Article
Oncology
Dan Moldoveanu, Ericka Iny, Chloe Theriault, Anca Florea, Stephanie M. Wong, Mark Basik, Jean-Francois Boileau, Richard Margolese, Manuela Pelmus, Sarkis Meterissian, Ipshita Prakash
Summary: This study found that positive resection margins were associated with an increased recurrence rate in patients with phyllodes tumors, while margin width was not significantly associated with recurrence. Individualized decisions regarding margin reexcision are important.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Dan Moldoveanu, Ericka Iny, Chloe Theriault, Anca Florea, Stephanie M. Wong, Mark Basik, Jean-Francois Boileau, Richard Margolese, Manuela Pelmus, Sarkis Meterissian, Ipshita Prakash
Summary: This retrospective study investigated clinical and prognostic factors of phyllodes tumors of the breast, and found that positive resection margins at the initial surgery were significantly associated with an increased recurrence rate, while margin width was not significantly correlated with recurrence.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
H. -J. Wang, P. -W. Cao, S. -M. Nan, X. -Y. Deng
Summary: This study investigated the use of mammography-based radiomics analysis and MG/US imaging features to predict the malignant risk of phyllodes tumours (PTs) of the breast. Clinical information, MG and US imaging characteristics, and histogram features were extracted and analyzed. The results showed that variance in the CC view and mean and variance in the MLO view were independent predictors of malignancy in PTs. The study concluded that MG-based radiomic features could potentially be used to differentiate benign and borderline/malignant PTs.
CLINICAL RADIOLOGY
(2023)
Article
Genetics & Heredity
Wei Li, Kun Fang, Jiaren Chen, Jian Deng, Dan Li, Hong Cao
Summary: This study aimed to explore prognostic risk factors in patients with malignant phyllodes tumors (PTs) of the breast and construct a survival prediction model. Age, tumor size, tumor stage, regional lymph node metastasis (N), distant metastasis (M), and tumor grade were found to be independent risk factors for the 5-year survival rate of patients. The constructed prediction model showed good predictive value and can aid in personalized management and treatment.
FRONTIERS IN GENETICS
(2023)
Review
Pathology
Puay Hoon Tan
Summary: Phyllodes tumours of the breast are challenging to classify due to multiple histological parameters. Lack of concordance among pathologists in typing and grading adds to the difficulty. Despite significant molecular information, it has not been translated into daily clinical practice. A multipronged approach is needed to refine the classification of phyllodes tumours.
Article
Oncology
Shuang Meng, Lihua Chen, Qinhe Zhang, Nan Wang, Ailian Liu
Summary: This study developed a novel mpMRI-based diagnostic model to predict surgical margins in prostate cancer patients, which showed higher specificity and predictive ability compared to a clinical-based model. The model can improve surgical planning and reduce the risk of positive surgical margins.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Benjamin Yongcheng Tan, Stephen B. Fox, Sunil R. Lakhani, Puay Hoon Tan
Summary: Grading of breast phyllodes tumors (PTs) varies due to differences in weighting of grading criteria by pathologists. Key diagnostic criteria include increased stromal cellularity, stromal overgrowth, increased stromal mitoses, stromal atypia, stromal fronding, irregular tumor borders, and/or lesional heterogeneity. Clinical and radiological findings, as well as age, also play important roles in determining the diagnosis.
Article
Surgery
Yufan Wei, Yongjing Dai, Qingyu Guan, Ningning Min, Rui Geng, Huayu Hu, Jie Li, Yiqiong Zheng, Mei Liu, Xiru Li
Summary: This article investigates the correlation between phyllodes tumor (PT) prognosis and clinicopathological features, treatment, and surgical margin. Analysis of data from patients with PT shows that age, fibroadenoma surgery history, treatment, mitotic activity, and surgical margin are independent factors for PT prognosis. A nomogram is proposed to predict the recurrence-free survival (RFS) of PT and shows good discriminative ability and calibration, accurately stratifying patients into prognostic groups.
