Article
Virology
Baodi Li, Guofeng Xiang, Jun He, Hongyu Li, Congshan Xu, Aihong Yu, Zhe Zhao, Xueying Wang, Lihua Zhang, Hui Zhang, Huimin Zhang, Mingjun Xie, Peng Wang, Deshan Yu
Summary: The fifth wave of Avian H7N9 influenza virus outbreak was reported in Gansu Province, China during 2016-2017, with 5 human cases detected. Environmental samples tested positive for H7N9, indicating potential threat to human health. Phylogenetic analysis suggested two distinct trade routes as potential sources of the virus introduction into Gansu.
Article
Medicine, Research & Experimental
Chengjun Li, Hualan Chen
Summary: In early 2013, human infections caused by a novel H7N9 avian influenza virus were first reported in China, which later evolved into highly pathogenic strains. Since 2017, nationwide vaccination of chickens has successfully controlled H7N9 avian influenza infections in poultry and prevented human infections.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2021)
Article
Microbiology
Yuncong Yin, Yuan Liu, Juan Fen, Kaituo Liu, Tao Qin, Sujuan Chen, Daxin Peng, Xiufan Liu
Summary: This study identifies the first evidence of the low-pathogenicity H7N9 avian influenza virus infecting camels, posing a high risk to public health.
MICROBIOLOGY SPECTRUM
(2023)
Article
Virology
Jun He, Sai Hou, Chenglong Xiong, Linjie Hu, Lei Gong, Junling Yu, Xiaoyu Zhou, Qingqing Chen, Yuan Yuan, Lan He, Meng Zhu, Weiwei Li, Yonglin Shi, Yong Sun, Haifeng Pan, Bin Su, Yihan Lu, Jiabing Wu
Summary: This study discusses the possible impact of H7N9 influenza A viruses (IAVs) on future influenza epidemics through gene reassortment events. A total of 61 human H7N9 isolates were obtained from Anhui province in China from 2013 to 2019, and bioinformatics analyses revealed the introduction of novel avian influenza A virus (AIV) subtypes through gene reassortment. The study also showed that H7N9, H9N2, and H5N1 can serve as persistent gene pools for AIVs in specific regions of China.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Microbiology
Jun Li, Rumeng Li, Qi Zhang, Peipei Peng, Xiaoquan Wang, Min Gu, Zenglei Hu, Xinan Jiao, Daxin Peng, Jiao Hu, Xiufan Liu
Summary: This study demonstrates that the H7N9 VLP vaccine provides complete clinical protection against HP H7N9 virus, significantly inhibits virus shedding, and abolishes viral replication in chickens. The VLP vaccine represents a promising alternative strategy for the development of novel H7N9 avian influenza vaccines for chickens.
VETERINARY MICROBIOLOGY
(2021)
Article
Virology
Dongchang He, Xiyue Wang, Huiguang Wu, Xiaoquan Wang, Yayao Yan, Yang Li, Tiansong Zhan, Xiaoli Hao, Jiao Hu, Shunlin Hu, Xiaowen Liu, Chan Ding, Shuo Su, Min Gu, Xiufan Liu
Summary: Reassortment between H9N2 and H7N9 viruses is frequent, but the patterns of reassortment are not fully understood. H7N9 virus and its progeny frequently exchange internal genes with H9N2, but rarely with other AIV subtypes. The rates of intrasubtype reassortment were high in waves 2-3 and 5, with PB2 c05 and M c02 clusters being dominant in wave 5.
Article
Veterinary Sciences
Jiajun Ou, Feiyan Zheng, Jiaojiao Cheng, Shaotang S. Ye, Cundong Ye, Kun Jia, Gang Lu, Shoujun Li
Summary: H3N2 canine influenza virus continues to circulate in dog populations in China, Korea, and the United States. Through the study of samples from veterinary hospitals in Guangdong Province, we have identified new emerging strains of H3N2 CIV that differ from previously reported strains in China.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Medicine, Research & Experimental
Iuliia M. Gilchuk, Sandhya Bangaru, Nurgun Kose, Robin G. Bombardi, Andrew Trivette, Sheng Li, Hannah L. Turner, Robert H. Carnahan, Andrew B. Ward, James E. Crowe Jr
Summary: This study examined the B cell response to H7 HA in individuals who had recovered from natural H7N9 virus infection. Circulating H7-reactive B cells were found to recognize a diverse antigenic landscape on the HA molecule and exhibit broad recognition of unrelated H7 strains. Functional testing of the antibodies revealed diverse patterns of inhibition, including neutralizing and HA trimer-disrupting activities.
