Review
Public, Environmental & Occupational Health
Cecilie Norby Lyhne, Merete Bjerrum, Anders Hammerich Riis, Marianne Johansson Jorgensen
Summary: This systematic review highlights the importance of addressing individual needs through continuous and coordinated care practices to prevent avoidable hospitalizations. Engaging healthcare professionals in preventive care work and considering implications for patient safety may be given higher priority. Support for preventive care delivery can be provided through targeted educational material and web-based information-sharing platforms.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Daniel L. L. Tagerman, Vicente Ramos-Santillan, Ali Kalam, Fei Wang, Jacob B. B. Schriner, Vanessa Arientyl, Ian Solsky, Patricia Friedmann, Abier Abdelnaby, Haejin In
Summary: This study aimed to analyze the reasons for potentially avoidable and prolonged hospitalizations in patients with suspected colon cancer in the emergency department. The results showed that a small percentage of patients had avoidable admissions, mostly for cancer workup. Additionally, most patients who required admissions but not urgent interventions had prolonged stays, primarily for non-urgent surgery and further oncologic workup.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Richard K. Leuchter, Chad Wes A. Villa, Keith C. Norris, Andrea Sorensen, Sitaram Vangala, Catherine A. Sarkisian
Summary: This study found that racial disparities in potentially avoidable hospitalizations increased during the COVID-19 pandemic, with a 50.3% decrease among non-Hispanic Whites but only an 8.0% decrease among African Americans. This highlights the need for further exploration of the complex factors contributing to these disparities.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Geriatrics & Gerontology
Yoko Hamasaki, Nobuo Sakata, Xueying Jin, Takehiro Sugiyama, Kojiro Morita, Kazuaki Uda, Shinya Matsuda, Nanako Tamiya
Summary: This study aimed to examine the association between various facility staffing and potentially avoidable hospitalizations of nursing home residents in Japan. The study found that nursing homes with full-time physicians and a higher number of dietitians were associated with a lower likelihood of potentially avoidable hospitalizations, while having nurses or trained caregivers during the night shift and a higher number of care managers were associated with a higher probability of potentially avoidable hospitalizations.
Article
Oncology
Eric M. Lander, Xuanyi Li, Li-Ching Huang, Amanda S. Cass, Wade T. Iams, Emily A. Skotte, Jennifer G. Whisenant, Robert A. Ramirez, Sally J. York, Travis J. Osterman, Jennifer A. Lewis, Christine M. Lovly, Yu Shyr, Leora Horn
Summary: This study aims to characterize the risk factors and outcomes of patients with lung cancer who were admitted to the hospital. The study found that 15% of hospitalizations among patients with lung cancer were potentially avoidable, with reasons including uncontrolled symptoms, delayed implementation of end-of-life care, and errors in medication reconciliation.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Health Care Sciences & Services
Alexandre Gouveia, Charlene Mauron, Pedro Marques-Vidal
Summary: The study shows that potentially avoidable hospitalizations (PAH) for asthma and COPD in Switzerland have increased from 1998 to 2018, resulting in a significant burden and economic costs for the country.
Article
Oncology
Lina Jansen, Josephine Kanbach, Isabelle Finke, Volker Arndt, Katharina Emrich, Bernd Holleczek, Hiltraud Kajueter, Joachim Kieschke, Werner Maier, Ron Pritzkuleit, Eunice Sirri, Lars Schwettmann, Cynthia Erb, Hermann Brenner
Summary: This study estimated the number of avoidable deaths attributable to socioeconomic inequalities in cancer survival in Germany and found that 4100 annual excess deaths could have been avoided each year if relative survival rates were comparable across all regions. Colorectal, oral and pharynx, prostate, and bladder cancer contributed the largest numbers of avoidable excess deaths. The results underscore the importance of cancer prevention and survival improvements in more deprived regions, providing valuable insights for intervention programs to reduce socioeconomic inequalities in cancer burden in Germany.
