4.7 Meeting Abstract

Use of epiregulin (EREG) and amphiregulin (AREG) gene expression to predict response to cetuximab (cet) in combination with oxaliplatin (Ox) and 5FU in the first-line treatment of advanced colorectal cancer (aCRC)

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JOURNAL OF CLINICAL ONCOLOGY
Volume 30, Issue 30, Pages -

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AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/jco.2012.30.30_suppl.32

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Article Oncology

Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival

Anna Morra, Maartje A. C. Schreurs, Irene L. Andrulis, Hoda Anton-Culver, Annelie Augustinsson, Matthias W. Beckmann, Sabine Behrens, Stig E. Bojesen, Manjeet K. Bolla, Hiltrud Brauch, Annegien Broeks, Saundra S. Buys, Nicola J. Camp, Jose E. Castelao, Melissa H. Cessna, Jenny Chang-Claude, Wendy K. Chung, Sarah Colonna, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Joe Dennis, Peter Devilee, Thilo Doerk, Alison M. Dunning, Miriam Dwek, Douglas F. Easton, Diana M. Eccles, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Tanja N. Fehm, Jonine D. Figueroa, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Jeanine A. Genkinger, Felix Grassmann, Melanie Guendert, Eric Hahnen, Christopher Haiman, Ute Hamann, Patricia A. Harrington, Jaana M. Hartikainen, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, Anna Jakubowska, Wolfgang Janni, Helena Jernstroem, Esther M. John, Nichola Johnson, Michael E. Jones, Vessela N. Kristensen, Allison Kurian, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Jan Lubinski, Michael P. Lux, Arto Mannermaa, Dimitrios Mavroudis, Anna Marie Mulligan, Taru A. Muranen, Heli Nevanlinna, Ines Nevelsteen, Patrick Neven, William G. Newman, Nadia Obi, Kenneth Offit, Andrew F. Olshan, Tjoung-Won Park-Simon, Alpa Patel, Paolo Peterlongo, Kelly-Anne Phillips, Dijana Plaseska-Karanfilska, Eric C. Polley, Nadege Presneau, Katri Pylkas, Brigitte Rack, Paolo Radice, Muhammad U. Rashid, Valerie Rhenius, Mark Robson, Atocha Romero, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Sabine Schuetze, Christopher Scott, Mitul T. Shah, Snezhana Smichkoska, Melissa C. Southey, William J. Tapper, Lauren R. Teras, Rob A. E. M. Tollenaar, Katarzyna Tomczyk, Ian Tomlinson, Melissa Troester, Celine Vachon, Elke van Veen, Qin Wang, Camilla Wendt, Hans Wildiers, Robert A. Winqvist, Argyrios Ziogas, Per Hall, Paul D. P. Pharoah, Muriel Adank, Antoinette Hollestelle, Marjanka K. Schmidt, Maartje Hooning

Summary: Breast cancer patients with the CHEK2 c.1100delC variant have an increased risk of contralateral breast cancer and worse survival. Systemic therapy is associated with reduced contralateral breast cancer risk, regardless of CHEK2 c.1100delC status. Patients with the CHEK2 c.1100delC variant have shorter survival, which is not fully explained by their contralateral breast cancer risk.

CANCER MEDICINE (2023)

Meeting Abstract Biochemistry & Molecular Biology

Estimating the prevalence of pathogenic germline variants in cancer susceptibility genes in 1,336 cases of renal cell carcinoma

Bryndis Yngvadottir, Avgi Andreou, Laia Bassaganyas, Alexey Larionov, Alex J. Cornish, Daniel Chubb, Charlie N. Saunders, Philip Smith, Huairen Zhang, Yasemin Cole, James Larkin, Lisa Browning, Samra Turajlic, Kevin Litchfield, Richard S. Houlston, Eamonn R. Maher

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

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