Article
Medicine, General & Internal
Diego Santos-Garcia, Ariadna Laguna, Jorge Hernandez-Vara, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Maria Cristina Iniguez-Alvarado, Iago Garcia Diaz, Silvia Jesus, Maria Teresa Boungiorno, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso G. Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Manuel Menendez Gonzalez, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. Lopez M. Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: This study analyzed sex difference manifestations in Spanish patients with Parkinson's disease (PD) and found important differences. Symptoms such as depression, fatigue, and pain were more frequent and/or severe in females, while symptoms such as hypomimia, speech problems, rigidity, and hypersexuality were more noted in males. Women received a lower levodopa equivalent daily dose and had worse perception of quality of life. After two years of follow-up, the NMS burden increased more significantly in males, while the functional capacity was more impaired in females.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Emmie Cohen, Allison A. Bay, Liang Ni, Madeleine E. Hackney
Summary: Apathy is often overlooked in Parkinson's Disease (PD) but can have a negative impact on quality of life and increase with disease severity. Early identification of apathy can aid in treatment and improve prognosis.
Article
Health Care Sciences & Services
Santos-Garcia Diego, De Deus Teresa, Carlos Cores, Hector Canfield, Jose M. Paz Gonzalez, Cristina Martinez Miro, Lorena Valdes Aymerich, Ester Suarez, Silvia Jesus, Miquel Aguilar, Pau Pastor, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez-Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. avila Rivera, Maria J. Catalan, Victor Nogueira, Victor Puente, Julio Dotor, Carmen Borrue, Berta Solano, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Gemma Alonso, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Marta Blazquez, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Oriol de Fabregues, Jessica Ardura, Ruben Alonso, Carlos Ordas, Luis M. Lopez Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: The study found a significant increase in NMS burden in Parkinson's disease patients over 2 years, while no change was observed in the control group. Worsening sleep problems and neuropsychiatric symptoms were identified as significant independent predictors of this NMS progression.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Dejan Georgiev, Marusa Mencinger, Robert Rajnar, Polona Music, Mitja Benedicic, Dusan Flisar, Roman Bosnjak, Jan Mehrkens, Zvezdan Pirtosek, Kai Boetzel, Maja Trost
Summary: A four-year longitudinal study found that bilateral stimulation of the subthalamic nucleus has beneficial effects on non-motor symptoms in patients with advanced Parkinson's disease, but may not be effective in all domains. Further research with larger cohorts and longer follow-up is needed to better understand the long-term effects of this treatment.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Psychology, Multidisciplinary
Francesca Mameli, Eleonora Zirone, Benedetta Capetti, Denise Mellace, Roberta Ferrucci, Giulia Franco, Alessio Di Fonzo, Sergio Barbieri, Fabiana Ruggiero
Summary: This review discusses the negative effects of the COVID-19 pandemic on the mental health of people with Parkinson's disease, highlighting the presence of depressive symptoms and reduced quality of life. However, there is limited evidence for the impact on anxiety disorders and sleep quality.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Qu Yi, Yu-Peng Chen, Jiang-Ting Li, Jing-Yi Li, Qi-Xiong Qin, Dan-Lei Wang, Jing-Wei Zhao, Zhi-Juan Mao, Yong-Jie Xiong, Min Zhe, Xue Zheng
Summary: Poor sleep is associated with more severe symptoms in Parkinson's disease (PD), and both insufficient and excessive time spent in bed and nocturnal sleep duration are correlated with higher non-motor symptom burdens. Non-motor symptoms play a mediating role in sleep quality, quality of life, PD severity, and motor symptoms.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Yi-Chieh Chen, Rou-Shayn Chen, Yi-Hsin Weng, Ying-Zu Huang, Chiung Chu Chen, June Hung, Yi-Ying Lin
