Article
Dentistry, Oral Surgery & Medicine
Stephany Gil, Manuel de la Rosa, Evelyn Mancini, Antonio Dias, Shayan Barootchi, Lorenzo Tavelli, Gerardo Mendoza-azpur
Summary: The study compared the 4-year esthetic outcomes of coronally advanced flap (CAF) versus CAF with a connective tissue graft (CTG) for the treatment of isolated maxillary gingival recessions. After 4 years, significant recession reduction was observed in both groups, with the CAF group showing a higher final esthetic score and better marginal tissue contour and gingival margin compared to the CAF + CTG group.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Renato Maluta, Mabelle Freitas Monteiro, Daiane Cristina Peruzzo, Julio Cesar Joly
Summary: This study compared xenogeneic dermal matrix (XDM) with connective tissue graft (CTG) in treating multiple gingival recession, finding similar outcomes in keratinized tissue gain, gingival recession reduction, and root coverage for both treatments, but CTG showed better promotion of complete root coverage. Additionally, the baseline amount of keratinized tissue was crucial in determining the success of complete root coverage when using XDM for multiple gingival recession treatment.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Chemistry, Multidisciplinary
Wojciech Bednarz, Jennifer Majer, Justyna Pakuszynska-Blaszczyk, Marzena Dominiak, Tomasz Gedrange, Agata Zielinska-Palasz
Summary: This study compared the treatment outcomes of using connective tissue grafts from augmented or nonaugmented palatal mucous membrane for multiple adjacent gingival recessions coverage. The results showed that the augmented CTG+CAF method achieved better clinical outcomes with increased gingival thickness compared to the nonaugmented intervention.
APPLIED SCIENCES-BASEL
(2021)
Review
Polymer Science
Manuel Toledano-Osorio, Esther Munoz-Soto, Manuel Toledano, Marta Vallecillo-Rivas, Cristina Vallecillo, Pablo Ramos-Garcia, Raquel Osorio
Summary: This study aimed to evaluate the efficacy of palatal mucosa and polymeric soft tissue substitutes in root coverage through a literature review and meta-analysis. The results showed that both coronal advanced flap and tunnel techniques achieved similar levels of root coverage. The only difference was observed in single recessions, where the coronal advanced flap technique provided a higher percentage of root coverage. There was no difference in root coverage when using either an autograft or a polymeric substitute with the tested surgical techniques.
Article
Dentistry, Oral Surgery & Medicine
Francesco Cairo, Pierpaolo Cortellini, Luigi Barbato, Lorenzo Masseti, Jana Mervelt, Michele Nieri, Giovan Paolo Pini Prato, Maurizio S. Tonetti
Summary: The aim of this study was to evaluate the long-term outcomes of root coverage after connective tissue graft plus coronally advanced flap (CTG + CAF) or CAF alone in maxillary gingival recession. After 10 years, the test group showed a significantly higher rate of complete root coverage compared to the control group. In addition, the addition of CTG resulted in greater keratinized tissue gain and papilla tip recession. There were no differences in recession reduction, root coverage aesthetic score, and patient satisfaction.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hikmat Bakhishov, Sila Cagri Isler, Bejna Bozyel, Benay Yildirim, Mustafa Agah Tekindal, Burcu Ozdemir
Summary: The study compared the clinical efficacy and postoperative morbidity of DGG+TUN and SCTG+TUN in treating MAGRs, finding that DGG+TUN had higher root coverage rates. However, the treatment method was not a significant predictive factor for the MRC outcomes, with RD, KTH, and GT being important predictors.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Carlo Bertoldi, Ugo Consolo, Michele Lalla, Davide Zaffe, Donato Tanza, Francesco Cairo, Pierpaolo Cortellini
Summary: This study evaluated the outcomes and predictive factors for the long-term stability of root coverage using a sub-epithelial connective tissue graft. The results showed that the graft was effective in treating gingival recessions and facilitated long-term stability of clinical outcomes. Higher baseline recession area was associated with unfavorable clinical outcomes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mikkili Rajya Lakshmi, Sruthima N. V. S. Gottumukkala, Gautami S. Penmetsa, K. S. V. Ramesh, P. Mohan Kumar, E. Santosh Vamsi, M. Bindu Mounica
Summary: The use of PDCM and MCAT technique showed better results in the treatment of multiple gingival recessions in smokers compared to the use of SCTG. PDCM demonstrated predictable and favorable outcomes for all root coverage parameters.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Chemistry, Multidisciplinary
Norberto Quispe-Lopez, Antonio Castano-Seiquer, Beatriz Pardal-Pelaez, Pablo Garrido-Martinez, Cristina Gomez-Polo, Jesus Mena-Alvarez, Javier Montero-Martin
Summary: This study aimed to evaluate the clinical and esthetic outcomes of the double lateral sliding bridge flap technique with CTG for treating isolated and multiple gingival recessions in the mandibular anterior region. After a mean follow-up of 36 months, the procedure showed significant improvement in recession depth reduction, increased keratinized tissue width, increased gingival thickness, and satisfactory esthetic results.
