Review
Biochemistry & Molecular Biology
Mariane Beatriz Sordi, Ricardo de Souza Magini, Layla Panahipour, Reinhard Gruber
Summary: Pyroptosis is a pathological mechanism in the cause of periodontitis, involving caspase activation, cleavage of gasdermin D, and secretion of interleukins to induce tissue destruction. Removing periopathogens' virulence factors that trigger pyroptosis may be a potential strategy to combat periodontal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Paavai Ilango, Jaideep Mahendra, Little Mahendra, Sanjay M. Cherian, Vasugi Suresh, Arulpari Mahalingam, Vinoth Khanna, Abirami Thanigaimalai
Summary: The study aimed to evaluate the prevalence of Epstein-Barr virus (EBV), cytomegalovirus (CMV), and herpes simplex virus (HSV) in patients with periodontitis and/or coronary artery disease (CAD) and compare it with their healthy controls. The results showed a higher prevalence of EBV and CMV in patients with periodontitis, indicating the significant role of these viruses in periodontitis. The study also found that HSV was more prevalent in patients with CAD, suggesting a potential link between CAD and periodontitis.
Article
Immunology
Giulia Melo Lettieri, Luander Medrado Santiago, Giancarlo Crosara Lettieri, Luiz Gustavo dos Anjos Borges, Leticia Marconatto, Laudimar Alves de Oliveira, Naile Dame-Teixeira, Loise Pedrosa Salles
Summary: This study characterized the oral phenotype and salivary microbiome of three sisters with Papillon-Lefevre syndrome (PLS). The main phenotypic characteristics of PLS were bone loss and premature tooth loss. They all presented hyposalivation, but the salivary microbiota differed among the sisters.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Jessica A. Ferreira, Karla Z. Kantorski, Nileshkumar Dubey, Arwa Daghrery, J. Christopher Fenno, Yuji Mishina, Hsun-Liang Chan, Gustavo Mendonca, Marco C. Bottino
Summary: This study developed personalized antibiotic-laden scaffolds for periodontitis treatment using electrospinning techniques. Evaluation through chemo-morphological analyses, cytocompatibility assessment, and antimicrobial validation showed promising results for promoting new bone formation, reducing bone loss, and lowering inflammatory response. The fabrication of defect-specific antibiotic-laden scaffolds holds potential for personalized medication and regenerative properties.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, General & Internal
Ana Maria Ramirez-Pena, Arturo Sanchez-Perez, Matilde Campos-Aranda, Francisco Javier Hidalgo-Tallon
Summary: This study assessed the effectiveness of ozone therapy as an adjunct to mechanical therapy in periodontitis patients. The results showed that ozone treatment significantly reduced the gingival index, improved clinical attachment, reduced mobility, and showed significant differences in subgingival flora. This suggests that ozone therapy is effective and well tolerated in cases of generalized chronic periodontitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ahmed Chaudhry, Nur Karyatee Kassim, Siti Lailatul Akmar Zainuddin, Haslina Taib, Hanim Afzan Ibrahim, Basaruddin Ahmad, Muhammad Hafiz Hanafi, Azreen Syazril Adnan
Summary: This study found that inflammatory biomarkers levels were higher in patients with chronic kidney disease (CKD) and chronic periodontitis (CP). After non-surgical periodontal therapy (NSPT), the levels of inflammatory biomarkers in CKD patients significantly reduced, and they showed a good response to the treatment. Therefore, it is important to screen and monitor the periodontal health of CKD patients.
Article
Dentistry, Oral Surgery & Medicine
Diana Estefania Ramos Pena, Emerson de Souza Santos, Rafael dos Santos Bezerra, Atila V. V. Nobre, Tabata L. S. Polvora, Benedito A. L. da Fonseca, Bruno Pozzetto, Alan G. Lourenco, Cassio do Nascimento, Ana Carolina F. Motta
Summary: HIV-1 infection is associated with periodontal disease, and non-surgical periodontal debridement (NSPD) affects the periodontal microbiota. This study found that HIV-1-infected individuals had lower microbiota diversity in the subgingival area compared to non-infected individuals. NSPD caused changes in the microbiota of both groups, with a greater impact on the HIV group, but also had a positive impact on immune markers in HIV-1-infected patients. Therefore, controlling periodontitis should be included in oral primary care to better control HIV-1 infection.
