Article
Psychology, Clinical
Ole Kohler-Forsberg, Louisa G. Sylvia, Vicki Fung, Lindsay Overhage, Michael Thase, Joseph R. Calabrese, Thilo Deckersbach, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Michael J. Ostacher, Dan V. Iosifescu, Andrew A. Nierenberg
Summary: In this study, adjunctive antidepressant treatment was not associated with lower depressive symptoms or higher mania symptoms in outpatients with bipolar disorder. There were no differences in treatment effects on mania scales, and potential biases due to nonrandomized design complicated causal interpretations, with no evidence suggesting better treatment effects of adjunctive antidepressants.
DEPRESSION AND ANXIETY
(2021)
Article
Psychiatry
Gianluca Serafini, Gustavo Vazquez, Fiammetta Monacelli, Matteo Pardini, Maurizio Pompili, Mario Amore
Summary: This study compared the socio-demographic and clinical features of bipolar disorder patients treated vs. not treated with antidepressant drugs (ADs). The results showed that patients treated with ADs were older, more likely to be retired, and more likely to have had a first major depressive episode. Patients receiving ADs also had more affective episodes and longer illness duration compared to those not treated with ADs.
PSYCHIATRY RESEARCH
(2021)
Article
Health Care Sciences & Services
Chih-Ken Chen, Lawrence Shih-Hsin Wu, Ming-Chyi Huang, Chian-Jue Kuo, Andrew Tai-Ann Cheng
Summary: This study investigates the effects of individual genomics and antidepressant medication on the risk of manic switch in bipolar I disorder. The results suggest that the rs10262219 variant on chromosome 7 and antidepressant treatment significantly increase the risk of manic switch after bipolar depression.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychiatry
Masataka Shinozaki, Norio Yasui-Furukori, Naoto Adachi, Hitoshi Ueda, Seiji Hongo, Takaharu Azekawa, Yukihisa Kubota, Eiichi Katsumoto, Koji Edagawa, Eiichiro Goto, Kazuhira Miki, Masaki Kato, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Kazutaka Shimoda, Reiji Yoshimura
Summary: The study found significant differences in the prescription rates of mood stabilizers, antipsychotics, and antidepressants between patients with BD-I and BD-II. BD-I patients were more commonly prescribed mood stabilizers and antipsychotics, while BD-II patients were more commonly prescribed antidepressants.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Clinical
Chittaranjan Andrade, Subramanian Arun Jyothi, Thampi Renitha, K. P. Anuroopa, Baiju Dona, T. Basila, George Nimmy
Summary: This study found that female outpatients of childbearing age who sought help for disorders related to psychiatry, neurology, and neurosurgery had a high exposure to valproate. If these findings can be applied to other medical practices and developing countries, it suggests the urgent need for regulatory guidance to avoid prescribing valproate to women of childbearing age. This is a globally important public health matter.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Psychiatry
Neslihan Inal, Cagatay Ermis, Dogukan Koc, Sena Aksoy, Gul Karacetin, Mustafa Tuncturk, Safak Eray, Berna Karabina, Omer Faruk Akca, Dilek Ozgul, Birim Gunay Kilic, Merve Cikili Uytun, Mert Besenek, Canem Kavurma, Oznur Bilac, Cem Gokcen, Zehra Topal, Ipek Percinel Yazici, Sermin Yalin Sapmaz, Gonca Ozyurt, Rasim Somer Diler
Summary: This study investigated the clinical characteristics of youth with PBD and found that female adolescents treated with antidepressants were more likely to have an earlier onset of mania. The research indicated that prior antidepressant treatments were associated with an earlier onset of mania in youth, particularly in adolescent females.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychiatry
Kuniyoshi Toyoshima, Yuki Kako, Atsuhito Toyomaki, Yusuke Shimizu, Teruaki Tanaka, Shin Nakagawa, Takeshi Inoue, Anabel Martinez-Aran, Eduard Vieta, Ichiro Kusumi
Summary: The euthymic state of bipolar disorder is often characterized by impaired cognitive function. Cognitive complaints, objective cognitive functions, and illness awareness were found to be associated in Japanese patients. Both subjective and objective cognitive functions were found to be associated with illness awareness in remitted bipolar outpatients.
