Article
Clinical Neurology
Erik Smedler, Timea Sparding, Lina Jonsson, Elin Horbeck, Mikael Landen
Summary: This study investigated the association between premorbid intelligence and functional outcome, illness severity, and comorbidity in male bipolar disorder patients in Sweden. The results showed that lower premorbid intelligence was associated with lower level of functioning, more severe illness, and higher psychiatric comorbidity. Further research is needed to develop targeted interventions for this subgroup of bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Family Studies
Eva Neumann, Jacqueline Rixe, Martin Driessen, Georg Juckel
Summary: This study aimed to explore the associations between childhood trauma and symptom severity and psychosocial functioning in schizophrenia, as well as whether psychosocial functioning mediated the association between childhood trauma and schizophrenic symptoms. The findings revealed correlations between childhood trauma and positive symptoms, as well as psychosocial functioning in the occupational and social areas and control over aggressive behavior. Psychosocial functioning was shown to mediate the association between childhood trauma and symptom severity.
CHILD ABUSE & NEGLECT
(2023)
Article
Engineering, Biomedical
Chih-Yuan Chuang, Yi-Ting Lin, Chen-Chung Liu, Lue-En Lee, Hsin-Yang Chang, An-Sheng Liu, Shu-Hui Hung, Li-Chen Fu
Summary: This study proposes a multimodal assessment model that predicts the severity of schizophrenia symptoms based on linguistic, acoustic, and visual behavior. The model combines deep learning techniques and a multimodal fusion framework to achieve superior performance in assessment.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Psychiatry
Tianqi Gao, Zetao Huang, Bingjie Huang, Tianhang Zhou, Chuan Shi, Xin Yu, Chengcheng Pu
Summary: Negative symptoms have a significant impact on the social functioning of patients with schizophrenia, and motivation plays a crucial role in determining their social outcomes. The study findings suggest that low motivation is associated with poor social functioning and unemployment. Therefore, targeting motivation could be a potential therapeutic approach to improve the social functioning of patients with schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Katharine Dunlop, Lindsay W. Victoria, Jonathan Downar, Faith M. Gunning, Conor Liston
Summary: This study found that major depressive disorder is associated with accelerated brain aging, which is selectively correlated with increased impulsivity and depression severity. Additionally, accelerated brain aging was unexpectedly associated with increased placebo response.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Ana Pelegrino, Anna Luiza Guimaraes, Walter Sena, Nwabunwanne Emele, Linda Scoriels, Rogerio Panizzutti
Summary: Our findings suggest that changes in LC-NA activity, as measured by task-evoked pupil dilation, are associated with schizophrenia symptoms. Interventions targeting noradrenergic responses may be suitable candidates for reducing schizophrenia symptomatology.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Lei Zhao, Shao-Wei Xue, Yun-Kai Sun, Zhihui Lan, Ziqi Zhang, Yichen Xue, Xuan Wang, Yuxin Jin
Summary: The study revealed that individuals with ASD exhibited alterations in dynamic functional connectivity and static functional connectivity in different insular subregions. These abnormal dynamic functional connectivity could significantly predict the symptom severity of individuals with ASD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Julia M. Longenecker, R. Michael Bagby, Kwame McKenzie, Bruce G. Pollock, Tony P. George, Peter Voore, Lena C. Quilty
Summary: The research indicates that internalizing symptoms are the strongest predictor of functional outcomes for outpatients with psychotic disorders, especially in individuals with high levels of substance use. The study also found similar results when using the clinician-rated World Health Organization Disability Assessment Schedule 2.0.
JOURNAL OF CLINICAL PSYCHIATRY
(2021)
Article
Psychology, Clinical
Shinsuke Koike, Eisuke Sakakibara, Yoshihiro Satomura, Hanako Sakurada, Mika Yamagishi, Jun Matsuoka, Naohiro Okada, Kiyoto Kasai
Summary: This study reveals a robust relationship between prefrontal function and behavioral outcomes across three major psychiatric disorders through a large-sample neuroimaging study.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Akanksha Chaurasiya, Jay Kumar Ranjan, Nityanand Pandey, Hari Shanker Asthana
Summary: The study aimed to develop a method to estimate premorbid IQ of Hindi speaking Indian population through the development and standardization of a Hindi vocabulary test. By developing equations for estimating premorbid verbal and performance IQ, the study found these equations to be significant and valid in both normal and brain injury population for predicting verbal and performance IQ.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Narmene F. Hamsho, Justin Kopec, Melissa Morton, Brian P. Rieger
Summary: This study examined the association between psychosocial variables and concussion symptom severity in a clinic-referred sample of youth. Results showed a strong correlation between youth-reported depression and concussion symptom severity, and significant correlations between parent-reported depression, academic stress, and quality of life with concussion symptom severity.
