Article
Neuroimaging
Miriam Langerbeck, Teresa Baggio, Irene Messina, Salil Bhat, Alessandro Grecucci
Summary: This study used the machine learning method KRR to investigate the neural correlates of subclinical borderline personality traits (BPT). The results showed that certain brain regions, including the frontal and parietal regions, as well as other structures, could predict borderline traits. Additionally, the study confirmed the role of the default mode network in borderline personality disorder (BPD) and found that the BPT circuit was not able to predict histrionic traits.
NEUROIMAGE-CLINICAL
(2023)
Article
Psychiatry
Motahareh Sadat Mirhaj Mohammadabadi, Homa Mohammadsadeghi, Mehrdad Eftekhar Adrebili, Zahra Partovi Kolour, Fatemeh Kashaninasab, Vahid Rashedi, Mohammadreza Shalbafan
Summary: This study aimed to investigate the factors affecting medication and psychotherapy adherence, as well as patients' attitudes toward medication, among individuals with borderline personality disorder. The findings showed that patients had more positive attitudes toward psychotherapy than medication, possibly due to the limited efficacy of medication on the symptoms of borderline personality disorder.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Jon E. Grant, Stephanie Valle, Eve Chesivoir, Dustin Ehsan, Samuel R. Chamberlain
Summary: The study evaluated brexpiprazole for the reduction of borderline personality disorder symptoms and found a significant interaction between treatment and time at week 12. Brexpiprazole was generally well tolerated, but secondary measures did not show significant differences from placebo.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Behavioral Sciences
Edna Lekgabe, Danielle Pogos, Susan M. Sawyer, Andrew Court, Elizabeth K. Hughes
Summary: The study found a close correlation between the severity of eating disorder symptoms and borderline personality disorder traits, especially identity disturbance and feelings of emptiness.
BRAIN AND BEHAVIOR
(2021)
Article
Psychology, Social
Gareth Richards, Sally Kelly, Darren Johnson, John Galvin
Summary: The co-occurrence of autism and borderline personality disorder (BPD) has been found to be more prevalent in women than men. However, the relationship between these conditions and the traits in the general population are still poorly understood. Two studies were conducted in UK and US adults, confirming the positive correlation between autistic and BPD traits in both samples. Furthermore, it was found that the association between autistic traits and BPD traits becomes non-significant once anxiety and depression symptoms are controlled for in the UK sample, while specific domains of autistic traits remained significantly associated with BPD traits in the US sample.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2023)
Review
Clinical Neurology
Kamila Belohradova Minarikova, Jan Prasko, Michaela Holubova, Jakub Vanek, Krystof Kantor, Milos Slepecky, Klara Latalova, Marie Ociskova
Summary: This review examines the characteristics and severity of hallucinations and other psychotic symptoms in patients with borderline personality disorder (BPD), highlighting the limited knowledge and treatment options in this area. The relationship between hallucinations and factors such as depression, anxiety, and loneliness in BPD requires further research.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Review
Medicine, General & Internal
Tina Wu, Jennifer Hu, Dimitry Davydow, Heather Huang, Margaret Spottswood, Hsiang Huang
Summary: Borderline personality disorder is a common mental health diagnosis observed in the primary care population and is associated with various challenges in diagnosis and treatment. This article aims to describe the impact of BPD in primary care, review current knowledge, and provide evidence-based treatment approaches for these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Psychiatry
L. R. Magni, C. Ferrari, S. Barlati, M. E. Ridolfi, E. Prunetti, G. Vanni, M. Bateni, G. Diaferia, A. Macis, S. Meloni, G. Perna, G. Occhialini, A. Vita, G. Rossi, R. Rossi
Summary: Most BPD patients receive medication rather than psychotherapy, despite international guidelines recommending psychotherapy as the primary treatment. The prescription of medication does not fully depend on the severity of the disorder, and is only partially influenced by comorbidity. This study highlights the need for more rigorous research to better understand BPD treatment management.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Odette de Wilde Brand, Sharon Clarke, Arnoud Arntz
Summary: Patients benefited from using the BPDSI-IV by gaining insight into their borderline personality disorder symptoms and feeling more understood by therapists. Therapists preferred the BPDSI-IV over other ROM instruments because of its disorder-specific nature, which provides insight into the patient's treatment course. Positive experiences of both patients and therapists suggest that using a disorder-specific ROM instrument like the BPDSI-IV is valuable and promising for evaluating treatment in healthcare institutions.