Article
Public, Environmental & Occupational Health
Shan Lu, Yan Zhang, Liang Zhang, Niek S. Klazinga, Dionne S. Kringos
Summary: This study aimed to assess the occurrence and costs of potentially preventable hospitalizations among high-cost patients in rural China. The study found that the occurrence of preventable hospitalization was significant among high-cost patients, and they accounted for a large proportion of the preventable inpatient cost.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Denise A. A. Tyler, Zhanlian Feng, David C. C. Grabowski, Lawren Bercaw, Micah Segelman, Galina Khatutsky, Joyce Wang, Angela Gasdaska, Melvin J. J. Ingber
Summary: Misaligned incentives between Medicare and Medicaid may result in avoidable hospitalizations among long-stay nursing home residents. Providing nursing homes with clinical staff, such as nurse practitioners, was more effective in reducing resident hospitalizations than providing Medicare incentive payments alone.
Article
Social Sciences, Interdisciplinary
Ting Chen, Jay Pan
Summary: This study examines the relationship between spatial access to primary care and potentially avoidable hospitalizations among the elderly in a Chinese city. The findings show that improving spatial access to primary care significantly reduces potentially avoidable hospitalizations among the elderly.
SOCIAL INDICATORS RESEARCH
(2022)
Article
Geriatrics & Gerontology
Claire Godard-Sebillotte, Erin Strumpf, Nadia Sourial, Louis Rochette, Eric Pelletier, Isabelle Vedel
Summary: This study aimed to investigate the association between high primary care continuity and potentially avoidable hospitalization in community-dwelling persons with dementia. The results showed that high primary care continuity can reduce the risk of potentially avoidable hospitalization, contributing to a decrease in hospital readmission and emergency department visits.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Medicine, General & Internal
Seonji Kim, Sung-keun Ko, Tae Young Lee, Jin-Hee Lee
Summary: Multiple chronic disorders and disabilities among older patients in long term care hospitals (LTCH) tend to increase healthcare burden and emergency department overcrowding. Older patients transferred from LTCH have higher rates of potentially avoidable hospitalizations and hospitalizations during non-office hours compared to patients living at home. LTCH patients visit hospitals more frequently, stay longer in the emergency department, have a greater prevalence of chronic diseases, higher rates of transfer, and higher admission rates and mortality than patients living at home.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Health Care Sciences & Services
Cristina Loureiro da Silva, Joao Victor Rocha, Rui Santana
Summary: This study analyzed the association between Troika intervention and hospitalizations for ACSC in Portugal. It found an increase in preventable hospitalizations during the economic crisis, with disparities between municipalities. The high resource utilization from ACSC hospitalizations and the effects of crisis measures are important considerations for health management.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Multidisciplinary Sciences
Lukas Higi, Angela Lisibach, Patrick E. Beeler, Monika Lutters, Anne-Laure Blanc, Andrea M. Burden, Dominik Staempfli
Summary: This study conducted an external validation of the PAR-Risk Score and found limited overall performance, although higher scores were associated with an increased risk for potentially avoidable readmissions. Patients in the high-risk group had significantly higher odds of being readmitted within 30 days.
Article
Geriatrics & Gerontology
Marilyn Rantz, A. Vogelsmeier, L. Popejoy, K. Canada, C. Galambos, C. Crecelius, G. L. Alexander
Summary: The study focused on the financial benefits of potential revenue recapture due to non-billable days from hospitalizations in nursing homes. Over $2.6 million in revenue was recaptured in 11 participating nursing homes, with savings of over $31 million to payers. Early detection of health status changes can lead to substantial cost reductions and revenue increases.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Medicine, General & Internal
Inas S. Khayal, Gabriel A. Brooks, Amber E. Barnato
Summary: This study developed a novel visual map using heatmaps to illustrate multidimensional utilization of end-of-life care over time. The analysis of hospital-level heatmaps identified nine distinct patterns of end-of-life care delivery. The heatmaps provided more information and heterogeneity compared to unidimensional measures.
