Article
Oncology
Tanya Moseley, Bella Desai, Gary J. Whitman, Emily K. Robinson, Tamara Saunders, Anneliese Gonzalez, Hongying He
Summary: The upgrade rate to malignancy was 2.9% in 102 patients with benign breast IDPs without atypia, while the upgrade rate to high-risk benign lesions was 7.8%. A personal history of breast cancer and larger lesion size were significantly associated with an upgrade to malignancy.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Pathology
Vanessa Reinaldo Lima, Beatriz da Costa Aguiar Alves, Fernando Luiz Affonso Fonseca, Debora Krutman Zveibil, Auro del Giglio
Summary: The creation of multigene panels allows for a more accurate indication of adjuvant chemotherapy for breast cancer patients. Variations in the pre-analytical processing of specimens can significantly affect the results of multigene panel amplification, potentially impacting clinical management.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2022)
Article
Oncology
Ahmed Bouras, Souhir Guidara, Melanie Leone, Adrien Buisson, Tanguy Martin-Denavit, Sophie Dussart, Christine Lasset, Sophie Giraud, Marie-Noelle Bonnet-Dupeyron, Zine-Eddine Kherraf, Damien Sanlaville, Sandra Fert-Ferrer, Marine Lebrun, Valerie Bonadona, Alain Calender, Nadia Boutry-Kryza
Summary: Hereditary Breast and Ovarian Cancer syndrome (HBOC) is a genetic condition that predisposes adults to earlier onset of cancer. BRCA1 and BRCA2 mutations are the most common causes of HBOC, but mutations in other genes are also present. A retrospective analysis of 4630 French HBOC suspected cases found pathogenic variants in several genes, including BRCA1, BRCA2, PALB2, RAD51C, TP53, and RAD51D. The study also highlighted the importance of retesting BRCA-negative individuals with an expanded panel and the relevance of functional splicing tests in variant classification.
Article
Oncology
Slavica Janeva, Toshima Z. Parris, Salmir Nasic, Shahin De Lara, Karolina Larsson, Riccardo A. Audisio, Roger Olofsson Bagge, Aniko Kovacs
Summary: The comparison between STRAT4 and IHC/SISH showed discrepancies in BC patients, potentially resulting in more adjuvant treatment.
Review
Pathology
Catarina Calle, Elaine Zhong, Matthew G. G. Hanna, Katia Ventura, Maria A. A. Friedlander, Monica Morrow, Hiram Cody III, Edi Brogi
Summary: Core needle biopsy of breast lesions is an important procedure for diagnosis and treatment planning. However, discrepancies in diagnosis between different laboratories can occur, leading to changes in treatment management. This study showed that a significant number of breast CNBs had discrepant diagnoses, with 2.5% of cases experiencing a change in diagnostic category that affected surgical management.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Hani Saghir, Srinivas Veerla, Martin Malmberg, Lisa Ryden, Anna Ehinger, Lao H. Saal, Johan Vallon-Christersson, Ake Borg, Cecilia Hegardt, Christer Larsson, Alaa Haidar, Ingrid Hedenfalk, Niklas Loman, Siker Kimbung
Summary: This study aimed to assess the reliability of using CNB for preoperative tumor characterization in early breast cancer. Results showed moderate to very good correlation between IHC and GEX assessment in paired CNB and surgical specimens, with some discrepancies observed in Ki67 and ER across different techniques, potentially impacting treatment decisions and patient outcomes.
Article
Oncology
Luca Licata, Deborah Cosentini, Rita De Sanctis, Monica Iorfida, Elena Rota Caremoli, Andrea Vingiani, Edda Lucia Simoncini, Giancarlo Pruneri, Elisabetta Munzone, Giampaolo Bianchini, Alberto Zambelli, Carlo Tondini
Summary: The increasing understanding of breast cancer biology has led to the development of multigene signatures to improve prognostication and risk stratification. The use of these tools in clinical practice has greatly influenced treatment decisions for patients with ER+/HER2- early breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Yuan Zhao, Dun Xiong, Bo Yang, Shaocai Xia, Xinzhi Zhang
Summary: Precision medicine is the future direction of medical development, especially in cancer diagnosis and treatment. The application scope of multigene panel testing in breast cancer is expanding and providing guidance for clinical decision-making. There are promising prospects for broader applications in the future.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2023)
Article
Pathology
S. Emily Bachert, Aaron Jen, Christine Denison, Dylan Kwait, Esther Rhei, Jane Karimova, Sona Chikarmane, Xuefei Hong, Susan C. Lester
Summary: This study explored the pathologic lesions associated with architectural distortion (AD) on mammography and found that approximately one-third of lesions associated with AD were invasive, low-grade, ER-positive, HER2-negative, and low stage carcinomas. There was a difference in the incidence of carcinomas between single-feature AD and multi-feature AD, with fewer carcinomas found on core needle biopsy (CNB) for single-feature AD. The rate of malignancy found on excision for benign lesions with a correlate for AD was low. The challenge of radiologic/pathologic correlation and decision-making for excision remains, particularly for patients with multi-feature AD who may have undetected invasive carcinomas.