JOURNAL OF PERIODONTOLOGY
(2022)
Review
Infectious Diseases
Luigi Nibali, Jacopo Buti, Luigi Barbato, Francesco Cairo, Filippo Graziani, Soren Jepsen
Summary: A systematic evaluation of studies on periodontal regenerative/reconstructive surgery suggests that systemic antibiotics may provide some clinical improvements in intrabony defects but not in furcations. The need for adjunctive use of systemic antibiotics in this context remains uncertain, considering the principles of antibiotic stewardship.
Article
Dentistry, Oral Surgery & Medicine
F. R. M. Leite, R. Lopez, J. B. Pajaniaye, G. G. Nascimento
Summary: This study investigated the influence of different levels of smoking on periodontal healing and found that heavy smokers had worse periodontal parameters compared to light smokers/quitters and moderate smokers after nonsurgical periodontal therapy. Therefore, smoking cessation should be included in periodontal therapy to achieve optimal treatment outcomes.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Immunology
Victor Vaernewyck, Boaz Arzi, Niek N. Sanders, Eric Cox, Bert Devriendt
Summary: Periodontal disease affects a large portion of adults and can lead to systemic disorders. Control options primarily focus on removing plaque and calculus, but altering host inflammatory response and reducing bacterial triggers are also important. Vaccines may provide a potent adjunct to mechanical debridement for prevention and treatment, but the complexity of periodontal disease complicates vaccine development. Recent advances in mucosal vaccination may help bridge this gap.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Tian-Jiao Li, Yi-hang Hao, Ya-ling Tang, Xin-hua Liang
Summary: Emerging evidence indicates a strong connection between periodontal diseases, including oral cancer. The pathogens responsible for periodontal diseases play a crucial role in the development of oral cancer by directly interacting with the host's epithelium and indirectly creating an inflammatory environment conducive to carcinogenesis. Additionally, the functional properties of the oral microbial community are associated with cancer development. Maintaining oral hygiene is essential for preventing oral diseases, particularly oral cancer.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
L. Nibali, V Sousa, M. Davrandi, L. S. Liu, D. Spratt, N. Donos
Summary: This study compared the subgingival microbiota of patients with aggressive and chronic periodontitis to healthy individuals and explored their associations with host genetic variants. The results showed limited microbial differences between AgP and CP, challenging the notion that periodontitis is associated with increased subgingival microbial diversity compared with periodontal health. Different microbial abundances were observed between periodontitis patients and healthy individuals, but no associations between genetic variants and microbial findings were detected.
JOURNAL OF DENTISTRY
(2022)
Review
Biochemistry & Molecular Biology
Mattia Di Stefano, Alessandro Polizzi, Simona Santonocito, Alessandra Romano, Teresa Lombardi, Gaetano Isola
Summary: The oral cavity harbors a complex microbial community, which can lead to periodontal damage. Periodontal disease is a common chronic inflammatory condition globally, with diverse clinical manifestations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Larissa Tursas, Merja Ylipalosaari, Suvi-Paivikki Sinikumpu, Laura Huilaja, Kaisa Tasanen, Antti Tiisanoja, Paula Tegelberg, Pekka Ylostalo, Anna-Maija Syrjala
Summary: According to this study, it was found that bleeding-deepened periodontal pockets are associated with seborrheic dermatitis and eczema nummulare. However, no association was found with atopic dermatitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alaa Aldoss, Rhodanne Lambarte, Fahd Alsalleeh
Summary: Hyperglycemic conditions limit the proliferation and migration of periodontal ligament fibroblasts (PDLFs) and enhance the expression of pro-inflammatory cytokines, leading to the development of periodontitis. The study investigated the effects of different glucose concentrations on PDLFs' viability, cytotoxicity, migration ability, and the expression of interleukins and Toll-like receptor (TLR)-4. The results showed that high glucose concentration (50 mM) decreased PDLFs viability and migration, and increased the expression of IL-6 and TLR-4.
Article
Endocrinology & Metabolism
Brian T. Steffen, Weihong Tang, Pamela L. Lutsey, Ryan T. Demmer, Elizabeth Selvin, Kunihiro Matsushita, Alanna C. Morrison, Weihua Guan, Mary R. Rooney, Faye L. Norby, Nathan Pankratz, David Couper, James S. Pankow
Summary: Proteomics analysis identified plasma proteins associated with the risk of type 2 diabetes. These proteins may serve as potential targets for intervention or pharmacological approaches to prevent, reverse, or slow down the progression of type 2 diabetes.
