Article
Biochemistry & Molecular Biology
Zoltan Horvath-Szalai, Rita Jakabfi-Csepregi, Balazs Szirmay, Daniel Ragan, Gerda Simon, Zoltan Kovacs-Abraham, Peter Szabo, David Sipos, Agnes Peterfalvi, Attila Miseta, Csaba Csontos, Tamas Koszegi, Ildiko Toth
Summary: In this study, the predictive value of serum non-enzymatic total antioxidant capacity (TAC) and the newly introduced TAC/lymphocyte ratio in COVID-19 was elucidated. The results showed that both TAC and TAC/lymphocyte ratio could provide valuable information regarding the severity of COVID-19, and TAC served as a promising marker for predicting systemic inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Enrico Prenesti, Silvia Berto, Fabio Gosmaro, Marco Bagnati, Giorgio Bellomo
Summary: The study aimed to define the reference intervals for TAC of human plasma in apparently healthy adults using the CUPRAC-BCS method. The results showed that the reference intervals for TAC in males and females were 727-1248 and 637-1048 respectively, with no significant age effect on TAC values.
Review
Biochemistry & Molecular Biology
Yago Gecy de Sousa Ne, Weslley Ferreira Lima, Paulo Fernando Santos Mendes, Daiane Claydes Baia-da-Silva, Leonardo Oliveira Bittencourt, Priscila Cunha Nascimento, Renata Duarte de Souza-Rodrigues, Luiz Renato Paranhos, Paulo Antonio Martins-Junior, Rafael Rodrigues Lima
Summary: This study aimed to analyze the research trends on salivary oxidative stress associated with dental caries and to perform bibliometric approaches for existing publications on this association. The findings show that India and Asia have the highest number of publications on this topic, non-stimulated total saliva is the most commonly collected sample, and total antioxidant capacity is the most frequently evaluated parameter. Cross-sectional studies are the most common study design, and articles published from 2017 to 2022 are the most frequent.
Article
Biochemistry & Molecular Biology
Enrico Prenesti, Silvia Berto, Fabio Gosmaro, Marco Bagnati, Giorgio Bellomo
Summary: This study investigated the relationship between the total antioxidant capacity (TAC) and the concentrations of redox-active biomolecules in the human plasma of healthy and cardiopathic individuals. The results showed that around 80% of the TAC in both groups comes from endogenous compounds, with different contributions from exogenous compounds. γ-tocopherol played a different role in the chemical models developed for the two groups.
Review
Medicine, General & Internal
Ahmed Alamoudi, Raghad Alamoudi, Yara Gazzaz, Aseel M. Alqahtani
Summary: Saliva plays a significant role in oral health and tooth protection. Salivary biomarkers may have potential value in dental caries diagnosis.
Article
Food Science & Technology
Daniel Rico, Ana Belen Cano, Sergio Alvarez Alvarez, Gustavo Rio Briones, Ana Belen Martin Diana
Summary: In recent years, the relationship between dietary antioxidant compounds and reducing chronic diseases has led to innovation in the baked product sector in order to develop healthier formulations. This study aims to develop a mathematical model-based tool for predicting the total antioxidant capacity (TAC) of baked goods. The variability of antioxidant properties in flours due to factors such as grain type, varieties, composition, and processing makes it challenging to innovate in food product development without specific analysis. Bayesian-type models based on parameterized double exponential curves were proposed to reflect the degradation and generation processes of antioxidant compounds. Support vector machines (SVM) with an exponential kernel were used to predict TAC values based on baking conditions, proteins, and fibers of each grain.
Review
Engineering, Chemical
Antonio Cano, Ana B. Maestre, Josefa Hernandez-Ruiz, Marino B. Arnao
Summary: ABTS is a widely used compound for determining the total antioxidant capacity (TAC) of various samples. It can be used in different determination methodologies, such as automated photometric measures and liquid chromatographic separation. The ABTS/TAC method allows for the determination of both hydrophilic and lipophilic antioxidant activity, providing total antioxidant activity values. This review highlights the major achievements and applications of the ABTS/TAC method.
Article
Dentistry, Oral Surgery & Medicine
Oscar Musalem-Dominguez, Jose Maria Montiel-Company, Veronica Ausina-Marquez, Jose Manuel Morales-Tatay, Jose Manuel Almerich-Silla
Summary: This study identified metabolomic differences in saliva between healthy children and children with active carious lesions, and developed a predictive model based on the salivary metabolomic profile. The results showed differences in metabolites, particularly saccharides and amino acids, between the two groups, suggesting their association with caries risk. These findings contribute to the research of salivary biomarkers, caries risk assessment, and personalized prevention strategies.
JOURNAL OF DENTISTRY
(2023)
Article
Biochemistry & Molecular Biology
Bahareh Nazemi Salman, Shayan Darvish, Ancuta Goriuc, Saeideh Mazloomzadeh, Maryam Hossein Poor Tehrani, Ionut Luchian
Summary: Salivary markers of oxidative stress are associated with clinical disease indices such as gingival bleeding and dental caries. The total antioxidant capacity (TAC) increased in patients with more gingival bleeding and decreased in adolescents with caries. Antioxidants could potentially be used as a preventive and therapeutic measure against oral diseases in the future.
