Article
Materials Science, Multidisciplinary
Carlos F. Guimaraes, Luca Gasperini, Alexandra P. Marques, Rui L. Reis
Summary: Microfluidic manipulation of hydrogels is a powerful tool for recapitulating functional biological architectures, and by tuning material properties and flow conditions, complex multi-compartment fibers can be created.
APPLIED MATERIALS TODAY
(2021)
Article
Multidisciplinary Sciences
Yoga Wienda Pratama, Piera Patrizio, Niall Mac Dowell
Summary: Net-zero emissions targets are increasingly adopted globally, but there is a disconnect between policy mechanisms and technological requirements. The absence of CO2 removal incentives can increase costs and hinder complete decarbonization. The combination of a carbon tax and negative emissions credit is critical in achieving net-zero targets effectively.
Article
Oncology
Victoria Huynh, Sudheer Vemuru, Karen Hampanda, Jessica Pettigrew, Marcella Fasano, Helen L. Coons, Kristin E. Rojas, Anosheh Afghahi, Gretchen Ahrendt, Simon Kim, Dan D. Matlock, Sarah E. Tevis
Summary: In this study, we characterized the education received by breast cancer patients regarding the potential sexual health effects of treatment and explored their preferences in terms of format, content, and timing of education. The findings revealed that few patients received information about the sexual health effects, despite experiencing symptoms. Patients expressed a desire for early and frequent education throughout treatment, covering topics such as mitigation strategies, sexual function, partner intimacy, and body image changes.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
William G. J. Kerrison, Alexander T. J. Lee, Khin Thway, Robin L. Jones, Paul H. Huang
Summary: Immunotherapy in soft tissue sarcoma has become a popular and promising therapeutic strategy, with immune checkpoint inhibitors showing effectiveness in certain subtypes. Combination therapies have also shown enhanced response rates.
Editorial Material
Immunology
Michael R. Ehrenstein, Muhammad Shipa
Summary: This Viewpoint discusses the application of experimental medicine in clinical trials to address unmet need in systemic lupus erythematosus (SLE), a prototypic autoimmune disease, with the aim of improving patient outcomes.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Engineering, Electrical & Electronic
Sonja Wogrin
Summary: One of the fundamental problems of using optimization models is the trade-off between model accuracy and computational tractability when using different time series as data input. To overcome computational intractability, traditional time series aggregation methods are commonly used to reduce the dimension of input data and model size. However, these methods often overlook the importance of the resulting output error in optimization results. In this paper, the authors challenge this belief and propose output-error based TSA methods with theoretical underpinnings, which have the potential of unprecedented computational efficiency and accuracy.
IEEE TRANSACTIONS ON SMART GRID
(2023)
Article
Communication
Axelle Asmar, Ilse Marien, Leo Van Audenhove
Summary: This article presents a conceptual model that explores mechanisms of inclusion and exclusion in digital inequalities. The model incorporates multiple indicators from both social and digital levels, going beyond traditional socio-demographic approaches. It makes a significant contribution to the understanding of inclusion and exclusion mechanisms.
NEW MEDIA & SOCIETY
(2022)
Article
Oncology
Do Weon Lee, Han-Soo Kim, Ilkyu Han
Summary: The study found that actual 5-year survival in stage III soft tissue sarcoma patients is associated with tumor size, histological grade, and ASA score. Nevertheless, the majority of long-term survivors still exhibit factors of poor prognosis.
Review
Pharmacology & Pharmacy
Tomoki Nakamura, Akihiro Sudo
Summary: Trabectedin is a safe and effective therapeutic option for patients with advanced STS. While it may be effective as first-line treatment in selected patients, doxorubicin remains the preferred choice for locally advanced or metastatic STS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Bi-Cheng Wang, Bo-Hua Kuang, Bo-Ya Xiao, Guo-He Lin
Summary: In this study, the addition of ifosfamide to doxorubicin/adriamycin did not show significant benefits for patients with advanced soft tissue sarcoma in first-line treatment, even with comparable tolerability.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Dmitri Ivanov, Taejoo Hwang, Lukasz Karol Sitko, Semin Lee, Anton Gartner
Summary: Cells constantly accumulate mutations, which reflect the status of DNA repair machinery and the exposure to genotoxins. Mutational signatures can shed light on cancer origins. Experimental mutational patterns are crucial to understand specific signatures caused by certain deficiencies. This article describes the use of different cell lines and model organisms to decipher mutational signatures in cancer genomes and how data from different experimental systems complement each other.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2023)
Article
Behavioral Sciences
Stephan Michel, Laura Kervezee
Summary: Adaptation of physiology and behavior to seasonal changes is essential for survival. Common mechanisms, such as the circadian system, signaling molecules, and hormones, play a role in photoperiodic regulation. Understanding the relevance of these mechanisms in the face of climate change is important for humans as well.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tamar B. Nobel, Smita Sihag, Xin Xing, Mahmoud Eljalby, Meier Hsu, Kay See Tan, David B. Sewell, Manjit S. Bains, Yelena Janjigian, Abraham Wu, Geoffrey Ku, David R. Jones, Daniela Molena
Summary: The presentation and prognosis of esophageal cancer recurrence differ by site, with lung oligometastases showing a more indolent course and potentially benefiting from more aggressive treatment to improve outcomes. This study suggests that a personalized approach to treatment based on the site of recurrence may be beneficial for esophageal cancer patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Economics
Raquel Ortega-Argiles
Summary: In the last two decades, entrepreneurship policies have undergone significant changes in many countries. New theoretical and empirical approaches have provided better understanding of the drivers, actors, and contributions of entrepreneurship to socio-economic prosperity. It has been found that the drivers and outcomes of entrepreneurship are heavily influenced by regional factors. This paper discusses the impacts of these influences, examines current evidence, and identifies areas for further research.
ANNALS OF REGIONAL SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Margareta Ramgard, Rathi Ramji, Anders Kottorp, Katarina Sjogren Forss
Summary: This study found that Community Based Participatory Research with lay health promoters played an important role during the pandemic by deepening the understanding of marginalized citizens' role in community resilience and sustainability, and promoting health work. Public health authorities need to consider the local context in their pandemic strategies to reach vulnerable groups.
