Article
Medicine, Research & Experimental
Emily S. Zhang, Bryan B. Hair, Eric D. Lamarre, Shlomo A. Koyfman, Brian B. Burkey
Summary: This study found a predominance of occult nodal metastases (ONM) in levels I-III for CN0 submandibular/sublingual and minor salivary gland cancers, suggesting the need for elective dissection in these levels.
Article
Medicine, General & Internal
Kun Chen, Guotao Yin, Wengui Xu
Summary: A radiomics model based on F-18-FDG PET/CT images was developed to predict occult axillary lymph node (ALN) metastases in patients with invasive ductal breast cancer (IDC) preoperatively. The RF model showed the best prediction results among the four models tested.
Article
Multidisciplinary Sciences
Bing Xue, Xihai Wang
Summary: The objective of this study was to quantitatively assess the probability of occult lymph node metastasis in AEOC defined by F-18-Fluorodeoxyglucose PET/CT and explore the relationship between OLNM and PET metabolic parameters. The results showed that the metastatic TLG index had a better diagnostic performance than other PET/CT-related metabolic parameters. Multivariate analysis identified the metastatic TLG index and primary tumor location as independent and significant factors associated with OLNM. The logistic model combining the metastatic TLG index, primary tumor location, and CA125 could effectively predict the individualized possibility of OLNM for AEOC patients.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Thomas Robbins, Tanya L. Hoskin, Courtney N. Day, Mary M. Mrdutt, Tina J. Hieken, James W. Jakub, Katrina Glazebrook, Judy C. Boughey, Amy C. Degnim
Summary: Patients with suspicious lymph nodes on ultrasound and negative fine needle aspiration (FNA) as well as patients with negative axillary ultrasound have a similarly low chance of positive nodes. Routine targeted excision of FNA-negative clipped nodes is not warranted.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
Pooja Unadkat, Aaron Fleishman, Aria F. Olumi, Andrew Wagner, Peter Chang, Simon P. Kim, Ruslan Korets, Boris Gershman
Summary: The study aimed to investigate the incidence of occult inguinal LN metastases and predictors of such metastases in cN0 penile cancer patients. The results showed that high tumor grade and lymphovascular invasion were better determinants of lymph node involvement than primary tumor stage, with an overall pN+ rate of 24% in the study population.
Article
Oncology
Ana del Castillo, Susana Gomez-Modet, Jose Maria Mata, Luis Tejedor
Summary: The purpose of this study is to evaluate the feasibility of targeted axillary dissection using 99mTechnetiumlabeled macroaggregated albumin (99mTc-MAA) injected preoperatively into the clipped lymph node of patients with axillary complete clinical response (ycN0) after neoadjuvant chemotherapy (NAC) for breast cancer. A retrospective observational study has shown that the use of radioguided occult lesion localization (ROLL) technique can successfully detect the 99mTc-MAA injection and avoid axillary lymph node dissection in 62.9% of the cases.
Article
Oncology
Liangyu Gan, Mingming Ma, Yinhua Liu, Qian Liu, Ling Xin, Yuanjia Cheng, Ling Xu, Naishan Qin, Yuan Jiang, Xiaodong Zhang, Xiaoying Wang, Jingming Ye
Summary: A clinical-radiomics model was developed to predict axillary pathologic complete response in breast cancer patients, integrating radiomics features extracted from MRI images and clinicopathologic factors, showing promising predictive performance in screening out patients who may benefit from avoiding lymph node dissection.
FRONTIERS IN ONCOLOGY
(2021)
Article
Urology & Nephrology
Teele Kuusk, Tobias Klatte, Patricia Zondervan, Brunolf Lagerveld, Niels Graafland, Kees Hendricksen, Umberto Capitanio, Andrea Minervini, Grant D. Stewart, Borje Ljungberg, Simon Horenblas, Axel Bex
Summary: The 5-year survival rate of patients with LN metastases varies from 13% to 43% depending on clinico-pathological group, grade, and tumor size. Patients with resected occult lymph node involvement (cN0/pN1 cM0) have the best prognosis with a considerable chance of long-term survival.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Oncology
Guixin Wang, Shuhao Zhang, Meiling Wang, Lin Liu, Yaqian Liu, Lianjun Tang, He Bai, Haidong Zhao
Summary: This meta-analysis found that occult metastases in axillary lymph nodes are associated with poorer prognosis in patients with breast cancer, with lower five-year and ten-year disease-free survival and overall survival rates.
Article
Oncology
Jiajia Xiong, Wei Zuo, Yu Wu, Xiuhua Wang, Wenqu Li, Qiaodan Wang, Hui Zhou, Mingxing Xie, Xiaojuan Qin
Summary: This study developed and validated a nomogram based on ultrasonography and clinicopathological features of primary tumors to predict the probability of axillary lymph node metastasis in T1-T2 breast cancer patients.
