Article
Immunology
Kissy Guevara-Hoyer, Jesus Fuentes-Antras, Eduardo de la Fuente-munoz, Miguel Fernandez-Arquero, Fernando Solano, Pedro Perez-Segura, Esmeralda Neves, Alberto Ocana, Rebeca Perez de Diego, Silvia Sanchez-Ramon
Summary: This study aims to explore the shared genomic basis between common variable immunodeficiency (CVID) and non-Hodgkin's lymphoma (NHL), in order to better understand the immunodeficiency phenotype of CVID in NHL. The study found that NHL samples harbored genetic variants associated with CVID, indicating the existence of shared pathological mechanisms and signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Kallergi, Alexandros Georgakopoulos, Vassiliki Lyra, Sofia Chatziioannou
Summary: This study investigated the value of tumor measurements in predicting treatment outcomes for Hodgkin's and Non-Hodgkin's lymphomas. Results showed that while SUVmax was the strongest prognostic indicator, automated metabolic tumor volume measurements and expert's metabolic maximum diameter measurements also provided valuable insights. Anatomic tumor measurements had poor prognostic value. The study suggests a paradigm shift towards identifying robust prognostic markers in PET/CT with the use of radiomics.
Article
Medicine, General & Internal
Jiamei Wu, Yin Zhou, Qingshu Li, Jing Zhang, Yun Mao
Summary: PBNHL is a rare disease with difficult preoperative diagnosis, so it should be considered when encountering cases with Epstein-Barr virus infection and typical imaging findings.
Article
Multidisciplinary Sciences
De Matteis Sara, Cosetta Minelli, Giorgio Broccia, Paolo Vineis, Pierluigi Cocco
Summary: This ecological study investigates the link between COVID-19 incidence, socio-economic covariates, and NHL incidence. The results show that COVID-19 cumulative incidence is positively associated with past NHL incidence, socioeconomic deprivation, and proportion of elderly residents, while negatively associated with urban residency. Further investigation is needed to explore shared susceptibility factors among the plausible underlying mechanisms.
Article
Multidisciplinary Sciences
Giorgio Broccia, Jonathan Carter, Cansu Ozsin-Ozler, Federico Meloni, Sara De Matteis, Pierluigi Cocco
Summary: The incidence of non-Hodgkin's lymphoma (NHL) in Sardinia showed an upward trend from 1974 to 2003, prompting further research on the genetic and environmental factors in the high-risk areas.
Article
Oncology
Weifeng Wang, Zhuo Zhang, Xiaocong Deng, Anqi Gu, Xianzhao Chen, Yizheng Cai, Yuting Zhao
Summary: In this case report, a 57-year-old male patient with diffuse large B-cell lymphoma was successfully treated with radiation therapy and medication, achieving complete remission.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Kathryn Lurain, Ramya Ramaswami, Ralph Mangusan, Anaida Widell, Irene Ekwede, Jomy George, Richard Ambinder, Martin Cheever, James L. Gulley, Priscila H. Goncalves, Hao-Wei Wang, Thomas S. Uldrick, Robert Yarchoan
Summary: The most common malignancy among people living with HIV in the USA is Non-Hodgkin's lymphoma (NHL). The study found that using pembrolizumab with or without pomalidomide to treat HIV-associated NHL elicited responses in several subtypes of HIV-associated NHL. This approach is worth further study in individuals living with HIV and NHL.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Richard A. Newcomb, P. Connor Johnson, Daniel Yang, Katherine Holmbeck, Joanna Choe, Anisa Nabily, Porsha Lark, Tejaswini Dhawale, Hermioni L. Amonoo, Areej El-Jawahri
Summary: Patients with indolent non-Hodgkin's lymphomas (iNHL) report significant psychological distress, a diversity of coping strategies, and complex cognitive understanding of their prognosis. Interventions that address prognostic uncertainty and promote positive emotional coping with prognosis may ameliorate psychological distress in this population.
