Article
Clinical Neurology
Priya Sunder, Ming -Fang Chia, Kate Filia, Craig Macneil, Melissa Hasty, Christopher Davey, Patrick McGorry, Michael Berk, Sue Cotton, Aswin Ratheesh
Summary: This study examined the impact of guideline concordance on outcomes in youth with early-stage BD-I. Higher concordance was associated with worse outcomes, but this relationship was moderated by illness characteristics, severity, and insight. More interventions or modified guidelines may be needed for youth with poor insight, greater severity, and mixed/rapid cycling features.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Viswam Subeesh, Eswaran Maheswari, Hemendra Singh, Reddy Neha, Faizan Mazhar
Summary: The study found that the treatment response at week 2 can predict the outcome after 8 weeks for patients with first-episode psychosis, while the response at week 4 provides a more accurate prediction.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Reeha Sharon, Theis Lange, Mia Aakjaer, Sarah Brogger Kristiansen, Morten Baltzer Houlind, Morten Andersen
Summary: The study aimed to investigate the association between acute kidney injury (AKI) and the use of second-generation antipsychotics (SGA) in older adults. The findings showed a significantly increased 90-day AKI risk associated with the use of olanzapine, an elevated but not significant risk with quetiapine, and no association with risperidone.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Clinical Neurology
Shuzhe Zhou, Qinhong Ma, Yiwei Lou, Xiaozhen Lv, Hongjun Tian, Jing Wei, Kerang Zhang, Gang Zhu, Qiaoling Chen, Tianmei Si, Gang Wang, Xueyi Wang, Nan Zhang, Yu Huang, Qi Liu, Xin Yu
Summary: This study utilized machine learning models to explore baseline variables for predicting the 8-week treatment outcome of patients with MDD receiving SSRIs. Results showed that neurocognitive functions and anxiety symptoms were important predictors, with SVM achieving an accuracy of 74.49% and sensitivity and specificity of 0.899 and 0.422, respectively.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
You-Cheng Li, Yu-Hsuan Shih, Tsung-Chih Chen, Jyh-Pyng Gau, Yu-Chen Su, Mei-Hui Chen, Chiann-Yi Hsu, Cai-Sian Liao, Chieh-Lin Jerry Teng
Summary: This study revealed that older age, poor clinical performance, and a high tumor burden are risk factors for early mortality in AML patients receiving remission induction chemotherapy. Patients with at least two of these factors are more likely to experience early mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Santiago Sanchez-Sosa, Carlos Rodriguez-Medina, Ruth Stuckey, Yanira Florido, Guillermo Santana, Jesus Maria Gonzalez Martin, Naylen Cruz-Cruz, Melissa Torres-Ochando, Rosa Fernandez, Nuria Sanchez-Farias, Antonia Cionfrini, Teresa Molero Labarta, Maria Teresa Gomez-Casares, Cristina Bilbao-Sieyro
Summary: Recent advances in sequencing technologies and genomics have led to the development of targeted therapies for personalized treatment of acute myeloid leukemia (AML). However, the molecular profiles of patients who will respond to induction therapy and novel directed therapies are still unknown.
Article
Clinical Neurology
Wei Zheng, Mei He, Li-Mei Gu, Guo-Hui Lao, Dan-Feng Wang, Jian-Xin Mai, Hua-Wang Wu, Sha Nie, Xiong Huang
Summary: Early symptom improvement can predict eventual remission in TRD patients undergoing ECT with ketofol anesthesia. A 45% reduction in HAMD-17 score after 3 ECT sessions was found to be the optimal definition of early improvement for predicting final remission.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Rheumatology
Jonathan Aldridge, Kerstin Andersson, Inger Gjertsson, Anna-Karin Hultgard Ekwall, Magnus Hallstrom, Ronald van Vollenhoven, Anna-Carin Lundell, Anna Rudin
Summary: This study found that the proportions of PD-1(+)TFh and CTLA-4(+) conventional CD4(+) T cells in circulation at baseline may serve as predictive biomarkers for remission in early RA after CTLA-4Ig treatment.
