Review
Materials Science, Ceramics
Sotoudeh Davaie, Tabassom Hooshmand, Sajjad Ansarifard
Summary: This study systematically reviewed the use of different types of bioceramics as direct dental pulp capping materials for dentin regeneration in permanent teeth. It found that calcium silicate-based materials, MTA, and Biodentine are currently the most effective bioceramics for this purpose, with calcium phosphates showing potential as future alternatives. Further well-designed in vitro and clinical studies are needed to confirm the most appropriate bioceramics for direct dental pulp capping procedures.
CERAMICS INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Rafiqul Islam, Md Refat Readul Islam, Toru Tanaka, Mohammad Khursheed Alam, Hany Mohamed Aly Ahmed, Hidehiko Sano
Summary: The aim of direct pulp capping (DPC) is to promote pulp healing and mineralized tissue barrier formation by placing a dental biomaterial directly over the exposed pulp. Successful application of this approach avoids the need for further and more extensive treatment. This review focuses on the DPC procedure, the materials used, and their mechanisms of action to promote pulpal healing.
JAPANESE DENTAL SCIENCE REVIEW
(2023)
Review
Chemistry, Physical
Ermin Nie, Jiali Yu, Rui Jiang, Xiangzhen Liu, Xiang Li, Rafiqul Islam, Mohammad Khursheed Alam
Summary: This systematic review evaluated the dentin regeneration efficacy of direct pulp capping biomaterials, concluding that MTA and Biodentine can induce dentin regeneration. The results suggest that MTA and its variants have better efficacy in the DPC procedure for dentin regeneration.
Article
Dentistry, Oral Surgery & Medicine
Chawan Manaspon, Chavin Jongwannasiri, Sujin Chumprasert, Noppadol Sa-Ard-Iam, Rangsini Mahanonda, Prasit Pavasant, Thantrira Porntaveetus, Thanaphum Osathanon
Summary: The study found that ProRoot(R) MTA and Biodentine(TM) have favorable in vitro biocompatibility and bioactive properties on human dental pulp stem cells, suggesting their superior regenerative potential compared with DyCal(R) and TheraCal(TM).
Article
Dentistry, Oral Surgery & Medicine
Ahmed ElSebaai, Ahmed Hamdy Wahba, Mohammed E. Grawish, Ibrahim Hassan Elkalla
Summary: The clinical and radiographic outcomes of direct pulp capping using calcium hydroxide, mineral trioxide aggregate, and premedicated direct pulp capping with formocresol in primary teeth were evaluated in this study. The three materials demonstrated clinical and radiographical efficacy when used as direct pulp capping materials.
PEDIATRIC DENTISTRY
(2022)
Article
Pathology
Ebtesam O. Abo El-Mal, Ashraf M. Abu-Seida, Salma H. El Ashry
Summary: The study compared the effects of Hesperidin, Mineral Trioxide Aggregate (MTA)-Angelus, and calcium hydroxide for direct pulp capping. Hesperidin was found to induce mild inflammation and promote good dentine bridge formation, making it a promising material for pulp capping.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shaimaa Nabil Sulyiman, Aiah A. El-Rashidy, Sara El Moshy, Marwa M. S. Abbas, Gihan Waly
Summary: The study compared the in vitro and in vivo bioactivities of nano eggshell-based slurry (NES) and calcium hydroxide (Ca(OH)(2)) as direct pulp-capping materials in a rabbit animal model. The results showed that NES demonstrated favorable bioactivity both in vitro and in vivo. NES released more elements over an extended period of time and exhibited better tissue response compared to Ca(OH)(2).
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Nevin Cobanoglu, Tuncay Alptekin, Haruaki Kitagawa, Markus B. Blatz, Satoshi Imazato, Fusun Ozer
Summary: This study found that direct pulp capping with Clearfil Protect Bond (CPB) self-etching adhesive containing an antibacterial monomer MDPB induced an acceptable healing response, with no severe inflammation or soft tissue disorganization observed in the CPB group compared to other control groups.