Article
Psychiatry
Molly Kelly Grealy, Emmet Godfrey, Finn Brady, Erin Whyte O'Sullivan, Grace A. A. Carroll, Tom Burke
Summary: This study found a positive influence of BPD traits on the recognition of negative valence stimuli in social cognitive tasks, and high levels of affect instability significantly influenced negative valence recognition. This finding supports the importance of assessing social cognitive processes in individuals with BPD or high BPD traits.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Kate E. A. Saunders, Tomos Jones, Amy Perry, Arianna Di Florio, Nick Craddock, Ian Jones, Katherine Gordon-Smith, Lisa Jones
Summary: Borderline personality traits are common in individuals with bipolar disorder, especially in those with bipolar II disorder. The severity of borderline traits is associated with younger age of bipolar disorder onset and higher prevalence of lifetime alcohol misuse. The presence of comorbid borderline personality traits should be considered in the management of all patients with bipolar disorder.
Article
Psychiatry
Kevork Danayan, Noah Chisamore, Nelson B. Rodrigues, Joshua D. Di Vincenzo, Shakila Meshkat, Zoe Doyle, Rodrigo Mansur, Lee Phan, Farhan Fancy, Edmond Chau, Aniqa Tabassum, Kevin Kratiuk, Anil Arekapudi, Kayla M. Teopiz, Roger S. McIntyre, Joshua D. Rosenblat
Summary: Borderline personality disorder (BPD) is often comorbid with mood disorders, particularly treatment-resistant depression (TRD), and this comorbidity is associated with poor response to antidepressants. This study aimed to evaluate the effectiveness of intravenous ketamine in a TRD population with comorbid BPD. The results showed that patients with TRD and comorbid BPD receiving ketamine experienced significant improvement in symptoms of depression, borderline personality, suicidality, and anxiety, with no significant difference between the BPD-positive and BPD-negative groups.
PSYCHIATRY RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Yngvill Ane Stokke Westad, Kristen Hagen, Egil Jonsbu, Stian Solem
Summary: The study aimed to identify when deliberate self-harm behavior ceased in patients with borderline symptoms undergoing DBT treatment. It found that self-harming behavior gradually decreased across the first year after starting DBT, with most patients ceasing the behavior within the first year. The study also found no significant differences between early and late responders in demographics, comorbidity, symptom severity, or treatment outcome.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
J. Lumikukka Socada, John J. Soderholm, Tom Rosenstrom, Jesper Ekelund, Erkki Isometsa
Summary: This study investigated the prevalence, severity, co-occurrence, and overlap of manic symptoms and borderline personality features in unipolar and bipolar major depressive episodes. The results showed that the presence of mixed and borderline features in MDEs is common, with differences in diagnosis-specific features among different subcohorts. The study highlighted the impact of hypomania on perceived BPD features and the correlation between manic symptoms and borderline features.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Adrienn Rivnyak, Melinda Poharnok, Bernadette Peley, Andras Lang
Summary: The study suggests that identity diffusion plays a crucial role in the treatment and screening of borderline personality disorder, showing a negative correlation with borderline traits in non-clinical adolescents. Strong feelings and interpersonal sensitivity are the most common borderline personality features among non-clinical adolescents.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Health Care Sciences & Services
Junjia Zhu, Muhammad Hussain, Aditya Joshi, Cristina Truica, Darya Nesterova, Jolene Collins, Erika F. H. Saunders, Michael Hayes, Joseph J. Drabick, Monika Joshi
BMJ SUPPORTIVE & PALLIATIVE CARE
(2020)
Review
Endocrinology & Metabolism
Marzieh Majd, Erika F. H. Saunders, Christopher G. Engeland
FRONTIERS IN NEUROENDOCRINOLOGY
(2020)
Article
Psychiatry
Faisal Akram, Claudia Gragnoli, Uttam K. Raheja, Soren Snitkerf, Christopher A. Lowry, Kelly A. Stearns-Yoder, Andrew J. Hoisington, Lisa A. Brenner, Erika Saunders, John W. Stiller, Kathleen A. Ryan, Kelly J. Rohan, Braxton D. Mitchell, Teodor T. Postolache
JOURNAL OF PSYCHIATRIC RESEARCH
(2020)
Article
Health Policy & Services
Peter P. Zandi, Yu-Hsun Wang, Paresh D. Patel, David Katzelnick, Carolyn L. Turvey, Jesse H. Wright, Olusola Ajilore, William Coryell, Christopher D. Schneck, Constance Guille, Erika F. H. Saunders, Sophie A. Lazarus, Valeria A. Cuellar, Sudhakar Selvaraj, Patricia Dill Rinvelt, John F. Greden, J. Raymond Depaulo
PSYCHIATRIC SERVICES
(2020)
Article
Cardiac & Cardiovascular Systems
Jody L. Greaney, Agus Surachman, Erika F. H. Saunders, Lacy M. Alexander, David M. Almeida
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Psychiatry
Kelly Ann Ryan, Pallavi Babu, Rebecca Easter, Erika Saunders, Andy Jinseok Lee, Predrag Klasnja, Lilia Verchinina, Valerie Micol, Brent Doil, Melvin G. McInnis, Amy M. Kilbourne
JMIR MENTAL HEALTH
(2020)
Article
Clinical Neurology
Guodong Liu, Lan Kong, Ritika Baweja, Djibril Ba, Erika F. H. Saunders
Summary: This study aimed to examine gender disparities in the diagnosis of bipolar disorder within a privately insured population in the United States. The results showed that males had a lower diagnosis rate compared to females, with gender differences remaining significant even after adjusting for demographics, comorbidity, and healthcare utilizations. Gender disparity was consistently strong among most age groups, but varied in other demographic subgroups.
