Article
Cell Biology
Liang Gao, Chao He, Aizhen Yang, Haibing Zhou, Qingxian Lu, Raymond B. Birge, Yi Wu
Summary: This study investigates the role of Tyro3, Axl, and Mertk in the pathogenesis of rheumatoid arthritis. The results demonstrate that Axl and Mertk-deficient mice develop more severe antibody-induced arthritis, accompanied by increased levels of cytokines in the joints. In contrast, Tyro3-deficient mice show diminished joint inflammation. Furthermore, TAMs show distinct expression patterns, with monocytes expressing Axl and Mertk while neutrophils express Axl and Tyro3.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Shakoora A. Sabree, Caitlin D. Lemke-Miltner, Sue E. Blackwell, Chaobo Yin, Aaron Bossler, Kareem Ebeid, Aliasger K. Salem, George J. Weiner
Summary: Vidutolimod, or CMP-001, is a virus-like particle that has shown promise in altering the tumor microenvironment and inducing an anti-tumor immune response when injected intratumorally. Its efficacy is dependent on the presence of antibodies that enhance opsonization and uptake by dendritic cells, ultimately affecting interferon production.
Article
Biochemical Research Methods
Wei Wang, Qing Chen
Summary: Fc gamma R binding characterization is critical during therapeutic antibody development. A new assay format using Surface plasmon resonance (SPR) was developed to characterize IgG-Fc gamma R interaction in the presence of antigen. The study provides evidence of antigen binding facilitating IgG-Fc gamma R interaction, especially for huIgG2. Evaluating the IgG-Fc gamma R interaction in the presence of antigen may help design safer and more effective biotherapeutics.
ANALYTICAL BIOCHEMISTRY
(2022)
Review
Immunology
Enrique Gomez Alcaide, Sinduya Krishnarajah, Fabian Junker
Summary: Despite significant progress in immunotherapy for cancer treatment, there is a need for novel strategies to improve treatment outcomes and accessibility. Cancer vaccines based on tumor antigens have emerged as an innovative approach, with dendritic cells playing a crucial role in their development. Targeting Fc gamma receptors for antigen delivery to dendritic cells shows promise for enhancing T-cell activation and potentially improving tumor vaccination strategies.
Article
Multidisciplinary Sciences
Zhongwei Xu, Bingze Xu, Susanna L. Lundstrom, Alex Moreno-Giro, Danxia Zhao, Myriam Martin, Erik Lonnblom, Qixing Li, Alexander Kramer, Changrong Ge, Lei Cheng, Bibo Liang, Dongmei Tong, Roma Stawikowska, Anna M. Blom, Gregg B. Fields, Roman A. Zubarev, Rikard Holmdahl
Summary: This study developed antibodies targeting type-II collagen and investigated their mechanism of action. The antibody R69-4 inhibits autoantibody-mediated arthritis by hindering FCGR3 signaling, highlighting its potential clinical utility in acute rheumatoid arthritis.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Elizabeth M. Bailey, Amit Choudhury, Harika Vuppula, Daniel F. Ortiz, John Schaeck, Anthony M. Manning, Carlos J. Bosques, Adam D. Hoppe
Summary: The valency of Fc differentially controls Fc gamma receptor activation and inhibition within distinct subcellular compartments. PentX activates Fc gamma receptors on the plasma membrane while SIF1 inhibits activation by stabilizing a ligated and inactive Fc gamma receptor.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Junho Kang, Eun Jung Kwon, Mihyang Ha, Hansong Lee, Yeuni Yu, Ji Wan Kang, Yeongjoo Kim, Eun Young Lee, Ji-Young Joo, Hye Jin Heo, Eun Kyoung Kim, Tae Woo Kim, Yun Hak Kim, Hae Ryoun Park
Summary: Through gene expression analysis, we identified common differentially expressed genes (DEGs) in periodontitis and type 2 diabetes, and constructed a protein-protein interaction network. These hub genes were up-regulated in both diseases and were most significantly enriched in the Fc gamma R-mediated phagocytosis pathway. These findings provide potential therapeutic targets for the treatment of periodontitis and type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Psychology, Biological
Fiona A. Hagenbeek, Jana S. Hirzinger, Sophie Breunig, Susanne Bruins, Dmitry V. Kuznetsov, Kirsten Schut, Veronika V. Odintsova, Dorret I. Boomsma
Summary: Twin studies compare genetic and environmental factors in identical and non-identical twins to understand behavior resemblance. Recent developments in twin studies show the need for increased representativeness. Twin concordance rates for major diseases challenge the belief in genetic determinism.