Article
Biochemistry & Molecular Biology
Teng Huang, Jiaheng Li, San Ming Wang
Summary: Abnormal gene expression plays a key role in cancer development. We hypothesized that in cancer, core promoter sequences could be mutated to interfere with transcriptional factors' interaction, resulting in altered transcriptional initiation, abnormal gene expression, and cancer development. Using triple-negative breast cancer (TNBC) as a model, we identified somatic and germline variants in core promoters of genes that affect gene expression and validated the findings. Comparison with core promoter variation data from unclassified breast cancer revealed TNBC-specific core promoter variants. This study demonstrates the mutability of core promoters in cancer and their impact on transcriptional initiation in TNBC and other cancer types.
Article
Oncology
Inna Jorg, Jann Wieler, Constanze Elfgen, Kristina Bolten, Claudia Hutzli, Julia Talimi, Denise Vorburger, Matthias Choschzick, Linda Moskovszky, Konstantin Dedes, Zsuzsanna Varga
Summary: Ultrasound-guided breast biopsy is a common diagnostic method, but discrepancies between imaging and pathology results are common. Interdisciplinary discussions are necessary to determine the next diagnostic steps in cases of discordance.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Rahmani Maha, Johnston Alison, Sugrue Michael, Varzgalis Manvydas
Summary: The diagnostic value of clinical core biopsies in non-suspicious palpable breast lesions is uncertain, and there is variation in clinical practice. In most cases, a clinical core biopsy is not required when the patient is assigned a clinical score of S3 and has normal radiology.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Surgery
Geraldine J. Ooi, Andrew Clouston, Yazmin Johari, William W. Kemp, Stuart K. Roberts, Wendy A. Brown, Paul R. Burton
Summary: Liver biopsy remains the gold standard for characterizing and evaluating treatment response in nonalcoholic fatty liver disease (NAFLD), but there is variability in individual components such as fibrosis stage between different biopsy sites. Clinicians should consider biopsies from varied sites to better assess liver disease severity, as a combination of biopsy techniques improves the detection of pathology.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Pawel Zayakin, Lilite Sadovska, Kristaps Eglitis, Nadezhda Romanchikova, Ilze Radovica-Spalvina, Edgars Endzelins, Inta Liepniece-Karele, Janis Eglitis, Aija Line
Summary: This study aimed to identify cancer-derived RNA biomarkers in plasma extracellular vesicles (EVs) from breast cancer patients. The results showed increased fractions of miRNAs, snRNAs, snoRNAs, and tRFs, but decreased fraction of lncRNAs in breast cancer EVs. Additionally, biomarker models were created that could accurately detect breast cancer and determine tumor estrogen receptor and HER2 status.
Article
Medical Laboratory Technology
Yuanxin Liang, Twisha Oza, Adriana Corben, Nebras Zeizafoun, Melissa Alexander, Shabnam Jaffer
Summary: The study analyzed the importance of measuring the size of invasive mammary carcinoma on biopsy and found that while most tumors are larger on excision, 18% are larger or equal on biopsy. Factors predictive of biopsy > excision tumors include stage 1 tumors, especially less than 5 mm, and sampled by mammotome. The study recommends measuring invasive carcinoma on both biopsy and excision.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Oncology
S. Loibl, C. Jackisch, A. Schneeweiss, S. Schmatloch, B. Aktas, C. Denkert, H. Wiebringhaus, S. Kuemmel, M. Warm, S. Paepke, M. Just, C. Hanusch, J. Hackmann, J. -U. Blohmer, M. Clemens, S. Dan Costa, B. Gerber, K. Engels, V. Nekljudova, G. von Minckwitz, M. Untch
ANNALS OF ONCOLOGY
(2017)
Article
Oncology
Barbara Ingold Heppner, Michael Untch, Carsten Denkert, Berit M. Pfitzner, Bianca Lederer, Wolfgang Schmitt, Holger Eidtmann, Peter A. Fasching, Hans Tesch, Christine Solbach, Mahdi Rezai, Dirk M. Zahm, Frank Holms, Manfred Glados, Petra Krabisch, Esther Heck, Angelika Ober, Petra Lorenz, Kurt Diebold, Jorg-Olaf Habeck, Sibylle Loib
