Article
Oncology
Ping Liu, Mei Ji, Yanxiang Kong, Zhifeng Huo, Qiubo Lv, Qinghuang Xie, Danbo Wang, Biliang Chen, Hailin Wang, Zhumei Cui, Qianqing Wang, Xiaonong Bin, Jinghe Lang, Chunlin Chen
Summary: The study found that after receiving radical radiotherapy and chemotherapy, patients with squamous cell carcinoma of the cervix had higher 5-year overall survival and disease-free survival rates compared to those with adenocarcinoma/adenosquamous carcinoma.
Article
Biochemistry & Molecular Biology
Xianfeng Li, Yan Wang, Qingjie Min, Weimin Zhang, Huajing Teng, Chao Li, Kun Zhang, Leisheng Shi, Bin Wang, Qimin Zhan
Summary: In this study, a comprehensive comparison of the transcriptomes of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) was conducted, revealing shared and distinct transcriptomic signatures between these two cancer subtypes and uncovering possible common and unique mechanisms involved in tumorigenesis.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Oncology
Saloe Bispo, Ticiana D. J. Farias, Patricia Savio de Araujo-Souza, Ricardo Cintra, Hellen Geremias dos Santos, Natasha Andressa Nogueira Jorge, Mauro Antonio Alves Castro, Gabriel Wajnberg, Nicole de Miranda Scherer, Maria Luiza Nogueira Dias Genta, Jesus Paula Carvalho, Luisa Lina Villa, Laura Sichero, Fabio Passetti
Summary: SCC and ADC are the most common histological types of cervical cancer, with ADC showing a worse prognosis. Molecular characterization revealed unique pathways for each histological type, such as epithelial maintenance in SCC and the MODY pathway in ADC. This study identified potential transcription factor networks associated with these pathways, which could be explored for more efficient diagnostic tools.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Carl Mathis Wild, Fabian Garrido, Christian Dannecker, Melitta B. Koepke, Marie-Christine Chateau, Florence Boissiere-Michot, Helene H. Heidegger, Aurelia Vattai, Mirjana Kessler, Udo Jeschke, Vincent Cavailles, Manel Juan Otero, George Valasoulis, Georgios Androutsopoulos, Georgios Michail, Thomas Vrekoussis
Summary: This study investigated the prognostic impact of tumor immune infiltration in cervical cancer and found that the level of tumor-infiltrating immune cells was significantly enhanced in cervix squamous cell carcinomas, which was positively correlated with patient survival.
Article
Pathology
Gianluca Businello, Matteo Fassan, Silvia Degasperi, Giulia Traverso, Melania Scarpa, Imerio Angriman, Andromachi Kotsafti, Ignazio Castagliuolo, Marta Sbaraglia, Romeo Bardini, Marco Scarpa
Summary: The study suggests that HPV infection is not a factor associated with esophageal squamous cell carcinoma (ESCC) after head and neck squamous cell carcinoma (HNSCC). Instead, p53 overexpression is common in HNSCC-associated ESCCs. The altered immune microenvironment, characterized by dysregulated lymphomonocytic infiltration, may play a crucial role in the development of metachronous ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Immunology
Na Li, Jiahong Wang, Xianquan Zhan
Summary: This study identified two reliable immune-related gene signature models that were significantly associated with prognosis and tumor microenvironment cell infiltration in LUAD and LUSC, respectively. Evaluation of these models could help predict response to immunotherapy and guide immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Xin-Yu Shu, Zhang Dai, Shuang Zhang, Hui-Xia Yang, Hui Bi
Summary: This article reports a case of cervical HSIL extending into the endometrium and progressing to SCC in the uterine cavity. More attention should be paid to the early detection and prevention of this disease.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Editorial Material
Medicine, General & Internal
Ha Young Woo, Hyun-Soo Kim
Summary: Papillary squamous cell carcinoma (PSCC) is a rare and aggressive type of cervical carcinoma. We present a rare case of recurrent PSCC in a young woman, which rapidly progressed within a short period.