Article
Surgery
Mustafa Tukenmez, Baran Mollavelioglu, Semen Onder, Selman Emiroglu, Mehmet Velidedeoglu, Sefa Ergun, Neslihan Cabioglu, Mahmut Muslumanoglu
Summary: This study aimed to determine the appropriate surgical margin in the treatment of phyllodes tumour (PT) of the breast. The results showed that negative surgical margins seem to be sufficient for benign PT, while at least 1 cm negative surgical margins must be achieved for malignant and borderline PT to avoid local recurrence.
ANZ JOURNAL OF SURGERY
(2023)
Article
Veterinary Sciences
Thomas De Ridder, Paul Reddell, Pamela Jones, Graham Brown, Justine Campbell
Summary: TT-mediated margins are generally less than half the length of margins calculated for surgical excision, particularly for MCTs <10 cm(3) in volume. This suggests that smaller and more targeted margins can be expected when treating MCTs with TT.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Cell Biology
Raluca Mihai, Grace Callagy, Omar L. Qassid, Mark O. Loughlin, Lena Al-Hilfi, Areeg Abbas, Michela Campora, Zsolt Hodi, Ian Ellis, Andrew H. S. Lee, Emad A. Rakha
Summary: The study evaluated the preoperative diagnosis of breast phyllodes tumors, finding that malignant tumors were larger, occurred in older patients, and were more challenging to surgically manage. Morphological features were associated with adverse outcomes, and larger tumor size and margin distance correlated with both local recurrence and metastasis behavior.
Article
Oncology
Ashley Cairns, Anees B. Chagpar, Elisabeth Dupont, Edward A. Levine, Jennifer S. Gass, Akiko Chiba, David W. Ollila, Marissa Howard-McNatt
Summary: A study involving 631 patients found that preoperative MRI was not associated with margin status for breast cancer patients undergoing BCS. Instead, age and tumor size were the only factors associated with margin status.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Bo Shi, Leiting Shen, Wenchang Huang, Linghao Cai, Sisi Yang, Yuanyuan Zhang, Jinfa Tou, Dengming Lai
Summary: This study explored and developed a diagnostic model for predicting the timing of surgical intervention in children with necrotizing enterocolitis (NEC). Clinical data, laboratory examinations, and radiological manifestations were collected, and a clinical prediction model based on logistic nomogram was developed using LASSO regression analysis and multivariate logistic regression analysis. The performance of the model was evaluated using ROC curve, calibration curves, and decision curve analysis, showing practicality, moderate predictive value, improved calibration, and enhanced clinical benefit.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Aojia Zhuang, Xuetong Yue, Hanxing Tong, Yong Zhang, Fuchu He, Weiqi Lu
Summary: This study developed a nomogram to predict the overall survival (OS) of patients with retroperitoneal leiomyosarcoma (RLMS) after surgical resection. The nomogram was constructed based on the COX regression model and showed good discrimination and calibration. The nomogram can be used for postoperative consultation and patient selection for clinical trials.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Rong Zhao, Jun Xing, Jinnan Gao
Summary: A nomogram was developed and validated to predict the status of breast-conserving margins in patients undergoing breast-conserving surgery. The nomogram, based on multiple indicators, showed good discrimination and calibration in both the modeling and validation groups.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Pei Sze Ng, Rick A. C. M. Boonen, Eldarina Wijaya, Chan Eng Chong, Milan Sharma, Sabine Knaup, Shivaani Mariapun, Weang Kee Ho, Joanna Lim, Sook-Yee Yoon, Nur Aishah Mohd Taib, Mee Hoong See, Jingmei Li, Swee Ho Lim, Ern Yu Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Veronique Kiat-Mien Tan, Rob Martinus van Dam, Kartini Rahmat, Cheng Har Yip, Sara Carvalho, Craig Luccarini, Caroline Baynes, Alison M. Dunning, Antonis Antoniou, Haico van Attikum, Douglas F. Easton, Mikael Hartman, Soo Hwang Teo
Summary: Rare protein-truncating variants (PTVs) in PALB2 confer increased risk of breast cancer in South-East Asian populations, with no association found between rare missense variants and breast cancer risk. Two novel rare missense variants were found to produce unstable proteins, leading to decreased DNA repair function. Despite genetic and lifestyle differences, the prevalence and risk of PALB2 PTVs in this population are similar to those reported in European populations.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Anesthesiology
E. Li
Summary: Surgical patients with peri-operative or recent SARS-CoV-2 infection are at increased risk of postoperative venous thromboembolism compared to those without a history of SARS-CoV-2. However, the optimal prophylaxis and treatment for venous thromboembolism in this patient population remains unknown. Venous thromboembolism is independently associated with 30-day mortality.
