Article
Oncology
Brett A. Miles, Marshall R. Posner, Vishal Gupta, Marita S. Teng, Richard L. Bakst, Mike Yao, Kryzsztof J. Misiukiewicz, Raymond L. Chai, Sonam Sharma, William H. Westra, Seunghee Kim-Schulze, Bheesham Dayal, Stanislaw Sobotka, Andrew G. Sikora, Peter M. Som, Eric M. Genden
Summary: This nonrandomized phase II trial investigated the efficacy of upfront surgery and neck dissection followed by reduced-dose adjuvant therapy for early-stage HPVOPC. The results showed favorable survival outcomes and excellent function in the population studied, supporting the potential for radiation dose reduction after transoral robotic surgery as a de-escalation strategy in HPVOPC.
Article
Oncology
T. J. Haller, X. L. Yin, T. J. O'Byrne, E. J. Moore, D. J. Ma, K. P. Price, S. H. Patel, M. L. Hinni, M. A. Neben-Wittich, L. A. McGee, D. L. Price, J. R. Janus, J. K. Kasperbauer, T. H. Nagel, D. M. Routman, S. C. Lester, J. C. M. Rwigema, A. V. Chintakuntlawar, P. S. Savvides, J. J. Garcia, R. L. Foote, K. M. Van Abel
Summary: This study investigated the dose de-escalation of adjuvant therapy in HPV(+)OPSCC patients through two clinical trials. The morbidity and mortality within 30 days of primary TORS resection were reported. The severity of postoperative bleeding and the occurrence of complications were also evaluated.
Article
Otorhinolaryngology
Ryan S. Jackson, Katelyn Stepan, Craig Bollig, Rahul K. Sharma, Mihir Patel, Sean Massa, Sidharth Puram, Jose P. Zevallos, Patrik Pipkorn, Joseph Zenga
Summary: This study analyzed the outcomes of patients with oropharyngeal squamous cell carcinoma who underwent transoral robotic surgery (TORS) using the National Cancer Database, finding that patients with early stage disease had significantly improved overall survival rates. These findings suggest that TORS may be considered in the treatment of HPV-negative OPSCC.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Otorhinolaryngology
Robert M. McKenzie, Harman S. Parhar, Tony L. Ng, Eitan Prisman
Summary: Pathologic muscle invasion (pMI) in oropharyngeal squamous cell carcinoma (OPSCC) is correlated with higher pathologic tumor staging, poor pathologic factors, and higher rates of positive margin on main specimen.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Celeste Kim, Eduardo Martinez, Marta Kulich, Mark S. Swanson
Summary: The study found variations in the management of HPV-related oropharyngeal cancer among otolaryngologists in the US based on surgeon background and preferences. Transoral robotic surgery (TORS) and primary radiation therapy (RT) were believed to offer similar oncologic control, but TORS was perceived to provide better quality of life (QOL). Additionally, surgeon demographics could affect management decisions, including patient selection for TORS and adjuvant therapy decision.
Review
Otorhinolaryngology
Craig A. Bollig, David S. Lee, Angela L. Mazul, Katelyn Stepan, Sidharth V. Puram, Sean T. Massa, Joseph Zenga, Daniel L. Faden, Michelle M. Doering, Ryan S. Jackson, Patrik Pipkorn
Summary: This systematic review found a low prevalence of second primary OPSCC in patients with p16+ OPSCC, with most patients being successfully treated. There is currently insufficient evidence to support routine elective tonsillectomy during surgical treatment of p16+ OPSCC patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Oncology
Andrea Costantino, Claudio Sampieri, Armando De Virgilio, Se-Heon Kim
Summary: This study demonstrates that NCT and TORS can achieve excellent tumor control and survival in patients with locoregionally advanced OPSCC. NCT may reduce the need for adjuvant treatments, but randomized clinical trials are needed to better define this aspect.
