4.7 Meeting Abstract

Clinico-pathological and molecular characterisation of BRAF mutant metastatic colorectal cancer (mCRC): Are all mutations created equal?

Journal

JOURNAL OF CLINICAL ONCOLOGY
Volume 36, Issue 15, Pages -

Publisher

AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/JCO.2018.36.15_suppl.3590

Keywords

-

Categories

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Oncology

CtDNA-guided rechallenge with anti-EGFR therapy in RASwt metastatic colorectal cancer: Evidence from clinical practice

Raffaella D'Onofrio, Francesco Caputo, Francesco Prampolini, Andrea Spallanzani, Fabio Gelsomino, Stefania Bettelli, Samantha Manfredini, Luca Reggiani Bonetti, Pietro Carotenuto, Alessandro Bocconi, Massimo Dominici, Gabriele Luppi, Massimiliano Salati

Summary: In this study, extended ctDNA-based RAS genotyping was applied to select eligible colorectal cancer patients for anti-EGFR treatment. The results showed that this approach had a higher objective response rate and longer survival compared to traditional clinical criteria, highlighting the importance of blood-based genetic testing in precision medicine.

TUMORI JOURNAL (2023)

Article Surgery

Demystifying BRAF Mutation Status in Colorectal Liver Metastases A Multi-institutional, Collaborative Approach to 6 Open Clinical Questions

Georgios A. Margonis, Thomas Boerner, Jean-Baptiste Bachet, Stefan Buettner, Roberto Moretto, Nikolaos Andreatos, Andrea Sartore-Bianchi, Jane Wang, Carsten Kamphues, Johan Gagniere, Sara Lonardi, Inger M. Loes, Doris Wagner, Andrea Spallanzani, Kazunari Sasaki, Richard Burkhart, Filippo Pietrantonio, Emmanouil Pikoulis, Timothy M. Pawlik, Stephanie Truant, Armando Orlandi, Anastasia Pikouli, Nicoletta Pella, Katharina Beyer, George Poultsides, Hendrik Seeliger, Federico N. Aucejo, Peter Kornprat, Klaus Kaczirek, Per E. Lonning, Martin E. Kreis, Christopher L. Wolfgang, Matthew J. Weiss, Chiara Cremolini, Stephane Benoist, Michael D'Angelica

Summary: This study investigated the clinical implications of BRAF-mutated colorectal liver metastases. The results showed that BRAF V600E mutation was associated with shorter overall survival but not recurrence-free survival. Patients with MSS tumors had shorter recurrence-free survival compared with those with MSI-high tumors. Resection of converted disease resulted in encouraging survival. Second hepatectomy improved outcomes for patients with recurrence.

ANNALS OF SURGERY (2023)

Editorial Material Nutrition & Dietetics

The Key Role of Patient Empowerment in the Future Management of Cancer-Related Malnutrition

Amanda Casirati, Valentina Da Prat, Emanuele Cereda, Francesco Serra, Lorenzo Perrone, Salvatore Corallo, Francesco De Lorenzo, Paolo Pedrazzoli, Riccardo Caccialanza

NUTRIENTS (2023)

Review Medicine, General & Internal

The likelihood of being helped or harmed as a patient-centred tool to assess cyclin dependent kinase 4/6 inhibitors clinical impact and safety in metastatic breast cancer: a systematic review and sensitivity-analysis

Luca Mastrantoni, Armando Orlandi, Antonella Palazzo, Giovanna Garufi, Alessandra Fabi, Gennaro Daniele, Diana Giannarelli, Giampaolo Tortora, Emilio Bria

Summary: This systematic review and meta-analysis examined the use of CDK4/6 inhibitors in hormone-receptor positive/HER2-negative metastatic breast cancer. The study found that CDK4/6 inhibitors had a significant benefit in terms of progression-free survival compared to placebo. In terms of adverse events, different CDK4/6 inhibitors had varying advantages and disadvantages. The study confirmed the reliability of LHH as a tool for balancing the risks and benefits of experimental drugs.

ECLINICALMEDICINE (2023)

Article Oncology

COVID-19 in patients with neuroendocrine neoplasms: 2-year results of the INTENSIVE study

Nicola Fazio, Lorenzo Gervaso, Thorvardur R. Halfdanarson, Mohamad Sonbol, Rachel A. Eiring, Sara Pusceddu, Natalie Prinzi, Benedetta Lombardi Stocchetti, Simona Grozinsky-Glasberg, David J. Gross, Thomas Walter, Patrick Robelin, Catherine Lombard-Bohas, Samuele Frassoni, Vincenzo Bagnardi, Lorenzo Antonuzzo, Clotilde Sparano, Sara Massironi, Fabio Gelsomino, Alberto Bongiovanni, Nicoletta Ranallo, Salvatore Tafuto, Maura Rossi, Mauro Cives, Ibrahim Rasul Kakil, Hytam Hamid, Alessandra Chirco, Michela Squadroni, Anna La Salvia, Jorge Hernando, Johannes Hofland, Anna Koumarianou, Sabrina Boselli, Darina Tamayo, Cristina Mazzon, Manila Rubino, Francesca Spada

Summary: This study investigated patients with neuroendocrine neoplasms (NENs) and confirmed SARS-CoV-2 positivity at the molecular level through a retrospective/prospective worldwide study. The findings indicate a decreasing trend in the incidence of COVID-19 over the years, with older age, non-gastroenteropancreatic primary sites, and diabetes mellitus associated with increased severity and mortality of COVID-19.