Article
Hematology
Brian T. Steffen, James S. Pankow, Faye L. Norby, Pamela L. Lutsey, Ryan T. Demmer, Weihua Guan, Nathan Pankratz, Aixin Li, Guning Liu, Kunihiro Matsushita, Adrienne Tin, Weihong Tang
Summary: This study identified proteomic signatures and pathways related to 23 gene loci associated with abdominal aortic aneurysm (AAA). The results suggest that low levels of neogenin and kit ligand may be novel risk factors for AAA development.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Olli Raitakari, Noora Kartiosuo, Katja Pahkala, Nina Hutri-Kahonen, Lydia A. Bazzano, Wei Chen, Elaine M. Urbina, David R. Jacobs Jr, Alan Sinaiko, Julia Steinberger, Trudy Burns, Stephen R. Daniels, Alison Venn, Jessica G. Woo, Terry Dwyer, Markus Juonala, Jorma Viikari
Summary: Elevated Lp(a) level in youth is associated with increased risk of adult atherosclerotic cardiovascular disease outcomes, but not with increased carotid intima-media thickness. This conclusion was derived from two similar studies.
Article
Cardiac & Cardiovascular Systems
Ravi Shah, Lyn M. Steffen, Matthew Nayor, Jared P. Reis, David R. Jacobs Jr, Norrina B. Allen, Donald Lloyd-Jones, Katie Meyer, Joanne Cole, Paolo Piaggi, Ramachandran S. Vasan, Clary B. Clish, Venkatesh L. Murthy
Summary: Metabolite signatures of diet are associated with long-term CM-CVD independent of lifestyle and traditional risk factors. Metabolomics improves precision to identify adverse consequences and pathways of diet-related CM-CVD.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemical Research Methods
Bruno Bohn, Pamela L. Lutsey, Weihong Tang, James S. Pankow, Faye L. Norby, Bing Yu, Christie M. Ballantyne, Eric A. Whitsel, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study compared the proteome of statin users and nonusers and found differences in proteins unrelated to lipid metabolism. Further investigation into these differences may help elucidate the pleiotropic effects of statins.
JOURNAL OF PROTEOMICS
(2023)
Letter
Respiratory System
Motahareh Vameghestahbanati, Coralynn Sack, Artur Wysoczanski, Eric A. Hoffman, Elsa Angelini, Norrina B. Allen, Alain G. Bertoni, Junfeng Guo, David R. Jacobs Jr, Joel D. Kaufman, Andrew Laine, Ching-Long Lin, Daniel Malinsky, Erin D. Michos, Elizabeth C. Oelsner, Steven J. Shea, Karol E. Watson, Andrea Benedetti, R. Graham Barr, Benjamin M. Smith
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Sport Sciences
Tyler D. Quinn, Abbi Lane, Kelley Pettee Gabriel, Barbara Sternfeld, David R. Jacobs, Peter Smith, Bethany Barone Gibbs
Summary: This study examined the associations between fitness and leisure-time physical activity (LTPA) and occupational physical activity (OPA). The results showed a positive correlation between LTPA and fitness, while OPA was negatively correlated with fitness. These findings are important for physical activity research and public health promotion.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Biochemistry & Molecular Biology
Drew R. R. Nannini, Yinan Zheng, Brian T. Joyce, Kyeezu Kim, Tao Gao, Jun Wang, David R. R. Jacobs, Pamela J. J. Schreiner, Kristine Yaffe, Philip Greenland, Donald M. M. Lloyd-Jones, Lifang Hou
Summary: The study reveals the association between marijuana use and DNA methylation levels, with a stronger correlation in recent and cumulative users. The research also identifies pathways and diseases related to cellular proliferation, hormone signaling, infections, schizophrenia, bipolar disorder, and substance-related disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Kelley Pettee Gabriel, Byron C. Jaeger, Cora E. Lewis, Stephen Sidney, Erin E. Dooley, Mercedes R. Carnethon, David R. Jacobs, Bjoern Hornikel, Jared P. Reis, Pamela J. Schreiner, JamesM. Shikany, Kara M. Whitaker, Alexander Arynchyn, Barbara Sternfeld
Summary: This study found that higher early-adulthood cardiorespiratory fitness and greater retention of early-adulthood cardiorespiratory fitness throughout midlife were associated with a lower risk of premature death and CVD events.
