Article
Infectious Diseases
Jose Molto, Fredzzia Graterol, Adrian Curran, Natalia Ramos, Arkaitz Imaz, Diego Sandoval, Francisco Perez, Lucia Bailon, Saye Khoo, Laura Else, Roger Paredes
Summary: This study evaluated the effect of haemodialysis on doravirine concentrations in people living with HIV (PLWH) undergoing routine haemodialysis. The results showed that despite moderate removal of doravirine by haemodialysis, trough doravirine concentrations in plasma after the haemodialysis sessions remained in excess of the protein-binding-adjusted EC50 (5 ng/mL). Therefore, doravirine dosage adjustments are unnecessary in PLWH undergoing intermittent haemodialysis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Health Care Sciences & Services
Chia-Chen Hsieh, Ming-Jen Chan, Yi-Jiun Su, Jen-Fen Fu, I-Kuan Wang, Chao-Yu Chen, Cheng-Hao Weng, Wen-Hung Huang, Ching-Wei Hsu, Tzung-Hai Yen
Summary: This study found that bone marrow pathology is more severe in patients with ESKD, with lower percentage of blasts and higher incidence of hypocellular bone marrow. ESKD status and megakaryocyte count within bone marrow were significant predictors for bone marrow hypocellularity.
Article
Biochemistry & Molecular Biology
Takeo Koshida, Tomohito Gohda, Takuya Sugimoto, Takashi Asahara, Rin Asao, Isao Ohsawa, Hiromichi Gotoh, Maki Murakoshi, Yusuke Suzuki, Yuichiro Yamashiro
Summary: The composition of the gut microbiome differs between patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) and those with normal renal function (NRF). This difference is associated with altered levels of stool organic acids, systemic inflammation, and accumulation of uremic toxins (UTs). Furthermore, the levels of UTs, inflammatory markers, and stool organic acids differ significantly between patients with NRF and those undergoing HD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Rodolfo J. Galindo, Francisco J. Pasquel, Priyathama Vellanki, Cesar Zambrano, Bonnie Albury, Citlalli Perez-Guzman, Zheng Ziduo, Guillermo E. Umpierrez
Summary: This study revealed significant metabolic differences among DKA patients with different levels of renal function, with beta-hydroxybutyrate levels potentially assisting in confirming the diagnosis of DKA in ESKD patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Lijun Zhao, Yutong Zou, Yucheng Wu, Linli Cai, Yuancheng Zhao, Yiting Wang, Xiang Xiao, Qing Yang, Jia Yang, Honghong Ren, Nanwei Tong, Fang Liu
Summary: This study investigated the pathological characteristics and the independent or mutual relations of obesity and metabolic abnormalities with end-stage kidney disease (ESKD) in patients with type 2 diabetes and associated diabetic kidney disease (DKD). The study found that obesity was associated with Kimmelstiel-Wilson nodules and severe mesangial expansion, while metabolic abnormalities were associated with severe interstitial fibrosis and tubular atrophy. Obesity itself was insignificantly associated with ESKD, but adding a metabolically unhealthy status to obesity increased the risk for progression to ESKD in T2D and biopsy-proven DKD patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Letter
Medicine, General & Internal
Vikram Fielding-Singh, Matthew W. Vanneman, Arden M. Morris, Glenn M. Chertow, Eugene Lin
Summary: This cohort study examines the relationship between patient characteristics and the time interval between hemodialysis and surgery in end-stage kidney disease patients.
Article
Medicine, General & Internal
Min Jun Seo, Dong Geon Lee, Se Yun Ko, Ga Yeong Song, Geon Yeong Lee, Sung Hwa Kim, Dae Ryong Kang, Jiye Kim, Jun Young Lee
Summary: Patients with end-stage kidney disease on dialysis are at a high risk of developing foot ulcerations and subsequent lower extremity amputation. Identifying risk factors associated with amputation can help predict and prevent its progression. Factors such as older age, male gender, lower income, non-metropolitan residence, diabetes mellitus, dialysis treatment, microvascular disease, peripheral vascular disease, endovascular procedure, and endovascular operation are associated with an increased risk of amputation. Close monitoring and consideration of kidney transplantation as a preventative measure are recommended for high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Urology & Nephrology
Orlando M. Gutierrez
Summary: Iron deficiency is common in individuals with chronic kidney disease and can lead to the development of anemia. Oral iron agents may not be effective, and consideration should be given to using intravenous formulations. Recent studies suggest that more aggressive repletion of iron may provide benefits for anemia management and severe clinical outcomes such as cardiovascular disease.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Urology & Nephrology
Oren Pleniceanu, Gilad Twig, Dorit Tzur, Gilad Sherman, Arnon Afek, Tomer Erlich, Lital Keinan-Boker, Karl Skorecki, Asaf Vivante, Ronit Calderon-Margalit
Summary: A history of pyelonephritis is significantly associated with an increased risk of treated ESKD, particularly when associated with kidney scarring or reduced baseline kidney function.