Article
Oncology
Jinyou Li, Gang Wu, Ju Yang, Jiai Yan, Dan Li, Qinyue Wang, Yanping Xia, Jie Zhu, Baoliang Guo, Fengyue Cheng, Jing Sun, Hong Cao, Feng Zhang
Summary: The composition of pulmonary microbiota in tissues adjacent to lung lesions showed significant differences between different lesion types. Ralstonia, Acinetobacter, and Microbacterium are the dominant genera in lung adenocarcinoma, lung squamous carcinoma, and benign lesions, respectively. The abundance ratio of Ralstonia to Acinetobacter in adenocarcinoma patients has diagnostic value. PICRUSt analysis revealed remarkable differences in metabolic pathways among different lesion types.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Fen Xue, Xiaoshuang Niu, Chaosu Hu, Xiayun He
Summary: This study aimed to determine the long-term risk of second primary lung adenocarcinoma (SPLAC) in nasopharyngeal cancer (NPC) patients after intensity-modulated radiotherapy (IMRT). The results showed that the incidence of SPLAC in NPC patients after IMRT was similar to that of the normal population, and most cases were detected in early stages during follow-up, with good surgical efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chengdi Wang, Qiuxiao Yu, Tingting Song, Zhoufeng Wang, Lujia Song, Ying Yang, Jun Shao, Jingwei Li, Yinyun Ni, Ningning Chao, Li Zhang, Weimin Li
Summary: An investigation into the immune landscape is crucial for immunotherapy strategies and predicting clinical responses in non-small-cell lung cancer patients. Using single-cell RNA sequencing, researchers have identified immune signature differences between lung adenocarcinoma and lung squamous cell carcinoma, the two major subtypes of NSCLC. They found that cytotoxic and effector T and NK cells, as well as distinct macrophage subtypes, play central roles in the immune microenvironment heterogeneity between the two subtypes. This comprehensive depiction of immune heterogeneity could aid in personalized treatment design.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Medicine, General & Internal
Ashley Wysong
Summary: Squamous-cell carcinoma is a common type of cancer in humans, with most cases being localized and treatable, but a small percentage of cases that recur or spread can be fatal. Immunocompromised patients are at particularly high risk.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Maria T. Brands, Gaby Campschroer, Matthias A. W. Merkx, Andre L. M. Verbeek, Boukje A. C. van Dijk, Sandra M. E. Geurts
Summary: The study aimed to determine the incidence, location, and timing of second primary tumors after diagnosis of oral squamous cell carcinoma, compare the risk with head and neck squamous cell carcinoma, and assess the need for a separate follow-up program. The results showed that OSCC SPT develops in different patterns and locations compared to HNSCC, suggesting the importance of a specific follow-up protocol.
Article
Multidisciplinary Sciences
Luana F. Tanaka, Dirk Schriefer, Kathrin Radde, Gunther Schauberger, Stefanie J. Klug
Summary: This study investigated the uptake of opportunistic cervical cancer screening and other risk factors in Germany. Results showed that frequent participation in screening reduced the risk of cervical cancer, while factors such as infrequent screening, multiple sexual partners, and obesity were associated with increased risk. Further investigation is needed to evaluate the quality of cytology and treatment of precancerous lesions in Germany.
Article
Oncology
Lois Eva, Lynn Sadler, John M. D. Thompson, Sukwinder Sahota, Kah Leng Fong, Ronald W. Jones, Susan M. Bigby
Summary: Patients with HPV-associated vulvar squamous cell carcinomas have better disease-specific survival compared to patients with HPV-independent tumors, regardless of the stage and age at diagnosis. HPV-independent tumors have worse outcomes even in early-stage disease.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Infectious Diseases
Monica S. Sierra, Sabrina H. Tsang, Carolina Porras, Rolando Herrero, Joshua N. Sampson, Bernal Cortes, John Schussler, Sarah Wagner, Loretto Carvajal, Wim Quint, Aimee R. Kreimer, Shangying Hu, Ana Cecilia Rodriguez, Byron Romero, Allan Hildesheim
Summary: This study estimated the prevalence and incidence of HPV infections in young adult women. The results showed that the incidence of HPV infections peaked at age 20 and steadily declined with age. The study also found that the incidence of HPV infections peaked within a year after first sexual intercourse and decreased over time. These findings suggest that HPV vaccination could be beneficial for young adult women in preventing cervical cancer and precancerous lesions.