APPLIED SCIENCES-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yoshinori Shirakata, Toshiaki Nakamura, Yoshiko Kawakami, Takatomo Imafuji, Yukiya Shinohara, Kazuyuki Noguchi, Anton Sculean
Summary: The combination therapy of coronally advanced flap (CAF) with cross-linked hyaluronic acid (HA) shows promising results in promoting gingival recession healing and periodontal regeneration in dogs. Clinical and histological evaluations revealed significant improvements in clinical measurements and tissue formation in the CAF/HA group compared to CAF alone, indicating a potential novel modality for the treatment of gingival recession defects.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shayan Barootchi, Lorenzo Tavelli
Summary: This study describes a new surgical design that combines the advantages of the coronally advanced flap and tunnel technique for treating isolated type 2 gingival recessions with deficient papilla. The preliminary results suggest that this new technique may enhance flap blood supply and graft vascularization, improving the clinical, aesthetic, and patient-reported outcomes of these kind of gingival recessions.
INTERNATIONAL JOURNAL OF ESTHETIC DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Martina Stefanini, Shayan Barootchi, Lorenzo Tavelli, Matteo Marzadori, Claudio Mazzotti, Ilham Mounssif, Matteo Sangiorgi, Hamoun Sabri, Hom-Lay Wang, Giovanni Zucchelli
Summary: This study introduces a difficulty score for evaluating the treatment of localized gingival recessions with the coronally advanced flap. The score showed good reproducibility among different operators. Further clinical intervention studies are needed to validate the clinical significance of the score.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Environmental Sciences
Wojciech Bednarz, Jennifer Majer, Justyna Pakuszynska-Blaszczyk, Marzena Dominiak, Tomasz Gedrange, Agata Zielinska-Palasz
Summary: This study compared the gingival thickness after gingival recession coverage using the laterally positioned flap supported by an augmented and non-augmented connective tissue graft. The results showed that the laterally positioned flap with augmented connective tissue graft is an effective alternative method for covering gingival recessions, resulting in improved coverage rate and gingival thickness.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fei Xue, Rui Zhang, Jia Liu, Jinyu Duan, Yong Zhang, Yu Cai
Summary: Digitally measured ERSA may predict the effectiveness of MCAT + DGG technique for treating MAGRs. ERSA, gingival biotype, KTW, tooth type, and cervical step-like morphology may correlate with MRC and CRC at 1-year postoperatively. The predictive accuracy of CRC can be tested using receiver-operator characteristic curves.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Fei Xue, Rui Zhang, Yong Zhang, Jia Liu, Yu Cai, Pei Cao, Qingxian Luan
Summary: This study compared the efficacy of concentrated growth factor (CGF) with connective tissue graft (CTG) combined with tunnel technique in treating multiple gingival recessions. The results showed better root coverage and gingival height, area, volume, and thickness increases in the CTG group, but lower pain scores in the CGF group.
JOURNAL OF DENTAL SCIENCES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Luigi Barbato, Francesco Bernardelli, Giovanni Braga, Marco Clementini, Claudio Di Gioia, Crisitnano Littarru, Francesco Oreglia, Mario Raspini, Eugenio Brambilla, Ivo Iavicoli, Vilma Pinchi, Luca Landi, Nicola Marco Sforza, Raffaele Cavalcanti, Alessandro Crea, Francesco Cairo
Summary: There is currently limited evidence on the effectiveness of surface disinfection and protective masks in reducing the spread of SARS-CoV-2 and other respiratory viruses in dental practice. Although 70% ethanol and 0.5% sodium hypochlorite seem to be effective in reducing infectivity, there is still a lack of sufficient evidence. The consistent use of respirators and routine surface disinfection is strongly recommended in dental practice, but further research is urgently needed to evaluate specific protection protocols for dental healthcare workers.
