Article
Medicine, General & Internal
Hari Petsos, Ilona Koronna, Tatjana Ramich, Katrin Nickles, Bettina Dannewitz, Beate Schacher, Peter Eickholz
Summary: Regenerative treatment of infrabony defects showed stability comparable to non-surgically treated, periodontally reduced sites over a 10-year period.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Nivedha Venkatesan, Vamsi Lavu, S. K. Balaji
Summary: The present study evaluated the efficacy of Amniotic membrane + Biphasic Calcium phosphate compared to Collagen membrane + Biphasic Calcium phosphate for managing periodontal intrabony defects. The results showed that both treatments achieved similar clinical outcomes, with no significant differences observed between the two groups.
BIOMATERIALS RESEARCH
(2021)
Review
Dentistry, Oral Surgery & Medicine
Luigi Nibali, Duaa Sultan, Claudia Arena, George Pelekos, Guo-Hao Lin, Maurizio Tonetti
Summary: Deeper defects with narrower angles and increased number of walls exhibit improved CAL and radiographic bone gain at 12 months post-regenerative surgery. More data are needed about other aspects of defect morphology such as extension to buccal/lingual surfaces.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Medicine, General & Internal
Aniela Brodzikowska, Bartlomiej Gorski, Marcin Szerszen, Mariano Sanz
Summary: This study compared the clinical and radiographic outcomes of two biomaterials in the treatment of periodontal intra-bony defects. It was found that both frozen radiation-sterilized allogenic bone grafts (FRSABG) and deproteinized bovine bone mineral (DBBM) combined with a bioabsorbable collagen membrane yielded successful clinical benefits, but FRSABG significantly enhanced pocket depth reduction and defect fill.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Pasquale Santamaria, Aysegul Sari, Luigi Nibali
Summary: The aim of this study was to assess the differential molecular profiling of gingival crevicular fluid (GCF) from infrabony and suprabony periodontal defects compared with healthy sites. The results showed that 14 biomarkers levels were elevated in GCF from infrabony and suprabony defects compared with healthy sites, while the difference between infrabony and suprabony defects was not significant in biomarker changes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Biology
Maha A. Bahammam, Mai S. Attia
Summary: The study showed that using PRF in combination with nano-HA was successful in regenerative periodontal therapy for managing periodontal IBDs, unlike using PRF alone. The increase in VEGF concentrations in all groups confirmed its crucial role in angiogenesis and osteogenesis in the early stages of bone defect healing.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Serhat Aslan, Nurcan Buduneli, Pierpaolo Cortellini
Summary: This study evaluated the clinical applicability of the entire papilla preservation technique in the regenerative treatment of deep intrabony defects, showing promising results in providing optimal biomaterial protection and healing conditions.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Muhammad Saad Shaikh, Muhammad Sohail Zafar, Ahmad Alnazzawi
Summary: The study compared the use of nanohydroxyapatite (NcHA) graft with other bone grafts (BGs) in treating periodontal infrabony lesions and found that they showed similar clinical outcomes, with the only difference being in gingival recession change when compared to synthetic BGs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jad Majzoub, Ali Salami, Shayan Barootchi, Lorenzo Tavelli, Hsun-Liang Chan, Hom-Lay Wang
Summary: This retrospective study compared the outcomes of non-surgical and surgical mechanical root debridement for infrabony defects, finding significant pocket depth reduction and potential gingival recession as a result of treatment. The survival rates of treated teeth after 5 years were also assessed, with multiple factors affecting clinical outcomes and tooth survival.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Lena Katharina Mueller-Heupt, Nadine Wiesmann-Imilowski, Sofia Schroeder, Jonathan Gross, Pablo Cores Ziskoven, Philipp Bani, Peer Wolfgang Kaemmerer, Eik Schiegnitz, Anja Eckelt, John Eckelt, Ulrike Ritz, Till Opatz, Bilal Al-Nawas, Christopher Synatschke, James Deschner
Summary: Periodontitis is a chronic inflammatory disease that leads to tooth loss and significantly impacts global health. A hyaluronic acid-based dispersion with controlled oxygen delivery shows potential as a treatment for periodontitis. In vitro and in vivo studies demonstrate the biocompatibility, antimicrobial activity against Porphyromonas gingivalis, and angiogenesis enhancement of the developed oxygen-releasing dispersion. This suggests the potential of oxygen-releasing biomaterials for periodontal tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Engineering, Biomedical
Soo-Ling Bee, Zuratul Ain Abdul Hamid
Summary: This article reviews the latest developments and applications of asymmetric barrier membranes used in periodontal regeneration. It first presents the requirements for constructing barrier membranes and the principles behind the asymmetric design, then discusses various innovative methods, and finally summarizes the application and evaluation of different types of asymmetric barrier membranes.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Review
Chemistry, Physical
Gerasimos Odysseas Georgiou, Francesco Tarallo, Enrico Marchetti, Sergio Bizzarro
Summary: This review provides an overview of the outcomes of using various regenerative materials for the treatment of molars with class II furcation defects in patients with periodontitis. The use of regenerative materials shows potential benefits compared to open flap debridement, although the heterogeneity in study protocols and low levels of evidence limit definitive conclusions.
