Article
Urology & Nephrology
Kevin Shee, Janet E. Cowan, Ashwin Balakrishnan, Domenique Escobar, Kevin Chang, Samuel L. Washington, Hao G. Nguyen, Katsuto Shinohara, Matthew R. Cooperberg, Peter R. Carroll
Summary: Although the American Urological Association and European Association of Urology do not use the very low-risk (VLR) subcategory for low-risk prostate cancer (PCa), the National Comprehensive Cancer Network (NCCN) still maintains this classification. However, a study found that the NCCN VLR criteria are less applicable in the era of imaging-targeted prostate biopsies, and the Cancer of the Prostate Risk Assessment (CAPRA) score may be a better tool for risk stratification in men on active surveillance. The study suggests that the VLR criteria should be reevaluated for its relevance in the modern era.
Article
Endocrinology & Metabolism
Wu Ding, Guodong Ruan, Yingli Lin, Jianming Zhu, Zhian Li, Dengfeng Ye
Summary: This study aims to establish appropriate management strategies for low-risk papillary thyroid carcinoma (PTC) patients by comparing outcomes of active surveillance (AS) in different tumor sizes and lymph node metastasis status. The study provides valuable insights for the effective management of such patients, addressing the issues and challenges associated with AS in practical clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Abhinav Sharma, Ruxandra Christodorescu, Ahmad Agbariah, Daniel Duda-Seiman, Diala Dahdal, Dana Man, Nilima Rajpal Kundnani, Octavian Marius Cretu, Simona Dragan
Summary: This narrative review focuses on the assessment and description of updated risk-prediction parameters for cardiovascular disease (CVD) in patients with rheumatic diseases. Various imaging techniques and biomarkers are found to be beneficial in both predicting CV risk and diagnosing early subclinical CVD. Physical exercise plays a crucial role in maintaining cardiovascular health and influencing underlying diseases. Certain lipid-lowering drugs are associated with a lower CV risk, while glucocorticoids and NSAIDs increase the risk of CVD. Therefore, it is essential to establish and implement CVD risk stratification models in rheumatic patients.
Article
Environmental Studies
Anthony Francis Burns, Abbas Rajabifard, Davood Shojaei
Summary: Governments establish land administration systems to recognize and protect property rights. However, many projects have failed to achieve their objectives, and the challenges often lie in policy and political decisions rather than economic or technical matters. It is necessary to reform the current approach to land administration reform and consider the political economy issues that affect the provision of efficient and effective land administration services.
Article
Gastroenterology & Hepatology
Mark Redston, Amy Noffsinger, Anthony Kim, Fahire G. Akarca, Marianne Rara, Diane Stapleton, Laurel Nowden, Richard Lash, Adam J. Bass, Matthew D. Stachler
Summary: This study developed a reliable criteria for grading abnormal p53 immunohistochemical expression and tested its utility as a biomarker for progression in Barrett's esophagus (BE). The findings showed that abnormal p53 expression was strongly associated with neoplastic progression in BE, regardless of histologic diagnosis and could predict progression among nondysplastic BE, indefinite for dysplasia, and low-grade dysplasia.
Letter
Gastroenterology & Hepatology
Endrit Shahini, Marcello Maida
Summary: There is still controversy surrounding the best surveillance strategies for high-risk patients following H. pylori eradication, indicating the need for further research to establish optimal and cost-effective monitoring strategies. Additionally, studies are required to refine risk stratification for patients with a high likelihood of gastric cancer evolution, taking into account racial, ethnic, immigration factors, and the development of new biomarkers for early diagnosis of malignancy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Chemistry, Physical
Johannes Novak Hansen, Hector Prats, Karl Krojer Toudahl, Niklas Morch Secher, Karen Chan, Jakob Kibsgaard, Ib Chorkendorff
Summary: Efforts to find cheap alternatives to platinum for the hydrogen evolution reaction have not yet found a catalyst with intrinsic activity that can compete with platinum. It is important to measure intrinsic catalytic activities and consider the impact of mass-transport limitations on observed activity. Despite achieving the highest turnover frequency for platinum, the true intrinsic HER activity for platinum in acid remains unknown due to mass transport limitations.
