Article
Psychology, Clinical
Romain Colle, Khalil El Asmar, Celine Verstuyft, Pierre-Marie Lledo, Francoise Lazarini, Kenneth Chappell, Eric Deflesselle, Abd El Kader Ait Tayeb, Bruno Falissard, Emmanuelle Duron, Samuel Rotenberg, Jean-Francois Costemale-Lacoste, Denis J. David, Florence Gressier, Alain M. Gardier, Thomas Hummel, Laurent Becquemont, Emmanuelle Corruble
Summary: The study found significant differences in olfactory performance between depressed patients and healthy controls, but after venlafaxine treatment, some patients showed improvements in olfaction, which were mediated by the alleviation of depressive symptoms.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Chuanjun Zhuo, Chunhua Zhou, Ziyao Cai, Jiayue Chen, Lei Yang, Qianchen Li, Qiuyu Zhang, Tao Fang, Hongjun Tian, Chongguang Lin, Xueqin Song
Summary: This study investigated the treatment effects of different medications for patients with schizophrenia and major depressive disorder using a mouse model. The results showed that ECS + venlafaxine + mirtazapine had significant effects in alleviating major depressive disorder, as reflected by brain Ca2+ activity and behavioral assay performance. Clozapine + venlafaxine + mirtazapine did not have an ideal treatment effect.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Kenneth Chappell, Abd El Kader Ait Tayeb, Romain Colle, Jerome Bouligand, Khalil El-Asmar, Florence Gressier, Severine Trabado, Denis Joseph David, Bruno Feve, Laurent Becquemont, Emmanuelle Corruble, Celine Verstuyft
Summary: This study found that genetic variants of ARRB1 may influence the response to antidepressant drug treatment in depressed patients. The analysis of rare variants showed significant associations with changes in HDRS scores and remission. The results suggest that beta-arrestin 1 and genetic variants of ARRB1 may serve as useful clinical biomarkers for clinical improvement following antidepressant drug treatment in depressed individuals.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Marta Gonzalez-Prieto, Irene L. Gutierrez, Borja Garcia-Bueno, Javier R. Caso, Juan C. Leza, Adriana Ortega-Hernandez, Dulcenombre Gomez-Garre, Jose L. M. Madrigal
Summary: Increased production of CX3CR1 was observed in the brain cortex of AD patients, and administration of the drug reboxetine further increased its expression in microglial cells, enhancing their reactivity towards amyloid beta plaques. However, direct administration of NA inhibited CX3CR1 production in microglia.
Article
Psychology, Multidisciplinary
Yves de Roten, Slimane Djillali, Fabienne Crettaz von Roten, Jean-Nicolas Despland, Gilles Ambresin
Summary: This study investigated the predictive value of defensive functioning and defense mechanisms in determining the effectiveness of brief psychodynamic psychotherapy for recurrent and chronic depression in an inpatient setting. The results showed that changes in defensive functioning along with mature and immature defense mechanisms during therapy were predictive of treatment response, with the addition of psychotic defenses enhancing the prediction of treatment outcomes. The findings support the role of defensive functioning as a predictor of treatment outcomes and a mechanism of change in psychotherapy.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huawei Zhang, Huiru Li, Li Yin, Ziqi Chen, Baolin Wu, Xiaoqi Huang, Zhiyun Jia, Qiyong Gong
Summary: This study utilized MRI to explore white matter microstructure in patients with depression, revealing significant diffusion property differences in certain brain regions of depressed suicidal individuals. The findings suggest a close association between suicidal tendencies in depression and white matter abnormalities in the frontal cortex and limbic system.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Neurosciences
Rafael Appel Flores, Renata Steinbach, Joao A. B. Pedroso, Martin Metzger, Jose Donato, Marta Aparecida Paschoalini
Summary: The study aimed to evaluate the effects of pharmacological manipulation of alpha-adrenergic agonists in the dorsal raphe nucleus on food intake in satiated rats. Administration of noradrenaline, adrenaline, and clonidine into the DR increased food intake and decreased latency to start consumption in satiated rats. The data suggest that the hyperphagia induced by noradrenaline or adrenaline treatment depends on alpha-2 adrenoceptors activation and that clonidine injections impact neuronal activity in the arcuate nucleus.
