Randomized Phase III Trial of Amrubicin Versus Topotecan As Second-Line Treatment for Patients With Small-Cell Lung Cancer

Topotecan/cisplatin (TP) compared to cisplatin/etoposide (PE) for patients with extensive disease-small cell lung cancer (ED- SCLC): Final results of a randomised phase III trial

(2017) D. F. Heigener et al.   JOURNAL OF CLINICAL ONCOLOGY

Genetic polymorphisms of metabolizing enzymes and transporters correlate with pharmacokinetics (PK) and pharmacodynamics (PD) of amrubicin.

(2017) Y. Makino et al.   JOURNAL OF CLINICAL ONCOLOGY

A phase II trial of combination chemotherapy with topotecan and amrubicin in small cell lung cancer (SCLC).

(2017) N. Nogami et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II study of amrubicin and carboplatin in patients with the refractory or relapsed small cell lung cancer (SCLC).

(2017) T. Hirose et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized phase III study (SPEAR) of picoplatin plus best supportive care (BSC) or BSC alone in patients (pts) with SCLC refractory or progressive within 6 months after first-line platinum-based chemotherapy.

(2017) T. Ciuleanu et al.   JOURNAL OF CLINICAL ONCOLOGY

C609T Polymorphism of NAD(P)H Quinone Oxidoreductase 1 As a Predictive Biomarker for Response to Amrubicin

(2011) Osamu Takakuwa et al.   Journal of Thoracic Oncology

Phase II Study of Amrubicin As Second-Line Therapy in Patients With Platinum-Refractory Small-Cell Lung Cancer

(2010) David S. Ettinger et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized Phase II Trial of Single-Agent Amrubicin or Topotecan as Second-Line Treatment in Patients With Small-Cell Lung Cancer Sensitive to First-Line Platinum-Based Chemotherapy

(2010) Robert Jotte et al.   JOURNAL OF CLINICAL ONCOLOGY

Small Cell Lung Cancer: Are We Making Progress?

(2009) Jonathan E. Dowell et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Phase III Trial of Irinotecan/Cisplatin Compared With Etoposide/Cisplatin in Extensive-Stage Small-Cell Lung Cancer: Clinical and Pharmacogenomic Results From SWOG S0124

(2009) Primo N. Lara et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase III Study of Pemetrexed Plus Carboplatin Compared With Etoposide Plus Carboplatin in Chemotherapy-Naive Patients With Extensive-Stage Small-Cell Lung Cancer

(2009) Mark A. Socinski et al.   JOURNAL OF CLINICAL ONCOLOGY

A phase II study of amrubicin, a synthetic 9-aminoanthracycline, in patients with previously treated lung cancer

(2009) Kyoichi Kaira et al.   LUNG CANCER

Salvage treatment with topotecan in patients with irinotecan-refractory small cell lung cancer

(2008) Se Hoon Park et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Randomized Phase II Trial Comparing Amrubicin With Topotecan in Patients With Previously Treated Small-Cell Lung Cancer: North Japan Lung Cancer Study Group Trial 0402

(2008) Akira Inoue et al.   JOURNAL OF CLINICAL ONCOLOGY

Comparison of gemcitabine and carboplatin versus cisplatin and etoposide for patients with poor-prognosis small cell lung cancer

(2008) S M Lee et al.   THORAX