Article
Medicine, General & Internal
Timothy J. Whelan, Sally Smith, Sameer Parpia, Anthony W. Fyles, Anita Bane, Fei-Fei Liu, Eileen Rakovitch, Lynn Chang, Christiaan Stevens, Julie Bowen, Sawyna Provencher, Valerie Theberge, Anna Marie Mulligan, Zuzana Kos, Mohamed A. Akra, K. David Voduc, Tarek Hijal, Ian S. Dayes, Gregory Pond, James R. Wright, Torsten O. Nielsen, Mark N. Levine
Summary: Among women with T1N0 grade 1 or 2 luminal A breast cancer who had undergone breast-conserving surgery and received endocrine therapy, the incidence of local recurrence at 5 years was low without radiotherapy.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Can Chen, Runlu Wang, Bing Wang, Yue Wu, Jingting Jiang
Summary: This study evaluated whether adjuvant radiotherapy after breast-conserving surgery can improve survival in older women with T1-2N0 estrogen receptor-negative breast cancer. The results showed that adjuvant radiotherapy was associated with better overall survival and breast cancer-specific survival in this patient population. However, the potential benefit may be relatively limited for patients aged 80 years or older, or those with T1mic+T1a, T1b tumors.
Article
Oncology
Ivica Ratosa, Gaber Plavc, Nina Pislar, Tina Zagar, Andraz Perhavec, Pierfrancesco Franco
Summary: This study compared survival outcomes in 1360 patients with early-stage breast cancer, showing that patients treated with breast-conserving therapy had lower rates of recurrence and equivalent overall survival compared to those treated with mastectomy alone. The findings emphasize the importance of adjuvant treatments, including radiation therapy, in improving disease-specific outcomes for early-stage breast cancer patients.
Review
Surgery
A. Fancellu, N. Houssami, V Sanna, A. Porcu, C. Ninniri, M. L. Marinovich
Summary: This meta-analysis compared the outcomes of breast-conserving surgery (BCS) versus mastectomy in patients with triple-negative breast cancer (TNBC). The results showed that BCS was associated with lower rates of locoregional recurrence, distant metastasis, and all-cause mortality compared to mastectomy. However, caution should be taken due to potential differences in patient selection for the two surgical options.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Oncology
Fei Wang, Ingrid Meszoely, Tuya Pal, Ingrid A. Mayer, Christina E. Bailey, Wei Zheng, Xiao-Ou Shu
Summary: The study found that elderly patients aged 70 and above who had undergone breast-conserving surgery for early-stage breast cancer had higher mortality rates if they did not receive post-surgery radiotherapy. This suggests that the current recommendations for radiotherapy omission in this patient group may need to be reconsidered.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Hyunjung Kim, Tae Gyu Kim, Byungdo Park, Jeong Ho Kim, Si-Youl Jun, Jun Ho Lee, Hee Jun Choi, Chang Shin Jung, Yoon Ju Bang, Hyoun Wook Lee, Jae Seok Lee, Hyun Yeol Nam, Seunghyeon Shin, Sung Min Kim, Haeyoung Kim
Summary: This study aimed to evaluate the effectiveness of high-dose radiation therapy for positive margins in breast cancer surgery and compare the local recurrence between patients with positive and negative margins. The results showed that positive margins were not associated with poor local control in older patients after a high-dose boost, but had higher risk of local recurrence in younger patients.