Article
Biochemistry & Molecular Biology
Fumi Seshima, Takahiro Bizenjima, Hideto Aoki, Kentaro Imamura, Daichi Kita, Daisuke Irokawa, Daisuke Matsugami, Yurie Kitamura, Keiko Yamashita, Hiroki Sugito, Sachiyo Tomita, Atsushi Saito
Summary: This study evaluated the long-term outcomes of using recombinant human fibroblast growth factor (rhFGF)-2 with or without deproteinized bovine bone mineral (DBBM) for treating periodontal intrabony defects. The results showed that the combination therapy significantly enhanced radiographic bone fill (RBF) and both treatments had favorable clinical and patient-reported outcomes.
Article
Dentistry, Oral Surgery & Medicine
Malgorzata Pietruska, Ewa Dolinska, Robert Milewski, Anton Sculean
Summary: This study found that there were no substantial added clinical benefits from postoperative administration of amoxicillin in conjunction with regenerative periodontal surgery using DBBM and GTR.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Pharmacology & Pharmacy
Shahla Mirzaeei, Alireza Ezzati, Saba Mehrandish, Kofi Asare-Addo, Ali Nokhodchi
Summary: This article reviews studies on guided tissue regeneration (GTR) systems and discusses their most important findings, including the main matrix component, fabrication methods, solvent systems used, and release patterns, in relation to the aim of drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Letter
Dentistry, Oral Surgery & Medicine
Katrin Hertrampf, Christian Floerke, Jonas Conrad, Nicole Passia, Burkhard Kunzendorf, Birte Groessner-Schreiber, Christof Doerfer, Matthias Kern, Wolfgang Orthuber, Joerg Wiltfang
Article
Dentistry, Oral Surgery & Medicine
Nihad El Sayed, Sonja Rahim-Woestefeld, Florian Stocker, Rouven Behnisch, Peter Eickholz, Bernadette Pretzl
Summary: This study aimed to assess the predictive accuracy of using the 2018 classification to predict likelihood of tooth loss. The results showed that patients with Stage IV or Grade C lost more teeth during SPT, and patients' adherence appeared to influence the predictability of the classification. Neither classification system alone (1999 vs 2018) showed a high predictive value for tooth loss.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Medicine, General & Internal
Katrin Nickles, Mischa Krebs, Beate Schacher, Hari Petsos, Peter Eickholz
Summary: This study retrospectively evaluated the treatment outcomes of dental implant in patients with Papillon-Lefevre syndrome (PLS) and found that patients who did not receive regular maintenance had a higher risk of peri-implantitis and implant loss.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Peter Eickholz, Patrizia Winkler, Ivana Elez, Gil Slutzkey, Michael Saminsky
Summary: Most dental hygiene professionals in Israel (IL) and Germany (GE) perform peri-implant probing and debridement, but there are some distinct differences between the two countries regarding the choice of instruments and treatment regimens.
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
(2023)
Article
Pediatrics
Antje Geiken, Louise Holtmann, Christof E. Doerfer, Christiane Schwarz, Christian Graetz
Summary: There is a lack of awareness and recommendations from midwives regarding early childhood caries screening and fluoride, and more educational work is needed to promote their understanding and implementation.
Article
Dentistry, Oral Surgery & Medicine
Christian Graetz, Naomi Sayk, Paulina Dueffert, Ralf Heidenreich, Christof E. Doerfer, Miriam Cyris
Summary: This study analyzed different methods for controlling air quality during and after aerosol-generating procedures (AGPs) in a small skills lab, focusing on the worst-case scenario for aerogen infection control in preclinical dental training. The combination of high-volume evacuation (HVE) and an extraoral mobile scavenger (EOS) was found to be similarly effective in controlling aerosol emissions of particles between one and ten micrometers during AGPs as compared to non-AGPs. After AGPs, air exchange with the air conditioning system (AC) should be complemented by opening doors for better air quality if natural ventilation through open windows is restricted.