PSYCHIATRY RESEARCH
(2021)
Review
Chemistry, Medicinal
Marek Krzystanek, Stanislaw Surma, Artur Palasz, Monika Romanczyk, Krzysztof Krysta
Summary: The antidepressant effects of memantine in bipolar depression are promising, with both experimental and clinical evidence supporting its efficacy. The presented case study demonstrates that memantine can be an effective and safe adjunct treatment for mood stabilization in bipolar depression. This suggests that memantine may offer a new approach for patients who do not respond well to traditional medications.
Article
Medicine, General & Internal
Paola Bozzatello, Benedetta Giordano, Cristiana Montemagni, Paola Rocca, Silvio Bellino
Summary: This study found that besides psychopathology and severity of the disease, several clinical, socio-demographic, and illness-related variables also predicted improvement of real-world functioning.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Elisa M. T. Melloni, Beatrice Bravi, Sara Poletti, Sara Dallaspezia, Barbara Barbini, Raffaella Zanardi, Francesco Benedetti
Summary: This study found that total sleep deprivation and light therapy can reduce the severity of depression, and this effect is closely related to changes in the concentrations of glutamate and glutamine+glutamate. This finding contributes to a better understanding of the antidepressant mechanism of chronotherapy.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Naoto Adachi, Yukihisa Kubota, Eiichiro Goto, Koichiro Watanabe, Reiji Yoshimura, Takashi Tsuboi, Norio Yasui-Furukori, Masaki Kato, Seiji Hongo, Takaharu Azekawa, Eiichi Katsumoto, Koji Edagawa, Atsuo Nakagawa, Toshiaki Kikuchi, Hitoshi Ueda, Kazuhira Miki
Summary: In Japan, the cost of outpatient treatments for bipolar disorder is mainly attributed to the expenses of medications, which are steadily increasing. Factors such as social adjustment, depressive symptoms, age, rapid cycling, psychotic symptoms, and comorbid mental disorders are strongly associated with the daily cost of psychotropic drugs. The annual cost of outpatient bipolar disorder treatments in Japan is equivalent to that of OECD countries (excluding the US) and higher than some Asian countries.
ANNALS OF MEDICINE
(2023)
Article
Psychiatry
M. Fornaro, S. Novello, A. Fusco, A. Anastasia, M. De Prisco, A. M. Mondin, P. Mosca, F. Iasevoli, A. de Bartolomeis
Summary: Drop-out from follow-up visits is common in depressed patients, particularly in those with bipolar disorder and major depressive disorder. Younger age, early onset, shorter illness duration, and certain clinical features were associated with higher drop-out rates. Specific interventions may be needed to improve treatment adherence in these patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Mao-Hsiu Hua, Mu-Hong Chen, Ju-Wei Hsu, Kai-Lin Huang, Shih-Jen Tsai, Cheng-Ta Li, Ya-Mei Bai
Summary: The study found that euthymic patients with bipolar I and bipolar II disorders showed similar levels of proinflammatory cytokines and cognitive function deficits (especially in working memory), with no significant differences between the two disorders. Further research is needed to explore whether there may be a common pathophysiology contributing to the shared inflammatory and cognitive alterations in bipolar I and bipolar II disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Sandeep Grover, Ajit Avasthi, Rahul Chakravarty, Amitava Dan, Kaustav Chakraborty, Rajarshi Neogi, Avinash Desouza, Omkar Nayak, Samir Praharaj, Vikas Menon, Raman Deep, Manish Bathla, Alka A. Subramanyam, Naresh Nebhinani, AbMajid Gania, Bhavesh Lakdawala, Ranjan Bhattacharya
Summary: This multicentric study from India examined the long term course and outcome of bipolar disorder (BD), finding that the average number of manic episodes in the study sample exceeded the average number of depressive episodes. A higher proportion of males had a history of co-morbid substance dependence.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Lakshmi N. Yatham, Shyam Sundar Arumugham, Muralidharan Kesavan, Kanchana Ramachandran, Nithyananda S. Murthy, Gayatri Saraf, Yongdong Ouyang, David J. Bond, Ayal Schaffer, Arun Ravindran, Nisha Ravindran, Benicio N. Frey, Andree Daigneault, Serge Beaulieu, Raymond W. Lam, Nithin Kondapuram, M. S. Reddy, R. P. Bhandary, Mysore V. Ashok, Kyooseob Ha, Yong Min Ahn, Roumen Milev, Hubert Wong, Y. C. Janardhan Reddy