DENTAL MATERIALS JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Milos Papic, Suzana Zivanovic, Tamara Vucicevic, Mirjana Papic, Dejan Zdravkovic, Nevena Milivojevic, Katarina Virijevic, Marko Zivanovic, Aleksandar Mircic, Biljana Ljujic, Miodrag L. Lukic, Milica Popovic
Summary: This study aimed to evaluate the effect of direct pulp capping on the expression of erythropoietin (Epo) and Epo-receptor (Epor) genes in relation to the expression of inflammatory and osteogenic genes in rat pulp. The study found that pulp capping can promote anti-inflammatory and pulp regeneration. The capped pulps showed higher expressions of Epo, while the untreated pulps had the highest expression of Epor and inflammatory cytokines. The materials used for capping played a positive role in regulating the expression of inflammatory and pulp osteogenic factors.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Takashi Matsuura, S. M. Ziauddin, Viviane K. S. Kawata-Matsuura, Kouji Sugimoto, Shizuka Yamada, Atsutoshi Yoshimura
Summary: This review evaluates the long-term effectiveness of calcium silicate-based cement and calcium hydroxide for direct pulp capping to human pulp-exposed permanent teeth. The meta-analyses show that there is a significant difference in success rate between CS and CH, with CS being more effective and predictable.
DENTAL MATERIALS JOURNAL
(2021)
Article
Engineering, Biomedical
Can Kaya, Ulku Sermet Elbay, Mesut Elbay, Gul Ucar
Summary: The study aimed to evaluate the success rates of pulpotomy with calcium hydroxide and biostimulation compared to other techniques in primary molars. Results showed that CH + PBMT had advantages in clinical and radiographic success rates, performing similarly to MTA and FC in clinical success but lower than MTA and FC in radiographic success.
LASERS IN MEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Mihai Andrei, Raluca Paula Vacaru, Anca Coricovac, Radu Ilinca, Andreea Cristiana Didilescu, Ioana Demetrescu
Summary: The vitality of dental pulp is essential for maintaining the health and functionality of the tooth. Hydraulic calcium-silicate cements can stimulate reparative dentinogenesis in direct pulp capping procedures, leading to the formation of new dentin bridges. Different degrees of pulp inflammatory response and dentin bridge formation were observed during pulp healing, showing positive effects on tertiary dentin formation and pulp vitality preservation.
Article
Dentistry, Oral Surgery & Medicine
Maria Luisa Leite, Caroline Anselmi, Igor Paulino Mendes Soares, Adriana Pigozzo Manso, Josimeri Hebling, Ricardo Marins Carvalho, Carlos Alberto de Souza Costa
Summary: This study developed and characterized different formulations of chitosan scaffolds associated with calcium silicate and evaluated their chemotactic and bioactive potential on human dental pulp cells. The results showed that increasing the amount of calcium silicate in the chitosan scaffold promoted cell migration, viability, proliferation, and odontogenic differentiation.
Article
Materials Science, Multidisciplinary
Yun Hu, Lingyun Wan, Yumei Xiao, Yuyi Wang, Zhiwu Wu, Weihua Guo, Hui Yang, Tao Hu
Summary: In this study, BCP ceramics with high CDHA content and strontium-incorporated CDHA were successfully synthesized. The results showed that BCP-A is a promising biomaterial for direct dental pulp capping, as it promotes the proliferation of dental pulp cells and the formation of reparative dentin bridges.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Andreea Igna, Cornel Igna, Mariana Ioana Miron, Larisa Schuszler, Roxana Dascalu, Mihaela Moldovan, Adrian Aristide Voicu, Carmen Darinca Todea, Marius Boariu, Maria-Alexandra Martu, Stefan-Ioan Stratul
Summary: This study aimed to evaluate the pulpal response of primary teeth using pulse-oximetry in a canine model after direct pulp capping. The results showed correlations between pulse-oximetry, laser Doppler flowmetry, computer tomographic densitometry, and histological analysis. Different pulp capping materials resulted in varying degrees of pulpal inflammation, which were not correlated with the obtained pulse-oximetry values.
