Article
Medicine, General & Internal
Xiangcheng Gao, Jinpeng Du, Yongyuan Zhang, Yining Gong, Bo Zhang, Zechao Qu, Dingjun Hao, Baorong He, Liang Yan
Summary: Through a retrospective study, we found that the independent influencing factors of bone cement displacement after PVA in Kummell's disease include thoracolumbar junction, Kummell's disease staging, anterior cortex defect, vertebral endplates defect, cement distribution, cement leakage, restoration of local Cobb angle, and postoperative anti-osteoporosis treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Juan P. Cabrera, Gaston Camino-Willhuber, Alfredo Guiroy, Charles A. Carazzo, Martin Gagliardi, Andrei F. Joaquim
Summary: A systematic review comparing the clinical and radiological outcomes of vertebral augmentation + short-segment fixation (VA + SSF) versus VA alone in Kummell's disease found no significant difference in pain and functional recovery between the two groups, but suggested that VA + SSF may provide superior long-term results.
NEUROSURGICAL REVIEW
(2022)
Article
Orthopedics
Hanpeng Xu, Qing Feng, Xiang Ma, Jie Lan, Jingtao Ji, Zepei Zhang, Jun Miao
Summary: This study investigated and evaluated the biomechanical behavior of a novel bone cement screw in the minimally invasive treatment of Kummell's disease through finite element analysis. It was found that the screw can effectively reduce the relative displacement of bone cement and provide a reference for clinical practice.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Endocrinology & Metabolism
Chao Zhang, Tianyong Wen, Chao Li, Dike Ruan, Qing He
Summary: Patients with GIOP have a higher risk of refractures after surgery, posing a challenge for treatment. Clinicians should pay more attention to comprehensive perioperative antiosteoporotic medications for patients with GIOP.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Biotechnology & Applied Microbiology
Yi Zhan, Chang Bao, Huiming Yang, Liang Li, Liang Yan, Lingbo Kong, Dingjun Hao, Biao Wang
Summary: This study compared the efficacy of bone cement and a novel bone cement bridging screw in the treatment of thoracolumbar Kummell disease. The results showed that the novel bone cement bridging screw had better biomechanical strength and could increase the strength of bone cement to prevent loosening and displacement.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Orthopedics
Youzhi An, Lili Li, Xuelin Lin, Zhen Zhang, Zhaoyun Zheng, Chengjiang Wang
Summary: This study aimed to investigate the risk of sandwich vertebral fractures in the treatment of osteoporotic vertebral compression fractures via percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP). The study found that PVP had a higher risk of sandwich vertebral fractures compared to PKP, potentially due to the larger amount of bone cement, higher rate of cement leakage, and larger Cobb angle.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Surgery
Yajian Wang, Bo Liu, Zhenwei Sun, Yaning Zhang, Jiangping Su
Summary: This study summarized the pros and cons of percutaneous vertebroplasty (PVP), percutaneous kyphoplasty (PKP), and bone-filling mesh containers (BFC) in the treatment of Kummell's disease (KD) through network meta-analysis. The results showed no statistical difference between the three procedures in terms of improving patients' clinical symptoms. PKP was most likely to be the most effective in correcting kyphosis, while BFC was likely to be the most effective in managing the occurrence of cement leakage. No statistical differences were found in the incidence of new vertebral fractures in adjacent segments.
FRONTIERS IN SURGERY
(2022)
Article
Surgery
Shou-qian Dai, Rong-qing Qin, Xiu Shi, Hui-lin Yang
Summary: This study compared the safety and clinical efficacy of PVP and PKP in treating KD, finding no significant differences in intraoperative blood loss and bone cement leakage between the two groups. PKP had significantly longer surgical time, higher operation costs, and more fluoroscopy times compared to PVP. Both procedures significantly improved pain and vertebral deformity, with PKP showing better results in height and kyphosis correction.
Article
Engineering, Biomedical
Xi Wang, Jin Xu, Jianming Kou, Wei Tian, Chong Gao, Fuzhai Cui, Zhiye Qiu
Summary: Treating Kummell's Disease with mineralized collagen modified polymethyl methacrylate bone cement can significantly reduce pain, promote vertebral height and Cobb angle recovery, and reduce the incidence of leakage complications, with good clinical outcomes.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Medicine, General & Internal
Shira Lidar, Khalil Salame, Michelle Chua, Morsi Khashan, Dror Ofir, Alon Grundstein, Uri Hochberg, Zvi Lidar, Gilad J. Regev
Summary: SOVF is a serious complication of osteoporosis, and sarcopenia may be an independent risk factor for it. This retrospective case-control study investigated the association between sarcopenia and SOVF in elderly patients who underwent percutaneous vertebral augmentation. The study found a significant correlation between sarcopenia and SOVF.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
An-Jhih Luo, Jen-Chung Liao, Lih-Hui Chen, Po-Liang Lai
Summary: High-viscosity bone cement (HVBC) and low-viscosity bone cement (LVBC) have similar clinical outcomes in the treatment of thoracic vertebral compression fractures, but HVBC has less cement leakage, a larger injection volume, and better postoperative pain relief.