ACS ENERGY LETTERS
(2021)
Article
Medicine, General & Internal
Manuel Vergillos Luna, Adyb-Adrian Khal, Kara A. Milliken, Federico Solla, Virginie Rampal
Summary: Pediatric foot deformities are common, affecting up to 44% of preschool aged children. There is a lack of international guidelines and uniform definitions and measurements, which complicates the management of pediatric flatfoot and the decision-making process for specialized care referral. This narrative review aims to provide guidance to primary care physicians treating these patients. The articles reviewed showed significant heterogeneity in definition and proposed management of pediatric flatfoot, making it a challenging condition to study. Flatfoot is a common finding in children under 10 years old, but should only be considered pathological if accompanied by stiffness or functional limitation. Surgical referral is appropriate for children with stiff or painful flatfoot, while observation is recommended for flexible, asymptomatic flatfeet.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Bettina Julia Wolf, Kathrin Kusch, Victoria Hunniford, Barbara Vona, Robert Kuhler, Daniel Keppeler, Nicola Strenzke, Tobias Moser
Summary: Hearing impairment is a common sensory deficit affecting millions of people worldwide, and there is a lack of effective treatment. Collaboration with cochlear implant users and the development of new therapies offer potential solutions for improving hearing restoration. Gene therapy and major innovations in cochlear implants are likely to be clinically translated within this decade.
EMBO MOLECULAR MEDICINE
(2022)
Article
Immunology
Christopher A. Czaja, Myles G. Cockburn, Kathryn Colborn, Lisa Miller, Deborah S. K. Thomas, Rachel K. Herlihy, Nisha Alden, Eric A. F. Simoes
Summary: The study found that neighborhoods in Denver with higher rates of adult hospitalizations due to laboratory-confirmed influenza had lower coverage of influenza vaccine among adults. Overall vaccine coverage was low, and hospitalization rates were associated with demographic and socioeconomic characteristics. Active immunization strategies in at-risk neighborhoods may be necessary to address disparities in influenza hospitalization rates.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Oncology
Alexandros Papachristodoulou, Cory Abate-Shen
Summary: Most prostate cancer cases are low-grade tumors that are monitored instead of immediately treated. However, a subset of men are likely to develop advanced prostate cancer, which could be fatal, and they would benefit from early intervention. In this review, the importance of precision intervention is discussed, focusing on the cumulative risk factors for developing or progressing to lethal prostate cancer in high-risk groups.
Review
Medicine, General & Internal
Renato Patrone, Nunzio Velotti, Stefania Masone, Alessandra Conzo, Luigi Flagiello, Chiara Cacciatore, Marco Filardo, Vincenza Granata, Francesco Izzo, Domenico Testa, Stefano Avenia, Alessandro Sanguinetti, Andrea Polistena, Giovanni Conzo
Summary: Active surveillance (AS) as an alternative treatment for thyroid cancer allows convenient monitoring of disease progression in low-risk patients. A large number of patients are eligible for AS, with some experiencing disease progression during the observation period requiring surgical intervention.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Damis Feruzi Kamna, Shiva Ilkhanizadeh
Summary: The study found that high-performance work practices significantly affect employee career competencies, which in turn significantly impact service quality, creative performance, and extra-role performance in banks. However, employee career competencies do not mediate the relationship between high-performance work systems and service quality in the banking industry.
Article
Medicine, General & Internal
Alexandra Maria Burlui, Anca Cardoneanu, Luana Andreea Macovei, Ciprian Rezus, Lucian Vasile Boiculese, Mariana Graur, Elena Rezus
Summary: The study evaluated the diet and nutritional status of scleroderma patients, finding significant associations between malnutrition and weight loss with cardiopulmonary diseases, liver enzymes, albumin levels, and extent of skin fibrosis. There is a need for further research on the long-term implications and management of nutritional impairment in patients with various clinical manifestations.
