Article
Oncology
Waseem Masalha, Dieter Henrik Heiland, Christine Steiert, Marie T. Krueger, Daniel Schnell, Christian Scheiwe, Oliver Schnell, Anca-L Grosu, Juergen Beck, Juergen Grauvogel
Summary: The study concluded that gross total resection is the most important prognostic factor for lower recurrence rates and longer progression-free survival in patients with spheno-orbital meningioma. Tumors invading the cavernous sinus and intraconal region showed significantly worse PFS compared to other locations. Postoperative high-precision radiotherapy did not lead to significantly better PFS outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Morgan Michalet, Ons Bettaieb, Samia Khalfi, Asma Ghorbel, Simon Valdenaire, Pierre Debuire, Norbert Ailleres, Roxana Draghici, Mailys De Meric De Bellefon, Marie Charissoux, Pierre Boisselier, Sylvain Demontoy, Alexis Marguerit, Morgane Cabaille, Marie Cantaloube, Aicha Keskes, Touria Bouhafa, Marie-Pierre Farcy-Jacquet, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: Stereotactic MR-guided Radiotherapy (MRgRT) is an interesting treatment option for adrenal gland metastases (AGM). This study reviewed data from 12 consecutive patients treated with MRgRT for AGM and assessed the treatment's impact on target volume coverage, organ protection, local control, and overall survival. The results showed improved dosimetric quality and good tolerance of the treatment, with high rates of local control and overall survival. Longer follow-up is needed to evaluate late toxicities and clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Carla Cases, Mariana Benegas, Marcelo Sanchez, Ivan Vollmer, Francesc Casas, Carles Goma, Meritxell Molla
Summary: Stereotactic ablative radiation therapy (SABR) is the standard treatment for inoperable early-stage non-small-cell lung cancer. Radiological changes were evaluated and correlated with the received Biological Equivalent Dose (BED).
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Bichun Xu, Xianzhi Zhao, Di Chen, Wenjuan Zhao, Xiaoyan Wang, Changhua Ding, Zhiyong Yuan, Huojun Zhang
Summary: This study reports the feasibility and effectiveness of stereotactic body radiation therapy (SBRT) in the treatment of adrenal gland metastases (AGMs) from liver cancer. The results suggest that SBRT is a safe and effective technique for treating AGMs, especially in patients with smaller tumors.
Article
Oncology
Felix Ehret, David Kaul, Markus Kufeld, Clara Vom Endt, Volker Budach, Carolin Senger, Christoph Fuerweger, Alfred Haidenberger, Alexander Muacevic
Summary: This study analyzed the outcomes of robotic-assisted short-course stereotactic body radiotherapy (SBRT) for adrenal gland metastases (AGMs). The results showed that short-course SBRT is an effective and safe treatment modality for AGMs, with sporadic and manageable treatment-associated side effects. The study suggests that short-course SBRT can be a preferable and time-saving treatment option for AGMs if an adequate biologically effective dose can be safely applied.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Yu-Ming Huang, Chih-Wen Chi, Pao-Shu Wu, Hung-Chi Tai, Ming-Nan Chien, Yu-Jen Chen
Summary: Adrenal radiotherapy may lead to fatigue and alterations in adrenal hormones.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Yen-Yu Lin, Hsiu-Mei Wu, Huai-Che Yang, Ching-Jen Chen, Yong-Sin Hu, Chung-Jung Lin, Wan-Yuo Guo, David Hung-Chi Pan, Wen-Yuh Chung, Cheng-Chia Lee
Summary: This study assessed the efficacy and safety of stereotactic radiosurgery (SRS) in the treatment of pituitary and cavernous sinus metastases. The results showed that SRS is a safe and effective treatment for pituitary and cavernous sinus metastases.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Oncology
Dor Reuven Dabush, Daniel Shepshelovich, Tzippy Shochat, Ariadna Tibau, Eitan Amir, Hadar Goldvaser
Summary: The study found that shorter restaging intervals are associated with a higher magnitude of progression-free survival benefit, particularly in non-first line trials and trials replacing standard treatment. However, there was no significant difference in overall survival benefit between short and long restaging intervals.
