Serum interleukin-6 may modulate periodontal inflammation in type 1 diabetic subjects

Aims: To evaluate the associations between serum inflammatory biomarkers and periodontal inflammation in subjects with type 1 diabetes mellitus (T1DM). Our hypothesis was that local host responses may be modulated by the serum inflammatory mediators. Material and methods: Plaque, bleeding on probing and probing pocket depth (PD) were examined in 80 T1DM subjects at the baseline and in 58 subjects 8 weeks after periodontal therapy. The levels of glycosylated haemoglobin, serum interleukin (IL)-6, ultrasensitive C-reactive protein and the lipid profile were measured at the baseline and after therapy. Stratification of the sample separately by smoking and body mass index (BMI) was performed. Adjusted associations between the levels of systemic biomarkers and periodontal parameters were studied using multiple regression models. Results: The level of serum IL-6 was associated with the extent of bleeding and PD >= 4mm at the baseline in non-smokers and in subjects with BMI <= 26 kg/m(2). These associations were also evident after periodontal therapy. Subjects with a high after-therapy IL-6 level presented poorer periodontal healing than those with a low level. Conclusions: The observed associations may be considered to be suggestive of a modulatory effect of IL-6 on host responses in T1DM subjects.