Article
Public, Environmental & Occupational Health
Michael W. Ross, Sarah L. Bennis, C. Mark Nichols, I. Niles Zoschke, J. Michael Wilkerson, B. R. Simon Rosser, Cyndee L. Stull, Alan G. Nyitray, Charlene Flash, Samir S. Khariwala
Summary: This study aimed to investigate the potential uptake and quality of oropharyngeal selfies taken by gay/bisexual men as a screening method for HPV-associated oropharyngeal cancer. The results showed that one-third of the invited men sent selfie images, and 28.3% of the images were of clinically acceptable quality.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
Annika Antonsson, Marjorie M. A. de Souza, Benedict J. Panizza, David C. Whiteman
Summary: Oropharyngeal cancer is increasingly caused by HPV, possibly due to changing sexual behavior. Sexual intercourse elicits a stronger immune response to HPV compared to oral sex, potentially leading to a weaker immune response in individuals who have their oral sex debut before or at the same time as sexual intercourse, increasing their risk of developing persistent oral HPV infection and oropharyngeal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Otorhinolaryngology
D. Spencer Nichols, Jing Zhao, Brian J. Boyce, Robert Amdur, William M. Mendenhall, Deepa Danan, Kathryn Hitchcock, Ke Ning, Kevin Keyes, Ji-Hyun Lee, Peter T. Dziegielewski
Summary: Based on the study findings, it seems that margins, extranodal extension, and adjuvant therapy may not significantly impact survival rates after transoral robotic surgery (TORS).
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Review
Microbiology
Takashi Hatano, Daisuke Sano, Hideaki Takahashi, Nobuhiko Oridate
Summary: The incidence of oropharyngeal cancer is increasing due to its association with HPV, which can evade the immune system and integrate into the host genome, contributing to oncogenesis.
Article
Otorhinolaryngology
Andrew J. Holcomb, Matthew Herberg, Madeleine Strohl, Edgar Ochoa, Allen L. Feng, Nicholas B. Abt, Tara E. Mokhtari, Krish Suresh, Christopher I. McHugh, Anuraag S. Parikh, Peter Sadow, William Faquin, Daniel Faden, Daniel G. Deschler, Mark A. Varvares, Derrick T. Lin, Carole Fakhry, William R. Ryan, Jeremy D. Richmon
Summary: This study retrospectively reviewed patients with HPV + OPSCC undergoing TORS and found that close surgical margins did not significantly impact local control, disease-free survival, and overall survival. Patients with close surgical margins after TORS without indications for adjuvant therapy may be considered for observation alone.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Oncology
Chen Lin, Daniel D. Sharbel, Michael C. Topf
Summary: The treatment of HPV-positive OPSCC is evolving with ongoing clinical trials investigating the role of surgery, radiation therapy, chemotherapy, and immunotherapy. TORS offers minimally invasive primary tumor resection and valuable pathologic staging, but may have some impact on patients' quality of life. Studies are exploring ways to optimize survival rates while improving quality of life for patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
Harman S. Parhar, Gregory S. Weinstein, Bert W. O'Malley, David Shimunov, Christopher H. Rassekh, Ara A. Chalian, Jason G. Newman, Devraj Basu, Steven B. Cannady, Karthik Rajasekaran, Alexander Lin, John N. Lukens, Samuel Swisher-McClure, Roger B. Cohen, Joshua M. Bauml, Charu Aggrawal, Robert M. Brody
Summary: The TORS approach for surgically resectable HPV-negative OPSCC resulted in encouraging oncologic outcomes with low perioperative morbidity rates.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Virology
Kathrine Kronberg Jakobsen, Amanda-Louise Fenger Carlander, Simone Kloch Bendtsen, Martin Garset-Zamani, Charlotte Duch Lynggaard, Christian Gronhoj, Christian von Buchwald
Summary: The study aimed to evaluate the diagnostic accuracy of HPV techniques in oropharyngeal cancer. It found high accuracy in detecting HPV in tumor tissue regardless of the method used, with lower accuracy in oral samples. Blood samples showed promising new possibilities for HPV detection.