Acute cholestatic hepatitis induced by fenofibrate

P>We report a case of acute liver injury probably due to fenofibrate. A 50-year-old female without a history of liver disease developed cholestatic hepatitis during her second week of fenofibrate treatment. Laboratory tests on admission showed serum bilirubin 534 center dot 0 mcmol/L (conjugated 444 center dot 0), alkaline phosphatase (AP) 8 center dot 76, gamma-glutamyl traspeptidase (GGT) 20 center dot 92, alanine aminotransferase (ALT) 2 center dot 6, aspartate aminotransferase (AST) 3 center dot 64 mckat/L. Fenofibrate withdrawal and ursodeoxycholic acid (750 mg daily) administration was rapidly followed by a favourable outcome.