SEXUALLY TRANSMITTED INFECTIONS
(2023)
Article
Oncology
Liisa Porra, Lauri Wendland, Tiina Seppala, Hanna Koivunoro, Hannu Revitzer, Jussi Tervonen, Leena Kankaanranta, Anu Anttonen, Mikko Tenhunen, Heikki Joensuu
Summary: The authors reviewed the results of 249 patients treated with boron neutron capture therapy (BNCT) at Helsinki University Hospital, Finland. They found that BNCT using l-boronophenylalanine-fructose (l-BPA-F) as the boron delivery agent was well tolerated and showed efficacy in the treatment of head and neck cancer and malignant glioma. They also described a new hospital BNCT facility that integrates a proton accelerator-based neutron source for treatment planning and positioning.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Oncology
Devyani Gholap, Rajesh Dikshit, Pankaj Chaturvedi, Anil K. Chaturvedi, Ankita Manjrekar, Sharayu Mhatre
Summary: This study found a strong association between the exclusive use of smokeless tobacco products and the risk of various subtypes of head and neck cancer (HNC) in India. Chewing gutka had the highest risk, followed by betel quid with tobacco, tobacco quid, Khaini, Mawa, and Mishri. Bidi smoking and exposure to secondhand smoke were also independently associated with an increased risk of HNC. This suggests that tobacco control policies should focus on raising awareness about the risks of different tobacco products and emphasize that switching between types is not a safe alternative to quitting completely.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Loretto J. Carvajal, Jaimie Z. Shing, Juan C. Vanegas, Emmanuel Gonzalez, Diego Guillen, Monica S. Sierra, Allan Hildesheim, Carolina Porras, Rolando Herrero, Guillermo Torres, Meredith S. Shiels, Alejandro Calderon, Aimee R. Kreimer
Summary: This study investigated the incidence and trends of head and neck cancer in Costa Rica, specifically focusing on the potentially human papillomavirus (HPV)-related and HPV-unrelated head and neck squamous cell carcinomas (HNSCC). The findings showed a decreasing incidence of HNSCC overall, but an increasing trend for HPV-related HNSCCs. This study is important for understanding the epidemiology of head and neck cancer and the impact of HPV.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Jouko Levijoki, Lasse Saloranta, Johanna Tuunainen, Janne Kaskinoro, Sari Pappinen, Sandra Nourry, Anne-Marie Betat, Anne Maurin, Maarit Pakarinen, Sari Hakkinen, Johanna Tervapuro, Hertta Pihlasvaara, Christophe Drieu La Rochelle, Heikki Joensuu
Summary: Ocular administration of palonosetron as eye drops can effectively prevent and treat nausea and vomiting. This method provides a quick and convenient way to deliver the medication when intravenous administration is not possible.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Oncology
W. K. Jacky Lam, Ann D. King, Jacob A. Miller, Zhiwei Liu, Kelly J. Yu, Melvin L. K. Chua, Brigette B. Y. Ma, Ming Yuan Chen, Benjamin A. Pinsky, Pei-Jen Lou, John K. S. Woo, Wan-Lun Hsu, Julia Simon, Denise L. Doolan, Tim Waterboer, Edwin P. Hui, Hui Li, Raymond K. Tsang, Kenneth C. W. Wong, Julian P. Goh, Alexander C. Vlantis, Qi Yong Ai, Lun M. Wong, Victor Abdullah, Jin Ching Lin, Chien-Jen Chen, Ruth M. Pfeiffer, Quynh-Thu Le, Anne W. M. Lee, Mingfang Ji, Sumei Cao, Jun Ma, Anthony T. C. Chan, K. C. Allen Chan, Allan Hildesheim
Summary: A meeting of experts in November 2021 discussed the performance and cost-effectiveness of EBV-based approaches for screening early stage nasopharyngeal carcinoma. Both serum EBV antibody and plasma EBV DNA testing methods were found to be favorable. Additionally, the use of MRI was recommended to increase the sensitivity of NPC detection without greatly impacting the cost-effectiveness of the screening program.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Zeni Wu, Yongli Han, Yunhu Wan, Xing Hua, Samantha S. Chill, Kedest Teshome, Weiyin Zhou, Jia Liu, Dongjing Wu, Amy Hutchinson, Kristine Jones, Casey L. Dagnall, Belynda D. Hicks, Linda Liao, Heather Hallen-Adams, Jianxin Shi, Christian C. Abnet, Rashmi Sinha, Anil Chaturvedi, Emily Vogtmann
Summary: This study found a relationship between oral microbiome and head and neck cancer. The presence of multiple microbial species, including periodontal pathogens, as well as higher microbial alpha-diversity and the presence of oral fungi, were associated with reduced risk of HNC. Larger studies are needed to further evaluate these associations.
Article
Oncology
Hans Henrik Storm, Siri Laronningen, Freddie Bray
Summary: The KIN project provided timely cancer statistics for cancer control planning in the Nordic countries, and the development of NORDCAN project reduced investment costs and increased scientific value.
