Ion Torrent next-generation sequencing for routine identification of clinically relevant mutations in colorectal cancer patients

Clinical Validation of KRAS, BRAF, and EGFR Mutation Detection Using Next-Generation Sequencing

(2014) Ming-Tseh Lin et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Clinical activity of FOLFIRI plus cetuximab according to extended gene mutation status by next-generation sequencing: findings from the CAPRI-GOIM trial

(2014) F. Ciardiello et al.   ANNALS OF ONCOLOGY

Abstract 36: The OncoNetwork Consortium: A European Collaborative Research study on the development of an Ion AmpliSeq gene panel targeting hot spots in colon and lung cancers.

(2014) Nicola Normanno et al.   CANCER RESEARCH

Comparison of KRAS mutation analysis of colorectal cancer samples by standard testing and next-generation sequencing

(2014) Nishi Kothari et al.   JOURNAL OF CLINICAL PATHOLOGY

Next-generation sequencing: a change of paradigm in molecular diagnostic validation

(2014) Manuel Salto-Tellez et al.   JOURNAL OF PATHOLOGY

Profiling Cancer Gene Mutations in Clinical Formalin-Fixed, Paraffin-Embedded Colorectal Tumor Specimens Using Targeted Next-Generation Sequencing

(2014) L. Zhang et al.   ONCOLOGIST

Navigating the Rapids: The Development of Regulated Next-Generation Sequencing-Based Clinical Trial Assays and Companion Diagnostics

(2014) Saumya Pant et al.   Frontiers in Oncology

Targeted Next-Generation Sequencing can Replace Sanger Sequencing in Clinical Diagnostics

(2013) Birgit Sikkema-Raddatz et al.   HUMAN MUTATION

KRAS testing in metastatic colorectal carcinoma: challenges, controversies, breakthroughs and beyond

(2013) Umberto Malapelle et al.   JOURNAL OF CLINICAL PATHOLOGY

Targeted, High-Depth, Next-Generation Sequencing of Cancer Genes in Formalin-Fixed, Paraffin-Embedded and Fine-Needle Aspiration Tumor Specimens

(2013) Andrew G. Hadd et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Panitumumab–FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer

(2013) Jean-Yves Douillard et al.   NEW ENGLAND JOURNAL OF MEDICINE

KRAS mutation detection by high-resolution melting analysis significantly predicts clinical benefit of cetuximab in metastatic colorectal cancer

(2012) U Malapelle et al.   BRITISH JOURNAL OF CANCER

Sanger sequencing in routine KRAS testing: a review of 1720 cases from a pathologist's perspective

(2012) Umberto Malapelle et al.   JOURNAL OF CLINICAL PATHOLOGY

Combining Highly Multiplexed PCR with Semiconductor-Based Sequencing for Rapid Cancer Genotyping

(2012) Carol Beadling et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

An integrated semiconductor device enabling non-optical genome sequencing

(2011) Jonathan M. Rothberg et al.   NATURE

Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer

(2010) M. Janakiraman et al.   CANCER RESEARCH

KRAS mutation analysis on cytological specimens of metastatic colo-rectal cancer

(2010) Giancarlo Troncone et al.   DIAGNOSTIC CYTOPATHOLOGY

Association of KRAS p.G13D Mutation With Outcome in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer Treated With Cetuximab

(2010) Wendy De Roock et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

American Society of Clinical Oncology Provisional Clinical Opinion: Testing forKRASGene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti–Epidermal Growth Factor Receptor Monoclonal Antibody Therapy

(2009) Carmen J. Allegra et al.   JOURNAL OF CLINICAL ONCOLOGY

Wild-TypeKRASIs Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer

(2008) Rafael G. Amado et al.   JOURNAL OF CLINICAL ONCOLOGY

K-rasMutations and Benefit from Cetuximab in Advanced Colorectal Cancer

(2008) Christos S. Karapetis et al.   NEW ENGLAND JOURNAL OF MEDICINE

KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program

(2008) J. H. J. M. van Krieken et al.   VIRCHOWS ARCHIV