Article
Biochemistry & Molecular Biology
Zhourui Ma, Shizhong Cai, Qianwei Xiong, Wei Liu, Hongliang Xia, Zhenhong Zhu, Zhijian Huang, Xiangming Yan, Qian Wang
Summary: This study reveals the role of WNT signaling in the chemoresistance of glioblastoma multiforme (GBM) to temozolomide (TMZ). The loss of function of p53 in GBM downregulates miR-34a expression, leading to the activation of WNT signaling and the resistance to TMZ. By targeting the miR-34a/WNT6 axis, drug sensitivity of p53-mutant GBM cells can be restored and overall survival can be extended.
Article
Immunology
Liu Liu, Yaqiong Zhou, Dan Luo, Xiaoying Sun, Hongjin Li, Yi Lu, Jiao Wang, Miao Zhang, Naixuan Lin, Chengqian Yin, Xin Li
Summary: Psoriasis is a chronic inflammatory skin disease mediated by immune and genetic factors. This study found that Wnt inhibitory factor 1 (WIF1) expression was reduced in psoriatic skin, and the WIF1 promoter region was hypermethylated. Injections of recombinant WIF1 improved the mouse model of psoriasis, and treatment with the DNA methylation inhibitor decitabine inhibited proliferation of human keratinocytes and ameliorated the disease in mice. These findings suggest that targeting DNA methylation could be a potential treatment strategy for psoriasis.
CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Krisztina Kerekes, Maria Trexler, Laszlo Banyai, Laszlo Patthy
Summary: The hedgehog (Hh) and Wnt pathways, essential for embryonic development and stem cell proliferation, have common evolutionary origins and similarities. Studies have found that the WIF1 protein regulates both pathways and efficiently inhibits the signaling activity of human Shh. This suggests a potential broader role for WIF1 beyond just being a Wnt inhibitor, particularly in its ability to antagonize human Shh.
Article
Pharmacology & Pharmacy
Erika Powe, Daniel Parschauer, Jessica Istifan, Stacy Lin, Huanyun Duan, Rebecca Gryka, Denise Jean-Louis, Amit K. K. Tiwari, Samson Amos
Summary: The overexpression of EGFR in glioblastoma leads to increased tumor cell proliferation, decreased apoptosis, and resistance to chemotherapy. The combination of erlotinib and luteolin inhibits cell proliferation and induces apoptosis in glioblastoma cells with EGFR mutations or expression. Additionally, this combination reduces the phosphorylation of downstream signaling molecules. This suggests that combining erlotinib with luteolin may be an effective treatment strategy for glioblastoma.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Szymon Grochans, Anna Maria Cybulska, Donata Siminska, Jan Korbecki, Klaudyna Kojder, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: Glioblastoma multiforme (GBM) is a highly aggressive malignancy with a median overall survival of approximately 15 months. This review analyzes the pathogenesis and epidemiological data of GBM, including age, gender, and tumor location. The data suggest that GBM is a higher-grade primary brain tumor and is significantly more common in men. Despite advancements in medicine, the risk of being diagnosed with glioma increases with age and median survival remains low. Additionally, the influence of stimulants, certain medications (such as NSAIDs), cell phone use, and exposure to heavy metals on GBM is difficult to determine clearly.
Article
Oncology
Myung-Hoon Han, Kyueng-Whan Min, Yung-Kyun Noh, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Yu Deok Won, Seong-Ho Koh, Jae Kyung Myung, Ji Young Park, Mi Jung Kwon
Summary: This study found that high expression of DKK3 in patients with GBM is associated with increased immunosuppressive response and decreased antitumoral immunity. High DKK3 expression is also correlated with poor prognosis and disease progression in GBM patients. The identification of navitoclax as an agent with potent activity against GBM cell lines with high DKK3 expression suggests that DKK3 could be a therapeutic target in GBM.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jing Zou, Wei Tan, Kangcheng Liu, Bolin Chen, TianQi Duan, Huizhuo Xu
Summary: WIF1 ameliorates mitochondrial dysfunction in DR by downregulating the AMPK/mTOR pathway, thereby improving the progression of DR.
Article
Multidisciplinary Sciences
Yuanning Zheng, Francisco Carrillo-Perez, Marija Pizurica, Dieter Henrik Heiland, Olivier Gevaert
Summary: In this study, two deep learning models were used to predict the transcriptional subtypes and prognosis of glioblastoma (GBM) cells from histology images. The results showed consistent associations between spatial cellular organization and patient prognosis. The study also confirmed that transcriptional heterogeneity and cell-state plasticity are key factors in the development of therapeutic resistance in GBM.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Nur Alisa Kamarudin, Nik Nur Hakimah Nik Salleh, Suat Cheng Tan
Summary: This study successfully extracted an anticancer compound, gallotannin, from QI galls and found that the extracted fraction exhibited significantly higher antioxidant activities and stronger inhibition on GBM cell growth. The developed extraction procedure could provide a natural gallotannin metabolite with high antioxidant potential and strong inhibitory effects on human GBM cells.