Article
Oncology
Heikki Joensuu, Eva Wardelmann, Mikael Eriksson, Annette Reichardt, Kirsten Sundby Hall, Jochen Schuette, Silke Cameron, Peter Hohenberger, Harri Sihto, Philipp J. Jost, Lars H. Lindner, Sebastian Bauer, Bengt Nilsson, Raija Kallio, Tommi Pesonen, Peter Reichardt
Summary: This study found that patients with KIT exon 11 deletion/indel mutation in gastrointestinal stromal tumor (GIST) had longer overall survival (OS) and recurrence-free survival (RFS) when treated with 3 years of adjuvant imatinib compared to 1 year of treatment. However, patients with KIT exon 9 mutation had poor OS regardless of the duration of adjuvant imatinib treatment.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Jessica L. Petrick, Andrea A. Florio, Jane Zen, Yanyu Wang, Andrew T. Gewirtz, Ruth M. Pfeiffer, Sarah Loftus, Jon Inglefield, Jill Koshiol, Baiyu Yang, Kelly Yu, Allan Hildesheim, Chien-Jen Chen, Hwai- Yang, Mei-Hsuan Lee, Katherine A. McGlynn
Summary: Research findings suggest that gut barrier dysfunction may lead to liver exposure to bacterial products from the gut, promoting liver diseases such as hepatitis and hepatocellular carcinoma. This study investigated the association between biomarkers of gut barrier dysfunction and HCC risk in HBV/HCV carriers. The results showed that a doubling of antiflagellin IgA or LBP levels in the blood was associated with a significantly increased risk of HBV-related HCC, while other markers did not show the same association.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Kaisa Lehtomaki, Eetu Heerva, Pirkko-Liisa Kellokumpu-Lehtinen, Harri Mustonen, Tapio Salminen, Heikki Joensuu, Kethe Hermunen, Mogens Karsbol Boisen, Julia Sidenius Johansen, Caj Haglund, Pia Osterlund
Summary: Based on the analysis of clinical data from patients with colorectal cancer undergoing adjuvant chemotherapy, it was found that CEA levels transiently increased in about half of the patients during the treatment. Compared to patients with a persistent increase, those with transiently increased CEA had better outcomes in terms of disease-free survival and overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Elina Salonen, Robert Bujila, Jean-Luc af Geijerstam, Hakan Nyman, Olof Flodmark, Peter Aspelin, Magnus Kaijser
Summary: This study examined whether the ionizing radiation dose from a CT head scan at the age of 6-16 years affects academic performance and high school eligibility. The results showed no statistically significant differences between the exposed and unexposed participants in any of the variables studied.
Article
Oncology
Sherif Samer Attalla, Jonathan Boucher, Hailey Proud, Tarek Taifour, Dongmei Zuo, Virginie Sanguin-Gendreau, Chen Ling, Gabriella Johnson, Vincent Li, Robin B. Luo, Hellen Kuasne, Vasilios Papavasiliou, Logan A. Walsh, Mark Barok, Heikki Joensuu, Morag Park, Philippe P. Roux, William J. Muller
Summary: The tumor-immune microenvironment (TIME) plays a crucial role in therapeutic response, and this study reveals the association of HER2A16 variant with poor clinical outcome in breast cancer and the immune cold phenotype of HER2A16 tumors. ENPP1 is identified as a functional regulator of the immune cold microenvironment, and targeting ENPP1 may have therapeutic potential in aggressive HER2 positive breast cancer.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Anil K. Giri, Mervi Aavikko, Linnea Wartiovaara, Toni Lemmetyinen, Juha Karjalainen, Juha Mehtonen, Kimmo Palin, Niko Valimaki, Max Tamlander, Riikka Saikkonen, Auli Karhu, Ekaterina Morgunova, Benjamin Sun, Heiko Runz, Priit Palta, Shuang Luo, Heikki Joensuu, Tomi P. Makela, Iiro Kostiainen, Camilla Schalin-Jantti, Aarno FinnGen, Aarno Palotie, Lauri A. Aaltonen, Saara Ollila, Mark J. Daly
Summary: This study is the largest genome-wide association study on small intestinal neuroendocrine tumors (SI-NETs) to date, and it identified 6 significant loci associated with SI-NET risk. Four of these loci are novel, and one of the top hits is a missense variant in the LGR5 gene, a marker of adult intestinal stem cells.
Review
Oncology
Heikki Joensuu
Summary: Gastrointestinal stromal tumor (GIST) is a common sarcoma arising from the gastrointestinal tract, mainly the stomach, with varying malignancy potential. Surgery is generally curative for localized GISTs. Adjuvant imatinib has been shown to improve recurrence-free survival and overall survival (OS) in high-risk GIST patients with an imatinib-sensitive mutation.