Article
Genetics & Heredity
Weang-Kee Ho, Mei-Chee Tai, Joe Dennis, Xiang Shu, Jingmei Li, Peh Joo Ho, Iona Y. Millwood, Kuang Lin, Yon-Ho Jee, Su-Hyun Lee, Nasim Mavaddat, Manjeet K. Bolla, Qin Wang, Kyriaki Michailidou, Jirong Long, Eldarina Azfar Wijaya, Tiara Hassan, Kartini Rahmat, Veronique Kiak Mien Tan, Benita Kiat Tee Tan, Su Ming Tan, Ern Yu Tan, Swee Ho Lim, Yu-Tang Gao, Ying Zheng, Daehee Kang, Ji-Yeob Choi, Wonshik Han, Han-Byoel Lee, Michiki Kubo, Yukinori Okada, Shinichi Namba, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Pei-Ei Wu, Boyoung Park, Kenneth R. Muir, Artitaya Lophatananon, Anna H. Wu, Chiu-Chen Tseng, Keitaro Matsuo, Hidemi Ito, Ava Kwong, Tsun L. Chan, Esther M. John, Allison W. Kurian, Motoki Iwasaki, Taiki Yamaji, Sun-Seog Kweon, Kristan J. Aronson, Rachel A. Murphy, Woon-Puay Koh, Chiea-Chuen Khor, Jian-Min Yuan, Rajkumar Dorajoo, Robin G. Walters, Zhengming Chen, Liming Li, Jun Lv, Keum-Ji Jung, Peter Kraft, Paul D. B. Pharoah, Alison M. Dunning, Jacques Simard, Xiao-Ou Shu, Cheng-Har Yip, Nur Aishah Mohd Taib, Antonis C. Antoniou, Wei Zheng, Mikael Hartman, Douglas F. Easton, Soo-Hwang Teo
Summary: This study developed breast cancer polygenic risk scores (PRSs) using data from Asian populations and evaluated their transferability across different ethnic subgroups. The results showed that the combined Asian and European PRSs had the best performance in stratifying the breast cancer risk for women of Asian ancestry.
GENETICS IN MEDICINE
(2022)
Article
Oncology
Tiffany Sin Hui Bong, Jun Kiat Thaddaeus Tan, Juliana Teng Swan Ho, Puay Hoon Tan, Wing Sze Lau, Tuan Meng Tan, Jill Su Lin Wong, Veronique Kiak Mien Tan, Benita Kiat Tee Tan, Preetha Madhukumar, Wei Sean Yong, Sue Zann Lim, Chow Yin Wong, Kong Wee Ong, Yirong Sim
Summary: This study identified factors predicting malignant upgrade for atypical ductal hyperplasia (ADH) diagnosed on core-needle biopsy (CNB) and developed a nomogram to facilitate decision making. The nomogram showed good discrimination of breast cancer risk prediction and identified a subset of low-risk women who may avoid surgical excision following a CNB diagnosis of ADH.
