Trametinib in pediatric patients with neurofibromatosis type 1 (NF-1)-associated plexiform neurofibroma: A phase I/IIa study.
JOURNAL OF CLINICAL ONCOLOGY (2018)
Journal
JOURNAL OF CLINICAL ONCOLOGY
Volume 36, Issue 15, Pages -Publisher
AMER SOC CLINICAL ONCOLOGY
Keywords
Categories
Ask authors/readers for more resources
Authors
I am an author on this paper
Reviews
Recommended
Trametinib therapy for children with neurofibromatosis type 1 and life-threatening plexiform neurofibroma or treatment-refractory low-grade glioma
Rebecca Ronsley, Celine D. Hounjet, Sylvia Cheng, Shahrad Rod Rassekh, Walter J. Duncan, Christopher Dunham, Jane Gardiner, Arvindera Ghag, Jeffrey P. Ludemann, David Wensley, Wingfield Rehmus, Michael A. Sargent, Juliette Hukin
CANCER MEDICINE (2021)
Epidemiological and clinical burden associated with plexiform neurofibromas in pediatric neurofibromatosis type-1 (NF-1): a systematic literature review
Ike Iheanacho, Hyun Kyoo Yoo, Xiaoqin Yang, Sophie Dodman, Rachel Hughes, Suvina Amin
NEUROLOGICAL SCIENCES (2022)
Management of neurofibromatosis type 1-associated plexiform neurofibromas
Michael J. Fisher, Jaishri O. Blakeley, Brian D. Weiss, Eva Dombi, Shivani Ahlawat, Srivandana Akshintala, Allan J. Belzberg, Miriam Bornhorst, Miriam A. Bredella, Wenli Cai, Rosalie E. Ferner, Andrea M. Gross, Gordon J. Harris, Robert Listernick, Ina Ly, Staci Martin, Victor F. Mautner, Johannes M. Salamon, Kilian E. Salerno, Robert J. Spinner, Verena Staedtke, Nicole J. Ullrich, Meena Upadhyaya, Pamela L. Wolters, Kaleb Yohay, Brigitte C. Widemann
NEURO-ONCOLOGY (2022)
RNA-sequencing highlights differential regulated pathways involved in cell cycle and inflammation in orbitofacial neurofibromas
Eddie Luidy Imada, Diego Strianese, Deepak P. Edward, Rawan AlThaqib, Antionette Price, Antje Arnold, Hailah Al-Hussain, Luigi Marchionni, Fausto J. Rodriguez
BRAIN PATHOLOGY (2022)
Congenital Craniofacial Plexiform Neurofibroma in Neurofibromatosis Type 1
Antonella Cacchione, Alessia Carboni, Mariachiara Lodi, Rita De Vito, Andrea Carai, Antonio Marrazzo, Marina Macchiaiolo, Ioan Paul Voicu, Angela Mastronuzzi, Giovanna Stefania Colafati
DIAGNOSTICS (2021)
Efficacy and Safety of Trametinib in Neurofibromatosis Type 1-Associated Plexiform Neurofibroma and Low-Grade Glioma: A Systematic Review and Meta-Analysis
Dun Wang, Lingling Ge, Zizhen Guo, Yuehua Li, Beiyao Zhu, Wei Wang, Chengjiang Wei, Qingfeng Li, Zhichao Wang
PHARMACEUTICALS (2022)
Trametinib for orbital plexiform neurofibromas in young children with neurofibromatosis type 1
Helen Toledano, Gad Dotan, Rivka Friedland, Rony Cohen, Iftach Yassur, Hagit Toledano-Alhadef, Shlomi Constantini, Mika Shapira Rootman
CHILDS NERVOUS SYSTEM (2021)
The Number of Surgical Interventions and Specialists Involved in the Management of Patients with Neurofibromatosis Type I: A 25-Year Analysis
Chih-Kai Hsu, Rafael Denadai, Chun-Shin Chang, Chuan-Fong Yao, Ying-An Chen, Pang-Yun Chou, Lun-Jou Lo, Yu-Ray Chen
JOURNAL OF PERSONALIZED MEDICINE (2022)
Peripheral Nerve Sheath Tumors in Patients With Neurofibromatosis Type 1: Morphological and Immunohistochemical Study
Reinhard E. Friedrich, Louisa K. N. Noernberg, Christian Hagel
ANTICANCER RESEARCH (2022)
Dermatologic Manifestations of Neurofibromatosis Type 1 and Emerging Treatments
Dina Poplausky, Jade N. N. Young, Hansen Tai, Ryan Rivera-Oyola, Nicholas Gulati, Rebecca M. M. Brown
CANCERS (2023)
Concomitant variants in NF1, LZTR1 and GNAZ genes probably contribute to the aggressiveness of plexiform neurofibroma and warrant treatment with MEK inhibitor
Eran Cohen-Barak, Hagit Toledano-Alhadef, Nada Danial-Farran, Ido Livneh, Banan Mwassi, Maysa Hriesh, Fadia Zagairy, Chen Gafni-Amsalem, Husam Bashir, Morad Khayat, Nassim Warrour, Osnat Sher, Daphna Marom, Sergey Postovsky, Tal Dujovny, Michael Ziv, Stavit A. Shalev
EXPERIMENTAL DERMATOLOGY (2022)