ENDOCRINE-RELATED CANCER (2023)

Article Oncology

Adjuvant durvalumab after concurrent chemoradiotherapy for patients with unresectable stage III NSCLC harbouring uncommon genomic alterations

Francesco Cortiula, Dirk De Ruysscher, Michelle Steens, Robin Wijsman, Anthonie van der Wekken, Martina Alberti, Lizza E. L. Hendriks

Summary: Adjuvant durvalumab is the standard treatment for stage III unresectable non-small cell lung cancer (NSCLC) patients without progression after chemo-radiation. Patients with EGFR mutations and ALK rearrangements do not benefit from durvalumab. This retrospective study showed that patients with uncommon driver genomic alterations (dGA), including KRAS mutations, had a meaningful survival benefit from adjuvant durvalumab.

EUROPEAN JOURNAL OF CANCER (2023)

Review Biochemistry & Molecular Biology

Evaluation of the Synovial Effects of Biological and Targeted Synthetic DMARDs in Patients with Psoriatic Arthritis: A Systematic Literature Review and Meta-Analysis

Maria Sofia Ciliento, Veronica Venturelli, Natale Schettini, Riccardo Bertola, Carlo Garaffoni, Giovanni Lanza, Roberta Gafa, Alessandro Borghi, Monica Corazza, Alen Zabotti, Sonia Missiroli, Caterina Boncompagni, Simone Patergnani, Mariasole Perrone, Carlotta Giorgi, Paolo Pinton, Marcello Govoni, Carlo Alberto Scire, Alessandra Bortoluzzi, Ettore Silvagni

Summary: The aim of this systematic literature review was to investigate the effects of b/tsDMARDs on the synovial membrane of PsA patients and identify biomarkers of response to therapy. A meta-analysis of 22 studies showed a significant reduction in CD3+ lymphocytes and CD68+ macrophages in synovial biopsies from patients treated with bDMARDs for 4-12 weeks. Reduction in CD3+ was correlated with clinical response. The most consistent finding in the literature was the reduction in CD3+/CD68+ sublining cells during the first 3 months of treatment with TNF inhibitors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Oncology

Survival outcomes from atezolizumab plus bevacizumab versus Lenvatinib in Child Pugh B unresectable hepatocellular carcinoma patients

Margherita Rimini, Mara Persano, Toshifumi Tada, Goki Suda, Shigeo Shimose, Masatoshi Kudo, Jaekyung Cheon, Fabian Finkelmeier, Ho Yeong Lim, Jose Presa, Francesca Salani, Sara Lonardi, Fabio Piscaglia, Takashi Kumada, Naoya Sakamoto, Hideki Iwamoto, Tomoko Aoki, Hong Jae Chon, Vera Himmelsbach, Marta Schirripa, Margarida Montes, Caterina Vivaldi, Caterina Solda, Atsushi Hiraoka, Takuya Sho, Takashi Niizeki, Naoshi Nishida, Christoph Steup, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Fujimasa Tada, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Hisashi Kosaka, Atsushi Naganuma, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Valentina Burgio, Mario Scartozzi, Stefano Cascinu, Andrea Casadei-Gardini

Summary: This study analyzed the efficacy of atezolizumab plus bevacizumab versus Lenvatinib as first-line treatment for patients with advanced hepatocellular carcinoma (HCC) and Child-Pugh (CP) class B. The results showed that Lenvatinib had a longer overall survival (OS) compared to atezolizumab plus bevacizumab in patients with CP B HCC.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2023)

Article Oncology

Irinotecan- vs. Oxaliplatin-Based Doublets in KRASG12C-Mutated Metastatic Colorectal Cancer-A Multicentre Propensity-Score-Matched Retrospective Analysis

Vincenzo Formica, Cristina Morelli, Veronica Conca, Maria Alessandra Calegari, Jessica Lucchetti, Emanuela Dell'Aquila, Marta Schirripa, Marco Messina, Lisa Salvatore, Federica Lo Prinzi, Giovanni Dima, Giovanni Trovato, Silvia Riondino, Mario Roselli, Ferdinandos Skoulidis, Hendrik-Tobias Arkenau, Chiara Cremolini

Summary: This retrospective study compared the effectiveness of irinotecan and oxaliplatin in the first-line treatment of KRASG12C-mutated colorectal cancer. The results demonstrated that irinotecan provided better survival outcomes, indicating that it should be preferred over oxaliplatin. These findings are important for investigating chemotherapy plus targeted agent combinations.