INTERNATIONAL JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Giuseppe Troiano, Luigi Nibali, Hari Petsos, Peter Eickholz, Muhammad H. A. Saleh, Pasquale Santamaria, Jao Jian, Shuwen Shi, Huanxin Meng, Khrystyna Zhurakivska, Hom-Lay Wang, Andrea Ravida
Summary: The aim of this study was to develop and validate models for predicting molar survival in periodontally affected patients using logistic regression and artificial intelligence. Clinical and radiographic data from four different centers across four continents were collected and used to train and test different machine learning algorithms. The ensembled model combining neural network and logistic regression showed the best performance in predicting molar loss.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Puria Parvini, Georgia Trimpou, Amira Begic, Emilio A. Cafferata, Hari Petsos, Katharina Melissa Mueller, Frank Schwarz, Peter Eickholz, Karina Obreja
Summary: This study assessed the esthetic and clinical performance of a novel self-tapping implant system for single-tooth restorations in the esthetic zone after immediate placement and provisionalization. The results showed that both the Straumann BLX and Ankylos implant systems achieved good peri-implant tissue esthetics and health during immediate implantation and restoration protocols for at least 12 months.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Leander Benz, Patrizia Winkler, Bettina Dannewitz, Katrin Nickles, Hari Petsos, Talal Aldiri, Peter Eickholz
Summary: The aim of this study was to evaluate the effects of subgingival instrumentation (SI) combined with systemic antibiotics (AB) in patients with periodontitis stage III and IV, grade B and C, after detection of Aggregatibacter actinomycetemcomitans infection. The results showed that SI combined with AB resulted in a higher success rate in achieving the treat-to-target endpoint compared to exclusive SI treatment in patients without the infection.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Katharina Korello, Peter Eickholz, Otto Zuhr, Christoph Ratka, Hari Petsos
Summary: This study analyzed the efficacy of non-surgical and surgical dental implant surface decontamination methods, with or without suprastructure. The results showed that the non-surgical method was more effective when the suprastructure was removed, and air powder abrasion had the highest cleaning efficacy. This study provides guidance for the decontamination of dental implant surfaces.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ilona Koronna, Beate Schacher, Iulia Dahmer, Katrin Nickles, Sarah K. Sonnenschein, Ti-Sun Kim, Peter Eickholz, Hari Petsos
Summary: The aim of this study was to assess the long-term stability of attachment gain in infrabony defects (IBDs) following regenerative treatment with an enamel matrix derivative (EMD). The results showed that regenerative therapy of IBDs exhibited stable clinical attachment levels (CAL) over 9 years, with significant improvements compared to baseline. CAL gain was associated with CAL after 12 months and the vertical extent of a three-walled defect component, while tooth loss was associated with plaque index after 12 months.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Daniel Hagenfeld, Sven Kleine Bardenhorst, Johannes Matern, Karola Prior, Inga Harks, Peter Eickholz, Katrin Lorenz, Ti-Sun Kim, Thomas Kocher, Jorg Meyle, Dogan Kaner, Ulrich Schlagenhauf, Dag Harmsen, Benjamin Ehmke
Summary: This study aimed to investigate the impact of adjunctive antibiotics on long-term microbiota changes in stage III-IV periodontitis patients. The results showed that mechanical periodontal therapy with adjunctive antibiotics induced significant changes in 16 bacterial strains, including Porphyromonas gingivalis, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans, over a 26-month period. The subgingival-microbial dysbiosis index (SMDI) decreased significantly in the antibiotic group, indicating a shift towards a healthier oral microbiome.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Peter Eickholz, Raphael Koch, Moritz Goede, Katrin Nickles, Thomas Kocher, Katrin Lorenz, Ti-Sun Kim, Joerg Meyle, Dogan Kaner, Ulrich Schlagenhauf, Inga Harks, Benjamin Ehmke
Summary: Assessment of treatment response after systemic amoxicillin/metronidazole adjunctive to subgingival instrumentation (SI) according to stages and grades of the 2018 classification of periodontal diseases. The percentage of disease progression was significantly lower in the treatment group compared to the placebo group in localized stage III, generalized stage III, and grade C.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Health Care Sciences & Services
Dagmar Schnabl, Felix Maximilian Thumm, Ines Kapferer-Seebacher, Peter Eickholz
Summary: Papillon-Lefevre syndrome is a rare hereditary disease characterized by excessive keratosis of the palms and soles, as well as periodontitis. Specific treatment strategies, such as tooth extraction, oral hygiene maintenance, regular periodontal care, and the use of antibiotics, can help slow down disease progression and control periodontitis in patients with this syndrome.
Article
Dentistry, Oral Surgery & Medicine
Christian Graetz, Viktor Huelsbeck, Paulina Dueffert, Susanne Schorr, Martin Strassburger, Antje Geiken, Christof E. Doerfer, Miriam Cyris
Summary: When performing aerosol-generating procedures in dentistry, the use of high-volume evacuation suction can significantly reduce splatter contamination. Specifically, using a 16mm diameter suction cannula with a flow rate of 250 l/min or higher resulted in the lowest splatter contamination values.
CLINICAL ORAL INVESTIGATIONS
(2022)