Article
Clinical Neurology
Tangyiheng Chen, Cheng Lin, Yujie Wang, Huilin Yang, Xuefeng Li, Genglei Chu, Weimin Jiang, Yijie Liu
Summary: This study aims to demonstrate the therapeutic benefit of repeat Percutaneous Vertebroplasty (PVP) in Kummell's disease patients with recurrent symptoms after initial Percutaneous Kyphoplasty (PKP) treatment. The results show that repeat PVP can ameliorate kyphosis and restore vertebral height to some extent, providing superior long-term outcomes in clinical and radiological aspects.
GLOBAL SPINE JOURNAL
(2023)
Article
Orthopedics
Dexin Zou, Shengjie Dong, Wei Du, Bing Sun, Xifa Wu
Summary: The study retrospectively analyzed 2344 patients who underwent PVP or PKP for OVCFs. It found that multiple involved vertebrae, thoracic fracture, operation timing, and operation methods are independent risk factors for PCE. The real incidence of PCE may be underestimated without routine postoperative pulmonary imaging examination.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Orthopedics
Ya-Ping Xiao, Ming-Jian Bei, Cui-Qing Yan, Jian-Zhong Chang
Summary: In patients with Kummell's disease treated by percutaneous vertebroplasty, those with bone cement leakage had longer disease course, older age, more severe kyphotic deformity, vertebral compression, and osteoporosis. However, there were no significant differences in the rate of adjacent vertebral refractures, visual analogue scale, and Oswestry dysfunction index between the leakage group and non-leakage group, indicating that bone cement leakage does not affect the surgical outcomes.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Medicine, General & Internal
Olga Adamska, Krzysztof Modzelewski, Artur Stolarczyk, Jurij Kseniuk
Summary: Minimally invasive surgery and conservative treatment are effective options for patients with osteoporotic vertebral compression fractures at risk for Kummell's disease. While there are inconsistencies in the efficacy of certain treatment methods, managing osteoporosis remains crucial, emphasizing the importance of prevention and early diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Jong-Hyeok Park, Sun-Ho Lee, Eun-Sang Kim, Whan Eoh
BRITISH JOURNAL OF NEUROSURGERY
(2020)
Article
Clinical Neurology
Hyukjun Kwon, Sungjoon Lee, Sun-Ho Lee, Eun-Sang Kim
Summary: This report describes a case of dural rupture and subsequent spinal cord herniation related to the use of closed suction drains in spinal surgery.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Jeong-Seob Won, Je Young Yeon, Hee-Jang Pyeon, Yu-Jeong Noh, Ji-Yoon Hwang, Chung Kwon Kim, Hyun Nam, Kyung-Hoon Lee, Sun-Ho Lee, Kyeung Min Joo
Summary: Stem cell-based therapeutics, particularly adult human multipotent neural cells (ahMNCs) from patients with hemorrhagic stroke, show potential in promoting significant locomotor recovery in spinal cord injury (SCI) through modulating glial scar formation, neuroprotection, and/or angiogenesis. The optimal transplantation dose of ahMNCs identified in this study could be beneficial in determining the appropriate injection dose for SCI patients in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Sung Soo Kim, Hee-Jang Pyeon, Yoon Kyung Bae, Hyun Nam, Chung Kwon Kim, Sun-Ho Lee, Kyeung Min Joo
Summary: Adult human multipotent neural cells (ahMNCs) derived from adult human temporal lobes exhibit unique characteristics, including distinctive cell marker expression, higher neural differentiation potentials, and increased expression of paracrine factors. These features set ahMNCs apart from other cell types such as pericytes, mesenchymal stem cells (MSCs), and fetal neural stem cells (fNSCs). The distinct properties of ahMNCs make them valuable for potential applications in regenerative medicine research and as comparative references for other cell types.