Article
Oncology
Debora L. S. Danilovic, George B. Coura-Filho, Giulianna M. Recchia, Luciana A. Castroneves, Suemi Marui, Carlos A. Buchpiguel, Ana O. Hoff, Peter Kopp
Summary: Radioiodine therapy is commonly recommended for intermediate-risk differentiated thyroid carcinomas (DTC). This study assesses the impact of preablation stimulated thyroglobulin levels (sTg) and diagnostic I-131 whole-body scans (DxWBS) on the management of intermediate-risk DTC. The findings indicate that pretherapy sTg and DxWBS contribute to the detection and management of metastatic disease in these patients.
ENDOCRINE-RELATED CANCER
(2022)
Review
Urology & Nephrology
M. Noureldin, D. Eldred-Evans, C. C. Khoo, M. Winkler, H. Sokhi, H. Tam, H. U. Ahmed
Summary: Traditionally, transrectal ultrasound (TRUS)-guided biopsy has been used in detecting prostate cancer, but alternative methods such as transperineal template biopsy are being explored. Current research is focused on refining biopsy techniques to maximize detection of significant cancers while minimizing risks and complications. MRI-targeted prostate biopsy has shown to be effective in detecting significant cancers and is an essential component in the diagnostic pathway of prostate cancer.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Luke P. O'Connor, Amir H. Lebastchi, Rahim Horuz, Ardeshir R. Rastinehad, M. Minhaj Siddiqui, Jeremy Grummet, Christof Kastner, Hashim U. Ahmed, Peter A. Pinto, Baris Turkbey
Summary: Multiparametric MRI plays a crucial role in the management of prostate cancer, addressing the limitations of traditional biopsy methods and improving the detection and characterization of high-risk cancers while reducing the diagnosis of clinically insignificant diseases. It also helps in selecting patients for active surveillance and treatment planning.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Philipp M. Huber, Naveed Afzal, Manit Arya, Silvan Boxler, Tim Dudderidge, Mark Emberton, Stephanie Guillaumier, Richard G. Hindley, Feargus Hosking-Jervis, Lucas Leemann, Henry Lewi, Neil McCartan, Caroline M. Moore, Raj Nigam, Chris Odgen, Raj Persad, Jaspal Virdi, Mathias Winkler, Hashim U. Ahmed
Summary: Treatment with focal HIFU on anterior prostate cancer lesions may be less effective compared to posterior lesions.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Mariana Bertoncelli Tanaka, Kirpal Sahota, James Burn, Alison Falconer, Mathias Winkler, Hashim U. Ahmed, Tina G. Rashid
Summary: The risk of prostate cancer in transgender women who have not undergone gender-affirming hormone therapy or surgery is the same as cis males. For transgender women on hormone therapy or after surgery, the incidence of prostate cancer is lower but diagnosis and treatment is more complex. Future research is needed to develop evidence-based guidelines for managing prostate cancer in transgender women.
Review
Oncology
E. J. Bass, A. Pantovic, M. J. Connor, S. Loeb, A. R. Rastinehad, M. Winkler, Rhian Gabe, H. U. Ahmed
Summary: Using MRI-guided biopsy offers superior detection rates of clinically significant PCa and reduces the detection of insignificant PCa compared to TRUS-GB in patients with suspected prostate cancer. However, no individual MRI-GB technique was found to be better in detecting csPCa. Prospective adequately powered randomized controlled trials are needed for further validation.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Tobias Penzkofer, Anwar R. Padhani, Baris Turkbey, Hashim U. Ahmed
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Giorgio Brembilla, Francesco Giganti, Harbir Sidhu, Massimo Imbriaco, Sue Mallett, Armando Stabile, Alex Freeman, Hashim U. Ahmed, Caroline Moore, Mark Emberton, Shonit Punwani
Summary: The study found that abbreviated biparametric MRI protocols can match the diagnostic accuracy of standard biparametric MRI and multiparametric MRI for detecting clinically significant prostate cancer. When used in low-prevalence settings, higher cut-offs for MRI positivity should be prioritized.