Article
Dentistry, Oral Surgery & Medicine
Caterina Masucci, Lorenzo Franchi, Debora Franceschi, Felicita Pierleoni, Veronica Giuntini
Summary: This study assessed the stability of the effects of the Alt-RAMEC and facial mask protocol at a post-pubertal observation. The results showed that the Alt-RAMEC/FM protocol produced favorable effects compared to the control group. There were no significant differences between the outcomes of the Alt-RAMEC/FM and RME/FM protocols at the post-pubertal or short-term observations.
EUROPEAN JOURNAL OF ORTHODONTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Riccardo Di Gianfilippo, Houssam Askar, James Henderson, Debora Franceschi, Hom-Lay Wang, Chin-Wei Wang, Jeff C. W. Wang
Summary: This study investigated examiner reliability and factors affecting peri-implant clinical measurements. The results showed that gingival index had higher variability compared to probing depth and recession. Probing depth and gingival index were found to be associated with each other and increased after multiple measurements.
JOURNAL OF ORAL IMPLANTOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Maria Denisa Statie, Debora Franceschi, Felicita Pierleoni, Valeria Barone, Nenad Popovic, Cosimo Nardi, Lorenzo Franchi, Veronica Giuntini
Summary: The aim of this study was to evaluate the effects of the mandibular anterior repositioning appliance (MARA) on skeletal, dentoalveolar, and airway dimensions in Class II malocclusion. The results showed that MARA was able to effectively improve Wits index, ANB angle, and dentoskeletal relationships in Class II malocclusion, but did not produce significant changes in sagittal airway dimensions.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Camilla Gavazzi, Debora Franceschi, Felicita Pierleoni, Valeria Barone, Francesco Kaitsas, Maria Giacinta Paolone, Lorenzo Franchi, Veronica Giuntini
Summary: The skeletal and dentoalveolar effects of the PK appliance in treating patients with Class II malocclusion were assessed. The results showed that the PK appliance significantly improved the patients' bite and facial appearance.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
Yang Yu, Huiwen Tang, Debora Franceschi, Prabhakar Mujagond, Aneesha Acharya, Yupei Deng, Bernd Lethaus, Vuk Savkovic, Ruediger Zimmerer, Dirk Ziebolz, Simin Li, Gerhard Schmalz
Summary: This study identifies the immune checkpoint genes associated with programmed death ligand-1 (PDL1) in oral and squamous cell carcinoma (OSCC) and determines the immune subtypes of these gene combinations. The findings provide a theoretical basis for prognostic immune subtyping of OSCC and highlight the importance of developing immunotherapeutic strategies for treating oral cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Debora Franceschi, Riccardo Di Gianfilippo, Ida Rubino, Lapo Serni, Giovan Paolo Pini Prato
Summary: This report presents a case of HSV-1 infection in a patient with Covid-19, highlighting the clinical manifestations. The case suggests a possible association between HSV-1 infection and COVID-19 disease.
CLINICAL CASE REPORTS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Valentina Rutili, Michele Nieri, Debora Franceschi, Felicita Pierleoni, Veronica Giuntini, Lorenzo Franchi
Summary: This study aimed to compare the dento-skeletal effects produced by the use or non-use of skeletal anchorage for the treatment of Class III malocclusion in growing patients. The results showed that the use of skeletally anchored facemask resulted in a significant increase in the SNA angle and a reduced inclination of maxillary incisors compared to dental-anchored facemask, although the clinical significance was not significant. However, there were greater risks of complications with skeletally anchored facemask.
EUROPEAN JOURNAL OF ORTHODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Riccardo Di Gianfilippo, Leandro Chambrone, Giovanpaolo Pini Prato, Myron Nevins, Debora Franceschi
Summary: Treatment decisions in dental implantology have evolved over the past five decades, influenced by recent changes such as osseointegration, biologic width bone remodeling, pen-implant soft tissue phenotype, definition of peri-implantitis, and advancements in digital technology.
INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Debora Franceschi, Marco Conti, Riccardo Di Gianfilippo, Giuseppe Spinelli
Summary: The free fibula flap is a reliable approach for reconstructing maxillofacial osseous defects. Advances in digital technology allow for preoperative virtual planning and the use of 3D-printed surgical plates for implant placement, resulting in improved accuracy of surgery and overall treatment efficiency.
INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY
(2022)
Article
Immunology
Simin Li, Yang Wang, Rui Sun, Debora Franceschi, Hongying Pan, Chenxuan Wei, Anthony Chukwunonso Ogbuehi, Bernd Lethaus, Vuk Savkovic, Sebastian Gaus, Ruediger Zimmerer, Dirk Ziebolz, Gerhard Schmalz, Xiao Jiang
Summary: This study examines the microenvironment of head and neck squamous cell carcinoma (HNSCC), particularly in relation to human papilloma virus (HPV). Through single-cell sequencing analysis, the researchers observed dynamic changes in cell composition and identified certain genes, such as AREG, TGFBI, CD27, CXCR3, MS4A1, and CD19, that were associated with worse overall survival in HPV-related HNSCC. The study highlights the importance of B-cell related pathways in HPV-related HNSCC and provides the basis for developing biomarkers and therapeutic targets in these patients.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Giovanpaolo Pini Prato, Riccardo Di Gianfilippo, Claudio M. M. Pannuti, Edward P. P. Allen, Sofia Aroca, Gustavo Avila-Ortiz, Philippe Bouchard, Francesco Cairo, Tali Chackartchi, Pierpaolo Cortellini, Debora Franceschi, Ajay Mahajan, Evelyn A. A. Mancini, Michael K. K. McGuire, Tea Natsvlishvili, Mauro P. P. Santamaria, E. Todd Scheyer, Hom-Lay Wang, Kenneth Kornman, Leandro Chambrone
Summary: The aim of this study was to investigate the inter- and intra-examiner agreement among international experts on the diagnosis of gingival recession defects. The results showed that the 2018 Classification of Gingival Recession Defects and Gingival Phenotype had highest intra- and inter-examiner agreement for keratinized tissue width (KTW) and lowest agreement for gingival thickness (GT).
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Geriatrics & Gerontology
Shaonan Hu, Simin Li, Wanchen Ning, Xiuhong Huang, Xiangqiong Liu, Yupei Deng, Debora Franceschi, Anthony Chukwunonso Ogbuehi, Bernd Lethaus, Vuk Savkovic, Hanluo Li, Sebastian Gaus, Ruediger Zimmerer, Dirk Ziebolz, Gerhard Schmalz, Shaohong Huang
Summary: This study aimed to identify the genetic linkage mechanisms between Parkinson's disease (PD) and periodontitis, and explore the role of immunology in the crosstalk between the two diseases. Gene expression analysis and clustering analysis were performed to identify crosstalk genes and inflammatory response-related genes (IRRGs). Five hub crosstalk genes were identified and showed significant correlation with hub IRRGs. Furthermore, immune infiltration analysis indicated the enrichment of immune cells in both diseases and their correlation with hub crosstalk genes. The findings suggest the importance of immunology in linking PD and periodontitis.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Dentistry, Oral Surgery & Medicine
Valentina Rutili, Michele Nieri, Debora Franceschi, Felicita Pierleoni, Veronica Giuntini, Lorenzo Franchi
Summary: This systematic review and meta-analysis compared patient-reported outcome measures (PROMs) between rapid maxillary expansion (RME) and slow maxillary expansion (SME) in growing patients. Results showed that pain intensity was significantly lower in the SME group during the first week of treatment, but there were no differences in pain between the two protocols in the following weeks. There were also no significant differences between the two groups in other indicators.
PROGRESS IN ORTHODONTICS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Marco Clementini, Mario Raspini, Luigi Barbato, Francesco Bernardelli, Giovanni Braga, Claudio Di Gioia, Cristiano Littarru, Francesco Oreglia, Eugenio Brambilla, Ivo Iavicoli, Vilma Pinchi, Luca Landi, Nicola Marco Sforza, Raffaele Cavalcanti, Alessandro Crea, Francesco Cairo
Summary: The aim of this narrative review is to explore the transmission modality of SARS-CoV-2 in order to provide appropriate advice for stakeholders and support the implementation of effective public health measures, particularly for protecting healthcare workers. Both in vivo and in vitro studies from laboratories and hospitals have confirmed the presence of surface contamination and the detection of SARS-CoV-2 in the air, especially in poorly ventilated indoor settings where aerosol-generating procedures take place.