CLINICAL CANCER RESEARCH
(2016)
Article
Oncology
G. von Minckwitz, M. Rezai, H. Tesch, J. Huober, B. Gerber, D. M. Zahm, J. Hilfrich, S. D. Costa, P. Dubsky, J. U. Blohmer, C. Denkert, C. Hanusch, C. Jackisch, S. Kuemmel, P. A. Fasching, A. Schneeweiss, S. Paepke, M. Untch, N. Burchardi, K. Mehta, S. Loibl
EUROPEAN JOURNAL OF CANCER
(2016)
Article
Oncology
Jan Budczies, Michael Bockmayr, Carsten Denkert, Frederick Klauschen, Stefan Groeschel, Silvia Darb-Esfahani, Nicole Pfarr, Jonas Leichsenring, Maristela L. Onozato, Jochen K. Lennerz, Manfred Dietel, Stefan Froehling, Peter Schirmacher, A. John Iafrate, Wilko Weichert, Albrecht Stenzinger
GENES CHROMOSOMES & CANCER
(2016)
Article
Pathology
Ulrike Unger, Carsten Denkert, Ioana Braicu, Jalid Sehouli, Manfred Dietel, Sibylle Loibl, Silvia Darb-Esfahani
Article
Medicine, General & Internal
Carsten Denkert, Cornelia Liedtke, Andrew Tutt, Gunter von Minckwitz
Article
Pathology
Berit M. Pfitzner, Bianca Lederer, Judith Lindner, Christine Solbach, Knut Engels, Mahdi Rezai, Karel Dohnal, Hans Tesch, Martin L. Hansmann, Christoph Salat, Michaela Beer, Andreas Schneeweiss, Peter Sinn, Agnes Bankfalvi, Silvia Darb-Esfahani, Gunter von Minckwitz, Bruno V. Sinn, Ralf Kronenwett, Karsten Weber, Carsten Denkert, Sibylle Loibl
Article
Oncology
Debora Fumagalli, David Venet, Michail Ignatiadis, Hatem A. Azim, Marion Maetens, Francoise Rothe, Roberto Salgado, Ian Bradbury, Lajos Pusztai, Nadia Harbeck, Henry Gomez, Tsai-Wang Chang, Maria Antonia Coccia-Portugal, Serena Di Cosimo, Evandro de Azambuja, Lorena de la Pena, Paolo Nuciforo, Jan C. Brase, Jens Huober, Jose Baselga, Martine Piccart, Sherene Loi, Christos Sotiriou
Article
Oncology
Ryan B. Corcoran, Thierry Andre, Chloe E. Atreya, Jan H. M. Schellens, Takayuki Yoshino, Johanna C. Bendell, Antoine Hollebecque, Autumn J. McRee, Salvatore Siena, Gary Middleton, Kei Muro, Michael S. Gordon, Josep Tabernero, Rona Yaeger, Peter J. O'Dwyer, Yves Humblet, Filip De Vos, A. Scott Jung, Jan C. Brase, Savina Jaeger, Severine Bettinger, Bijoyesh Mookerjee, Fatima Rangwala, Eric Van Cutsem
Article
Oncology
Aleix Prat, Jan Christoph Brase, Yuan Cheng, Paolo Nuciforo, Laia Pare, Tomas Pascual, Debora Martinez, Patricia Galvan, Maria Vidal, Barbara Adamo, Gabriel N. Hortobagyi, Jose Baselga, Eva Ciruelos
Article
Cell Biology
Ulrike Rueder, Carsten Denkert, Catarina Alisa Kunze, Paul Jank, Judith Lindner, Korinna Joehrene, Hagen Kulbe, Jalid Sehouli, Manfred Dietel, Elena Braicu, Silvia Darb-Esfahani
HISTOLOGY AND HISTOPATHOLOGY
(2019)
Article
Oncology
P. Nuciforo, T. Pascual, J. Cortes, A. Llombart-Cussac, R. Fasani, L. Pare, M. Oliveira, P. Galvan, N. Martinez, B. Bermejo, M. Vidal, S. Pernas, R. Lopez, M. Munoz, I. Garau, L. Manso, J. Alarcon, E. Martinez, V. Rodrik-Outmezguine, J. C. Brase, P. Villagrasa, A. Prat, E. Holgado
ANNALS OF ONCOLOGY
(2018)
Article
Oncology
Ariella B. Hanker, Joan T. Garrett, Monica Valeria Estrada, Preston D. Moore, Paula Gonzalez Ericsson, James P. Koch, Emma Langley, Sharat Singh, Phillip S. Kim, Garrett M. Frampton, Eric Sanford, Philip Owens, Jennifer Becker, M. Reid Groseclose, Stephen Castellino, Heikki Joensuu, Jens Huober, Jan C. Brase, Samira Majjaj, Sylvain Brohee, David Venet, David Brown, Jose Baselga, Martine Piccart, Christos Sotiriou, Carlos L. Arteaga
CLINICAL CANCER RESEARCH
(2017)
Article
Oncology
M. H. Kulke, P. Ruszniewski, E. Van Cutsem, C. Lombard-Bohas, J. W. Valle, W. W. De Herder, M. Pavel, E. Degtyarev, J. C. Brase, L. Bubuteishvili-Pacaud, M. Voi, R. Salazar, I. Borbath, N. Fazio, D. Smith, J. Capdevila, R. P. Riechelmann, J. C. Yao
ANNALS OF ONCOLOGY
(2017)
Article
Oncology
Mattea Reinisch, Jens Huober, Gunter von Minckwitz, Jens-Uwe Blohmer, Carsten Denkert, Claus Hanusch, Christian Jackisch, Sherko Kuemmel, Andreas Schneeweiss, Kerstin Rhiem, Bianca Lederer, Michael Untch, Valentina V. Nekljudova, Sibylle Loibl