Article
Oncology
Clara Farley, Roland Bassett, Funda Meric-Bernstam, Isabelle Bedrosian, Abigail Caudle, Sarah Desnyder, Kelly Hunt, Henry Kuerer, Puneet Singh, Susie Sun, Nina Tamirisa, Mediget Teshome, Rosa F. Hwang
Summary: This study aimed to identify preoperative factors predictive of four or more positive axillary lymph nodes (ALNs) in patients with cN0 disease and develop a predictive nomogram. The findings suggest that postmenopausal women with early-stage cN0 hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer and a single positive sentinel lymph node (SLN) have a very low risk of having four or more positive nodes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Chi-Chang Yu, Yun-Chung Cheung, Shir-Hwa Ueng, Yung-Chang Lin, Wen-Ling Kuo, Shih-Che Shen, Yung-Feng Lo, Shin-Cheh Chen
Summary: This study aimed to investigate the factors associated with axillary lymph node (ALN) status in breast cancer patients initially diagnosed with clinically node-negative (cN0) tumors who underwent neoadjuvant chemotherapy (NAC). The results showed that achieving a pathologic complete response in the breast was associated with negative ALN status, while the presence of lymphovascular invasion was associated with positive ALN status.
Article
Oncology
Carla Meler-Claramonte, Francesc Xavier Aviles-Jurado, Isabel Vilaseca, Ximena Terra, Paloma Bragado, Gemma Fuster, Xavier Leon Vintro, Mercedes Camacho
Summary: This study found that the expression of semaphorin-3F and neuropilin-2 is related to the risk of occult lymph node metastasis in patients with head and neck squamous cell carcinoma. Patients with high semaphorin-3F and low neuropilin-2 expression had a lower risk of occult lymph node metastasis. These results suggest that the SEMA3F-NRP2 axis could be a potential biomarker for predicting lymph node metastasis risk.
Article
Oncology
Gilles Houvenaeghel, Alexandre de Nonneville, Nicolas Chopin, Jean-Marc Classe, Chafika Mazouni, Marie-Pierre Chauvet, Fabien Reyal, Christine Tunon de Lara, Eva Jouve, Roman Rouzier, Emile Darai, Pierre Gimbergues, Charles Coutant, Anne Sophie Azuar, Richard Villet, Patrice Crochet, Sandrine Rua, Marie Bannier, Monique Cohen, Jean-Marie Boher
Summary: A study of 1421 breast cancer patients under the age of 75 found that omitting completion axillary lymph node dissection (cALND) in patients with micro-metastases in sentinel nodes was associated with an increased risk of recurrence and death.
Article
Otorhinolaryngology
Yu Heng, Chengzhi Xu, Hanqing Lin, Xiaoke Zhu, Liang Zhou, Ming Zhang, Chunping Wu, Lei Tao
Summary: This study established a new post-operative strategy selection flow chart based on a predictive nomogram, which can effectively predict the individualized possibility of occult lymph node metastasis for patients with glottic squamous cell carcinoma (GSCC).
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Retraction
Biochemistry & Molecular Biology
Kotha Subbaramaiah, Robert Benezra, Clifford Hudis, Andrew J. Dannenberg
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Retraction
Biochemistry & Molecular Biology
Kotha Subbaramaiah, Clifford Hudis, Sung-Hee Chang, Timothy Hla, Andrew J. Dannenberg
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Oncology
Elizabeth Garrett-Mayer, Melinda W. Kaltenbaugh, Rebecca Spence, Suanna S. Bruinooge, Clifford A. Hudis, Dina Michels, Richard L. Schilsky
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Mark P. S. Dunphy, Christina Pressl, Nagavarakishore Pillarsetty, Milan Grkovski, Shanu Modi, Komal Jhaveri, Larry Norton, Bradley J. Beattie, Pat B. Zanzonico, Danuta Zatorska, Tony Taldone, Stefan O. Ochiana, Mohammad M. Uddin, Eva M. Burnazi, Serge K. Lyashchenko, Clifford A. Hudis, Jacqueline Bromberg, Heiko M. Schoder, Josef J. Fox, Hanwen Zhang, Gabriela Chiosis, Jason S. Lewis, Steven M. Larson
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Alyssa A. Schatz, Thomas K. Oliver, Robert A. Swarm, Judith A. Paice, Deepika S. Darbari, Deborah Dowell, Salimah H. Meghani, Katy Winckworth-Prejsnar, Eduardo Bruera, Robert M. Plovnick, Lisa Richardson, Neha Vapiwala, Dana Wollins, Clifford A. Hudis, Robert W. Carlson
