Article
Clinical Neurology
Andrei Brinzeu, Marc Sindou
Summary: At the end of the 1950s, Pierre Wertheimer established the Pierre Wertheimer Neurological and Neurosurgical Hospital in Lyon, which served as a center for neuroscience, combining hospital and training facilities. The hospital's structure focused on spatial unity, specialized fields, a large patient population, structured training, and cross-communication between areas. The hospital made significant contributions to functional neurosurgery, pain surgery, physiology, epilepsy surgery, and spasticity surgery, fostering collaboration between different teams and laying the groundwork for a neuroscientific doctoral school.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Andrew M. Hersh, A. Daniel Davidar, Carly Weber-Levine, Divyaansh Raj, Safwan Alomari, Brendan F. Judy, Nicholas Theodore
Summary: Significant advancements in the treatment of spinal cord injury (SCI) were developed in military conflicts, improving outcomes for soldiers and civilians. Modern military SCIs resulting from blast mechanisms are different from traumatic SCIs sustained by civilians, and new forms of war and weapons have influenced the rise in SCIs among causes of casualties and wounds.
NEUROSURGICAL FOCUS
(2022)
Article
Veterinary Sciences
Stephanie A. Thomovsky, Niwako Ogata
Summary: Physical rehabilitation is crucial for improving muscle elasticity, joint mobility, and nerve health in patients with spinal cord injury. It can also help in relieving pain and enhancing cardiopulmonary fitness. The psychological state of the patient plays a significant role in the success of rehabilitation and treatment outcomes.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Behavioral Sciences
K. Hakvoort, C. Conzen-Dilger, A. Gutzmann, E. Losse, S. C. Tauber, N. Chechko, A. Hoellig
Summary: Gender disparity in academic neuroscience, particularly in neurosurgery, neurology, and psychiatry, is evident based on this review. The percentage of female authors and their role as the last author varies across different specialties. The reasons behind this gender disparity in clinical neuroscience should be addressed considering cultural and historical factors.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Critical Care Medicine
Gabriel Mateus Bernardo Harrington, Paul Cool, Charlotte Hulme, Aheed Osman, Joy Roy Chowdhury, Naveen Kumar, Srinivasa Budithi, Karina Wright
Summary: This study assesses the prognostic value of routinely measured blood biomarkers in SCI patients by developing models for AIS scores at discharge and 12 months post-injury. Results show that blood measures associated with liver function and components of a total blood count can improve predictions of neurological outcomes, supporting the idea that routine blood measures are valuable in predicting SCI outcomes, particularly markers of liver function.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Mohammad Anas, Tayyab Hasan, Usman Raja, Wajid A. Raza
Summary: This study found a correlation between serum procalcitonin (PCT) levels and sepsis in spinal cord injury (SCI) patients, suggesting that PCT may be a reliable indicator for better prognosis and earlier diagnosis compared to other common biomarkers such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cells (WBC), blood culture, and body temperature.
EUROPEAN SPINE JOURNAL
(2023)
Review
Veterinary Sciences
Stephanie A. Thomovsky
Summary: This article discusses the shift from bed rest to physical rehabilitation as a treatment for spinal cord injury, highlighting the importance of rehabilitation in improving mobility and overall health in veterinary patients with spinal cord injury. The lack of research on the effects of inactivity for veterinary patients with spinal cord injury is also emphasized.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Medicine, General & Internal
Berjo Dongmo Takoutsing, Alvaro Yanez Touzet, Jay J. Park, Seong Hoon Lee, Emily R. Bligh, Abdullah Egiz, Conor S. Gillespie, Anthony Figaji
Summary: This study aims to review and compare the management and outcomes of infant MMC-associated hydrocephalus in low-income and middle-income countries (LMICs) and high-income countries. The study will involve a systematic review and meta-analysis of relevant studies. The findings will contribute to improving the management of infant hydrocephalus in LMICs.
Review
Medicine, General & Internal
Rikke Guldager, Sara Nordentoft, Lena Aadal, Mia Ingerslev Loft, Maria Amalie Vilhelmsen, Ingrid Poulsen
Summary: This scoping review explores the needs of relatives of patients with brain injuries or brain tumors, highlighting the importance of their involvement. It aims to identify and map interventions that facilitate and enhance relative involvement throughout the disease trajectory. The review will consider studies describing interventions provided by healthcare professionals and will collect data on various aspects of the interventions.
Article
Medicine, General & Internal
Benjamin M. Davies, Alvaro Yanez Touzet, Oliver D. Mowforth, Keng Siang Lee, Danyal Khan, Julio C. Furlan, Michael G. Fehlings, James S. Harrop, Carl Moritz Zipser, Ricardo Rodrigues-Pinto, James Milligan, Ellen Sarewitz, Armin Curt, Vafa Rahimi-Movaghar, Bizhan Aarabi, Timothy F. Boerger, Lindsay Tetreault, Robert Chen, James D. Guest, Sukhvinder Kalsi-Ryan, Iwan Sadler, Shirley Widdop, Angus G. K. McNair, Brian K. Kwon, Mark R. N. Kotter
Summary: Inconsistent measurement and reporting in degenerative cervical myelopathy (DCM) research hinder progress, highlighting the need for a core measurement set (CMS). This protocol outlines the steps for developing the CMS, including identifying constructs to be measured, conducting systematic reviews to identify measurement tools, and selecting the instruments through a consensus meeting. The CMS implementation guidance will be developed following instrument selection.
Article
Clinical Neurology
Christiana M. Cornea, Nicole A. Silva, William Sanders Marble, Kristopher Hooten, Brian Sindelar
Summary: This article describes the historical shift in the management of spinal cord injuries (SCIs) through the two world wars, highlighting the significant impact of these treatment experiences on military and modern civilian treatment of SCIs.
NEUROSURGICAL FOCUS
(2022)
Review
Immunology
Jiansong Chen, Yiguo Shen, Xiaobo Shao, Weiliang Wu
Summary: Spinal cord injury (SCI) and spinal cord tumor cause significant damage to the spinal cord, leading to multiple impairments and high morbidity and mortality. The treatment options for these conditions are limited and the underlying molecular mechanisms remain unclear. In the review, the role of inflammasomes in SCI and spinal cord tumors is highlighted, and targeting inflammasomes is suggested as a potential therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Shuai Ren, Weihua Zhang, HongMiao Liu, Xin Wang, Xiangchen Guan, Mingzhe Zhang, Jian Zhang, Qiong Wu, Yan Xue, Dan Wang, Yong Liu, Jianyu Liu, Xiaoping Ren
Summary: The study focused on investigating the restoration of motor function following spinal cord injury through transplanting a vascularized pedicle of hemisected spinal cord to bridge the transected spinal cord. Results showed that electrical continuity was restored, leading to motor function recovery, supporting the potential effectiveness of similar operative techniques in treating SCI patients previously considered to have irreversible damage or paralysis.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Xiaoping Ren, Weihua Zhang, Jie Qin, Jian Mo, Yi Chen, Jie Han, Xinjian Feng, Sitan Feng, Haibo Liang, Liangjue Cen, Xiaofei Wu, Linxuan Han, Rongyu Lan, Haixuan Deng, Huihui Yao, Zhongquan Qi, Hongjun Gao, Lishan Wei, Shuai Ren
Summary: This study tested spinal cord fusion (SCF) using the neuroprotective agent polyethylene glycol (PEG) in different animal models and developed a new clinical procedure called vascular pedicle hemisected spinal cord transplantation (vSCT) for the treatment of paraplegic patients. The results demonstrated the feasibility and efficacy of vSCT in re-establishing the continuity of spinal nerve fibers, potentially restoring motor, sensory, and autonomic nervous functions in paraplegic patients. Further clinical trials are needed to validate these findings.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Hao Li, Jinbo Huang, Shisheng Ye, Hai Chen, Li Yuan, Geng Liao, Weijie Du, Chaomao Li, Ling Fang, Sheng Liu, Pengfei Yang, Yongwei Zhang, Pengfei Xing, Xiaoxi Zhang, Xiaofei Ye, Ya Peng, Jie Cao, Liyong Zhang, Zhi Yang, Jianmin Liu
Summary: This study aimed to identify predictors of 90-day mortality in acute ischemic stroke patients treated with mechanical thrombectomy. The results showed that symptomatic intracranial hemorrhage, high post-thrombectomy NIHSS score, high NIHSS score on admission, and high glucose level at hospital arrival were significant independent predictors of mortality. Smoking may also be associated with mortality, but further research is needed to confirm this.
Article
Clinical Neurology
Ralph J. Mobbs, Praveenan Sivabalan, Jane Li
JOURNAL OF CLINICAL NEUROSCIENCE
(2012)
Article
Clinical Neurology
C. S. Johnson, D. N. Wilson, R. J. Mobbs
JOURNAL OF CLINICAL NEUROSCIENCE
(2013)
Review
Clinical Neurology
Anthony M. T. Chau, Lileane L. Xu, Rhys van der Rijt, Johnny H. Y. Wong, Cristian Gragnaniello, Ralph E. Stanford, Ralph J. Mobbs
JOURNAL OF NEUROSURGERY-SPINE
(2012)
Article
Clinical Neurology
Ralph Jasper Mobbs, Jane Li, Praveenan Sivabalan, Darryl Raley, Prashanth J. Rao
JOURNAL OF NEUROSURGERY-SPINE
(2014)
Review
Clinical Neurology
Anthony Minh Tien Chau, Lileane Liang Xu, Johnny Ho-Yin Wong, Ralph Jasper Mobbs
NEUROSURGICAL REVIEW
(2014)
Article
Clinical Neurology
Matt D. Schiller, Ralph J. Mobbs, S. Fiona Bonar
Article
Orthopedics
Ralph J. Mobbs
ORTHOPAEDIC SURGERY
(2013)
Review
Orthopedics
Ralph J. Mobbs, Aji Loganathan, Vivian Yeung, Prashanth J. Rao
ORTHOPAEDIC SURGERY
(2013)
Article
Orthopedics
Ralph J. Mobbs, Praveenan Sivabalan, Jane Li, Peter Wilson, Prashanth J. Rao
ORTHOPAEDIC SURGERY
(2013)
Review
Orthopedics
Ralph J. Mobbs, Mina Chung, Prashanth J. Rao
ORTHOPAEDIC SURGERY
(2013)
Article
Orthopedics
Prashanth J. Rao, Ralph J. Mobbs
ORTHOPAEDIC SURGERY
(2014)
Review
Orthopedics
Prashanth J. Rao, Matthew H. Pelletier, William R. Walsh, Ralph J. Mobbs
ORTHOPAEDIC SURGERY
(2014)
Correction
Clinical Neurology
Joshua L. Burnard, William C. H. Parr, Wen Jie Choy, William R. Walsh, Ralph J. Mobbs
EUROPEAN SPINE JOURNAL
(2020)
Article
Clinical Neurology
Ralph J. Mobbs, Darryl A. Raley
JOURNAL OF SPINAL DISORDERS & TECHNIQUES
(2014)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
