Allopurinol enhanced thiopurine treatment for inflammatory bowel disease: safety considerations and guidelines for use

Use of Allopurinol with Low-Dose 6-Mercaptopurine in Inflammatory Bowel Disease to Achieve Optimal Active Metabolite Levels: A Review of Four Cases and the Literature

(2016) Todd N Witte et al.   CANADIAN JOURNAL OF GASTROENTEROLOGY

494 Association Between Thiopurines Metabolites Levels and Clinical Remission in IBD Patients: An Updated Meta-Analysis

(2015) Amelie C. Moreau et al.   GASTROENTEROLOGY

Tu1157 Low-Dose Thiopurine and Allopurinol Co-Therapy Results in Significant Cost Savings At a District General Hospital

(2015) Heather E. Johnson et al.   GASTROENTEROLOGY

Tu1166 Genetic and Serologic Associations With 6-MMP Preferential Metabolizers Reveal Novel Pathways That May Be Involved in Thiopurine Metabolism

(2015) Sundip S. Karsan et al.   GASTROENTEROLOGY

Su1752 Identification of New Genetic Variants Related to Thiopurine-Induced Myelotoxicity in Inflammatory Bowel Disease (IBD) Patients With Normal Thiopurines-Methyltransferase (TPMT): A Genome-Wide Association Study

(2015) Maria Chaparro et al.   GASTROENTEROLOGY

955 Effect of Allopurinol on Clinical, Endoscopic and Metabolic Outcomes of Thiopurine Therapy in IBD

(2015) Brigitte Moreau et al.   GASTROENTEROLOGY

Su1224 Long Term Outcome of Azathioprine Therapy in 353 Consecutive IBD Patients

(2015) Heather E. Johnson et al.   GASTROENTEROLOGY

Allopurinol safely and effectively optimises thiopurine metabolites in patients with autoimmune hepatitis

(2013) Y. S. de Boer et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Mucosal Improvement in Patients With Moderate to Severe Postoperative Endoscopic Recurrence of Crohn’s Disease and Azathioprine Metabolite Levels

(2013) Sieglinde Angelberger et al.   INFLAMMATORY BOWEL DISEASES

Nomenclature for alleles of the thiopurine methyltransferase gene

(2013) Malin L. Appell et al.   Pharmacogenetics and Genomics

Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolism

(2012) D. Q. Shih et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Why thiopurine metabolites are relevant

(2012) A. B. Friedman et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Use of a xanthine oxidase inhibitor in autoimmune hepatitis

(2012) Safa Al-Shamma et al.   HEPATOLOGY

Safety and Effectiveness of Long-term Allopurinol–Thiopurine Maintenance Treatment in Inflammatory Bowel Disease

(2012) Frank Hoentjen et al.   INFLAMMATORY BOWEL DISEASES

Therapeutic drug monitoring of thiopurine metabolites in adult thiopurine tolerant IBD patients on maintenance therapy

(2012) Lennard P.L. Gilissen et al.   Journal of Crohns & Colitis

Optimising outcome on thiopurines in inflammatory bowel disease by co-prescription of allopurinol

(2012) Melissa A. Smith et al.   Journal of Crohns & Colitis

Current relevance of pharmacogenetics in immunomodulation treatment for Crohn's disease

(2012) Rebecca L Roberts et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Thiopurine metabolites and TPMT activity measurement in inflammatory bowel disease

(2011) E. Louis   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Efficacy of Immunosuppressive Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

(2011) Khurram J Khan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Allopurinol Enhances the Activity of Hypoxanthine-Guanine Phosphoribosyltransferase in Inflammatory Bowel Disease Patients During Low-Dose Thiopurine Therapy: Preliminary Data of an Ongoing Series

(2011) Margien L. Seinen et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease

(2010) A. ANSARI et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Influence of 5-aminosalicylic acid on 6-thioguanosine phosphate metabolite levels: a prospective study in patients under steady thiopurine therapy

(2010) P de Graaf et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prolonged thioguanine therapy is well tolerated and safe in the treatment of ulcerative colitis

(2010) Dirk P. van Asseldonk et al.   DIGESTIVE AND LIVER DISEASE

Thiopurine metabolism monitoring: implications in inflammatory bowel diseases

(2010) Olivier Dewit et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Natural history of azathioprine-associated lymphopenia in inflammatory bowel disease patients

(2010) Ahmad Al Rifai et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Thiopurine therapy in inflammatory bowel disease patients: Analyses of two 8-year intercept cohorts

(2010) B. Jharap et al.   INFLAMMATORY BOWEL DISEASES

Incidence of nodular regenerative hyperplasia in inflammatory bowel disease patients treated with azathioprine

(2010) Philippe Seksik et al.   INFLAMMATORY BOWEL DISEASES

Combination of thiopurines and allopurinol: Adverse events and clinical benefit in IBD

(2010) Shail M. Govani et al.   Journal of Crohns & Colitis

Assessment of non-cirrhotic portal hypertension associated with thiopurine therapy in inflammatory bowel disease

(2010) Emma Calabrese et al.   Journal of Crohns & Colitis

Azathioprine and allopurinol: A two-edged interaction

(2010) Richard B Gearry et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Switching metabolism—can two drugs be better than one?

(2010) Miles P. Sparrow   Nature Reviews Gastroenterology & Hepatology

Monitoring of Azathioprine Metabolites in Pediatric Patients With Autoimmune Hepatitis

(2010) Thi-Mai-Hoang Nguyen et al.   THERAPEUTIC DRUG MONITORING

Management of Crohn's Disease in Adults

(2009) Gary R Lichtenstein et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Algorithms Outperform Metabolite Tests in Predicting Response of Patients With Inflammatory Bowel Disease to Thiopurines

(2009) Akbar K. Waljee et al.   Clinical Gastroenterology and Hepatology

Monitoring of Thiopurine Metabolites in Patients With Inflammatory Bowel Disease-What Is Actually Measured?

(2009) Svante Vikingsson et al.   THERAPEUTIC DRUG MONITORING

A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout

(2009) Jeannie Chao et al.   Current Rheumatology Reports

Clinical pharmacology and pharmacogenetics of thiopurines

(2008) Srikumar Sahasranaman et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Risk Factors for Opportunistic Infections in Patients With Inflammatory Bowel Disease

(2008) Murat Toruner et al.   GASTROENTEROLOGY

Further experience with the use of 6-thioguanine in patients with Crohnʼs disease

(2008) Azhar Ansari et al.   INFLAMMATORY BOWEL DISEASES

Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease

(2008) Riad M. Rahhal et al.   INFLAMMATORY BOWEL DISEASES