Letter
Critical Care Medicine
Gabrielle Y. Liu, Laura A. Colangelo, Raul San Jose Estepar, Anthony J. Esposito, Samuel Y. Ash, Bina Choi, David R. Jacobs, Mercedes R. Carnethon, George R. Washko, Ravi Kalhan
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Brian T. Steffen, David R. Jacobs, So-Yun Yi, Simon J. Lees, James M. Shikany, James G. Terry, Cora E. Lewis, John J. Carr, Xia Zhou, Lyn M. Steffen
Summary: This study aimed to determine whether long-term intake of artificial sweeteners and diet beverages is associated with higher fat deposition and risk of obesity. The results showed that long-term intake of sweeteners and diet beverages was associated with increased fat deposition, weight gain, and higher risk of obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniel A. Duprez, David R. Jacobs Jr
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Genetics & Heredity
Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian L. Lino Cardenas, Doris Wong, Haojie Lu, Chani J. Hodonsky, Lennart P. L. Landsmeer, Adam W. Turner, Minjung Kho, Natalie R. Hasbani, Paul S. de Vries, Donald W. Bowden, Sandesh Chopade, Joris Deelen, Ernest Diez Benavente, Xiuqing Guo, Edith Hofer, Shih-Jen Hwang, Sharon M. Lutz, Leo-Pekka Lyytikaeinen, Lotte Slenders, Albert V. Smith, Maggie A. Stanislawski, Jessica van Setten, Quenna Wong, Lisa R. Yanek, Diane M. Becker, Marian Beekman, Matthew J. Budoff, Mary F. Feitosa, Chris Finan, Austin T. Hilliard, Sharon L. R. Kardia, Jason C. Kovacic, Brian G. Kral, Carl D. Langefeld, Lenore J. Launer, Shaista Malik, Firdaus A. A. Mohamed Hoesein, Michal Mokry, Reinhold Schmidt, Jennifer A. Smith, Kent D. Taylor, James G. Terry, Jeroen van der Grond, Joyce van Meurs, Rozemarijn Vliegenthart, Jianzhao Xu, Kendra A. Young, Nuno R. Zilhao, Robert Zweiker, Themistocles L. Assimes, Lewis C. Becker, Daniel Bos, J. Jeffrey Carr, L. Adrienne Cupples, Dominique P. v. de Kleijn, Menno de Winther, Hester M. den Ruijter, Myriam Fornage, Barry I. Freedman, Vilmundur Gudnason, Aroon D. Hingorani, John E. Hokanson, M. Arfan Ikram, Ivana Isgum, David R. Jacobs, Mika Kaehoenen, Leslie A. Lange, Terho Lehtimaeki, Gerard Pasterkamp, Olli T. Raitakari, Helena Schmidt, P. Eline Slagboom, Andre G. Uitterlinden, Meike W. Vernooij, Joshua C. Bis, Nora Franceschini, Bruce M. Psaty, Wendy S. Post, Jerome I. Rotter, Johan L. M. Bjoerkegren, Christopher J. O'Donnell, Lawrence F. Bielak, Patricia A. Peyser, Rajeev Malhotra, Sander W. van der Laan, Clint L. Miller
Summary: This study conducted a large-scale analysis and identified eleven new risk loci for coronary artery calcification (CAC), a measure of subclinical atherosclerosis. These new loci are related to bone mineralization, phosphate catabolism, and hormone metabolic pathways. The findings contribute to a better understanding of the genetic architecture of CAC and provide potential targets for therapeutic interventions.