JOURNAL OF BREAST CANCER
(2022)
Article
Oncology
Boon Hong Ang, Weang Kee Ho, Eldarina Wijaya, Pui Yoke Kwan, Pei Sze Ng, Sook Yee Yoon, Siti Norhidayu Hasan, Joanna M. C. Lim, Tiara Hassan, Mei-Chee Tai, Jamie Allen, Andrew Lee, Nur Aishah Mohd Taib, Cheng Har Yip, Mikael Hartman, Swee Ho Lim, Ern Yu Tan, Benita K. T. Tan, Su-Ming Tan, Veronique K. M. Tan, Peh Joo Ho, Alexis J. Khng, Alison M. Dunning, Jingmei Li, Douglas F. Easton, Antonis C. Antoniou, Soo Hwang Teo
Summary: This study developed a new model, the Asian Risk Calculator, to estimate the likelihood of carrying a pathogenic BRCA1 or BRCA2 variant in Asian breast cancer patients. The model showed good discrimination and calibration, and the inclusion of tumor grade improved its performance. Adding grade to the existing clinical genetic testing criteria reduced the proportion of patients referred for testing, thereby improving overall efficacy.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Surgery
Joshua S. H. Lim, Yirong Sim, Joanne Ngeow, Jeanette Yuen, Veronique K. M. Tan, Benita Kiat Tee Tan, Wei-Sean Yong, Chow Yin Wong, Sue Zann Lim, Julie Liana B. Hamzah, Si Ying Tan, Fuh Yong Wong, Preetha Madhukumar
Summary: This study analyzed the institutional experience of male breast cancer (MBC) over a 20-year period in Singapore and found that the survival outcome and prognosis of MBC were similar to female breast cancer patients.
ANZ JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Peh Joo Ho, Weang Kee Ho, Alexis J. Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong, Wei Sean Yong, Chin Mui Seah, Siau Wei Tang, Celene Wei Qi Ng, Zhiyan Yan, Jung Ah Lee, Kartini Rahmat, Tania Islam, Tiara Hassan, Mei-Chee Tai, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Xueling Sim, Alison M. Dunning, Manjeet K. Bolla, Antonis C. Antoniou, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Summary: Family history and genetic and non-genetic risk stratification tools complement each other in identifying women at high risk of developing breast cancer.
Article
Oncology
Peh Joo Ho, Alexis Jiaying Khng, Benita Kiat-Tee Tan, Ern Yu Tan, Su-Ming Tan, Veronique Kiak Mien Tan, Geok Hoon Lim, Kristan J. Aronson, Tsun L. Chan, Ji-Yeob Choi, Joe Dennis, Weang-Kee Ho, Ming-Feng Hou, Hidemi Ito, Motoki Iwasaki, Esther M. John, Daehee Kang, Sung-Won Kim, Allison W. Kurian, Ava Kwong, Artitaya Lophatananon, Keitaro Matsuo, Nur Aishah Mohd-Taib, Kenneth Muir, Rachel A. Murphy, Sue K. Park, Chen-Yang Shen, Xiao-Ou Shu, Soo Hwang Teo, Qin Wang, Taiki Yamaji, Wei Zheng, Manjeet K. Bolla, Alison M. Dunning, Douglas F. Easton, Paul D. P. Pharoah, Mikael Hartman, Jingmei Li
Summary: This study investigated the association between HLA genes and breast cancer susceptibility in Asian women. The results showed no significant association between any HLA allele and breast cancer risk in this population.
Article
Oncology
Zi Lin Lim, Geok Hoon Lim, Peh Joo Ho, Alexis Jiaying Khng, Yen Shing Yeoh, Amanda Tse Woon Ong, Benita Kiat Tee Tan, Ern Yu Tan, Su-Ming Tan, Veronique Kiak-Mien Tan, Jingmei Li, Mikael Hartman
Summary: This study investigated the association between pre-diagnostic physical activity and the aggressiveness of breast cancer. The results showed that higher levels of pre-diagnostic physical activity were associated with less aggressive breast tumors, further highlighting the importance of physical activity in improving patient prognosis.
