatment response in svPPA.
Article
Computer Science, Information Systems
Zoe Ezzes, Sarah M. Schneck, Marianne Casilio, Davida Fromm, Antje S. Mefferd, Michael de Riesthal, Stephen M. Wilson
Summary: This study aims to create a resource library containing audiovisual recordings of connected speech samples from individuals with aphasia, along with consensus ratings of APROCSA features, to provide a useful tool for researchers, clinicians, and students to learn how to evaluate aphasic speech with an auditory-perceptual approach.
Article
Linguistics
Mackenzie Philips, Sarah M. Schneck, Deborah F. Levy, Stephen M. Wilson
Summary: By studying the neural correlates of linguistic and non-linguistic tasks in the auditory modality, it was found that the language network is modulated by linguistic demand, while the multiple demand network is not. This suggests that linguistic processing may have specific regulatory mechanisms at the neural level.
NEUROBIOLOGY OF LANGUAGE
(2023)
Article
Clinical Neurology
John P. Andrews, Nathan Cahn, Benjamin A. Speidel, Jason E. Chung, Deborah F. Levy, Stephen M. Wilson, Edward F. Chang, Mitchel S. Berger
Summary: This study examined the neuroanatomical areas most likely to result in Broca's aphasia following surgical lesions. The results showed that Broca's aphasia is typically associated with resections of the ventral sensorimotor cortex and supramarginal gyri. The fluency scores were negatively correlated with the resected components of these areas.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Marco Riva, Stephen M. Wilson, Ruofan Cai, Antonella Castellano, Kesshi M. Jordan, Roland G. Henry, Maria Luisa Gorno Tempini, Mitchel S. Berger, Edward F. Chang
Summary: Electrocortical stimulation mapping (ECS) was used during awake surgery in 6 patients to investigate sentence-level processing. Stimulation of the inferior frontal gyrus disrupted comprehension of passive sentences in all subjects, while simpler tasks remained unaffected. These findings suggest the presence of language regions that contribute differently to sentence processing, and sentence-level tasks are best for identifying them. The functional consequences of resecting these sites need further investigation.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
E. Diachek, V. L. Morgan, S. M. Wilson
Summary: This study compared two adaptive language mapping paradigms with the currently recommended standard paradigms, and found that the adaptive semantic paradigm resulted in the most strongly lateralized activation maps and the greatest extent of frontal and temporal activations.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)