Article
Genetics & Heredity
Lisa de las Fuentes, Karen L. M. Schwander, Michael R. Brown, Amy R. Bentley, Thomas W. Winkler, Yun Ju Sung, Patricia B. Munroe, Clint L. Miller, Hugo Aschard, Stella Aslibekyan, Traci M. Bartz, Lawrence F. Bielak, Jin Fang Chai, Ching-Yu Cheng, Rajkumar Dorajoo, Mary F. Feitosa, Xiuqing Guo, Fernando P. Hartwig, Andrea Horimoto, Ivana Kolcic, Elise Lim, Yongmei Liu, Alisa K. Manning, Jonathan Marten, Solomon K. Musani, Raymond Noordam, Sandosh Padmanabhan, Tuomo Rankinen, Melissa A. Richard, Paul M. Ridker, Albert V. Smith, Dina Vojinovic, Alan B. Zonderman, Maris Alver, Mathilde Boissel, Kaare Christensen, Barry I. Freedman, Chuan Gao, Franco Giulianini, Sarah E. Harris, Meian He, Fang-Chi Hsu, Brigitte Kuehnel, Federica Laguzzi, Xiaoyin Li, Leo-Pekka Lyytikainen, Ilja M. Nolte, Alaitz Poveda, Rainer Rauramaa, Muhammad Riaz, Antonietta Robino, Tamar Sofer, Fumihiko Takeuchi, Bamidele O. Tayo, Peter J. van der Most, Niek Verweij, Erin B. Ware, Stefan Weiss, Wanqing Wen, Lisa R. Yanek, Yiqiang Zhan, Najaf Amin, Dan E. Arking, Christie Ballantyne, Eric Boerwinkle, Jennifer A. Brody, Ulrich Broeckel, Archie Campbell, Mickael Canouil, Xiaoran Chai, Yii-Der Ida Chen, Xu Chen, Kumaraswamy Naidu Chitrala, Maria Pina Concas, Ulf de Faire, Renee de Mutsert, H. Janaka de Silva, Paul S. de Vries, Ahn Do, Jessica D. Faul, Virginia Fisher, James S. Floyd, Terrence Forrester, Yechiel Friedlander, Giorgia Girotto, C. Charles Gu, Goeran Hallmans, Sami Heikkinen, Chew-Kiat Heng, Georg Homuth, Steven Hunt, M. Arfan Ikram, David R. Jacobs, Maryam Kavousi, Chiea Chuen Khor, Tuomas O. Kilpelainen, Woon-Puay Koh, Pirjo Komulainen, Carl D. Langefeld, Jingjing Liang, Kiang Liu, Jianjun Liu, Kurt Lohman, Reedik Magi, Ani W. Manichaikul, Colin A. McKenzie, Thomas Meitinger, Yuri Milaneschi, Matthias Nauck, Christopher P. Nelson, Jeffrey R. O'Connell, Nicholette D. Palmer, Alexandre C. Pereira, Thomas Perls, Annette Peters, Ozren Polasek, Olli T. Raitakari, Kenneth Rice, Treva K. Rice, Stephen S. Rich, Charumathi Sabanayagam, Pamela J. Schreiner, Xiao-Ou Shu, Stephen Sidney, Mario Sims, Jennifer A. Smith, John M. Starr, Konstantin Strauch, E. Shyong Tai, Kent D. Taylor, Michael Y. Tsai, Andre G. Uitterlinden, Diana van Heemst, Melanie Waldenberger, Ya-Xing Wang, Wen-Bin Wei, Gregory Wilson, Deng Xuan, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Diane M. Becker, Amelie Bonnefond, Donald W. Bowden, Richard S. Cooper, Ian J. Deary, Jasmin Divers, Tonu Esko, Paul W. Franks, Philippe Froguel, Christian Gieger, Jost B. Jonas, Norihiro Kato, Timo A. Lakka, Karin Leander, Terho Lehtimaki, Patrik K. E. Magnusson, Kari E. North, Ioanna Ntalla, Brenda Penninx, Nilesh J. Samani, Harold Snieder, Beatrice Spedicati, Pim van der Harst, Henry Voelzke, Lynne E. Wagenknecht, David R. Weir, Mary K. Wojczynski, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Claude Bouchard, Daniel Chasman, Michele Evans, Ervin R. Fox, Vilmundur Gudnason, Caroline Hayward, Bernardo L. Horta, Sharon L. R. Kardia, Jose Eduardo Krieger, Dennis O. Mook-Kanamori, Patricia A. Peyser, Michael M. Province, Bruce M. Psaty, Igor Rudan, Xueling Sim, Blair H. Smith, Rob M. van Dam, Cornelia M. van Duijn, Tien Yin Wong, Donna K. Arnett, Dabeeru C. Rao, James Gauderman, Ching-Ti Liu, Alanna C. Morrison, Jerome I. Rotter, Myriam Fornage
Summary: This study conducted a genome-wide meta-analysis to investigate the interaction between educational attainment and lipid levels. They identified novel lipid loci that were not previously detected by analyses limited to main genetic effects. The study also highlighted the potential importance of brain-adipose-liver communication in lipid metabolism and identified gene targets that interact with drugs approved by the FDA.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Daniel J. Mcdonough, Mahesh Mathew, Zachary C. Pope, Pamela J. Schreiner, David R. Jacobs Jr, Lisa B. Vanwagner, John Jeffrey Carr, James G. Terry, Kelley Pettee Gabriel, Jared P. Reis, Mark A. Pereira
Summary: This study examined the association between lifestyle factors and NAFLD and found that regular moderate-vigorous aerobic and muscle-strengthening activities, along with reduced television viewing time, significantly reduce the risk of NAFLD.
JOURNAL OF CLINICAL MEDICINE
(2023)