Article
Medicine, General & Internal
Yin Ping Wong, Roziasyazni Che Abdul Aziz, Azimatun Noor Aizuddin, Muhamad Fakhri Mohd Saleh, Roslina Mohd Arshad, Geok Chin Tan
Summary: Accumulating data suggests that EZH2 and IDH1 are involved in promoting tumourigenesis in gliomas. This study aimed to explore the immunoexpression of EZH2 in gliomas and its correlation with clinicopathological variables. The study found that high EZH2 expression was significantly associated with older age, higher tumour grade, negative IDH1 R132H expression, shorter 5-year progression-free survival and overall survival. In IDH1 R132H-negative gliomas, high EZH2 expression was associated with shorter 5-year progression-free survival and overall survival.
Article
Genetics & Heredity
Gang Wang, Wei Du, Lingyi Che, Xianzheng Gao, Ruihua Zhao, Juan Duan, Zhuoyu Gu, Qian Ma
Summary: PLAGL2 is implicated in the development and progression of various malignancies, including glioblastoma, with dysregulated expression commonly observed. Its overexpression in high-grade glioma (HGG) is associated with poor prognosis and potential therapeutic target, making it an independent prognostic biomarker in HGG patients.
FRONTIERS IN GENETICS
(2022)
Article
Clinical Neurology
Emma van Kessel, Irene M. C. Huenges Wajer, Carla Ruis, Tatjana Seute, Susanne Fonville, Filip Y. F. L. De Vos, Joost J. C. Verhoeff, Pierre A. Robe, Martine J. E. van Zandvoort, Tom J. Snijders
Summary: This study found that cognitive functioning is independently related to survival in diffuse glioma patients, with impairments in executive functioning and memory significantly correlated with survival. Extensive domain-specific neuropsychological assessment was more strongly correlated to survival than MMSE.
JOURNAL OF NEUROLOGY
(2021)
Article
Oncology
Marko Hojnik, Snjezana Frkovic Grazio, Ivan Verdenik, Tea Lanisnik Rizner
Summary: The study found that AKR1B1 and AKR1B10 play protective roles in endometrioid endometrial cancer and have the potential as prognostic biomarkers. Patients with higher immunohistochemical levels of both AKR1B1 and AKR1B10 showed better survival rates. However, no significant differences were observed in patients with serous endometrial cancer.
Article
Clinical Neurology
Shiyuan Jing, Lei Chen, Song Han, Ning Liu, MingYang Han, Yakun Yang, Changxiang Yan
Summary: The study demonstrated that TCF7L2 is significantly overexpressed in glioblastoma and associated with long-term prognosis of the tumor. Overexpression of TCF7L2 is linked to poor overall survival and serves as an independent prognostic factor for glioma patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Riyao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Weiya Xia, Boning Liu, Yu-Yi Chu, Laura Bover, Long Vien, Mien-Chie Hung
Summary: This study reports the development of two novel Gal-9-neutralizing antibodies that effectively protect human T cells from Gal-9-induced cell death and promote T cell-mediated killing of tumor cells. These findings demonstrate the potential of targeting Gal-9 for cancer immunotherapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Oncology
Xuqiang Zhu, Di Chen, Yiyu Sun, Shuo Yang, Weiguang Wang, Bing Liu, Peng Gao, Xueyuan Li, Lixin Wu, Siqi Ma, Wenyang Lin, Jiwei Ma, Dongming Yan
Summary: This study aimed to assess the value of WEE2-AS1 as a potential prognostic marker of glioma. The findings showed that WEE2-AS1 is overexpressed in various cancers, including glioma, and is associated with glioma progression. It was also determined that WEE2-AS1 expression may serve as an independent risk factor for the survival and prognosis of glioma patients.
Article
Oncology
Sun-Young Jun, Seung-Mo Hong, Kee-Taek Jang
Summary: The expression of Cyclin D1 in small intestinal adenocarcinomas (SIACs) has not been comprehensively studied. This study found that Cyclin D1 is commonly overexpressed in SIACs, and high expression of Cyclin D1 is associated with favorable prognostic indicators.