Article
Neurosciences
Ramin M. Farahani, Saba Rezaei-Lotfi, Mary Simonian, Munira Xaymardan, Neil Hunter
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Cell Biology
Ramin Farahani, Saba Rezaei-Lotfi, Mary Simonian, Neil Hunter
Article
Cell Biology
Saba Rezaei-Lotfi, Neil Hunter, Ramin M. Farahani
Article
Cell Biology
Filip Vujovic, Neil Hunter, Ramin M. Farahani
CELL COMMUNICATION AND SIGNALING
(2019)
Article
Cell Biology
Saba Rezaei-Lotfi, Ramin M. Farahani
Article
Mathematical & Computational Biology
Ramin M. Farahani, Saba Rezaei-Lotfi, Neil Hunter
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2020)
Article
Cell Biology
Sukran Ozsoy, Filip Vujovic, Mary Simonian, Valentina Valova, Neil Hunter, Ramin M. Farahani
Summary: Research has found that during embryonic development, neuroepithelial cells can accelerate neuronal differentiation by cannibalizing erythroblasts in the yolk sac blood vessels. This process is achieved by activating the mitochondrial electron transport chain and increasing the production of reactive oxygen species.
Article
Biochemistry & Molecular Biology
Filip Vujovic, Saba Rezaei-Lotfi, Neil Hunter, Ramin M. Farahani
Summary: This study uncovers a natural antisense transcript, nAS25, which regulates the fate of notch-1 transcript in daughter cells to compensate for perturbations of cell cycle in mother cells. This mechanism stabilizes gene expression in future generations by transmitting antisense transcripts, ensuring coordination of cell cycle within cell lineage.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell Biology
Ramin M. Farahani
Summary: This article reviews the mechanistic basis for the diverse and sometimes contradictory roles of mural pericytes in the brain. It discusses the concept of a metastable archival state that conceals a neural progenitor identity in pericytes, and their contribution to neural regeneration through transdifferentiation. The genomic basis for neural transdifferentiation of pericytes is also reviewed.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Filip Vujovic, Neil Hunter, Ramin M. Farahani
Summary: During the early Cambrian period, metazoan life forms diverged at an accelerated rate to occupy multiple ecological niches on earth. While various explanations have been proposed for the Cambrian explosion, the biological basis for the accelerated emergence of species diversity remains conjectural.
Article
Neurosciences
Hamze Shahali, Ramin Hamidi Farahani, Parham Hazrati, Ebrahim Hazrati
Summary: This article reports a case of acute vestibular neuritis triggered by COVID-19 vaccination, with symptoms of dizziness, nausea, and vomiting. After treatment, the symptoms gradually subsided, but signs of vestibular imbalance persisted after one year.
JOURNAL OF NEUROVIROLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Parsa Firoozi, Bahareh Nazemi Salman, Naser Aslaminabadi
Summary: This study compared the clinical and radiographic success rates of Biodentine and Formocresol in pulpotomy treatment. The results showed that Biodentine was superior to Formocresol in terms of radiographic success rate. However, there was no significant difference between the two in terms of clinical efficacy.
EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY
(2022)
Review
Biochemistry & Molecular Biology
Filip Vujovic, Claire E. Shepherd, Paul K. Witting, Neil Hunter, Ramin M. Farahani
Summary: This article reviews the network topology of key signaling pathways, with a focus on redox-sensitive proteins such as PTEN and Ras GTPase, which have the ability to reshape the connectivity profile of signaling pathways based on altered redox states. It proposes that redox-mediated rewiring is essential for regulating the rate of transmission of biological signals and suggests the existence of a programmable cellular clock that orchestrates the pace of biological phenomena. Furthermore, it discusses the evidence that abnormal redox-mediated modulation of the cellular clock output contributes to pathological conditions affecting the human brain.
Article
Immunology
Hamze Shahali, Ramin Hamidi Farahani, Ali Asgari, Ebrahim Hazrati
Summary: This case report presents a 72-year-old male who developed a thalamic stroke leading to uncontrollable movements due to vaccine-induced immune thrombocytopenia. The patient's symptoms appeared after receiving the vaccine, and improved gradually after treatment, highlighting the importance of clinicians' awareness in recognizing and managing this novel immune-mediated response.
CLINICAL AND EXPERIMENTAL VACCINE RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Saba Rezaei-Lotfi, Filip Vujovic, Mary Simonian, Neil Hunter, Ramin M. Farahani
Summary: The study reveals that the global transcriptional landscape not only influences the functional cellular identity of pericytes, but also stabilizes lineage memory by silencing the competing neural program within a repressed chromatin state. This is achieved through the abrupt destabilization of higher-order chromatin topology and expression of pro-neural genes, followed by probabilistic induction of R-loops in key myogenic loci.