Vinblastine/Methotrexate for Debilitating and Progressive Plexiform Neurofibroma in Children and Young Adults with Neurofibromatosis Type 1: A Phase 2 Study
Chelsea Kotch, Kristina Wagner, J. Harris Broad, Eva Dombi, Jane E. E. Minturn, Peter Phillips, Katherine Smith, Yimei Li, Ian N. N. Jacobs, Lisa M. M. Elden, Michael J. J. Fisher, Jean Belasco
CANCERS (2023)
Surgical Treatment and Complications of Deep-Seated Nodular Plexiform Neurofibromas Associated with Neurofibromatosis Type 1
Kunihiro Ikuta, Yoshihiro Nishida, Tomohisa Sakai, Hiroshi Koike, Kan Ito, Hiroshi Urakawa, Shiro Imagama
JOURNAL OF CLINICAL MEDICINE (2022)
Neurofibroma Development in Neurofibromatosis Type 1: Insights from Cellular Origin and Schwann Cell Lineage Development
Ling-Ling Ge, Ming-Yan Xing, Hai-Bing Zhang, Zhi-Chao Wang
CANCERS (2022)
Epidemiological profile and clinical characteristics of 491 Brazilian patients with neurofibromatosis type 1
Luiz Guilherme Darrigo Junior, Victor Evangelista de Faria Ferraz, Marina Candido Visontai Cormedi, Luissa Hikari Hayashi Araujo, Mariana Prado Silva Magalhaes, Rafaella Curis Carneiro, Luis Henrique Nunes Sales, Mendel Suchmacher, Karin Soares Cunha, Aguinaldo Bonalumi Filho, David Rubem Azulay, Mauro Geller
BRAIN AND BEHAVIOR (2022)
Comprehensive analysis of the ErbB receptor family in pediatric nervous system tumors and rhabdomyosarcoma
Pascale Varlet, Eric Bouffet, Michela Casanova, Felice Giangaspero, Manila Antonelli, Darren Hargrave, Ruth Ladenstein, Andy Pearson, Cynthia Hawkins, Fatima Barbara Koenig, Josef Rueschoff, Christian Schmauch, Claudia Buehnemann, Pilar Garin-Chesa, Norbert Schweifer, Martina Uttenreuther-Fischer, Neil Gibson, Carina Ittrich, Nicole Kraemer, Flavio Solca, Britta Stolze, Birgit Geoerger
PEDIATRIC BLOOD & CANCER (2022)
Location, symptoms, and management of plexiform neurofibromas in 127 children with neurofibromatosis 1, attending the National Complex Neurofibromatosis 1 service, 2018-2019
Yoshua Colyn Collins-Sawaragi, Rosalie Ferner, Grace Vassallo, Germana De Agro, Simon Eccles, Jill Cadwgan, Darren Hargrave, Eileen Hupton, Judith Eelloo, Lauren Lunt, Vivian Tang, Emma Burkitt Wright, Karine Lascelles
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2022)
A 40-Year Cohort Study of Evolving Hypothalamic Dysfunction in Infants and Young Children (<3 years) with Optic Pathway Gliomas
Stefania Picariello, Manuela Cerbone, Felice D'Arco, Hoong-Wei Gan, Patricia O'Hare, Kristian Aquilina, Enrico Opocher, Darren Hargrave, Helen A. Spoudeas
CANCERS (2022)
Joint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0
Arnoldo Piccardo, Nathalie L. Albert, Lise Borgwardt, Frederic H. Fahey, Darren Hargrave, Norbert Galldiks, Nina Jehanno, Lars Kurch, Ian Law, Ruth Lim, Egesta Lopci, Lisbeth Marner, Giovanni Morana, Tina Young Poussaint, Victor J. Seghers, Barry L. Shulkin, Katherine E. Warren, Tatjana Traub-Weidinger, Pietro Zucchetta
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)
Visual outcomes and predictors in optic pathway glioma: a single centre study
R. Bowman, B. Walters, V Smith, K. L. Prise, S. E. Handley, K. Green, K. Mankad, P. O'Hare, C. Dahl, M. Jorgensen, E. Opocher, D. Hargrave, D. A. Thompson
EYE (2023)
Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric BRAF V600-Mutant Low-Grade Glioma
Eric Bouffet, Birgit Geoerger, Christopher Moertel, James A. Whitlock, Isabelle Aerts, Darren Hargrave, Lisa Osterloh, Eugene Tan, Jeea Choi, Mark Russo, Elizabeth Fox
JOURNAL OF CLINICAL ONCOLOGY (2023)
A novel diagnostic method for a rare fungus: FcMBL facilitates Wickerhamomyces anomalus identification in an immunocompromised neonate
Conor J. Higgins, Kerry-Anne Kite, Nigel Klein, Michael Super, Michael T. Mccurdy, Darren Hargrave
MEDICAL MYCOLOGY CASE REPORTS (2023)
Dabrafenib plus trametinib (dab plus tram) in relapsed/refractory (r/r) BRAF V600-mutant pediatric high-grade glioma (pHGG): Primary analysis of a phase II trial.
