Journal
JOURNAL OF CLINICAL NEUROSCIENCE
Volume 19, Issue 1, Pages 183-184Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2011.05.013
Keywords
Aging; Gender; Basal ganglia; Dopamine; Menopause; Parkinson's disease; Positron emission tomography
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Funding
- Department of Veterans Affairs
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Gender differences in brain dopaminergic activity have been variably reported in the literature. We performed an evaluation for gender effects on striatal dopamine transporter (DAT) binding in a group of normal subjects. Community-dwelling adults (n = 85, 50F/35M, mean age 62.7 +/- 16.2 SD, range 20-85) underwent DAT[C-11]-beta-carbomethoxy-3 beta-(4-fluorophenyl) tropane (beta-CFT) positron emission tomography (PET) imaging. Gender effects for DAT binding were compared using ANCOVA for two subgroups; young-to-middle aged adults and older adults, using an age threshold of 60 years. There were 54 subjects (24M/30F; mean age 72.9 +/- 7.3) 60 years and older and 31 (11M/20F; mean age 45.0 +/- 11.4) subjects younger than 60. Age-adjusted striatal DAT gender effects were present in the young-to-middle (F = 10.4, P = 0.003) but not in the elderly age group (F = 0.5, ns). Gender differences in nigrostriatal dopaminergic innervation are present, with higher levels of DAT binding in young-to-middle age women compared to men, but not present in the elderly. Published by Elsevier Ltd.
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