NATURE HUMAN BEHAVIOUR
(2023)
Review
Biochemistry & Molecular Biology
Isabell Lang, Olena Zaitseva, Harald Wajant
Summary: Inhibitory targeting of the CD40L-CD40 system is a promising therapeutic option in organ transplantation and autoimmune diseases. Lack of Fc gamma receptor (Fc gamma R)-binding is crucial for the development of safe inhibitory antibodies targeting CD40L or CD40. Recent clinical studies have shown that blocking CD40 antibodies not interacting with Fc gamma Rs are well tolerated and have initial clinical efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Deepti Maheshwari, Keshav Saini, Prabhat Singh, Mohit Singla, Kaustuv Nayak, Charu Aggarwal, Yadya M. Chawla, Prashant Bajpai, Manpreet Kaur, Sivaram Gunisetty, Christiane S. Eberhardt, Rajni Nyodu, Kathryn Moore, Mehul S. Suthar, Guruprasad R. Medigeshi, Evan Anderson, Rakesh Lodha, Sushil K. Kabra, Rafi Ahmed, Anmol Chandele, Kaja Murali-Krishna
Summary: This study provides a detailed transcriptional analysis of human monocyte subsets in both healthy children and children with dengue. The findings suggest that certain monocyte subsets in dengue patients upregulate genes related to inflammation and vascular dysfunction, while other subsets downregulate genes related to vasoconstriction and endothelial stability.
Article
Medicine, Research & Experimental
Janessa Y. J. Tan, Danielle E. Anderson, Abhay P. S. Rathore, Aled O'Neill, Chinmay Kumar Mantri, Wilfried A. A. Saron, Cheryl Q. E. Lee, Chu Wern Cui, Adrian E. Z. Kang, Randy Foo, Shirin Kalimuddin, Jenny G. Low, Lena Ho, Paul Tambyah, Thomas W. Burke, Christopher W. Woods, Kuan Rong Chan, Jorn Karhausen, Ashley L. St John
Summary: Lung inflammation is a key symptom of COVID-19 and is believed to be immune mediated. Research has found widespread degranulation of mast cells (MCs) in SARS-CoV-2 infected mice and nonhuman primates. In humans, the activation of MCs is significantly correlated with disease severity and biomarkers of vascular dysregulation. These findings suggest the involvement of MCs in lung tissue damage during SARS-CoV-2 infection and potential strategies for intervention.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Obstetrics & Gynecology
Jianjun Hu, Emanuela Molinari, Sarah K. Darmon, Lin Zhang, Pasquale Patrizio, David H. Barad, Norbert Gleicher
Summary: The study found that the granulation patterns of donor oocytes are predictive of IVF success rates, with higher quality granulation patterns associated with higher pregnancy and live birth rates in fresh donor oocytes. Similar trends were observed in thawed donor oocytes, but with relatively worse outcomes.
FERTILITY AND STERILITY
(2021)
Article
Oncology
Manuela Pigors, Sabrina Patzelt, Niklas Reichhelm, Jenny Dworschak, Stanislav Khil'chenko, Shirin Emtenani, Katja Bieber, Maxi Hofrichter, Mayumi Kamaguchi, Stephanie Goletz, Gabriele Koehl, Joerg Koehl, Lars Komorowski, Christian Probst, Katrien Vanderheyden, Bianca Balbino, Ralf J. Ludwig, Peter Verheesen, Enno Schmidt
Summary: This study demonstrates that the pathogenic effects of Col17-targeting IgG outside of NC16A are partly mediated by Fc gamma R and C5aR1 mechanisms, and skin inflammation can be alleviated by inhibiting FcRn.
JOURNAL OF PATHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Patricia Gogesch, Simone Dudek, Ger van Zandbergen, Zoe Waibler, Martina Anzaghe
Summary: Efforts have been made to ensure the safety and efficacy of therapeutic monoclonal antibodies since the approval of the first mAb in 1986. Various cell-based assays have been established to evaluate Fc-mediated effector functions of therapeutic mAbs. Optimization strategies such as point mutations and altered glycosylation patterns have led to the development of next-generation therapeutic mAbs with improved efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ailin Qu, Qian Wang, Qing Chang, Jingkang Liu, Yongmei Yang, Xin Zhang, Yanli Zhang, Xiaoshi Zhang, Hongchun Wang, Yi Zhang
Summary: By analyzing tissue samples from stage II colon cancer patients, we developed a predictive model based on long non-coding RNA (lncRNA) to improve the accuracy of prognosis prediction. This model consists of 11 lncRNAs and can categorize patients into high-risk and low-risk groups. It has independent predictive value and stronger prognostic ability compared to current clinical risk factors. The model can facilitate personalized treatment decisions and postoperative counseling, ultimately leading to improved survival.
SCIENTIFIC REPORTS
(2023)