CANCERS (2023)

Article Oncology

Conservative Surgery in cT4 Breast Cancer: Single-Center Experience in the Neoadjuvant Setting

Antonio Franco, Alba Di Leone, Alessandra Fabi, Paolo Belli, Luisa Carbognin, Elisabetta Gambaro, Fabio Marazzi, Elena Jane Mason, Antonino Mule, Armando Orlandi, Antonella Palazzo, Ida Paris, Alessandro Rossi, Lorenzo Scardina, Daniela Andreina Terribile, Giordana Tiberi, Diana Giannarelli, Giovanni Scambia, Riccardo Masetti, Gianluca Franceschini

Summary: Screening programs have led to a decrease in the diagnosis of locally advanced breast cancer, but the optimal surgical treatment strategy is still under debate. This study compared conservative breast surgery (CBS) with radical breast surgery (RBS) in cT4 breast cancer patients who underwent neoadjuvant chemotherapy (NA) and surgery. The results suggest that CBS may be a safe alternative to RBS in patients with major or complete response to NA, while RBS remains the best choice for patients with poor response to NA.

CANCERS (2023)

Editorial Material Oncology

A brave NEO world: Neoadjuvant osimertinib in resectable EGFR-mutant NSCLC

F. Cortiula, J. Naidoo

LUNG CANCER (2023)

Article Oncology

Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force Dermatology for Cancer Patients International Study

Pietro Sollena, Nikolaou Vasiliki, Elias J. Kotteas, Alexander J. Stratigos, Davide Fattore, Armando Orlandi, Maria Mannino, Marcello Di Pumpo, Monika Fida, Michela Starace, Zoe Apalla, Maria Concetta Romano, Julia Riganti, Sonia Segura, Azael Freites Martinez, Gabriella Fabbrocini, Vincent Sibaud, Ketty Peris

Summary: Treatment with CDK4/6 inhibitor in combination with endocrine therapies can improve progression-free survival in patients with hormone receptor-positive, HER2-negative, advanced breast cancer. However, limited data exists on its cutaneous adverse events. This retrospective study investigated the prevalence, types, and management of cutaneous adverse events during CDK4/6 inhibitor treatment.

CANCERS (2023)

Article Health Care Sciences & Services

An Innovative Scoring System to Select the Optimal Surgery in Breast Cancer after Neoadjuvant Chemotherapy

Antonio Franco, Alba Di Leone, Marco Conti, Alessandra Fabi, Luisa Carbognin, Andreina Daniela Terribile, Paolo Belli, Armando Orlandi, Martin Alejandro Sanchez, Francesca Moschella, Elena Jane Mason, Giovanni Cimino, Alessandra De Filippis, Fabio Marazzi, Ida Paris, Giuseppe Visconti, Liliana Barone Adesi, Lorenzo Scardina, Sabatino D'Archi, Marzia Salgarello, Diana Giannarelli, Riccardo Masetti, Gianluca Franceschini, Kenneth P. H. Pritzker

Summary: This study developed a post-Neoadjuvant Score System (pNESSy) to choose the appropriate surgery and improve oncological and aesthetic outcomes. The system uses clinical and radiological features to predict the optimal surgery method post-neoadjuvant chemotherapy.

JOURNAL OF PERSONALIZED MEDICINE (2023)

Article Cell Biology

Transient receptor potential ankyrin 1 (TRPA1) mediates reactive oxygen species-induced Ca2+ entry, mitochondrial dysfunction, and caspase-3/7 activation in primary cultures of metastatic colorectal carcinoma cells

Pawan Faris, Agnese Rumolo, Giorgia Pellavio, Matteo Tanzi, Mauro Vismara, Roberto Berra-Romani, Andrea Gerbino, Salvatore Corallo, Paolo Pedrazzoli, Umberto Laforenza, Daniela Montagna, Francesco Moccia

Summary: Colorectal carcinoma (CRC) is a common cancer and a leading cause of cancer-related death. Activation of TRPA1 channel by oxidative stress may lead to mitochondrial ion imbalance and apoptosis in metastatic CRC cells. Targeting TRPA1 could enhance the sensitivity of CRC to oxidative stress and potentially eradicate metastatic CRC.

CELL DEATH DISCOVERY (2023)

Article Oncology

Bone Metastases from Intrahepatic Cholangiocarcinoma Confer Worse Prognosis

Ingrid Garajova, Fabio Gelsomino, Massimiliano Salati, Francesco Leonardi, Stefania De Lorenzo, Alessandro Granito, Francesco Tovoli

Summary: This study aimed to investigate the prognostic role of bone metastases in patients with intrahepatic cholangiocarcinoma. Among 186 patients, around 11% developed bone metastases, which were associated with shorter median overall survival compared to patients with liver involvement only. Poor performance status and absence of second-line treatment were also associated with worse outcomes.

CURRENT ONCOLOGY (2023)

No Data Available