Summary: This study investigated whether adjunctive antidepressant treatment after remission of depression could prevent relapse of any mood episode in patients with bipolar I disorder. The results showed no significant difference between the group receiving adjunctive treatment and the group receiving placebo during the 52-week maintenance treatment period.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Clinical Neurology
Eva Z. Reininghaus, Mirko Manchia, Nina Dalkner, Nina Bonkat, Alessio Squassina, Isabel Hodl, Eduard Vieta, Andreas Reif, Tomas Hajek, Mikael Landen, Christoph U. Correll, Jan Scott, Bruno Etain, Marcella Rietschel, Veerle Bergink, Monica Martinez-Cengotitabengoa, Lars Vedel Kessing, Andrea Fagiolini, Michael Bauer, Guy Goodwin, Ana Gonzalez-Pinto, Ralph W. Kupka, Thomas G. Schulze, Trine Lagerberg, Aysegul Yildiz, Chantal Henry, Gunnar Morken, Phillip Ritter, Rene Ernst Nieslen, Rasmus W. Licht, Andreas Bechdolf, Ole A. Andreassen, Frederike Tabea Fellendorf
Summary: Patients with bipolar disorder may have a higher risk of contracting COVID-19, leading to worsened clinical outcomes. However, research on vaccination in individuals with BD is limited and lacks substantial evidence.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Afra van der Markt, Ursula M. H. Klumpers, Annemiek Dols, Marco P. Boks, Annabel Vreeker, Aartjan T. F. Beekman, Ralph W. Kupka
Summary: This study aimed to identify a combination of clinical characteristics associated with progression in two clinical staging models for bipolar disorder. The results showed that factors such as familial loading, childhood abuse, earlier onset, longer illness duration, psychiatric comorbidity, and treatment resistance were predictors for a higher stage in the progression of the disorder.
Article
Geriatrics & Gerontology
Nadine P. G. Paans, Nicole Korten, Melis Orhan, Anne Ensing, Sigfried N. T. M. Schouws, Ralph Kupka, Patricia van Oppen, Annemiek Dols
Summary: Previous research has shown that non-affective cognition is positively associated with social functioning in adult patients with bipolar disorder (BD), while the association between affective cognition and social functioning is not significant. However, there is an interaction between non-affective and affective cognition.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Editorial Material
Clinical Neurology
Afra van der Markt, Ursula Klumpers, Annemiek Dols, Aartjan Beekman, Edward Shorter, Ralph Kupka
Review
Pharmacology & Pharmacy
Heinz Grunze, Michael Soyka
Summary: This paper explores the available pharmacotherapies for AUD, BD, and their potential utility in comorbid BD and AUD. It also touches on the epidemiology, diagnosis, and common neurobiological traits of comorbid BD and AUD to some extent.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Miriam von Mucke Similon, Cecilia Paasche, Fas Krol, Bernard Lerer, Guy M. Goodwin, Michael Berk, Andreas Meyer-Lindenberg, Terence A. Ketter, Lakshmi N. Yatham, Joseph F. Goldberg, Gin S. Malhi, Rif El-Mallakh, Rasmus W. Licht, Allan H. Young, Flavio Kapczinski, Marnina Swartz, Michal Hagin, Carla Torrent, Alessandro Serretti, Aysegul Yildiz, Anabel Martinez-Aran, Sergio Strejilevich, Janusz Rybakowski, Gabriele Sani, Heinz Grunze, Gustavo Vazquez, Ana Gonzales Pinto, Jean Michel Azorin, Willem Nolen, Othman Sentissi, Carlos Lopez-Jaramillo, Benicio N. Frey, Andrew Nierenberg, Gordon Parker, David J. Bond, Adam Cohen, Alfonso Tortorella, Giulio Perugi, Eduard Vieta, Dina Popovic
Summary: This study provides consensus recommendations for the selection of clinical trial design in psychiatry by surveying clinical and academic experts. The expert panel achieved consensus on 7 out of 21 recommendations regarding the use of randomized clinical trials, strongly supporting their use.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Roger S. McIntyre, Martin Aida, Ross J. Baldessarini, Michael Bauer, Michael Berk, Christoph U. Correll, Andrea Fagiolini, Kostas Fountoulakis, Mark A. Frye, Heinz Grunze, Lars Kessing, David J. M. Iklowitz, Gordon Parker, Robert M. Post, Alan C. Swann, Trisha Suppes, Eduard Vieta, Allan Young, Mario Maj
Summary: This paper aims to synthesize the clinical characteristics of patients with bipolar disorder to improve their health outcomes and treatment choices. Existing data indicate that certain features of bipolar disorder are associated with illness trajectory, treatment response, and suicide risk. Early environmental exposure is also related to the complexity of the illness.