Article
Clinical Neurology
Erika F. H. Saunders, Dahlia Mukherjee, Tiffany Myers, Emily Wasserman, Ahmad Hameed, Venkatesh Bassappa Krishnamurthy, Beth Maclntosh, Anthony Domenichiello, Christopher E. Ramsden, Ming Wang
Summary: The study investigated the preliminary efficacy of a high n-3 plus low n-6 (H3-L6) dietary intervention in improving mood stability in Bipolar Disorder (BD) patients. Results showed that the H3-L6 group had reduced variability in mood, energy, irritability, and pain compared to the control group, but no significant differences were found in mean ratings of mood symptoms between the two groups. The dietary intervention showed potential in improving mood symptom variability in BD participants.
Article
Cardiac & Cardiovascular Systems
Ann-Katrin Grotle, Ashley M. Darling, Erika F. Saunders, Paul J. Fadel, Daniel W. Trott, Jody L. Greaney
Summary: This study provides the first evidence of augmented T-cell mitochondrial reactive oxygen species (T-cell mitoROS) in young, otherwise healthy adults with MDD. Although the elevated T-cell mitoROS did not correspond to a proinflammatory profile, these findings suggest that elevated T-cell mitoROS may be an early marker of immune system dysregulation in young adults with MDD.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Clinical Neurology
Ashley M. Darling, Rauchelle E. Richey, John D. Akins, Erika F. H. Saunders, R. Matthew Brothers, Jody L. Greaney
Summary: In young adults with major depressive disorder (MDD), cerebral vasodilatory reactivity is blunted and further modulated by current depressive symptomology, suggesting that improving depressive symptoms may have a positive impact on cerebrovascular health.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Jody L. Greaney, Erika F. H. Saunders, Lacy M. Alexander
Summary: Activation of NF-kappa B, through increased vascular ROS production, contributes to reduced NO-dependent endothelial dilation in young adults with MDD. Short-term treatment with NF-kappa B inhibitor salsalate improves NO-mediated endothelium-dependent dilation in MDD patients, while acute localized ROS scavenging with apocynin enhances NO-dependent dilation before salsalate administration.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Proceedings Paper
Computer Science, Information Systems
Johnna Blair, Dahlia Mukherjee, Erika F. H. Saunders, Saeed Abdullah
Summary: This paper explores the acceptance, needs, and concerns regarding a preemptive assessment and intervention system for bipolar disorder management. Through interviews with individuals living with bipolar disorder, requirements for effective behavioral monitoring during illness episodes were identified, and design recommendations were proposed to support dynamic, longitudinal interventions.
PROCEEDINGS OF THE 2023 CHI CONFERENCE ON HUMAN FACTORS IN COMPUTING SYSTEMS (CHI 2023)
(2023)
Article
Psychology, Clinical
Erika F. H. Saunders, Dahlia Mukherjee, Daniel A. Waschbusch, Duanping Liao, Amanda M. Pearl, Errol Aksu, Edward O. Bixler
Summary: The use of structured interviews helped physicians identify major depressive disorder by the second visit in patients with complex psychopathology. Patients with high complexity/severity of symptoms and more difficulty with functioning were less commonly identified with bipolar disorder even with the assistance of a structured interview.Structured assessment tools may improve the detection of psychiatric illness by clinicians at the first visit.
DEPRESSION AND ANXIETY
(2021)
Editorial Material
Education & Educational Research
Erika F. H. Saunders, Ashley Rice
ACADEMIC PSYCHIATRY
(2020)
Article
Psychology, Clinical
Natania A. Crane, Alvaro Verges, Masoud Kamali, Runa Bhaumik, Kelly A. Ryan, David F. Marshall, Erika F. H. Saunders, Michelle T. Kassel, Anne L. Weldon, Melvin G. McInnis, Scott A. Langenecker