Review
Neurosciences
Wentao Hu, Hongyu Liu, Ze Li, Jialin Liu, Ling Chen
Summary: This study aimed to assess the impact of multiple factors on glioblastoma multiforme (GBM) immunotherapy prognosis and investigate the potential predictors. The results showed that factors such as O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, gross total resection, and no baseline steroid use were associated with favorable overall survival (OS) and progression-free survival (PFS) following immunotherapy. On the other hand, a Karnofsky Performance Status score < 80 and undergoing two prior relapses were associated with worse OS. Age, gender, tumor programmed death-ligand 1 expression, and history of chemotherapy did not affect survival outcomes. Notably, immunotherapy significantly improved OS among patients undergoing two prior relapses.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Immunology
Xiaomin Cai, Zheng Chen, Caiquan Huang, Jie Shen, Wenxian Zeng, Shuang Feng, Yu Liu, Shiting Li, Ming Chen
Summary: This study aimed to construct a prognostic signature based on glycolysis-related genes (GRGs) for IDH1-associated glioblastoma multiforme (GBM) and investigate its relationship with immunity. Through genomic data analysis and statistical methods, GRGs that were associated with prognosis were identified and a prognostic signature was constructed. Further validation showed that the prognostic signature independently predicted the prognosis of GBM patients and was significantly correlated with clinical characteristics, tumor immunogenicity, and immune infiltration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Raffaella Iurlaro, Inja Waldhauer, Ester Planas-Rigol, Ester Bonfill-Teixidor, Alexandra Arias, Valeria Nicolini, Anne Freimoser-Grundschober, Isabel Cuartas, Alba Martinez-Moreno, Francisco Martinez-Ricarte, Esteban Cordero, Marta Cicuendez, Simona Casalino, Xavier Guardia-Reyes, Linda Fahrni, Thomas Poschinger, Virginie Steinhart, Marine Richard, Stefanie Briner, Joerg Mueller, Franz Osl, Johannes Sam, Sara Colombetti, Marina Bacac, Christian Klein, Estela Pineda, Luis Reyes-Figueroa, Alberto Di Somma, Josep Gonzalez, Paolo Nuciforo, Joan Carles, Maria Vieito, Josep Tabernero, Pablo Umana, Joan Seoane
Summary: T-cell bispecific antibodies (TCB) are engineered molecules that can bind both the T-cell receptor and tumor-specific antigens, showing potential therapeutic effects for EGFRvIII mutation in glioblastoma (GBM). We designed and developed a novel EGFRvIII-TCB with specificity and potent antitumor activity, promoting T-cell activation and cytokine secretion for tumor cell killing, as well as T-cell recruitment into tumors. In GBM animal models, including humanized orthotopic patient-derived xenograft models, EGFRvIII-TCB induced tumor regression. These results support the clinical testing of EGFRvIII-TCB.
MOLECULAR CANCER THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Marianna Makowska, Beata Smolarz, Hanna Romanowicz
Summary: Glioblastoma multiforme (GBM) is a common, malignant brain tumor with a poor prognosis. Traditional treatments have limited success due to the tumor's infiltrating growth and resistance. The search for new therapies is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Farzana Kabir, Mohd Nazmul Hasan Apu
Summary: Glioblastoma (GBM) is a malignant and intractable central nervous system tumor. It is important to search for new markers associated with GBM pathogenesis. In this study, microarray datasets were integrated and analyzed, and differentially expressed genes (DEGs) in GBM tissue samples were identified. Functional analysis showed that upregulated genes related to extracellular matrix (ECM) were associated with the invasive nature of GBM, while downregulated DEGs were related to neuronal processes and structures. Additionally, crucial pathways and hub genes were identified, and high expression of FN1 was found to be associated with poor prognosis.
Article
Chemistry, Medicinal
Hsiao-Hang Chung, Ming-Ju Hsieh, Yih-Shou Hsieh, Pei-Ni Chen, Chung-Po Ko, Nuo-Yi Yu, Chiao-Wen Lin, Shun-Fa Yang
Summary: The leaf extracts of Terminalia catappa (TCE) were found to significantly inhibit the migration and invasion abilities of GBM cell lines through regulating the p38 pathway, suggesting potential therapeutic applications for treating GBM brain tumors.
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
