4.6 Article

Analysis of Vis-NIR spectra changes to measure the inflammatory response in the nasal mucosal region of influenza A and B virus-infected patients

Journal

JOURNAL OF CLINICAL VIROLOGY
Volume 55, Issue 4, Pages 334-338

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.jcv.2012.08.015

Keywords

Influenza A virus; Influenza B virus; Respiratory diseases; Respiratory infection; Vis-NIR spectra

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Funding

  1. Japan Science and Technology Agency
  2. Grants-in-Aid for Scientific Research [23406017, 23659297] Funding Source: KAKEN

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Background: Human influenza A and B viruses cause severe seasonal respiratory tract infections, especially in infants and young children. Influenza A and B viruses have been reported to produce different symptoms and/or severity in infected patients, although these remain inconclusive. Objectives and study design: In this study, non-invasive visible and near-infrared (Vis-NIR) spectroscopy was used for comparative analysis of the inflammatory response to influenza A and B virus infections, by measuring changes in water peak (970 nm) spectra collected from patient nasal mucosal regions. Results: The results suggested that infection with influenza B virus induced more severe inflammatory responses in the nasal mucosal region than influenza A virus. Conclusions: These are the first data showing different inflammatory responses to influenza A and B viruses at the sites of virus infection. (C) 2012 Elsevier B.V. All rights reserved.

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