Article
Psychiatry
Rima Abdul Razzak, Haitham Jahrami, Mariwan Husni, Maryam Ebrahim Ali, Jeff Bagust
Summary: This study compares the contextual modulation between patients with schizophrenia and healthy controls in the rod and frame test. The results show that only the variability measure is sensitive enough to distinguish between the two groups. Patients with schizophrenia have greater inconsistency in rod alignment, and those with more severe negative symptoms have larger variability in rod alignment.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Alejandra Caqueo-Urizar, Felipe Ponce-Correa, Carla Semir-Gonzalez, Alfonso Urzua
Summary: Premorbid adjustment refers to psychosocial functioning in areas such as education, occupation, and relationships prior to the onset of characteristic positive symptoms in schizophrenia. This study found that premorbid adjustment is significantly correlated with recovery indicators and that patients with better premorbid adjustment show better outcomes in terms of subjective recovery and stigma resistance. These findings highlight the importance of psychosocial functioning prior to psychosis in shaping patients' subjective experiences, understanding of the disorder, and recovery process.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Silvia Amoretti, Gisela Mezquida, Adriane R. Rosa, Miquel Bioque, Manuel J. Cuesta, Laura Pina-Camacho, Clemente Garcia-Rizo, Fe Barcones, Ana Gonzalez-Pinto, Jessica Merchan-Naranjo, Iluminada Corripio, Eduard Vieta, Inmaculada Baeza, Romina Cortizo, C. Mar Bonnin, Carla Torrent, Miguel Bernardo
Summary: Functional impairment is a defining feature of psychotic disorders, and the Functional Assessment Short Test (FAST) is a widely used instrument for measuring psychosocial functioning. This study aimed to analyze the psychometric properties of the FAST and establish cut-off values for different severity gradations in first-episode non-affective psychosis patients. The FAST demonstrated strong psychometric properties and the established cut-off scores could be used in clinical and research practice to assess the psychosocial functional outcome of non-affective FEP populations.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Daniel J. Hauke, Andre Schmidt, Erich Studerus, Christina Andreou, Anita Riecher-Roessler, Joaquim Radua, Joseph Kambeitz, Anne Ruef, Dominic B. Dwyer, Lana Kambeitz-Ilankovic, Theresa Lichtenstein, Rachele Sanfelici, Nora Penzel, Shalaila S. Haas, Linda A. Antonucci, Paris Alexandros Lalousis, Katharine Chisholm, Frauke Schultze-Lutter, Stephan Ruhrmann, Jarmo Hietala, Paolo Brambilla, Nikolaos Koutsouleris, Eva Meisenzahl, Christos Pantelis, Marlene Rosen, Raimo K. R. Salokangas, Rachel Upthegrove, Stephen J. Wood, Stefan Borgwardt
Summary: This study developed a multimodal predictive model to forecast negative symptom severity and functional impairments in individuals at clinical high risk for psychosis. The baseline SIPS-N and gyrification models showed significant accuracies in predicting negative symptoms, with the combined model achieving the highest accuracy. Additionally, the baseline SIPS-N model demonstrated transdiagnostic generalizability to patients with recent-onset psychosis.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychology, Clinical
Arad Kodesh, Stephen Z. Levine, Vahe Khachadourian, Rayees Rahman, Avner Schlessinger, Paul F. O'Reilly, Jakob Grove, Diana Schendel, Joseph D. Buxbaum, Lisa Croen, Abraham Reichenberg, Sven Sandin, Magdalena Janecka
Summary: The study found 16 maternal diagnoses associated with ASD in offspring, including metabolic, genitourinary, and psychiatric disorders. Mothers of children with ASD were also less likely to attend prenatal care appointments.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Yael Travis-Lumer, Arad Kodesh, Yair Goldberg, Abraham Reichenberg, Sophia Frangou, Stephen Z. Levine
Summary: This study analyzed the association between COVID-19 biopsychosocial exposure and incident schizophrenia using an interrupted time-series study design. The results showed a reduced risk of schizophrenia during the pandemic, suggesting that there was no immediate triggering of new onsets. However, once the restrictions are lifted, there could be an increase in incident cases.
EUROPEAN PSYCHIATRY
(2022)
Article
Clinical Neurology
Jonathan Rabinowitz, Alon A. Rabinowitz
Summary: Subtle symptoms in affective disorders can lead to incorrect estimation of change. Empirically-based outlier-pattern flags were developed to detect imprecisions in ratings, providing cutting points to identify potential careless responses. These flags appear to be a useful adjunct to expert-derived flags in improving measurement in clinical trials.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Yael Travis-Lumer, Arad Kodesh, Yair Goldberg, Sophia Frangou, Stephen Z. Levine
Summary: This study aims to investigate the association between COVID-19 pandemic exposure and suicide attempt rates. The findings suggest that there is a negative association between the interval exposed to the COVID-19 pandemic and the risk of suicide attempts. However, the projections indicate that the suicide attempt rate may increase 10 months after lifting social mitigation policies.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Anat Rotstein, Efrat Shadmi, David Roe, Marc Gelkopf, Stephen Z. Levine
Summary: Evidence suggests that females with schizophrenia report lower quality of life than males, but the relationship between quality of life and subsequent psychiatric admissions differs between genders. While higher quality of life is associated with reduced hospitalization risk for males, this association is not present for females. Quality of life in schizophrenia should be considered as a gender-specific construct in clinical practice and research.