Article
Clinical Neurology
Rosalie A. L. Beekman, Margreet ten Have, Ron de Graaf, Ralph W. Kupka, Eline J. Regeer
Summary: This study examines the characteristics, course, and risk factors for an unfavourable course of subthreshold manic symptoms (subM), which are a risk factor for bipolar disorder. The study found that subM had a three-year prevalence of 4.9% and that 25.0% of individuals with subM had persistent symptoms and 6.1% transitioned to full manic episodes. The study also identified 11 risk factors for an unfavourable course, including a history of depression, living alone, and elevated neuroticism score.
Article
Clinical Neurology
Alexandra J. M. Beunders, Federica Klaus, Almar A. L. Kok, Sigfried N. T. M. Schouws, Ralph W. Kupka, Hilary P. Blumberg, Farren Briggs, Lisa T. Eyler, Brent P. Forester, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Benoit H. Mulsant, Regan E. Patrick, Soham Rej, Martha Sajatovic, Kaylee Sarna, Ashley Sutherland, Joy Yala, Eduard Vieta, Luca M. Villa, Nicole C. M. Korten, Annemieke Dols
Summary: This study compared bipolar I disorder (BD-I) and bipolar II disorder (BD-II) in a large, global sample and found no significant differences between the two in terms of general functioning, cognition, and somatic burden. These findings suggest that the distinction between BD-I and BD-II may not be applicable to geriatric bipolar disorder patients.
Review
Psychiatry
Anna Grunze, Sergey Mosolov, Heinz Grunze, Christoph Born
Summary: This narrative review examines the epidemiology, consequences, and treatment options of tobacco use disorder (TUD) and nicotine dependence (ND) in individuals with bipolar disorder (BD). The study found that smoking rates are 2-3 times higher in individuals with BD compared to community samples. Smoking has a detrimental impact on both mental and physical health as well as mortality in individuals with BD. Treatment options include pharmacological interventions and psychosocial interventions.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Jannis T. Kraiss, Peter M. ten Klooster, Melissa Chrispijn, Anja Stevens, Bennard Doornbos, Ralph W. Kupka, Ernst T. Bohlmeijer
Summary: This study evaluated the effectiveness of a multicomponent positive psychology intervention (PPI) as an adjunct to treatment for euthymic patients with bipolar disorder (BD). The results showed that the PPI group had significantly improved mental well-being and personal recovery compared to the group that received only usual treatment. Therefore, this intervention method is valuable for the treatment of euthymic BD patients.
Article
Clinical Neurology
Imke Hanssen, Peter ten Klooster, Marloes Huijbers, Marc Lochmann van Bennekom, Elvira Boere, Ebtisam El Filali, Bart Geerling, Peter Goossens, Ralph Kupka, Anne Speckens, Eline Regeer
Summary: This article presents the development and psychometric evaluation of the Manic Thought Inventory (MTI), a self-report inventory designed to assess the presence of typical (hypo)manic cognitions. Results from two studies demonstrate that the MTI has good psychometric properties and can be valuable in both research and clinical practice.
Editorial Material
Clinical Neurology
Heinz Grunze
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Heinz Grunze
Summary: The comorbidity of substance use disorder with schizophrenia significantly increases morbidity and mortality compared to schizophrenia alone. Dopaminergic dysregulation appears to be a common pathophysiological basis of this comorbidity. Cariprazine, a partial agonist of D3 and D2 dopamine receptors, shows promising results in early clinical observations for the therapy of dual disorder.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Psychology, Clinical
Afra van der Markt, Ursula Klumpers, Annemiek Dols, Nicole Korten, Marco P. Boks, Roel A. Ophoff, Aartjan Beekman, Ralph Kupka, Neeltje E. M. van Haren, Hugo Schnack
Summary: This study investigates the association between brain structures and illness progression in bipolar disorder (BD) and explores the potential of brain-predicted age difference (brain-PAD) as a biomarker for BD staging. The results suggest that higher brain-PAD is associated with impaired inter-episodic functioning, but this association loses significance after considering confounding factors such as lithium-use and comorbid anxiety disorders. There is no significant association between global and (sub)cortical brain measures and illness stages.
PSYCHOLOGICAL MEDICINE
(2023)