Journal
NEW JOURNAL OF CHEMISTRY
Volume 39, Issue 6, Pages 4631-4639Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nj00302d
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Funding
- Council of Scientific and Industrial Research, New Delhi, India [01(2427)/10/EMR-II, 8644-A]
- Council of Scientific and Industrial Research
- University Grants Commission-Special Assistance Programme, New Delhi
- DST [SB/FT/CS-147/2013]
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A copper catalyzed regioselective synthesis of 2,3,4-trisubstituted 1H-pyrroles using a novel three-component coupled domino reaction of aldehydes, ketones and alkyl isocyanoacetates is reported. This transformation proceeds through the formation of a chalcone followed by a [3+2] cycloaddition reaction to obtain a-cuprioisocyanide, a cyclic organocopper intermediate, which on copper-hydrogen exchange followed by oxidation exclusively offers 2,3,4-trisubstituted 1H-pyrrole.
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