Article
Oncology
Matthew B. B. Yurgelun, Hajime Uno, C. Sloane Furniss, Chinedu Ukaegbu, Miki Horiguchi, Amal Yussuf, Holly LaDuca, Anu Chittenden, Judy E. E. Garber, Sapna Syngal
Summary: This study developed and validated a clinical prediction model called PREMMplus for multigene panel testing (MGPT) risk assessment. The PREMMplus model accurately identifies individuals with pathogenic germline variants (PGVs) in a diverse spectrum of cancer susceptibility genes with high sensitivity and negative-predictive value (NPV).
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Mathematical & Computational Biology
Savannah Bergquist, Gabriel A. Brooks, Mary Beth Landrum, Nancy L. Keating, Sherri Rose
Summary: This study demonstrates the use of claims data to develop prediction algorithms for classifying lung cancer stages. It also highlights a method for incorporating classification uncertainty into survival estimation.
STATISTICS IN MEDICINE
(2022)
Article
Communication
Darlene K. Drummond, Satveer Kaur-Gill, Genevra F. Murray, Karen E. Schifferdecker, Rebecca Butcher, Amanda N. Perry, Gabriel A. Brooks, Nirav S. Kapadia, Amber E. Barnato
Summary: This study described racially discordant oncology encounters involving end-of-life decision-making. The communication between non-Black providers and Black patients was found to be complex and anxiety-inducing. Provider perceptions of Black distrust, cultural differences, and religion influenced their ability to communicate effectively with patients.
HEALTH COMMUNICATION
(2023)
Article
Oncology
Kenneth L. Kehl, Hajime Uno, Alexander Gusev, Stefan Groha, Samantha Brown, Jessica A. Lavery, Deborah Schrag, Katherine S. Panageas
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Health Care Sciences & Services
Niveditta Ramkumar, Qianfei Wang, Gabriel A. Brooks, Anna N. A. Tosteson, Sandra L. Wong, Andrew P. Loehrer
Summary: This study examined the association between rural residence and the use of palliative care and hospice services. The results showed that patients in small town and rural areas had lower odds of receiving hospice care compared to those in metropolitan areas. This highlights the need to improve access to hospice services in rural communities and enhance the quality of end-of-life care for patients.
JOURNAL OF RURAL HEALTH
(2023)
Article
Mathematical & Computational Biology
Hajime Uno, Miki Horiguchi
Summary: The traditional hazard ratio (HR) approach has drawbacks when the proportional hazards (PH) assumption does not hold and when the clinical significance of the treatment effect is unclear. In this study, average hazard with survival weight (AH-SW) is proposed as a summary metric to evaluate the treatment effect. The AH-SW is interpreted as a person-time incidence rate that is not affected by random censoring. Numerical studies show that the proposed approach offers similar statistical power to the HR-based approach and can better detect delayed-difference patterns in immunotherapy trials.
STATISTICS IN MEDICINE
(2023)
Article
Mathematical & Computational Biology
Miki Horiguchi, Lu Tian, Hajime Uno
Summary: The pattern of difference between survival curves in immunotherapy clinical trials is often not proportional hazards, and the treatment effect appears delayed. The commonly used logrank test and hazard ratio estimation may not be optimal for testing and estimation in these trials. The long-term restricted mean survival time (LT-RMST) approach is a promising alternative but has challenges in specifying the lower end of the time window. This paper proposes a flexible LT-RMST-based approach that does not require specifying a lower end of the time window and demonstrates minimal power loss compared to the standard approach.
STATISTICS IN MEDICINE
(2023)
Article
Oncology
Liyang Yu, You-Chi Liu, Sarah L. Cornelius, Bruno T. Scodari, Gabriel A. Brooks, Alistair James O'Malley, Tracy Onega, Erika L. Moen
Summary: This study examined the use of telehealth and changes in patient-sharing networks among oncologists in response to the COVID-19 pandemic. The results showed that telehealth use varied by cancer type, suggesting different approaches for integrating telehealth across clinical groups. However, the study was limited to the immediate years following the outbreak, and longer-term follow-up may reveal delayed effects.