Editorial Material
Urology & Nephrology
Alexander Light, Hashim U. Ahmed, Taimur T. Shah
Summary: Recurrence of prostate cancer is common after radical radiotherapy, and accurate detection and localization of the recurrent disease is crucial for treatment planning. While PET-CT is increasingly used to detect metastatic disease, its value for identifying and characterizing intraprostatic recurrence needs improvement.
NATURE REVIEWS UROLOGY
(2022)
Article
Medicine, General & Internal
Samuel William David Merriel, Stephanie Archer, Alice S. Forster, David Eldred-Evans, John McGrath, Hashim Uddin Ahmed, Willie Hamilton, Fiona M. Walter
Summary: This study explored patient and GP experiences of prostate cancer diagnostic pathways in England. Patients preferred "one-stop" pathways integrating MRI and specialist consultations, while GPs were uncertain about identifying patients needing urgent prostate cancer testing.
Letter
Urology & Nephrology
Edward J. J. Bass, Hashim U. U. Ahmed
Editorial Material
Primary Health Care
Samuel W. D. Merriel, Andrew Seggie, Hashim Ahmed
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Urology & Nephrology
Martin J. J. Connor, Michael A. A. Gorin, David Eldred-Evans, Edward J. J. Bass, Ankit Desai, Tim Dudderidge, Mathias Winkler, Hashim U. U. Ahmed
Summary: Approaches and techniques for diagnostic prostate biopsy have evolved significantly in recent decades, with advancements from finger-guided techniques to MRI-directed strategies, aspiration cytology to tissue core sampling, and transrectal to transperineal approaches. Transperineal biopsy approaches have particularly improved antibiotic stewardship and reduced infectious complications. Additionally, future prostate biopsy methods may integrate novel techniques such as 3D-ultrasonography fusion reconstruction, molecular targeting based on PET imaging, and autonomous robotic-assisted biopsy. This Perspective reviews the history of prostate biopsy and discusses the current and future role of imaging in prostate biopsy.
NATURE REVIEWS UROLOGY
(2023)
Article
Oncology
Dmitri Pchejetski, Ewan Hunter, Mehrnoush Dezfouli, Matthew Salter, Ryan Powell, Jayne Green, Tarun Naithani, Christina Koutsothanasi, Heba Alshaker, Jiten Jaipuria, Martin J. Connor, David Eldred-Evans, Francesca Fiorentino, Hashim Ahmed, Alexandre Akoulitchev, Mathias Winkler
Summary: Prostate cancer is a common disease affecting one out of six men during their lifetime. The current prostate-specific antigen (PSA) blood test is not accurate, leading to unnecessary biopsies and false reassurance. A new epigenetic test, combined with the PSA test, has been developed and shows better diagnostic accuracy. The new test, called the PSE test, is accurate, rapid, minimally invasive, and inexpensive, and has the potential to significantly improve prostate cancer diagnosis.
Letter
Urology & Nephrology
Alexander Light, Xiaomeng Li, Marjorie Otieno, Hashim U. Ahmed, Taimur T. Shah
Article
Multidisciplinary Sciences
Oliver Brunckhorst, Jaroslaw Liszka, Callum James, Jack B. Fanshawe, Mohamed Hammadeh, Robert Thomas, Shahid Khan, Matin Sheriff, Hashim U. Ahmed, Mieke Van Hemelrijck, Gordon Muir, Robert Stewart, Prokar Dasgupta, Kamran Ahmed
Summary: This study aims to explore the potential treatment, patient, and oncological factors associated with mental wellbeing outcomes in newly diagnosed prostate cancer patients. It will recruit 300 participants undergoing different treatment options for 12-month follow-up and collect questionnaire-based data for analysis. The results will provide clinical value in guiding future prognosis research and identifying individuals in need of additional monitoring or support.
