Pharmacological Modulation of Peripheral T and B Lymphocytes by a Selective Sphingosine 1-Phosphate Receptor-1 Modulator

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

(2010) M. Mehling et al.   NEUROLOGY

A Placebo-Controlled Trial of Oral Cladribine for Relapsing Multiple Sclerosis

(2010) Gavin Giovannoni et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS

(2009) Laura J. Sim-Selley et al.   JOURNAL OF NEUROCHEMISTRY

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

Cyclical and Dose-Dependent Responses of Adult Human Mature Oligodendrocytes to Fingolimod

(2008) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects

(2008) John M. Kovarik et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Modulating tone: the overture of S1P receptor immunotherapeutics

(2008) Hugh Rosen et al.   IMMUNOLOGICAL REVIEWS

A Mechanistic Study to Assess Whether Isoproterenol Can Reverse the Negative Chronotropic Effect of Fingolimod

(2008) Joh M. Kovarik et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Use of an Exposure-Response Model to Aid Early Drug Development of an Oral Sphingosine 1-Phosphate Receptor Modulator

(2008) Shashank Rohatagi et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Accumulation of Fingolimod (FTY720) in Lymphoid Tissues Contributes to Prolonged Efficacy

(2008) S.-C. Sensken et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis

(2008) M. Mehling et al.   NEUROLOGY

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

FTY720 modulates human oligodendrocyte progenitor process extension and survival

(2007) Veronique E. Miron et al.   ANNALS OF NEUROLOGY