Article
Clinical Neurology
Anat Rotstein, Stephen Z. Levine, Myrto Samara, Kazufumi Yoshida, Yair Goldberg, Andrea Cipriani, Takeshi Iwatsubo, Stefan Leucht, Toshiaki A. Furukawa
Summary: Psychometric network analysis presents a new conceptualization of cognitive impairment in Alzheimer's disease and reveals treatment effects and key aspects of cognitive impairment through computational networks.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Jonathan Rabinowitz, Janet B. W. Williams, Ariana Anderson, Dong Jing Fu, Nanco Hefting, Bashkim Kadriu, Alan Kott, Atul Mahableshwarkar, Jan Sedway, David Williamson, Christian Yavorsky, Nina R. Schooler
Summary: This study explores the impact of measurement imprecisions on outcome assessment in the treatment of depression and proposes flags for logical and statistical consistency checks. The results show that nearly 30% of the depression treatments have inconsistent scoring and statistical outliers, which should be reviewed and addressed to improve the reliability and validity of clinical trial data.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Stephen Z. Levine, Yair Goldberg, Kazufumi Yoshida, Myrto Samara, Andrea Cipriani, Takeshi Iwatsubo, Stefan Leucht, Toshiaki A. Furukawa
Summary: This study examined the association between early improvement and subsequent change in cognition in antidementia clinical trials. The results showed that early responders to antidementia medication had more significant improvement in cognition compared to non-early responders, which was supported by sensitivity analysis.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Mathematical & Computational Biology
Valentin Vancak, Yair Goldberg, Stephen Z. Levine
Summary: This study introduces a theoretically-based framework to estimate the conditional and harmonic mean NNT in the presence of explanatory variables. The effectiveness of the framework is demonstrated through several examples and numerical simulations. The results show that parameter estimators with nonparametric bootstrap-based confidence intervals perform better in most cases.
STATISTICS IN MEDICINE
(2022)
Article
Psychiatry
Anat Rotstein, Arad Kodesh, Yair Goldberg, Abraham Reichenberg, Stephen Z. Levine
Summary: This study examines the association between serum folate deficiency and the risks of dementia and all-cause mortality in a large national sample of older adults. The results show that the presence of serum folate deficiency is associated with increased risks of dementia and all-cause mortality. Evidence for reverse causation is moderate for dementia and mild for all-cause mortality. Serum folate concentrations may function as a biomarker for identifying those at risk of dementia and mortality.
EVIDENCE-BASED MENTAL HEALTH
(2022)
Article
Pharmacology & Pharmacy
Myrto T. Samara, Stephen Z. Levine, Stefan Leucht
Summary: The study aims to understand and interpret the clinical significance of the Young Mania Rating Scale (YMRS) scores by examining their linkages with the Clinical Global Impression (CGI) ratings. The results of the study provide clinicians with meaningful cutoff values to interpret YMRS scores, which can contribute to the definition of treatment targets, response, remission, and entry criteria in mania trials.
PHARMACOPSYCHIATRY
(2023)
Article
Psychology, Clinical
Sophia Frangou, Yael Travis-Lumer, Arad Kodesh, Yair Goldberg, Faye New, Abraham Reichenberg, Stephen Z. Levine
Summary: The study found a significant increase in the use of antidepressant medications during the COVID-19 pandemic, particularly among women. These findings underscore the negative impact of the pandemic on mental health.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Jonathan Rabinowitz, Janet B. W. Williams, Nanco Hefting, Ariana Anderson, Brianne Brown, Dong Jing Fu, Bashkim Kadriu, Alan Kott, Atul Mahableshwarkar, Jan Sedway, David Williamson, Christian Yavorsky, Nina R. Schooler
Summary: The International Society for CNS Clinical Trials and Methodology developed consistency checks for the widely used Hamilton Anxiety Rating Scale (HAM-A) and Clinical Global Impression of Severity of anxiety (CGI-S). The checks revealed that 35% of ratings had at least one flag of inconsistency, with 19% having one flag and 16% having two or more. Applying flags to clinical ratings can aid in detecting imprecise measurement and improve the reliability and validity of trial data.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Jonathan Rabinowitz, Corinne Staner, Jay Saoud, Mark Weiser, Ramana Kuchibhatla, Michael Davidson, Phillip D. Harvey, Remy Luthringer
Summary: Roluperidone, a drug with antagonistic properties for various receptors, showed improvement in negative symptoms of schizophrenia and social functioning in two controlled trials. The protocol specified analysis of two open-label extension studies, lasting 24 and 40 weeks, further demonstrated sustained improvement without adverse effects or worsening of psychosis. These results support Roluperidone as a treatment for negative symptoms and social functioning deficits in patients with moderate to severe negative symptoms of schizophrenia.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Anwar Khatib, Vered Ben-David, Marc Gelkopf, Stephen Z. Levine
Summary: The PTG total score was higher for Jewish widows compared to Muslim and Druze widows, with no significant difference between the latter two. Social support contributed more to increased PTG among Jewish widows, while there was no significant association between social support and PTG among Druze widows.
JOURNAL OF COMMUNITY PSYCHOLOGY
(2021)