JOURNAL OF NEPHROLOGY
(2021)
Article
Nutrition & Dietetics
Maciej Sledzinski, Aleksandra Hliwa, Justyna Golebiewska, Adriana Mika
Summary: The levels of fatty acids in the serum of kidney transplant recipients significantly decrease after transplantation, which may contribute to an increased cardiovascular risk.
Article
Medicine, General & Internal
Lorry Aitkens, Jennifer L. Waller, Stephanie L. Baer, Azeem Mohammed, Sarah Tran, Budder Siddiqui, Sandeep Padala, Lufei Young, Mufaddal Kheda, Wendy B. Bollag
Summary: This study found that psoriasis is protective against pneumonia in patients with end-stage renal disease, with other factors such as the Charlson Comorbidity Index (CCI) and tobacco use being more strongly associated with increased risk for pneumonia.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Timothy Nguyen, Beatrice Polyakova, John Cerenzio, Josh Renzo Ramilo
Summary: "Limited studies are available on the use of diphenhydramine in patients with end-stage kidney disease and undergoing dialysis, with potential risks of toxicity due to its high protein binding. Information on diphenhydramine in the dialysis population is scarce, and dosing toxicity remains unknown. Clinicians should exercise caution when prescribing diphenhydramine to this patient population."
AMERICAN JOURNAL OF THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Giuseppina Crugliano, Raffaele Serra, Nicola Ielapi, Yuri Battaglia, Giuseppe Coppolino, Davide Bolignano, Umberto Marcello Bracale, Antonio Pisani, Teresa Faga, Ashour Michael, Michele Provenzano, Michele Andreucci
Summary: Anemia is a common complication of chronic kidney disease (CKD) due to EPO deficiency and functional iron deficiency (FID). Current treatment for anemia in CKD involves the use of ESAs and iron supplementation, but there is no evidence that ESAs can significantly reduce the risk of cardiovascular events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jong Joo Moon, Yong Woo Kim, Baek-Lok Oh, Kyungdo Han, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Ki Ho Park, Hajeong Lee, Yong Chul Kim, Jin Wook Jeoung
Summary: This nationwide cohort study found that the incidence of primary open-angle glaucoma (POAG) was higher in patients with end stage renal disease (ESRD) and kidney transplantation recipients (KTRs) compared to healthy controls, but adjusting for confounding factors did not show a significant increase in risk. The incidence of primary angle-closure glaucoma (PACG) was higher in ESRD patients compared to healthy controls, while KTRs had a lower risk of PACG compared to ESRD patients.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Adrian Vasile Muresan, Eliza Russu, Emil Marian Arbanasi, Reka Kaller, Ioan Hosu, Eliza Mihaela Arbanasi, Septimiu Toader Voidazan
Summary: This study found that the neutrophil-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) are effective markers for assessing the outcome of end-stage kidney disease (ESKD) patients. Elevated values of these ratios are associated with higher mortality rates, longer hospital stays, and more dialysis sessions.