Review
Oncology
Kuo-Chuan Hung, Cheuk-Kwan Sun, Yang-Pei Chang, Jheng-Yan Wu, Po-Yu Huang, Ting-Hui Liu, Chien-Hung Lin, Wan-Jung Cheng, I-Wen Chen
Summary: This article is a systematic review and meta-analysis studying the association between Prognostic Nutritional Index (PNI) and prognosis in glioma patients. The study found that a high PNI was associated with better overall survival and progression-free survival in glioma patients, and this finding remained consistent even after sensitivity analysis. These findings have important implications in the treatment of glioma patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mourad Assidi, Fatimah M. Yahya, Maryam H. Al-Zahrani, Razan Elkhatib, Ali Zari, Aisha Elaimi, Jaudah Al-Maghrabi, Ashraf Dallol, Abdelbaset Buhmeida, Muhammad Abu-Elmagd
Summary: This study investigated the expression pattern and methylation profiles of leptin (LEP) in ovarian cancer (OC), and found that high LEP protein expression is associated with better survival outcomes. The results suggest that LEP expression in OC may be regulated by promoter hypermethylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Salagacka-Kubiak, Dawid Zawada, Lias Saed, Radzislaw Kordek, Agnieszka Jelen, Ewa Balcerczak
Summary: ABCG2 is a cell membrane pump encoded by the ABCG2 gene, which can protect cells against compounds initiating and/or intensifying neoplasia and is considered a marker of cancer stem cells. Its prognostic significance in colorectal cancer remains unclear. Using publicly available data, ABCG2 was shown to be underexpressed in colon and rectum adenocarcinomas, and this downregulation could result from the methylation level of some sites of the ABCG2 gene. However, no association was found between ABCG2 expression level and survival of colorectal cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Maria Bucova, Kristina Kluckova, Jan Kozak, Boris Rychly, Magda Suchankova, Marian Svajdler, Viktor Matejcik, Juraj Steno, Eszter Zsemlye, Vladimira Durmanova
Summary: HLA-G plays an important role in tumor prognosis. The 14 nt insert of HLA-G is more frequent in glioma patients, and elevated plasma levels of sHLA-G are negatively associated with their survival.
Article
Biochemistry & Molecular Biology
Jiangbo Chen, Pin Gao, Lin Peng, Tianqi Liu, Fan Wu, Kai Xu, Lei Chen, Fei Tan, Pu Xing, Zaozao Wang, Jiabo Di, Beihai Jiang, Xiangqian Su
Summary: This study found that STK25 plays a crucial role in colorectal cancer and inhibits autophagy by activating the JAK2/STAT3 pathway, providing a potential indicator for therapies targeting CRC.
MOLECULAR CARCINOGENESIS
(2022)
Article
Medicine, General & Internal
Haipeng Liu, Liangfang Shen, Xinqiong Huang, Guangying Zhang
Summary: The study found that the maximal tumor diameter in the preoperative tumor MRI T2 image is associated with the prognosis of grade II gliomas patients and serves as an independent factor for predicting patient outcome. Researchers also identified this diameter as a prognostic factor for overall survival (OS) and as an independent risk factor for event-free survival (EFS) in patients with grade II glioma.
Article
Oncology
Yuanbing Chen, Miao Tang, Jianbing Xiong, Qiongjue Gao, Wuyang Cao, Jun Huang
Summary: GRB10 expression is positively correlated with the histological grades of gliomas. Glioma patients with lower GRB10 expression have longer survival. Knockdown of GRB10 inhibits cell proliferation, colony formation, and tumor formation in xenograft models. Cell cycle assay shows that GRB10 knockdown inhibits cells from entering the G2/M phase from the S phase. GSEA analysis suggests a positive correlation between GRB10 expression and hypoxia and EMT signaling pathways. These findings indicate that GRB10 plays a vital role in glioma tumorigenesis and progression and could serve as a potential prognostic marker.
CANCER CELL INTERNATIONAL
(2022)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)