Article
Oncology
Seeu Si Ong, Peh Joo Ho, Alexis Jiaying Khng, Elaine Hsuen Lim, Fuh Yong Wong, Benita Kiat-Tee Tan, Swee Ho Lim, Ern Yu Tan, Su-Ming Tan, Veronique Kiak Mien Tan, Rebecca Dent, Tira Jing Ying Tan, Joanne Ngeow, Preetha Madhukumar, Julie Liana Bte Hamzah, Yirong Sim, Geok Hoon Lim, Jinnie Siyan Pang, Veronica Siton Alcantara, Patrick Mun Yew Chan, Juliana Jia Chuan Chen, Sherwin Kuah, Jaime Chin Mui Seah, Shaik Ahmad Buhari, Siau Wei Tang, Celene Wei Qi Ng, Jingmei Li, Mikael Hartman
Summary: The study investigated the relationship between a validated breast cancer polygenic risk score and chemotherapy-induced neutropenia and febrile neutropenia in Asian breast cancer patients, finding no strong association between the two.
Article
Oncology
Yirong Sim, Cindy Lim, Nitar Phyu, Kiat Tee Benita Tan, Lita Sui Tjien Chew, Chow Yin Wong, Preetha Madhukumar, Wei Sean Yong, Sue Zann Lim, Julie Liana Bte Hamzah, Si Ying Tan, Wen Yee Chay, Fuh Yong Wong, Puay Hoon Tan, Veronique Kiak-Mien Tan
Summary: This study found a correlation between the use of statin and a reduced risk of breast cancer recurrence in an Asian population, especially for patients with hormone receptor-positive and HER2-negative invasive breast cancers.
FRONTIERS IN ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Jue Tao Lim, Jemima Jia En Koh, Peh Joo Ho, Jenny Liu, Swee Ho Lim, Ern Yu Tan, Benita Kiat Tee Tan, Veronique Kiak Mien Tan, Su Ming Tan, Wei Sean Yong, Mikael Hartman, Cynthia Chen
Summary: The study found that subsidies have lowered the barriers to Herceptin uptake for marginalized individuals, especially among Indians. Education level has an impact on the uptake rate of Herceptin, but this impact was alleviated after subsidies were introduced.
VALUE IN HEALTH REGIONAL ISSUES
(2022)
Article
Medicine, General & Internal
Zi Lin Lim, Peh Joo Ho, Alexis Jiaying Khng, Yen Shing Yeoh, Amanda Tse Woon Ong, Benita Kiat Tee Tan, Ern Yu Tan, Su-Ming Tan, Geok Hoon Lim, Jung Ah Lee, Veronique Kiak-Mien Tan, Jesse Hu, Jingmei Li, Mikael Hartman
Summary: The participation in mammography screening (MAM) is associated with favorable characteristics and overall survival in breast cancer (BC) patients. Disparities in the utilization of MAM services suggest the need for different strategies to improve uptake.
Article
Pathology
Jian Yuan Goh, Chik Hong Kuick, Masahiro Sugiura, Sze Jet Aw, Manli Zhao, Hongfeng Tang, Sandini Gunaratne, Fucun Zhu, Lin Cai, Bin Tean Teh, Paul S. Thorner, Kenneth Tou En Chang
Summary: This study analyzed two cases of CCSK and one case of PMMTI using Archer FusionPlex technology and found a novel BCOR ITD mutation, which is unusually long and difficult to detect using typical primer design strategies and DNA sequencing.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2022)
Review
Oncology
Sabrina Ngaserin, Allen Wei-Jiat Wong, Faith Qi-Hui Leong, Jia-Jun Feng, Yee Onn Kok, Benita Kiat-Tee Tan
Summary: Endoscopic total mastectomy with abdominal-based flap reconstruction can achieve scarless mastectomy and reconstruction through minimal incisions, ensuring surgical safety and good aesthetic outcomes.
JOURNAL OF BREAST CANCER
(2023)