Summary: In Taiwanese PD patients, the severity of NMSs worsens with disease duration, and the increase in medication dosage is independent of the progression of NMSs.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Poornima D. E. Weerasinghe-Mudiyanselage, Sohi Kang, Joong-Sun Kim, Changjong Moon
Summary: Despite being classified as a movement disorder, Parkinson's disease exhibits a wide range of non-motor symptoms that significantly impact patients' quality of life. However, there is a lack of clear evidence-based therapy recommendations for these symptoms. Animal models of PD have been useful for understanding and treating motor symptoms, but they may also provide insight into therapies for non-motor symptoms. This paper highlights the non-motor symptoms in preclinical models of PD and the current status of preclinical therapeutic approaches for these symptoms.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Si-Chun Gu, Qing Ye, Chang-De Wang, Shao-Rong Zhao, Jie Zhou, Chen Gao, Yu Zhang, Zhen-Guo Liu, Can-Xing Yuan
Summary: Pingchan granule (PCG) has a long-lasting and extensive symptomatic efficacy for both motor and non-motor symptoms of Parkinson's disease (PD) with good tolerance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Ruwei Ou, Yanbing Hou, Qianqian Wei, Junyu Lin, Kuncheng Liu, Lingyu Zhang, Zheng Jiang, Bei Cao, Bi Zhao, Wei Song, Huifang Shang
Summary: The study of global non-motor symptoms (NMS) in Chinese patients with Parkinson's disease (PD) showed an increase in the majority of NMS domains except for mood/apathy and sexual dysfunctions. The evolution of overall NMS in early PD was found to be mild and multidimensional, with a high NMS burden predicting faster motor progression of PD. This longitudinal study provides valuable insights into the progression of NMS in PD.
NPJ PARKINSONS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Frank C. Church
Summary: Parkinson's disease is a progressive neurodegenerative disorder that mainly affects older adults. Treatment options include rehabilitation, therapy, restorative programs, maintenance with complementary and alternative medicine, and surgery as a last resort. Currently, there is no cure for PD and the focus is on slowing disease progression and improving quality of life for patients.
Article
Clinical Neurology
Yasushi Shimo, Tetsuya Maeda, Shih-Wei Chiu, Takuhiro Yamaguchi, Kenichi Kashihara, Yoshio Tsuboi, Masahiro Nomoto, Nobutaka Hattori, Hirohisa Watanabe, Hidemoto Saiki
Summary: This study evaluated the impact of istradefylline on non-motor symptoms in Japanese patients with Parkinson's disease. The results showed that istradefylline did not significantly affect NMSs, but it could still be a treatment option for patients with advanced PD.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Nursing
Pei-Ling Wu, Megan Lee, Shey-Lin Wu, Hsueh-Hou Ho, Ming-Hong Chang, Hsia-Sui Lin, Tzu-Ting Huang
Summary: Home-based exercise was found to significantly improve motor symptoms, non-motor symptoms, and health-related quality of life in Parkinson's disease patients. Exercising 150 minutes per week was effective in improving HRQOL, depression, motor ability, ADL, fatigue, and sleep quality.
JAPAN JOURNAL OF NURSING SCIENCE
(2021)
Article
Nursing
Pei-Ling Wu, Megan Lee, Shey-Lin Wu, Hsueh-Hou Ho, Ming-Hong Chang, Hsia-Sui Lin, Tzu-Ting Huang
Summary: The study explored the impact of home-based exercise on motor symptoms, non-motor symptoms, and health-related quality of life in patients with Parkinson's disease. Results showed that exercising 150 minutes a week significantly improved HRQOL, depression, motor ability, ADL, fatigue, and sleep quality.
JAPAN JOURNAL OF NURSING SCIENCE
(2021)
Article
Plant Sciences
Si-Chun Gu, Rong Shi, Chen Gaoag, Xiao-Lei Yuan, You Wu, Yu Zhang, Chang De Wang, Rui-Dong Fan, Xiqun Chen, Can-Xing Yuan, Qing Ye
Summary: This study aimed to evaluate the efficacy and safety of the traditional Chinese medicine, Pingchan granule (PCG), for motor symptoms, gait impairments, and quality of life in patients with Parkinson's disease (PD). The results showed that PCG significantly improved motor symptoms, gait, and quality of life in PD patients, with good tolerance. PCG might be a viable alternative in the management of PD.
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)