Article
Medicine, General & Internal
Harald Krenzlin, Dominik Wesp, Jan Schmitt, Christina Frenz, Elena Kurz, Julia Masomi-Bornwasser, Johannes Lotz, Florian Ringel, Thomas Kerz, Naureen Keric
Summary: This study found that the decrease in SOD and increase in TAC in patients with aneurysmal SAH were associated with poorer neurological outcomes. Lower SOD concentration in the cerebrospinal fluid and higher TAC were linked to deteriorating cognitive abilities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
R. Raksakmanut, P. Thanyasrisung, S. Sritangsirikul, K. Kitsahawong, A. L. Seminario, W. Pitiphat, O. Matangkasombut
Summary: Dental caries, the most common chronic disease in children, has negative effects on their health, development, and well-being. Early preventive interventions are crucial, but there is still a lack of accurate caries risk predictors for infants before caries onset.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Pediatrics
Bojan Petrovic, Nebojsa Stilinovic, Ana Tomas, Sanja Kojic, Goran M. Stojanovic
Summary: This study evaluated the antioxidant status and levels of leptin and adiponectin in the saliva of children with severe early childhood caries (S-ECC). The results showed that the levels of leptin were significantly higher in the saliva of children with S-ECC than in caries free children, while there was no significant difference in adiponectin levels. These findings suggest that leptin may play a role in the inflammatory and immune responses in the development of early childhood caries.
FRONTIERS IN PEDIATRICS
(2022)
Article
Geriatrics & Gerontology
Miriam Palomar-Bonet, Mercedes Atienza, Blanca Hernandez-Ledesma, Jose L. Cantero
Summary: The study found that salivary total antioxidant capacity (TAC) was associated with better cognitive function, lower amyloid-beta load, and higher glucose metabolism in the brain, making it a potential marker for screening cerebral vulnerability to Alzheimer's disease (AD). Further research is needed to evaluate the clinical utility of salivary TAC.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Allergy
Omer Hatipoglu, Fatma Pertek Hatipoglu
Summary: This meta-analysis examined the association between asthma and caries-related salivary factors. The results showed that salivary flow rate and pH were significantly reduced in asthma patients, particularly when saliva was unstimulated. No significant associations were found between asthma and other salivary components.
Article
Microbiology
Lucia Aparecida Federighi Pereira Leme, Karina Ferreira Rizzardi, Isis Bolsonaro Santos, Thais Manzano Parisotto
Summary: This research aimed to explore the relationship between TNF-alpha, L. acidophilus, L. gasseri, obesity, and early childhood caries. The study found that in obese children, an increase in BMI and TNF-alpha levels was associated with an increase in the number of decayed surfaces. In eutrophic children, the presence of L. gasseri and L. acidophilus was linked to an increase in the number of decayed surfaces.
Article
Medicine, Legal
Neil De Souza, R. Manju, Amitha M. Hegde
FORENSIC SCIENCE INTERNATIONAL
(2018)
Article
Dentistry, Oral Surgery & Medicine
Vabitha Shetty, Lekshmi R. Suresh, Amitha M. Hegde
JOURNAL OF CLINICAL PEDIATRIC DENTISTRY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Rachaita Chhabra, Shama Rao, B. Mohana Kumar, A. Veena Shetty, Amitha M. Hegde, Meghna Bhandary
Summary: The study isolated and characterized stem cells from deciduous teeth with different levels of root resorption. Results showed that SHED (2/3) exhibited better growth kinetics and phenotypic marker expression, while SHED (1/3) and SHED (2/3) had slightly higher differentiation ability for osteogenic and adipogenic cell lineages compared to SHED (COMP). This suggests that SHED (2/3) could be a useful source for tissue regeneration and merits further investigation.
JOURNAL OF CLINICAL PEDIATRIC DENTISTRY
(2021)
Review
Medicine, General & Internal
Amitha M. Hegde, Sonali Sodhi
Summary: Traumatic injuries to teeth are common in children and adolescents, requiring immediate attention. Understanding patterns and risk factors of trauma incidence is crucial. Changes in lifestyle have contributed to an increase in dental trauma prevalence.
JOURNAL OF EVOLUTION OF MEDICAL AND DENTAL SCIENCES-JEMDS
(2021)
Editorial Material
Public, Environmental & Occupational Health
Lekshmi R. Suresh, Amitha M. Hegde
Summary: The COVID-19 pandemic has accelerated the need for healthcare organizations to utilize digital platforms to expand traditional healthcare services, prompting a major overhaul in dentistry towards preventive practices and teledentistry platforms. Therefore, the transition to teledentistry platforms should be systematically advanced, starting with feasibility analysis, to reduce strain on resources and manpower.
WORLD MEDICAL & HEALTH POLICY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Devika J. Nair, Amarshree A. Shetty, Amitha M. Hegde
Summary: The study evaluated the effectiveness of ATPb technique on the oral health of visually-impaired children. Results showed that all three techniques were successful when reinforced periodically, but only ATP and ATPb were successful during periods without reinforcement. Among them, the ATPb technique was the most effective, allowing visually-impaired children to retain oral hygiene information without intervention.
JOURNAL OF CLINICAL PEDIATRIC DENTISTRY
(2021)
Article
Medicine, General & Internal
G. Geethanjali, Amarshree A. Shetty, Amitha M. Hegde
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2020)
Article
Medicine, General & Internal
G. Geethanjali, Amarshree A. Shetty, Amitha M. Hegde, Delisha Y. Fernandes
JOURNAL OF EVOLUTION OF MEDICAL AND DENTAL SCIENCES-JEMDS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Y. Rajmohan Shetty, Anisha Keshan, Amitha M. Hegde, R. Manju, Ashutosh Shetty
SPECIAL CARE IN DENTISTRY
(2017)
Article
Dentistry, Oral Surgery & Medicine
R. Manju, Amitha M. Hegde, Anisha Keshan
JOURNAL OF ADVANCED ORAL RESEARCH
(2017)
Article
Clinical Neurology
R. Manju, Amitha M. Hegde, Paul Parlees, Anisha Keshan
JOURNAL OF NEUROSCIENCES IN RURAL PRACTICE
(2017)