Article
Oncology
Judy C. C. Boughey, Kari M. M. Rosenkranz, Karla V. V. Ballman, Linda McCall, Bruce G. G. Haffty, Laurie W. W. Cuttino, Charlotte S. D. Kubicky, Huong T. T. Le-Petross, Armando E. E. Giuliano, Kimberly J. J. Van Zee, Kelly K. K. Hunt, Olwen M. M. Hahn, Lisa A. A. Carey, Ann H. H. Partridge
Summary: This study is a prospective trial to evaluate the effectiveness of breast-conserving therapy in patients with multiple foci of breast cancer. The results demonstrate that breast-conserving surgery with adjuvant radiation can significantly reduce the 5-year recurrence rate. It suggests that breast-conserving therapy is a reasonable option, especially for patients evaluated with preoperative breast MRI.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Ian H. H. Kunkler, Linda J. J. Williams, Wilma J. L. Jack, David A. A. Cameron, J. Michael Dixon
Summary: This study suggests that omission of radiotherapy in older women with low-risk, hormone receptor-positive early breast cancer may increase the risk of local recurrence, but has no detrimental effect on distant recurrence and overall survival.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
Akriti Nanda, Jesse Hu, Sarah Hodgkinson, Sanah Ali, Richard Rainsbury, Pankaj G. Roy
Summary: The evidence is uncertain about the oncological outcomes of OBCS compared to other surgical options for breast cancer. OBCS may have benefits in terms of reducing re-excision rates, but may also lead to more complications and higher recall rates. Further research is needed to evaluate the safety and efficacy of OBCS.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Oncology
Carolina E. Fasola, Hadley J. Sharp, Nicholas W. Clavin, Wei Sha, Courtney R. Schepel, Sally J. Trufan, Elaina Graham, Anna Hecksher, Richard L. White Jr, Lejla Hadzikadic-Gusic
Summary: This study aimed to evaluate the delay in initiating adjuvant radiation therapy (RT) after breast-conserving surgery (BCS) in patients who underwent oncoplastic reduction mammoplasty (ORM) compared to a matched cohort of patients who did not undergo ORM. Medical records of 112 women with early-stage breast cancer treated with BCS were reviewed, and it was found that patients who underwent ORM experienced a significant delay in initiating RT. ORM was associated with increased risk of wound complications, but it did not impact local control.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Sungchan Gwark, Hwa Jung Kim, Jisun Kim, Il Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn, Sae Byul Lee
Summary: In breast cancer patients treated with neoadjuvant chemotherapy, breast-conserving surgery plus radiotherapy improves 5-year disease-free survival, distant metastasis-free survival, and overall survival compared to mastectomy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Alton Wern Jie Hong, J. James, D. Stoney, M. Law
Summary: This study compares the concordance between surgeon's cosmetic score and patient's own assessment, and finds a poor agreement between the two.
WORLD JOURNAL OF SURGERY
(2022)
Article
Oncology
Mingdi Zhang, Kejin Wu, Peng Zhang, Maoli Wang, Fang Bai, Hongliang Chen
Summary: BCS shows independent favorable prognostic factor and can be acceptable and preferable alternative to mastectomy for well-selected early-stage T1 or T2 CLBC patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Caiqin Mo, Weihong Ruan, Junyu Lin, Huaying Chen, Xiangjin Chen
Summary: Repeat breast-conserving surgery (RBCS) has a higher secondary local recurrence rate compared to salvage mastectomy (SM) for patients with ipsilateral breast tumour recurrence (IBTR), but it does not significantly affect survival rates. RBCS may be considered as an alternative method for IBTR patients after breast-conserving surgery (BCS).
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Icro Meattini, Lorenzo Livi, Nicla Lorito, Carlotta Becherini, Marina Bacci, Luca Visani, Alessandra Fozza, Liliana Belgioia, Mauro Loi, Monica Mangoni, Matteo Lambertini, Andrea Morandi
Summary: Significant progress has been made in precision medicine for breast cancer patients through the development of molecular targeted therapies. The combination of these therapies with radiation therapy has the potential for synergistic effects, but safety concerns should be taken into account. Currently, there is limited evidence on the quality assurance of radiation therapy and safety reports in the context of new drugs, especially in advanced cases. Preclinical studies could contribute to effectively combining radiation and targeted therapies in breast cancer.