Article
Microbiology
Jie Liu, Huaying Fang, Na Hong, Chaolan Lv, Qihua Zhu, Yinping Feng, Bo Wang, Jiashuang Tian, Yue Yu
Summary: Patients with ulcerative colitis (UC) have low response rates to anti-integrin medications in the latest VARSITY study. Our study aimed to identify differences in the gut microbiome and metabonomics patterns between early remission and nonremission patients, and to explore the diagnostic value in predicting clinical remission to anti-integrin therapy accurately. We found that Verrucomicrobiota, butyric acid, and isobutyric acid improved the diagnosis of early remission to anti-integrin therapy.
MICROBIOLOGY SPECTRUM
(2023)
Article
Emergency Medicine
Sung Jin Kim, Hanjin Cho, Sejoong Ahn, Joo Yeong Kim, Juhyun Song, Jong-Hak Park
Summary: Clinical research on drug intoxication in emergency departments is important, but there are currently no clear biomarkers for predicting adverse events. This study aimed to evaluate the prognostic value of serum lactate concentrations and kinetics in patients with acute drug overdose. The results showed limited predictive utility of lactate concentrations and kinetics in predicting adverse events in these patients and caution is advised when considering them for clinical decision-making.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Surgery
Christophe Masset, Julien Branchereau, Georges Karam, Maryvonne Hourmant, Jacques Dantal, Magali Giral, Claire Garandeau, Aurelie Meurette, Clarisse Kerleau, Delphine Kervella, Simon Ville, Gilles Blancho, Diego Cantarovich
Summary: The study evaluated the clinical interest of C-peptide monitoring after pancreas transplantation, highlighting its value in early identification of graft function failure.
TRANSPLANT INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Tomonori Takahashi, Hiroyuki Iwano, Kentaro Shibayama, Takeshi Kitai, Hidekazu Tanaka, Hirotsugu Yamada, Masataka Sata, Kenya Kusunose
Summary: The predictive value of the Forrester classification based on Doppler echocardiography at admission for the short-term prognosis of patients with acute HF was evaluated. Patients with low CI had a higher risk of composite outcome.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ki-Woong Nam, Chi Kyung Kim, Byung-Woo Yoon, Inpyeong Hwang, Chul-Ho Sohn
Summary: This study evaluated the effects of perfusion deficits in multiphase ASL on the occurrence of ERIL in AIS patients. The results showed that ASL perfusion deficit was positively associated with ERIL, and this association was attenuated by ATA and enhanced by IAS.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Lida Alkisti Xenaki, Pentagiotissa Stefanatou, Eirini Ralli, Alex Hatzimanolis, Stefanos Dimitrakopoulos, Rigas Filippos Soldatos, Ilias I. Vlachos, Mirjana Selakovic, Stefania Foteli, Ioannis Kosteletos, Nikos Nianiakas, Aggeliki Ntigridaki, Theoni -Fani Triantafyllou, Marina Voulgaraki, Leonidas Mantonakis, Apostolos Tsapas, Vasilios P. Bozikas, Konstantinos Kollias, Nikos C. Stefanis
Summary: This study investigated the relationship between severity, early clinical improvement, and symptom remission in first episode psychosis (FEP) with jumping to conclusions (JTC) as a explanatory factor. The findings indicate that severity of positive symptoms is not associated with hastiness in decision-making, but rather with a heightened conservatism in terms of increased data gathering.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Economics
Roger S. McIntyre, Sara Higa, Quan Doan, Diana Amari, David Oliveri, Patrick Gillard, Amanda Harrington
Summary: This study aimed to investigate the place of care and associated costs during acute bipolar I disorder episodes. The findings revealed that most patients chose outpatient treatment, and inpatient care was 8-10 times more expensive than outpatient care.
JOURNAL OF MEDICAL ECONOMICS
(2022)