Article
Nutrition & Dietetics
S. Sridharan, J. Wong, E. Vilar, K. Farrington
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2016)
Article
Biochemistry & Molecular Biology
Oscar Swift, Enric Vilar, Belinda Rahman, Lucy Side, Daniel P. Gale
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2016)
Article
Multidisciplinary Sciences
Sivakumar Sridharan, Enric Vilar, Andrew Davenport, Neil Ashman, Michael Almond, Anindya Banerjee, Justin Roberts, Ken Farrington
Article
Transplantation
Raja Mohammed Kaja Kamal, Ken Farrington, Amanda D. Busby, David Wellsted, Humza Chandna, Laura J. Mawer, Sivakumar Sridharan, Enric Vilar
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2019)
Article
Biochemistry & Molecular Biology
Jonathan Wong, Kaatje Lenaerts, Dennis M. Meesters, Steven W. M. Olde Damink, Hans M. H. van Eijk, Enric Vilar, Ken Farrington
BIOSCIENCE REPORTS
(2019)
Article
Urology & Nephrology
Damien Ashby, Natalie Borman, James Burton, Richard Corbett, Andrew Davenport, Ken Farrington, Katey Flowers, James Fotheringham, R. N. Andrea Fox, Gail Franklin, Claire Gardiner, R. N. Martin Gerrish, Sharlene Greenwood, Daljit Hothi, Abdul Khares, Pelagia Koufaki, Jeremy Levy, Elizabeth Lindley, Jamie Macdonald, Bruno Mafrici, Andrew Mooney, James Tattersall, Kay Tyerman, Enric Villar, Martin Wilkie
Article
Urology & Nephrology
Jonathan Wong, Yonglong Zhang, Oscar Swift, Malcolm Finkelman, Ashish Patidar, Sivaramakrishnan Ramanarayanan, Enric Vilar, Ken Farrington
Article
Medicine, General & Internal
Raja Mohammed Kaja Kamal, Ken Farrington, David Wellsted, Sivakumar Sridharan, Bassam Alchi, James Burton, Andrew Davenport, Enric Vilar
Article
Transplantation
Sivakumar Sridharan, Enric Vilar, Sivaramakrishnan Ramanarayanan, Andrew Davenport, Ken Farrington
Summary: A novel physical activity questionnaire (CKD-PAQ) was developed and compared with the validated RPAQ in patients with advanced chronic kidney disease. The CKD-PAQ showed comparable performance to RPAQ, but was shorter, easier to complete, and improved discrimination between low activity groups.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Nutrition & Dietetics
Enric Vilar, Sivakumar Sridharan, Jonathan Wong, Jocelyn Berdeprado, Ken Farrington
Summary: This study aimed to investigate the relationship between metabolic rate in CKD patients and reduced renal function, finding that decreased glomerular filtration rate was not directly related to total energy expenditure and resting energy expenditure, but rather associated with factors such as age, sex, and weight.
JOURNAL OF RENAL NUTRITION
(2021)
Article
Urology & Nephrology
Enric Vilar, Raja M. Kaja Kamal, James Fotheringham, Amanda Busby, Jocelyn Berdeprado, Ewa Kislowska, David Wellsted, Bassam Alchi, James O. Burton, Andrew Davenport, Ken Farrington
Summary: This study explored the feasibility and effects of twice-weekly hemodialysis on kidney function preservation. The results showed that twice-weekly hemodialysis is safe and cost-saving in incident patients with adequate kidney function, but it did not demonstrate benefits in terms of kidney function protection or quality of life.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
James Fotheringham, Enric Vilar, Tarun Bansal, Paul Laboi, Andrew Davenport, Louese Dunn, Arne Risa Hole
Summary: This study quantified the relative importance and acceptability of longer and more frequent hemodialysis sessions to patients. The findings showed that longer and more frequent sessions were associated with improved survival, quality of life, reduced need for fluid restriction, and avoidance of access complications. Younger age, fatigue, previous experience of access complications, absence of heart failure, and shorter travel time to the dialysis center were associated with a preference for more frequent sessions. These results highlight the need for further research on the clinical effectiveness of these intensive regimens and consideration of patient choice in dialysis selection.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Review
Urology & Nephrology
Oscar Swift, Shivani Sharma, Sivaramakrishnan Ramanarayanan, Hamza Umar, Keith R. Laws, Enric Vilar, Ken Farrington
Summary: This study analyzed the coexistence of chronic liver disease (CLD) in dialysis patients and found a high prevalence of cirrhosis and non-alcoholic fatty liver disease (NAFLD). Hepatitis B and C were identified as risk factors for cirrhosis. However, further research is needed to understand the impact of NAFLD and NASH on cirrhosis.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Transplantation
Emma Caton, Shivani Sharma, Enric Vilar, Kenneth Farrington
Summary: Incremental initiation of haemodialysis is as safe and effective as standard treatment, with similar mortality rates and potential benefits in reducing hospitalization and costs.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Sivakumar Sridharan, Enric Vilar, Andrew Davenport, Neil Ashman, Michael Almond, Anindya Banerjee, Justin Roberts, Ken Farrington
AMERICAN JOURNAL OF KIDNEY DISEASES
(2017)