Journal
JOURNAL OF CLINICAL NEUROSCIENCE
Volume 21, Issue 1, Pages 33-39Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2013.06.014
Keywords
Anticonvulsants; Azo dyes; Blood-brain barrier; Chronic neurological condition
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The well-established medical involvement of derivatives of the azo dye industry lent credibility to the 1935 announcement by Stanley Cobb of the use of vital brilliant red dye as an anticonvulsant. Although in the fullness of time clinical experience would discard this concept, nevertheless it was to give rise to Robert Aird who posited that the mechanism of action of this dye was due to its ability to decrease the permeability of the blood-brain barrier. In a very prolonged exploration of this concept, Aird concluded that blood-brain barrier permeability underlay the causation of a long list of chronic neurological conditions - a concept that was eventually abandoned. This article examines the details and the effects of this concept and its impact upon neurology. (C) 2013 Elsevier Ltd. All rights reserved.
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