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2020)
Article
Oncology
Mark Jesus M. Magbanua, Laura H. Hendrix, Terry Hyslop, William T. Barry, Eric P. Winer, Clifford Hudis, Deborah Toppmeyer, Lisa Anne Carey, Ann H. Partridge, Jean-Yves Pierga, Tanja Fehm, Jose Vidal-Martinez, Dimitrios Mavroudis, Jose A. Garcia-Saenz, Justin Stebbing, Paola Gazzaniga, Luis Manso, Rita Zamarchi, Maria Luisa Antelo, Leticia De Mattos-Arruda, Daniele Generali, Carlos Caldas, Elisabetta Munzone, Luc Dirix, Amy L. Delson, Harold J. Burstein, Misbah Qadir, Cynthia Ma, Janet H. Scott, Francois-Clement Bidard, John W. Park, Hope S. Rugo
Summary: This study identified 4 novel prognostic groups in metastatic breast cancer (MBC) based on similarities in circulating tumor cell (CTC) trajectory patterns during chemotherapy. Patients with intermediate+high CTCs (19.4%) had significantly poorer outcomes and may benefit from more effective treatment. This novel prognostic classification approach may guide future prospective clinical trials in MBC.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Retraction
Oncology
Kotha Subbaramaiah, Patrick G. Morris, Xi Kathy Zhou, Monica Morrow, Baoheng Du, Dilip Giri, Levy Kopelovich, Clifford A. Hudis, Andrew J. Dannenberg
Editorial Material
Oncology
Clifford A. Hudis
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Jennifer A. Ligibel, Luke Huebner, Hope S. Rugo, Harold J. Burstein, Debra L. Toppmeyer, Carey K. Anders, Cynthia Ma, William T. Barry, Vera Suman, Lisa A. Carey, Ann H. Partridge, Clifford A. Hudis, Eric P. Winer
Summary: In metastatic breast cancer patients, high rates of obesity and inactivity were observed, but they were not significantly associated with PFS and OS. Greater than 9 MET hours of PA per week may be marginally associated with improved PFS and OS outcomes.
JNCI CANCER SPECTRUM
(2021)
Meeting Abstract
Oncology
Cynthia X. Ma, Vera Suman, A. Marilyn Leitch, Souzan Sanati, Kiran Vij, Gary W. Unzeitig, Jeremy Hoog, Mark Watson, Olwen Hahn, Joseph Guenther, Abigail Caudle, Erika Crouch, Horacio Maluf, Amy Tiersten, Monica Mita, Wajeeha Razaq, Tina J. Hieken, Yang Wang, Travis Dockter, Jo Anne Zujewski, Anna Weiss, Kelly Hunt, Clifford Hudis, Eric P. Winer, Matthew J. Ellis, Lisa A. Carey, Ann H. Partridge
Meeting Abstract
Oncology
Matthew J. Ellis, Vera Suman, A. Marilyn Leitch, Souzan Sanati, Kiran Vij, Gary W. Unzeitig, Jeremy Hoog, Mark Watson, Olwen Hahn, Joseph Guenther, Abigail Caudle, Erika Crouch, Horacio Maluf, Mitch Dowsett, Amy Tiersten, Monica Mita, Wajeeha Razaq, Tina J. Hieken, Yang Wang, Travis Dockter, Jo Anne Zujewski, Anna Weiss, Clifford Hudis, Eric P. Winer, Kelly Hunt, Ann H. Partridge, Cynthia X. Ma, Lisa A. Carey
Letter
Oncology
Clifford A. Hudis, Richard L. Schilsky
JCO ONCOLOGY PRACTICE
(2020)
Article
Oncology
Alyssa A. Schatz, Thomas K. Oliver, Robert A. Swarm, Judith A. Paice, Deepika S. Darbari, Deborah Dowell, Salimah H. Meghani, Katy Winckworth-Prejsnar, Eduardo Bruera, Robert M. Plovnick, Lisa Richardson, Neha Vapiwala, Dana Wollins, Clifford A. Hudis, Robert W. Carlson
JCO ONCOLOGY PRACTICE
(2020)
Meeting Abstract
Oncology
Cynthia X. Ma, Vera J. Suman, A. Marilyn Leitch, Souzan Sanati, Kiran R. Vij, Gary Walter Unzeitig, Jeremy Hoog, Mark Watson, Olwen Mary Hahn, J. Michael Guenther, Abigail Suzanne Caudle, Travis Dockter, Larissa A. Korde, Anna Weiss, Kelly Hunt, Clifford A. Hudis, Eric P. Winer, Ann H. Partridge, Lisa A. Carey, Matthew James Ellis
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Pedram Razavi, Maura N. Dickler, Payal D. Shah, Weiyi Toy, David N. Brown, Helen H. Won, Bob T. Li, Ronglai Shen, Neil Vasan, Shanu Modi, Komal Jhaveri, Betty Ann Caravella, Sujata Patil, Pier Selenica, Stephen Zamora, Aimee M. Cowan, Elizabeth Comen, Andy Singh, Anne Covey, Michael F. Berger, Clifford A. Hudis, Larry Norton, Rebecca J. Nagy, Justin I. Odegaard, Richard B. Lanman, David B. Solit, Mark E. Robson, Mario E. Lacouture, Edi Brogi, Jorge S. Reis-Filho, Mary Ellen Moynahan, Maurizio Scaltriti, Sarat Chandarlapaty