CANCER TREATMENT REVIEWS
(2022)
Letter
Oncology
Gustavo Nader Marta, Philip Poortmans, Alfredo C. de Barros, Jose Roberto Filassi, Ruffo Freitas-Junior, Riccardo A. Audisio, Max Senna Mano, Sarkis Meterissian, Sarah M. DeSnyder, Thomas A. Buchholz, Tarek Hijal
Article
Forestry
John S. Gunn, Thomas Buchholz
Article
Oncology
Aaron J. Grossberg, Xiudong Lei, Ting Xu, Simona F. Shaitelman, Karen E. Hoffman, Elizabeth S. Bloom, Michael C. Stauder, Welela Tereffe, Pamela J. Schlembach, Wendy A. Woodward, Thomas A. Buchholz, Benjamin D. Smith
Article
Oncology
Fabiana A. Miranda, Lorine A. B. Teixeira, Rebeca N. Heinzen, Felipe Eduardo M. de Andrade, Tarek Hijal, Thomas A. Buchholz, Fabio Y. Moraes, Philip Poortmans, Gustavo N. Marta
Article
Oncology
Simona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Daniel Buchholz, Gregory Chronowski, Tomas Dvorak, Emily Grade, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, Thomas A. Buchholz, Benjamin D. Smith
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Article
Oncology
Harold J. Burstein, Christina Lacchetti, Holly Anderson, Thomas A. Buchholz, Nancy E. Davidson, Karen A. Gelmon, Sharon H. Giordano, Clifford A. Hudis, Alexander J. Solky, Vered Stearns, Eric P. Winer, Jennifer J. Griggs
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Medicine, Research & Experimental
Sarah M. DeSnyder, Parviz Kheirkhah, Marigold L. Travis, Susan E. Lilly, Isabelle Bedrosian, Thomas A. Buchholz, Mark V. Schaverien, Simona F. Shaitelman
LYMPHATIC RESEARCH AND BIOLOGY
(2019)
Article
Oncology
Kaitlin Christopherson, Xiudong Lei, Carlos Barcenas, Thomas A. Buchholz, Naveen Garg, Karen E. Hoffman, Henry Mark Kuerer, Elizabeth Mittendorf, George Perkins, Simona F. Shaitelman, Grace L. Smith, Michael Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Benjamin D. Smith
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Biographical-Item
Oncology
J. Frank Wilson, Thomas A. Buchholz, Ritsuko Komaki
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Oncology
Bruce G. Haffty, Linda M. McCall, Karla V. Ballman, Thomas A. Buchholz, Kelly K. Hunt, Judy C. Boughey
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Oncology
Shane R. Stecklein, Kelly J. Rosso, Jenny Nuanjing, Audree B. Tadros, Anna Weiss, Sarah M. DeSnyder, Henry M. Kuerer, Mediget Teshome, Thomas A. Buchholz, Michael C. Stauder, Naoto T. Ueno, Anthony Lucci, Wendy A. Woodward
PRACTICAL RADIATION ONCOLOGY
(2019)
Article
Economics
Thomas Buchholz, William S. Keeton, John S. Gunn
FOREST POLICY AND ECONOMICS
(2019)
Article
Oncology
Wendy A. Woodward, William E. Barlow, Reshma Jagsi, Thomas A. Buchholz, Steven Shak, Frederick Baehner, Timothy J. Whelan, Nancy E. Davidson, James N. Ingle, Tari A. King, Peter M. Ravdin, C. Kent Osborne, Debasish Tripathy, Robert B. Livingston, Julie R. Gralow, Gabriel N. Hortobagyi, Daniel F. Hayes, Kathy S. Albain
Article
Oncology
Bhavana Chapman, Xiudong Lei, Prithvi Patil, Shikha Tripathi, Krista M. Nicklaus, Aaron J. Grossberg, Simona F. Shaitelman, Alastair M. Thompson, Kelly K. Hunt, Thomas A. Buchholz, Fatima Merchant, Mia K. Markey, Benjamin D. Smith, Jay P. Reddy
ADVANCES IN RADIATION ONCOLOGY
(2020)
Article
Oncology
Renae D. Van Wyhe, Abigail S. Caudle, Simona F. Shaitelman, George H. Perkins, Thomas A. Buchholz, Karen E. Hoffman, Eric A. Strom, Benjamin D. Smith, Welela Tereffe, Wendy A. Woodward, Michael C. Stauder
ADVANCES IN RADIATION ONCOLOGY
(2018)