CANCER TREATMENT REVIEWS
(2021)
Article
Oncology
Priscilla K. Stumpf, Ellen D. Yorke, Issam El Naqa, Kyle C. Cuneo, Jimm Grimm, Karyn A. Goodman
Summary: This study reviewed literature on SBRT for adrenal metastases published from 2008 to 2017, and developed treatment guidelines and a tumor control probability model based on the findings. The research recommended tumor doses greater than or equal to 116.4 Gy (α/β = 10 Gy) for achieving high LC rates, while further studies following unified reporting standards are needed for more robust prediction.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Fan Kou, Lei Wu, Yan Guo, Bailu Zhang, Baihui Li, Ziqi Huang, Xiubao Ren, Lili Yang
Summary: The study found that SCNAs were a better predictor of progression-free survival in patients with lung adenocarcinoma receiving radiotherapy compared to those with lung squamous carcinoma, particularly in stage I cancer patients. Combining SCNAs with TNM provided a better model for predicting long-term progression-free survival. High SCNA levels may activate the cell cycle pathway and induce tumorigenesis.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Oncology
Tae Hyung Kim, Taek-Keun Nam, Sang Min Yoon, Tae Hyun Kim, Young Min Choi, Jinsil Seong
Summary: This multi-institutional retrospective study investigated the clinical efficacy of SABR in patients with oligometastatic hepatocellular carcinoma. The results showed that SABR appeared to be an effective and safe treatment for all metastatic lesions. Patients with good performance status and liver function could achieve long-term survival.
Article
Oncology
Ting-Shi Su, Qiu-Hua Liu, Xiao-Fei Zhu, Ping Liang, Shi-Xiong Liang, Lin Lai, Ying Zhou, Yong Huang, Tao Cheng, Le-Qun Li
Summary: This study found that higher radiotherapy doses are associated with better outcomes for HCC patients, with SaRT and SbRT showing better improvement in OS, PFS, and intrahepatic control compared to ScRT.
RADIATION ONCOLOGY
(2021)
Article
Oncology
I. F. Remmerts de Vries, Max Dahele, Hassan Mostafavi, Ben Slotman, Wilko Verbakel
Summary: The study evaluated the use of kV imaging for tumor tracking during lung SBRT treatment and found that 3D positional verification during single fraction lung SBRT is feasible but improvements are needed. The results showed that the treatment time with this method was fast, but there was a significant amount of time where the tumor position could not be determined.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Ronald Wihal Oei, Yingchen Lyu, Lulu Ye, Fangfang Kong, Chengrun Du, Ruiping Zhai, Tingting Xu, Chunying Shen, Xiayun He, Lin Kong, Chaosu Hu, Hongmei Ying
Summary: This study compared the performance of the Cox proportional hazards model (CPH) with the conditional survival forest (CSF) and DeepSurv, two state-of-the-art machine learning algorithms, for disease progression prediction in nasopharyngeal carcinoma (NPC), with DeepSurv achieving the best performance.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Weiming Han, Lan Wang, Chen Li, Junqiang Chen, Wencheng Zhang, Xin Wang, Qingsong Pang, Yidian Zhao, Xinchen Sun, Kaixian Zhang, Gaofeng Li, Ling Li, Xueying Qiao, Miaoling Liu, Yadi Wang, Lei Deng, Wenqing Wang, Nan Bi, Tao Zhang, Wei Deng, Wenjie Ni, Xiao Chang, Zongmei Zhou, Jun Liang, Qinfu Feng, Lvhua Wang, Dongfu Chen, Jima Lv, Shuchai Zhu, Chun Han, Zefen Xiao
Summary: This study aimed to investigate whether PFS can serve as a surrogate endpoint for OS in ESCC patients and characterize the prognostic factors and survival of these patients. The study found that three-year PFS may act as a potential surrogate endpoint for five-year OS, and TNM stage was considered a significant prognostic factor.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)