Editorial Material
Oncology
Sharyn D. Baker, Susan E. Bates, Gabriel A. Brooks, William L. Dahut, Robert B. Diasio, Wafik S. El-Deiry, William E. Evans, William D. Figg, Dan L. Hertz, J. Kevin Hicks, Suneel Kamath, Pashtoon Murtaza Kasi, Todd C. Knepper, Howard L. McLeod, Peter H. O'Donnell, Mary V. Relling, Michelle A. Rudek, Tristan M. Sissung, D. Max Smith, Alex Sparreboom, Sandra M. Swain, Christine M. Walko
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Gabriel A. Brooks, Marisa R. Tomaino, Niveditta Ramkumar, Qianfei Wang, Nirav S. Kapadia, A. James O'Malley, Sandra L. Wong, Andrew P. Loehrer, Anna N. A. Tosteson
Summary: Pancreatectomy is less likely to be performed and 1-year mortality is higher for pancreatic cancer patients living in nonmetropolitan areas. The study also found that socioeconomic deprivation and race are associated with disparities in treatment and outcomes.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Zoe Guan, Theodore Huang, Anne Marie McCarthy, Kevin Hughes, Alan Semine, Hajime Uno, Lorenzo Trippa, Giovanni Parmigiani, Danielle Braun
Summary: BRCAPRO is a breast cancer risk prediction model that does not consider non-genetic risk factors. We expand BRCAPRO by combining it with BCRAT, a model that uses mostly non-genetic risk factors, and show improved prediction accuracy. Accurate risk stratification is essential for targeted screening and prevention of cancer.
Article
Health Care Sciences & Services
Rebekah Wilson, Dong-Woo Kang, Meghan Tahbaz, Mary Norris, Hajime Uno, Jennifer Ligibel, Jeffrey Guenette, Cameron Christopher, Christina Dieli-Conwright
Summary: This study aims to investigate the effects of high-intensity interval training (HIIT) on cognitive function in breast cancer patients undergoing chemotherapy. The study will randomize 50 patients into two groups, with one group receiving HIIT intervention and the other group receiving stretching exercises. The study will assess various outcomes, including cognitive function and brain imaging. The results of this study may establish HIIT as a potential standard of care for breast cancer patients undergoing chemotherapy.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Health Care Sciences & Services
Anna N. A. Tosteson, Kathryn B. Kirkland, Megan M. Holthoff, Aricca D. Van Citters, Gabriel A. Brooks, Amelia M. Cullinan, Miriam C. Dowling-Schmitt, Anne B. Holmes, Kenneth R. Meehan, Brant J. Oliver, Garrett T. Wasp, Matthew M. Wilson, Eugene C. Nelson
Summary: The coproduction learning health system (CLHS) model expands the concept of a learning health system by involving patients, care partners, healthcare teams, administrators, and scientists in collaboration to improve health outcomes, care value, and generate new knowledge. The CLHS model emphasizes a partnership for coproduction supported by data for individual patient care, quality improvement, and research. We present a case study that demonstrates the application of this model to transform care in an oncology program at an academic medical center.
JOURNAL OF AMBULATORY CARE MANAGEMENT
(2023)
Article
Oncology
Jennifer W. Mack, Colin Cernik, Hajime Uno, Lanfang Xu, Cecile A. Laurent, Lauren Fisher, Nancy Cannizzaro, Julie Munneke, Robert M. Cooper, Joshua R. Lakin, Corey M. Schwartz, Mallory Casperson, Andrea Altschuler, Lori Wiener, Lawrence Kushi, Chun R. Chao
Summary: This study aimed to characterize the prevalence and timing of conversations about goals of care and advance care planning among adolescents and young adults (AYAs) with cancer at the end of life, and to analyze the relationship between such conversations and end-of-life care measures.
JOURNAL OF CLINICAL ONCOLOGY
(2023)