Article
Oncology
Jingwen Li, Fei Peng, He Huang, Zhen Cai
Summary: The relative and cumulative risk of developing second primary malignancies significantly increased in patients diagnosed with non-Hodgkin's lymphoma in recent years. The risk was associated with certain clinical and demographic variables.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Runhong Yu, Linna Cheng, Shiwei Yang, Yufeng Liu, Zunmin Zhu
Summary: This study utilized iTRAQ-based proteomic analysis to screen and verify potential serum biomarkers of pediatric NHL. S100A8 and LRG1 were identified as promising candidate biomarkers for pediatric NHL, and these differential proteins indicate a novel pathogenesis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Satyan Nanda, Rahul Handa, Atul Prasad, Rajiv Anand, Dhruv Zutshi, Sujata K. Dass, Prabhjeet Kaur Bedi, Aarti Pahuja, Pankaj Kumar Shah, Bipan Sharma, Nalin Malhotra
Summary: Neurological manifestations are common in COVID-19 patients, with encephalitis being a relatively rare but serious complication. It is crucial to differentiate between herpes encephalitis and COVID-19-associated encephalitis due to differences in treatment and prognosis. Physicians should maintain a high level of suspicion for COVID-19 infection in patients with encephalitis symptoms and respiratory complaints.
NEUROLOGICAL SCIENCES
(2021)
Review
Oncology
Lara Mussolin, Christine Damm-Welk, Marta Pillon, Wilhelm Woessmann
Summary: The detection of minimal residual disease (MRD) is crucial for relapse risk assessment in leukemia and treatment optimization in adult lymphomas. However, the application of MRD studies in childhood non-Hodgkin lymphomas is complex due to various challenges such as stratified treatment, high cure rates, limited patient numbers, and different clinical applications based on subtypes. Validation of MRD as prognostic parameters in childhood lymphomas is necessary, with next-generation sequencing-based methods offering new possibilities.
Review
Oncology
Min Zhu, Zhixuan Wu, Zhaoxia Yang, Bo Ning, Shengjie Yu, Xiling Gu, Huihong Yu
Summary: Peritoneal lymphomatosis is a rare disease with poor prognosis that can be easily neglected and misdiagnosed. Early pathological diagnosis is crucial for initiating the correct treatment, and the discovery of lymphomatosis in the peritoneum is a rare finding.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Satya Vijay Chigurupati, Mridula Shukla, Manoj Pandey
Summary: Primary sacral diffuse large B cell non-Hodgkin's lymphoma is a rare entity with only 11 reported cases. Diagnosis requires histopathological examination and immunohistochemistry. In this case, the patient underwent chemotherapy and radiotherapy, with a 3-year follow-up showing no evidence of disease recurrence.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
I Hadi, A. Schummer, M. Dreyling, C. Eze, R. Bodensohn, O. Roengvoraphoj, C. Belka, M. Li
Summary: This study analyzed the effectiveness and toxicities of radiotherapy in indolent non-Hodgkin's lymphoma (iNHL) patients treated in the institution. The results showed that radiotherapy was highly effective for early stage iNHL treatment with low toxicity. Younger patients had significantly superior progression-free survival (PFS) compared to older patients.
SCIENTIFIC REPORTS
(2021)
Review
Critical Care Medicine
Shannon M. Fernando, Alexandre Tran, Wei Cheng, Behnam Sadeghirad, Yaseen M. Arabi, Deborah J. Cook, Morten Hylander Moller, Sangeeta Mehta, Robert A. Fowler, Karen E. A. Burns, Philip S. Wells, Marc Carrier, Mark A. Crowther, Damon C. Scales, Shane W. English, Kwadwo Kyeremanteng, Salmaan Kanji, Michelle E. Kho, Bram Rochwerg
Summary: In critically ill adults, low-molecular-weight heparin (LMWH) reduces the incidence of deep vein thrombosis (DVT) compared to control treatment, and unfractionated heparin (UFH) may also reduce the risk of DVT. LMWH is likely more effective in reducing DVT compared to UFH. Mechanical compressive devices may decrease the risk of DVT, but the evidence is limited. The efficacy and safety of combination pharmacologic therapy and mechanical compressive devices are still unclear.