Darren R. Hargrave, Keita Terashima, Junichi Hara, Uwe R. Kordes, Santhosh A. Upadhyaya, Felix Sahm, Eric Bouffet, Roger J. Packer, Olaf Witt, Lali Sandalic, Agnieszka Kieloch, Mark W. Russo, Kenneth J. Cohen
JOURNAL OF CLINICAL ONCOLOGY (2022)
Update on phase 1 study of tazemetostat, an enhancer of zeste homolog 2 inhibitor, in pediatric patients with relapsed or refractory integrase interactor 1-negative tumors.
Susan N. Chi, Franck Bourdeaut, Michela Casanova, Lindsay Baker Kilburn, Darren R. Hargrave, Geoffrey Brian McCowage, Navin R. Pinto, Jay Yang, Raminder Chadha, Bhaskar Kahali, Coya Tapia, Karsten Nysom
JOURNAL OF CLINICAL ONCOLOGY (2022)
THE EFFICACY OF FIBRE AND PREBIOTIC INTERVENTIONS ON CLINICAL OUTCOMES IN CANCER AND HAEMATOPOIETIC STEM CELL THERAPIES: SYSTEMATIC LITERATURE REVIEW
Breeana Gardiner, Hannah Wardill, Graeme O'Connor, Darren Hargrave, Gary Frost, Aaron Lett
PEDIATRIC BLOOD & CANCER (2022)
Pediatric high-grade gliomas and the WHO CNS Tumor Classification-Perspectives of pediatric neuro-oncologists and neuropathologists in light of recent updates
Gerrit H. Gielen, Joshua N. Baugh, Dannis G. van Vuurden, Sophie E. M. Veldhuijzen van Zanten, Darren Hargrave, Maura Massimino, Veronica Biassoni, Andres Morales la Madrid, Michael Karremann, Maria Wiese, Ulrich Thomale, Geert O. Janssens, Andre O. von Bueren, Thomas Perwein, Gunther Nussbaumer, Eelco W. Hoving, Pitt Niehusmann, Marco Gessi, Robert Kwiecien, Simon Bailey, Torsten Pietsch, Felipe Andreiuolo, Christof M. Kramm
NEURO-ONCOLOGY ADVANCES (2022)
Multimorbidity patterns and risk of hospitalisation in children: A population cohort study of 3.6 million children in England, with illustrative examples from childhood cancer survivors
Sheng-Chia Chung, Stefanie Mueller, Katherine Green, Wai Hoong Chang, Darren Hargrave, Alvina G. Lai
LANCET REGIONAL HEALTH-EUROPE (2022)
Imaging response assessment for CNS germ cell tumours: consensus recommendations from the European Society for Paediatric Oncology Brain Tumour Group and North American Children's Oncology Group
Giovanni Morana, Dennis Shaw, Shannon M. MacDonald, Claire Alapetite, Thankamma Ajithkumar, Aashim Bhatia, Herve Brisse, Camilo Jaimes, Thomas Czech, Girish Dhall, Jason Fangusaro, Cecile Faure-Conter, Maryam Fouladi, Darren Hargrave, Julie H. Harreld, Dipayan Mitra, James C. Nicholson, Mark Souweidane, Beate Timmermann, Gabriele Calaminus, Ute Bartels, Brigitte Bison, Matthew J. Murray
LANCET ONCOLOGY (2022)
DNA methylation machine learning and radiological features predict molecular classification of glioneuronal tumours
T. Stone, K. Mankad, A. Tan, W. Jan, J. Pickles, M. Gogou, J. Chalker, M. Kristiansen, T. Mistry, O. Ogunbiyi, S. Ahmed, H. Cross, M. Hubank, D. Hargrave, T. Jacques
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2022)
DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Elisa Izquierdo, Diana M. Carvalho, Alan Mackay, Sara Temelso, Jessica K. R. Boult, Giulia Pericoli, Elisabet Fernandez, Molina Das, Valeria Molinari, Yura Grabovska, Rebecca F. Rogers, Maria Antonietta Ajmone-Cat, Paula Z. Proszek, Mark Stubbs, Sarita Depani, Patricia O'Hare, Lu Yu, Georgia Roumelioti, Jyoti S. Choudhary, Matthew Clarke, Amy R. Fairchild, Thomas S. Jacques, Richard G. Grundy, Lisa Howell, Susan Picton, Jenny Adamski, Shaun Wilson, Juliet C. Gray, Bassel Zebian, Lynley Marshall, Fernando Carceller, Jacques Grill, Maria Vinci, Simon P. Robinson, Michael Hubank, Darren Hargrave, Chris Jones
CANCER DISCOVERY (2022)