Article
Virology
Xizi Deng, Zhiwei Liang, Weiping Cai, Feng Li, Junbin Li, Fengyu Hu, Yun Lan
Summary: This study revealed the diversity and distribution of HCV subgenotypes among HIV/HCV-coinfected patients in Guangdong, China. Marital status was found to potentially influence the formation of HCV transmission networks.
Article
Infectious Diseases
Dongchang He, Jinyuan Gu, Min Gu, Huiguang Wu, Juan Li, Tiansong Zhan, Yu Chen, Naiqing Xu, Zhichuang Ge, Guoqing Wang, Xiaoli Hao, Xiaoquan Wang, Jiao Hu, Zenglei Hu, Shunlin Hu, Xiaowen Liu, Xiufan Liu
Summary: The Avian Influenza Virus (AIV) H7N9 emerged in 2013 in Eastern China and has caused severe disease in humans in multiple waves, with highly pathogenic variants appearing in 2016. Studies show ongoing evolution in H7N9 AIV since 2017, with vaccination programs potentially intensifying natural selection. Enhanced surveillance is needed to understand the current situation of the virus.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Microbiology
Zhibin Shi, Lili Wei, Pengfei Wang, Shida Wang, Zaisi Liu, Yongping Jiang, Jingfei Wang
Summary: This study conducted a spatial and temporal Bayesian evolutionary analysis to understand the spread and evolution process of the H7N9 influenza A virus. The findings showed that the virus likely emerged in August 2012 in a border area of Anhui Province, 6 months earlier than the first reported human case. By the end of 2013, two major epicenters had formed in the Yangtze River Delta and Pearl River Delta regions, and the virus spread to other regions at an average speed of 6.57 km/day. The study also developed a model based on the random forest algorithm to predict the occurrence risk of the H7N9 virus.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Swan Tan, Muhammad Farhan Sjaugi, Siew Chinn Fong, Li Chuin Chong, Hadia Syahirah Abd Raman, Nik Elena Nik Mohamed, Joseph Thomas August, Asif M. Khan
Summary: Avian influenza virus H7N9, which has been circulating in avian hosts for decades, was identified as a human pathogen in 2013. Through comparing sequences from avian and human H7N9 datasets, it was found that the virus has undergone significant amino acid substitutions possibly essential for human adaptation. The rapid evolution of the avian H7N9 virus has resulted in almost identical protein sequences in avian and human viruses, leading to increased risk of human infection and potential human-to-human transmission.
Article
Public, Environmental & Occupational Health
Qingxia He, Luis M. Dias Martins, Shibin Wang, Qishan Zhan, Xiao Yu, Zhiqiong Ba, Wangjiu Li, Huigen Huang
Summary: The objective of this study was to explore the sense of job security and its influencing factors among healthcare workers in Guangdong, China. A cross-sectional study was conducted using stratified random sampling to enroll healthcare workers employed by hospitals in Guangdong province between September 2020 and October 2020. The results showed that multiple factors, including work experience, education level, job position, specialty unit, employment type, marital status, job satisfaction, workplace violence frequency, sleep duration, overtime hours, average monthly earnings, hospital level, and region, were significantly associated with the sense of job security among healthcare workers.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Virology
Dongchang He, Min Gu, Xiyue Wang, Xiaoquan Wang, Gairu Li, Yayao Yan, Jinyuan Gu, Tiansong Zhan, Huiguang Wu, Xiaoli Hao, Guoqing Wang, Jiao Hu, Shunlin Hu, Xiaowen Liu, Shuo Su, Chan Ding, Xiufan Liu
Summary: Since the emergence of highly pathogenic H7N9 avian influenza virus in China in 2016, with at least 33 human infections, it has been primarily circulating in Northern China in recent years, with signs of parallel evolution and positive selection in the hemagglutinin gene.
Article
Veterinary Sciences
Hao Tang, Chaojian Shen, Lianbin Zou, Chang Cai, John Edwards, Mieghan Bruce, Youming Wang, Ian Robertson, Baoxu Huang
Summary: Yellow broilers play a crucial role in the value chain in Guangxi, China, where biosecurity issues are prevalent. The study highlighted the lack of comprehensive understanding, governance structures, and relevant practices in the value chain, suggesting a need for government-industry partnerships to address gaps in biosecurity management.
PREVENTIVE VETERINARY MEDICINE
(2021)