Article
Rehabilitation
Anastasia N. L. Newman, Michelle E. Kho, Jocelyn E. Harris, Alison Fox-Robichaud, Patricia Solomon
Summary: The study explored clinicians' experiences and perceptions of using in-bed cycling for rehabilitation in the intensive care unit. Results indicated that teamwork, confidence in the method, and appropriate patient selection are key factors for successful cycling, while barriers include inadequate staffing, bike size, and time for cycling.
DISABILITY AND REHABILITATION
(2022)
Review
Rehabilitation
Julia (Shi-Peng) Xiong, Sarah E. Reedman, Michelle E. Kho, Brian W. Timmons, Olaf Verschuren, Jan Willem Gorter
Summary: This study aimed to explore the operationalization and measurement of sedentary behavior in individuals with cerebral palsy. Results showed that sitting and lying are considered sedentary postures in individuals with CP, defined as <= 1.5 METs. There is variability in the tools used to measure SB in this population, highlighting the need for consensus on the definition and reporting of sedentary behavior.
DISABILITY AND REHABILITATION
(2022)
Editorial Material
Critical Care Medicine
Michelle E. Kho, Julie C. Reid
Article
Medicine, Research & Experimental
Julie C. Reid, Alex Molloy, Geoff Strong, Laurel Kelly, Heather O'Grady, Deborah Cook, Patrick M. Archambault, Ian Ball, Sue Berney, Karen E. A. Burns, Frederick D'Aragon, Erick Duan, Shane W. English, Francois Lamontagne, Amy M. Pastva, Bram Rochwerg, Andrew J. E. Seely, Karim Serri, Jennifer L. Y. Tsang, Avelino C. Verceles, Brenda Reeve, Alison Fox-Robichaud, John Muscedere, Margaret Herridge, Lehana Thabane, Michelle E. Kho
Summary: The COVID-19 pandemic has disrupted non-COVID critical care trials. This study uses the CONSERVE statement to report the impact of the pandemic on the CYCLE trial and describes the mitigation approaches.
Article
Respiratory System
Ana Maria Ilicic, Dina Brooks, Michelle Kho, Roger Goldstein, Ana Oliveira
Summary: Pulmonary rehabilitation is an important intervention for controlling respiratory symptoms in people with chronic respiratory diseases. However, this study found that chronic cough is rarely assessed and managed in pulmonary rehabilitation. Education and standardized strategies were suggested as important factors for improving the assessment and management of chronic cough.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Editorial Material
Critical Care Medicine
Oleksa G. Rewa, Michelle Kho
CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Michelle E. Kho, Sue Berney, Bronwen Connolly
INTENSIVE CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Carol L. Hodgson, Michelle E. Kho, Vinicius Maldaner da Silva
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Michelle E. Kho, Julie Reid, Alexander J. Molloy, Margaret S. Herridge, Andrew J. Seely, Jill C. Rudkowski, Lisa Buckingham, Diane Heels-Ansdell, Tim Karachi, Alison Fox-Robichaud, Ian M. Ball, Karen E. A. Burns, Joseph R. Pellizzari, Christopher Farley, Sue Berney, Amy M. Pastva, Bram Rochwerg, Frederick D'Aragon, Francois Lamontagne, Erick H. Duan, Jennifer L. Y. Tsang, Patrick Archambault, Shane W. English, John Muscedere, Karim Serri, Jean-Eric Tarride, Sangeeta Mehta, Avelino C. Verceles, Brenda Reeve, Heather O'Grady, Laurel Kelly, Geoff Strong, Abby H. Hurd, Lehana Thabane, Deborah J. Cook
Summary: This article describes the protocol for an international, multicentre randomised controlled trial (RCT) to determine the effectiveness of early in-bed cycling versus routine physiotherapy (PT) in critically ill, mechanically ventilated adults. The primary outcome is the Physical Function ICU Test-scored (PFIT-s) at 3 days post-ICU discharge.
