Biology of Cancer and Aging: A Complex Association With Cellular Senescence

Answering the ultimate question “What is the Proximal Cause of Aging?”

(2016) Mikhail V. Blagosklonny   Aging-US

Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes

(2015) Albert E. Berman et al.   Oncotarget

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion

(2013) Hugo J. Snippert et al.   EMBO REPORTS

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

(2013) Annamaria Biroccio et al.   NATURE CELL BIOLOGY

One Identity or More for Telomeres?

(2013) Marie-Josèphe Giraud-Panis et al.   Frontiers in Oncology

Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

(2012) David Gems et al.   ANTIOXIDANTS & REDOX SIGNALING

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

(2012) Jianwei Wang et al.   CELL

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

The CD47–SIRPα pathway in cancer immune evasion and potential therapeutic implications

(2012) Mark P Chao et al.   CURRENT OPINION IN IMMUNOLOGY

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

(2012) A. G. Schepers et al.   SCIENCE

Expression of p16INK4a prevents cancer and promotes aging in lymphocytes

(2011) Y. Liu et al.   BLOOD

Peak and decline in cancer incidence, mortality, and prevalence at old ages

(2011) Charles Harding et al.   CANCER

Evolved Tumor Suppression: Why Are We So Good at Not Getting Cancer?

(2011) J. DeGregori   CANCER RESEARCH

Antioxidant defense and aging inC. elegans: Is the oxidative damage theory of aging wrong?

(2011) David Gems et al.   CELL CYCLE

Relative fitness of hematopoietic progenitors influences leukemia progression

(2011) C C Porter et al.   LEUKEMIA

Old cells under attack

(2011) Daniel S. Peeper   NATURE

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging

(2011) Claudia E. Rübe et al.   PLoS One

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program

(2010) Mikhail V Blagosklonny   CELL CYCLE

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

(2010) Tanya Bondar et al.   Cell Stem Cell

Protein aggregation as a paradigm of aging

(2009) Ariel B. Lindner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Senescence-Associated Oxidative DNA Damage Promotes the Generation of Neoplastic Cells

(2009) K. Gosselin et al.   CANCER RESEARCH

Balancing dormant and self-renewing hematopoietic stem cells

(2009) Anne Wilson et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cellular senescence in vivo: a barrier to tumorigenesis

(2008) Alexandre Prieur et al.   CURRENT OPINION IN CELL BIOLOGY

Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice

(2008) Jichun Chen et al.   EXPERIMENTAL HEMATOLOGY

HGPS and related premature aging disorders: From genomic identification to the first therapeutic approaches

(2008) Sandrine Pereira et al.   MECHANISMS OF AGEING AND DEVELOPMENT

WRN Is Required for ATM Activation and the S-Phase Checkpoint in Response to Interstrand Cross-Link–Induced DNA Double-Strand Breaks

(2008) Wen-Hsing Cheng et al.   MOLECULAR BIOLOGY OF THE CELL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY