Article
Clinical Neurology
Isabel C. Hostettler, Ghil Schwarz, Gareth Ambler, Duncan Wilson, Gargi Banerjee, David J. Seiffge, Clare Shakeshaft, Surabhika Lunawat, Hannah Cohen, Tarek A. Yousry, Rustam Al-Shahi Salman, Gregory Y. H. Lip, Martin M. Brown, Keith W. Muir, Henry Houlden, Hans Rolf Jager, David J. Werring
Summary: CT-based cerebral small vessel disease biomarkers are associated with 6-month functional outcome after intracerebral hemorrhage, but adding them does not significantly improve the performance of the existing ICH prediction score.
Article
Clinical Neurology
Wen-Song Yang, Yi-Qing Shen, Xiao Wei, Li-Bo Zhao, Qing-Jun Liu, Xiong-Fei Xie, Zhi-Wei Zhang, Lan Deng, Xin-Ni Lv, Shu-Qiang Zhang, Xin-Hui Li, Qi Li, Peng Xie
Summary: The study developed the dynamic ICH (dICH) score and ultra-early ICH (uICH) score to improve the prediction of functional outcomes in patients with ICH by incorporating hematoma expansion, IVH growth, and independent non-contrast CT markers. Compared to the original ICH score, these new scores exhibited better performance in predicting poor functional outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Steven D. Shapiro, Miryam Alkayyali, Alexandra Reynolds, Kaitlin Reilly, Magdy Selim, Neha Dangayach, J. Mocco, Christopher P. Kellner, John W. Liang
Summary: This study suggests that minimally invasive hematoma evacuation with the SCUBA technique for ICH may reduce predicted 30-day mortality, with a number needed to treat of 4 to prevent 1 mortality.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
G. Schwarz, B. Kanber, F. Prados, S. Browning, R. Simister, H. R. Jager, G. Ambler, C. A. M. Gandini Wheeler-Kingshott, D. J. Werring
Summary: This study found that small vessel disease is the most common cause of spontaneous intracerebral hemorrhage and is associated with widespread microstructural brain tissue disruption, which can be quantified using diffusion tensor imaging metrics. The study found that whole-brain microstructural alterations are associated with functional outcome after intracerebral hemorrhage and have better predictive ability than existing hemorrhage scores.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
I. Putu Eka Widyadharma, Angga Krishna, Andreas Soejitno, A. A. A. Putri Laksmidewi, Kumara Tini, I. B. Kusuma Putra, I. G. N. Budiarsa, I. A. Sri Indrayani
Summary: The modified ICH (mICH) score was found to be more accurate and effective in predicting 30-day mortality and good outcome for non-traumatic ICH patients compared to the original ICH score (oICH).
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Neurosciences
Adrian Balasa, Dana Ghiga, Razvan-Sebastian Andone, Ancuta Elena Zahan, Ioan Alexandru Florian, Rares Chinezu
Summary: This study found that surgical treatment may be beneficial for ICH patients with volumes between 30 to 50 mL and GCS scores of 10 points or higher, but did not significantly improve overall mortality rates.
Article
Clinical Neurology
Shen Wang, Xuxu Xu, Qiang Yu, Haicheng Hu, Chao Han, Ruhai Wang
Summary: This study aimed to evaluate the relationship between modified Graeb Score (mGS) at admission and clinical outcomes of spontaneous intracerebral hemorrhage (sICH), and investigate if combining ICH score could improve outcome prediction accuracy. The results showed that mGS was an independent risk factor for poor outcome and combining ICH score with mGS improved the ability to predict postoperative outcome.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biology
Yantao Xing, Hongyi Cheng, Chenxi Yang, Zhijun Xiao, Chang Yan, Feifei Chen, Jiayi Li, Yike Zhang, Chang Cui, Jianqing Li, Chengyu Liu
Summary: Classification and outcome prediction of ICH based on SKNA signals is a feasible method with high accuracy. There are significant differences in SKNA signals between healthy control subjects and ICH patients. The features of change rate and complexity can be used to characterize the difference in SKNA signals of different groups.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Medicine, General & Internal
Peter B. Sporns, Marios-Nikos Psychogios, Gregoire Boulouis, Andreas Charidimou, Qi Li, Enrico Fainardi, Dar Dowlatshahi, Joshua N. Goldstein, Andrea Morotti
Summary: Intracerebral hemorrhage (ICH) accounts for 10% to 20% of all strokes worldwide and is associated with high morbidity and mortality. Neuroimaging plays a crucial role in the rapid diagnosis of ICH, identification of ICH expansion, and assessment of early hematoma expansion risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Rui Liu, Changcun Chen, Yutong Zhao, Yuguang Tang, Weiwei Shen, Zongyi Xie
Summary: This study aimed to investigate the relationship between the Osaka Prognostic Score (OPS) and Naples Prognostic Score (NPS) and the short-term outcomes of patients with intracerebral hemorrhage (ICH). The study found that higher OPS and NPS on admission were associated with poor outcomes at six months following ICH, suggesting their potential as markers for predicting the prognosis of ICH patients.
Article
Clinical Neurology
Christopher P. Kellner, Rui Song, Muhammad Ali, Dominic A. Nistal, Milan Samarage, Neha S. Dangayach, John Liang, Ian McNeill, Xiangnan Zhang, Joshua B. Bederson, J. Mocco
Summary: This retrospective analysis of 90 patients undergoing minimally invasive endoscopic intracerebral hemorrhage evacuation found that younger age, absence of intraventricular hemorrhage, lobar location, and early time to evacuation were independently associated with good long-term functional outcomes. The odds ratio for time to evacuation suggests a 5% reduction in the odds of achieving a favorable outcome for each additional hour.
Article
Critical Care Medicine
David Lin, Michael Minyetty, Magdy Selim, Sarah Marchina, Filipa Carvalho, Elizabeth Heistand, Gogia Bhanu, Saad Hasan, Sandeep Kumar
Summary: The study externally validated the GRAVo score for predicting PEG tube placement after intracerebral hemorrhages (ICH) and found that it was valid but less accurate compared to the derivation cohort. The inclusion of race as a variable did not significantly affect the model's performance.
NEUROCRITICAL CARE
(2022)
Article
Clinical Neurology
Audrey C. Leasure, Lindsey R. Kuohn, Kevin N. Vanent, Matthew B. Bevers, W. Taylor Kimberly, Thorsten Steiner, Stephan A. Mayer, Charles C. Matouk, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth
Summary: Higher admission IL-6 levels in patients with spontaneous intracerebral hemorrhage are associated with worse 90-day functional outcome, larger ICH volume, and larger perihematomal edema volume.
Article
Multidisciplinary Sciences
Zhang Liang, He Liu, Li Xue, Bin Ma, Ling-Zhi Yang, Qing-Le Liang, Zhang-Ming Zhou
Summary: This study aimed to determine the association between systemic immune-inflammation index (SII) on different days of admission and the severity and 180-day functional outcomes in patients with basal ganglia ICH. It was found that a low SII was associated with favorable outcomes and a high hematoma volume. The SII independently and strongly predicted the outcomes of basal ganglia ICH.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuanliang Xie, Faxiang Chen, Yan Wu, Hua Fu, Qing Zhong, Jun Chen, Xiang Wang, Hui Li
Summary: The study found that radiomic analysis based on initial NCCT scans can predict the outcomes of patients with intracerebral hemorrhage (ICH), and the clinical-radiomics model has better accuracy in predicting poor outcomes and 30-day mortality following ICH.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Clinical Neurology
Jose A. Canseco, Gregory D. Schroeder, Parthik D. Patel, Giovanni Grasso, Michael Chang, Frank Kandziora, Emiliano N. Vialle, F. Cumhur Oner, Klaus J. Schnake, Marcel F. Dvorak, Jens R. Chapman, Lorin M. Benneker, Shanmuganathan Rajasekaran, Christopher K. Kepler, Alexander R. Vaccaro
Summary: Regardless of geographic location or years of practice experience, over half of responding surgeons identified MRI as the preferred imaging modality for managing cervical facet dislocation injuries, and tend to choose an anterior approach for surgical management. The study found a general consensus in management preferences for cervical facet dislocation injuries globally.
EUROPEAN SPINE JOURNAL
(2021)
Article
Critical Care Medicine
Melissa Wagner, Krista Lim-Hing, Mary Ann Bautista, Brigid Blaber, Taghi Ryder, Joseph Haymore, Neeraj Badjatia
Summary: The study demonstrates that continuous noninvasive temperature monitoring is a suitable alternative method for assessing core temperature during TTM. The results show good agreement between the superficial temperature monitor and core temperature measures in all patients overall.
NEUROCRITICAL CARE
(2021)
Article
Critical Care Medicine
Neeraj Badjatia, Nidhi Gupta, Stephanie Sanchez, Joseph Haymore, Hemantkumar Tripathi, Rushil Shah, Casey Hannan, Harikrishna Tandri
Summary: This study tested the safety and feasibility of a novel transnasal evaporative cooling device for inducing and maintaining normothermia in febrile stroke patients. Results showed 90% of patients achieved normothermia without significant adverse events or shivering. A multicenter trial testing the device's ability to maintain normothermia for 24 hours is currently underway.
NEUROCRITICAL CARE
(2021)
Article
Clinical Neurology
Brian A. Karamian, Gregory D. Schroeder, Martin Holas, Andrei F. Joaquim, Jose A. Canseco, Shanmuganathan Rajasekaran, Lorin M. Benneker, Frank Kandziora, Klaus J. Schnake, F. Cumhur Oner, Christopher K. Kepler, Alexander R. Vaccaro
Summary: The study revealed variations in global treatment practices for subaxial unilateral cervical spine facet fractures based on surgeon experience, practice setting, and surgical subspecialty. Most surgeons prefer operative treatment for facet fractures with radicular symptoms, with F2N2 fractures as a threshold for surgery.
EUROPEAN SPINE JOURNAL
(2021)
Editorial Material
Critical Care Medicine
Neeraj Badjatia, Benjamin S. Abella, Kees H. Polderman, Romergryko G. Geocadin, Robert Silbergleit
THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT
(2021)
Article
Medicine, General & Internal
Benjamin L. Brett, Mark D. Kramer, John Whyte, Michael A. McCrea, Murray B. Stein, Joseph T. Giacino, Mark Sherer, Amy J. Markowitz, Geoffrey T. Manley, Lindsay D. Nelson
Summary: This study identified four distinct neurobehavioral phenotypes in patients with TBI two weeks after injury, which significantly improved estimation of association with 6-month outcomes when added to demographic characteristics and other injury characteristics in models. These distinct phenotypes may assist in clinical decision-making and patient selection for clinical trials.
Article
Medicine, General & Internal
Harvey S. Levin, Nancy R. Temkin, Jason Barber, Lindsay D. Nelson, Claudia Robertson, Jeffrey Brennan, Murray B. Stein, John K. Yue, Joseph T. Giacino, Michael A. McCrea, Ramon Diaz-Arrastia, Pratik Mukherjee, David O. Okonkwo, Kim Boase, Amy J. Markowitz, Yelena Bodien, Sabrina Taylor, Mary J. Vassar, Geoffrey T. Manley
Summary: This study identified that women are more susceptible than men to persistent mTBI-related cognitive and somatic symptoms, with no sex differences observed after orthopedic injury. Post-concussion symptoms were also more severe in women aged 35 to 49 than in younger and older women.
Article
Clinical Neurology
Aparna Vadlamani Chauhan, Jack Guralnik, Susan dosReis, John D. Sorkin, Neeraj Badjatia, Jennifer S. Albrecht
Summary: This study aimed to determine the incidence and risk factors for repetitive traumatic brain injury (TBI) among older adults in the United States. It found that epilepsy was the strongest predictor of repetitive TBI, followed by Alzheimer disease and related dementias. Future work should focus on reducing the risk of repetitive TBI and assessing related outcomes.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Critical Care Medicine
Murad Megjhani, Kalijah Terilli, Lakshman Kalasapudi, Justine Chen, John Carlson, Serenity Miller, Neeraj Badjatia, Peter Hu, Angela Velazquez, David J. Roh, Sachin Agarwal, Jan Claassen, E. S. Connolly, Xiao Hu, Nicholas Morris, Soojin Park
Summary: The study developed an automatic method to predict the onset of ventriculitis by analyzing intracranial pressure waveform morphology. The results showed that intracranial pressure waveform morphology analysis can classify ventriculitis without cerebrospinal fluid sampling.
NEUROCRITICAL CARE
(2022)
Article
Critical Care Medicine
Matthew N. Jaffa, Ruchira M. Jha, Jonathan Elmer, Adam Kardon, Jamie E. Podell, Benjamin E. Zusman, Madeleine C. Smith, J. Marc Simard, Gunjan Y. Parikh, Michael J. Armahizer, Neeraj Badjatia, Nicholas A. Morris
Summary: This study identified five distinct pain trajectories following SAH, with groups 3 and 5 showing higher risk for continued opioid use at follow-up. Additionally, a history of depression and belonging to a racial/ethnic minority were also associated with prolonged opioid use.
NEUROCRITICAL CARE
(2021)
Article
Critical Care Medicine
Brittany Bolduc Lachance, WanTsu Chang, Melissa Motta, Gunjan Parikh, Jamie Podell, Neeraj Badjatia, J. Marc Simard, Gary T. Schwartzbauer, Nicholas A. Morris
Summary: This study retrospectively reviewed six cases of refractory intracranial hypertension and found that verticalization intervention can effectively reduce ICP, decrease ICP spikes, and lower the percentage of ICP values greater than 20 mmHg.
NEUROCRITICAL CARE
(2022)
Article
Critical Care Medicine
Neeraj Badjatia, Joseph Haymore, Marc E. Voorhees, Kevin Goundry, Corey Lewis, Gabriella Judd, Stephanie Sanchez
Summary: This study demonstrates that resting energy expenditure (REE) can be accurately estimated using heat transfer data from a surface gel pad temperature modulating device (TMD) and clinical characteristics of patients. Factors associated with REE include patient age, sex, body surface area, temperature, and heat transfer.
THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT
(2022)
Review
Critical Care Medicine
Jamie Podell, Melissa Pergakis, Shiming Yang, Ryan Felix, Gunjan Parikh, Hegang Chen, Lujie Chen, Catriona Miller, Peter Hu, Neeraj Badjatia
Summary: Subtle and profound changes in autonomic nervous system function occur in critical illness, particularly in neurocritical illness, and can be measured quantitatively at the bedside. Data analytics can identify physiological changes that precede clinical detection of meaningful events, providing a window for time-sensitive therapies. This review discusses data-analytic approaches to measuring autonomic nervous system dysfunction and their potential for early detection and monitoring.
NEUROCRITICAL CARE
(2022)
Article
Critical Care Medicine
Shannon Arnold, Michael Armahizer, Luis F. Torres, Hemant Tripathi, Harikrishna Tandri, Jason J. Chang, H. Alex Choi, Neeraj Badjatia
Summary: This study compared a novel transnasal temperature-modulating device (tnTMD) with surface cooling temperature-modulating devices (sTMDs) in achieving and maintaining normothermia in mechanically ventilated febrile neurocritical care patients. The results showed that the tnTMD approach achieved similar time to normothermia and temperature burden with less shivering compared to the sTMD approach. This suggests that transnasal cooling could be a feasible option for this patient population.
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Matthew N. Jaffa, Jamie E. Podell, Madeleine C. Smith, Arshom Foroutan, Adam Kardon, Wan-Tsu W. Chang, Melissa Motta, Gunjan Y. Parikh, Kevin N. Sheth, Neeraj Badjatia, Michael J. Armahizer, J. Marc Simard, Nicholas A. Morris
Summary: The study found that continued opioid use following aneurysmal subarachnoid hemorrhage (aSAH) is common and related to pain burden during acute illness, but not to the opioid dose during hospitalization. New analgesic strategies are needed to reduce continued opioid use in these patients.
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
