Journal
JOURNAL OF CLINICAL PATHOLOGY
Volume 62, Issue 8, Pages 757-759Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/jcp.2008.063669
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This report describes a case of aleukaemic myeloid sarcoma of the small intestine in a 50-year-old woman presenting with small bowel obstruction. Fluorescence in situ hybridisation analysis of interphase nuclei revealed a split CBF beta signal, consistent with an underlying inversion of chromosome 16, inv(16)(p13q22). The resultant type A CBF beta/MYH11 transcript was detected by reverse transcriptase PCR. Immunohistochemistry with the AH107 antibody to the CBF beta-SMMHC chimeric protein showed strong nuclear staining of the tumour cell nuclei. This represents the first use of this antibody in the diagnosis of this subtype of myeloid sarcoma in the small intestine.
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