Review
Nutrition & Dietetics
Shinsuke Yamada, Masaaki Inaba
Summary: Potassium is the main intracellular cation that plays a vital role in maintaining cellular functions. Kidney function is crucial in regulating serum potassium levels, and tailored potassium management is necessary for individuals with impaired renal function. Abnormalities in potassium metabolism can lead to dangerous arrhythmias or sudden cardiac death, emphasizing the importance of monitoring and early intervention for high-risk patients.
Review
Critical Care Medicine
Fengkai Mao, Dongcheng Liang, Zewen Tang, Yuxuan Xu, Leqing Lin
Summary: Combination therapy of terlipressin and norepinephrine shows potential benefits in the treatment of septic shock, improving cardiac output and central venous pressure.
Review
Medicine, Research & Experimental
Guy M. Goodwin
Summary: Anxiety and depression often coexist, with evidence suggesting genetic basis for their comorbidity. However, current clinical classification and treatment guidelines do not fully address the specific needs of patients with anxious depression, highlighting the need for more research and tailored therapies in this area.
ADVANCES IN THERAPY
(2021)
Article
Clinical Neurology
Shuzhe Zhou, Qinhong Ma, Yiwei Lou, Xiaozhen Lv, Hongjun Tian, Jing Wei, Kerang Zhang, Gang Zhu, Qiaoling Chen, Tianmei Si, Gang Wang, Xueyi Wang, Nan Zhang, Yu Huang, Qi Liu, Xin Yu
Summary: This study utilized machine learning models to explore baseline variables for predicting the 8-week treatment outcome of patients with MDD receiving SSRIs. Results showed that neurocognitive functions and anxiety symptoms were important predictors, with SVM achieving an accuracy of 74.49% and sensitivity and specificity of 0.899 and 0.422, respectively.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Cell Biology
Feipeng Zhu, Lina Liu, Jie Li, Bing Liu, Qinglong Wang, Ruiying Jiao, Yongxin Xu, Lun Wang, Suhua Sun, Xiaoxuan Sun, Muhammad Younus, Changhe Wang, Tomas Hokfelt, Bo Zhang, Howard Gu, Zhi-Qing David Xu, Zhuan Zhou
Summary: This study demonstrates that cocaine directly increases the frequency of quantal NE release through regulation of NET and downstream PKC signaling, which modulates the activity of LC-NE neurons and cocaine-induced stimulant behavior.
Article
Neurosciences
Nora-Isabell Griebsch, Johanna Kern, Jonas Hansen, Michael Rullmann, Julia Luthardt, Stephanie Helfmeyer, Franziska J. Dekorsy, Marvin Soeder, Mohammed K. Hankir, Franziska Zientek, Georg-Alexander Becker, Marianne Patt, Philipp M. Meyer, Arne Dietrich, Matthias Blueher, Yu-Shin Ding, Anja Hilbert, Osama Sabri, Swen Hesse
Summary: Serotonin and noradrenaline are important regulators of brain functions, including appetite control. This study aimed to investigate if serotonin and noradrenaline transporters can predict weight loss and treatment success. The results showed that serotonin transporter availability in the dorsal raphe nucleus before intervention was associated with significant BMI reduction after surgery.
Article
Nutrition & Dietetics
Assaf Buch, Rebecca Goldsmith, Lesley Nitsan, Miri Margaliot, Gabi Shefer, Yonit Marcus, Naftali Stern
Summary: The study indicates that higher potassium excretion is associated with a lower risk of metabolic syndrome, and individuals with higher MS scores tend to have lower potassium excretion. Potassium excretion correlates with all components of MS and can predict the syndrome independently from other variables.
Article
Psychiatry
Lea Sirignano, Josef Frank, Laura Kranaster, Stephanie H. Witt, Fabian Streit, Lea Zillich, Alexander Sartorius, Marcella Rietschel, Jerome C. Foo
Summary: This study investigated the effects of electroconvulsive therapy (ECT) on the methylome of depressed patients and identified differentially methylated CpG sites associated with ECT response. Despite the limited sample size, the results suggest that this approach has the potential to inform the study of mechanisms involved in ECT and treatment-resistant depression.
TRANSLATIONAL PSYCHIATRY
(2021)