Article
Critical Care Medicine
Michelle E. Kho, Bronwen Connolly
CRITICAL CARE CLINICS
(2023)
Article
Critical Care Medicine
Heather K. O'Grady, Lara Edbrooke, Christopher Farley, Sue Berney, Linda Denehy, Zudin Puthucheary, Michelle E. Kho
Summary: Among three progressive outcome measures evaluated in this study, the 30 s STS test appears to have the most favorable clinimetric properties to assess function at ICU and hospital discharge in moderate to severely ill participants.
Review
Rehabilitation
Ana Maria Ilicic, Ana Oliveira, Razanne Habash, Yejin Kang, Michelle Kho, Roger Goldstein, Dina Brooks
Summary: The evidence of non-pharmacological therapies for non-productive chronic cough is limited. Existing studies reflect the heterogeneity in study design, sample size, and outcome measures.
FRONTIERS IN REHABILITATION SCIENCES
(2022)
Article
Rehabilitation
Kenneth S. Noguchi, Linda Nguyen, Ava Mehdipour, Elise Wiley, Stephanie Saunders, Kevin Moncion, Julie C. Reid, Nora Bakaa, Laura Garcia Diaz, Jill Van Damme, Cassandra D'Amore, Anne Kumurenzi, Ze Lu, Erin Knobl, Marla K. Beauchamp, Luciana G. Macedo, Brenda Vrkljan, Sandra E. Moll, Lisa C. Carlesso, Lori J. Letts, Michelle E. Kho, Julie Richardson
Summary: Rehabilitation researchers faced challenges during the COVID-19 pandemic including protocol adjustments, participant accessibility, and knowledge dissemination. They suggested strategies such as implementing virtual approaches, engaging community stakeholders, and revisiting timeframes for knowledge dissemination.
FRONTIERS IN REHABILITATION SCIENCES
(2022)
Article
Respiratory System
Luis Felipe Reyes, Srinivas Murthy, Esteban Garcia-Gallo, Mike Irvine, Laura Merson, Ignacio Martin-Loeches, Jordi Rello, Fabio S. Taccone, Robert A. Fowler, Annemarie B. Docherty, Christiana Kartsonaki, Irene Aragao, Peter W. Barrett, Abigail Beane, Aidan Burrell, Matthew Pellan Cheng, Michael D. Christian, Jose Pedro Cidade, Barbara Wanjiru Citarella, Christl A. Donnelly, Susana M. Fernandes, Craig French, Rashan Haniffa, Ewen M. Harrison, Antonia Ying Wai Ho, Mark Joseph, Irfan Khan, Michelle E. Kho, Anders Benjamin Kildal, Demetrios Kutsogiannis, Francois Lamontagne, Todd C. Lee, Gianluigi Li Bassi, Jose Wagner Lopez Revilla, Catherine Marquis, Jonathan Millar, Raul Neto, Alistair Nichol, Rachael Parke, Rui Pereira, Sergio Poli, Pedro Povoa, Kollengode Ramanathan, Oleksa Rewa, Jordi Riera, Sally Shrapnel, Maria Joao Silva, Andrew Udy, Timothy Uyeki, Steve A. Webb, Evert-Jan Wils, Amanda Rojek, Piero L. Olliaro
Summary: This study investigated the clinical outcomes of severe COVID-19 patients treated outside the ICU, compared to those treated in the ICU. It found that patients admitted to an ICU had a longer hospital stay and a lower 28-day fatality ratio.