STEM CELLS INTERNATIONAL
(2021)
Article
Oncology
Haeyoung Kim, Hongryull Pyo, Hee Chul Park, Do Hoon Lim, Jeong Il Yu, Won Park, Yong Chan Ahn, Doo Ho Choi, Dongryul Oh, Jae Myoung Noh, Won kyung Cho, Gyu Sang Yoo, Sang Hoon Jung, Eun-Sang Kim, Sun-Ho Lee, Se-Jun Park, Chong-Suh Lee
Summary: This study aimed to evaluate the incidence of vertebral compression fracture (VCF) in patients undergoing SBRT for spinal bone metastases and determine contributing factors. Results showed that the dosimetric parameter PTV_V15 Gy was the most significant for predicting VCF, while primary tumor site and PTV_V-15 Gy were also associated with VCF incidence.
JOURNAL OF BONE ONCOLOGY
(2021)
Article
Clinical Neurology
Scott L. Zuckerman, Sun-Ho Lee, George J. Chang, Garrett L. Walsh, Reza J. Mehran, Ziya L. Gokaslan, Ganesh Rao, Claudio E. Tatsui, Laurence D. Rhines
Summary: The study revealed that negative margin resection of sacral chordoma was associated with decreased local recurrence, but did not affect patient's survival and functional outcomes. Most patients experienced complications after surgery, but these complications did not significantly impact the patient's survival, recurrence, or function.
GLOBAL SPINE JOURNAL
(2021)
Article
Clinical Neurology
Soo Heon Kim, Sun Ho Lee, Dong Ah Shin
Summary: This study aimed to investigate whether machine learning (ML) can predict postoperative C5 palsy of cervical ossification of the posterior longitudinal ligament (OPLL) patients better than a conventional logistic regression. Four sampling methods were used to balance the data, and six ML algorithms and conventional logistic regression were compared. The results showed that the ML algorithm using adaptive reinforcement learning and downsampling had the highest AUC and outperformed logistic regression. Age, surgical method, and involvement of OPLL at C1-C3 were significantly associated with C5 palsy, and postoperative shoulder pain was closely related to postoperative C5 palsy of OPLL patients.
CLINICAL SPINE SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Chung Kwon Kim, Jeong-Seob Won, Jae Yeol An, Ho Jin Lee, Ah-Jin Nam, Hyun Nam, Ji Yeoun Lee, Kyung-Hoon Lee, Sun-Ho Lee, Kyeung Min Joo
Summary: Adult human neural stem cells (ahNSCs) can improve motor function and provide neuroprotective effects for spinal cord injury (SCI) patients by inhibiting apoptosis of spinal cord neurons. The conditioned medium (CM) of ahNSCs was found to have paracrine effects through the release of various cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Sungjoon Lee, Sunghoon Min, Junghoon Han, Eun Sang Kim, Sun-Ho Lee
Summary: This study aimed to determine the long-term clinical and radiologic outcomes using L-shaped mini-plates for laminoplasty. The results showed that laminoplasty using L-shape Leibinger mini-plates had a fusion rate of 89.3% and no displacement of the re-attached laminae was observed. It is considered a safe and feasible option for surgeries for intraspinal pathologies.
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
Sungjoon Lee, Hyun Nam, Kyeung-Min Joo, Sun-Ho Lee
Summary: Spinal cord injury is a devastating injury that leads to severe disabilities. Stem cell therapy, specifically neural stem cells, has shown promising results in regenerating damaged neural tissues. Preclinical and clinical studies have demonstrated positive outcomes, although there are still challenges to overcome.
Article
Multidisciplinary Sciences
Junghoon Han, Chang-Min Ha, Woon Tak Yuh, Young San Ko, Jun-Hoe Kim, Tae-Shin Kim, Chang-Hyun Lee, Sungjoon Lee, Sun-Ho Lee, Asfandyar Khan, Chun Kee Chung, Chi Heon Kim
Summary: This study compared the reduction of spondylolisthesis and the placement of the cage between the OLIF-one and OLIF-con procedures. The results showed that OLIF-one achieved better reduction of spondylolisthesis and placement of the cage at the desired location.
Article
Cell Biology
Geun-Hyoung Ha, Eun Ji Kim, Jee Soo Park, Ji Eun Kim, Hyun Nam, Je Young Yeon, Sun-Ho Lee, Kyunghoon Lee, Chung Kwon Kim, Kyeung Min Joo
Summary: This study demonstrated the neuroprotective and pro-angiogenic effects of adult human neural stem cells (ahNSCs) in the treatment of ischemic stroke. Tissue analysis showed that ahNSCs reduced brain tissue atrophy and functional loss, and preserved neurons by decreasing reactive astrogliosis and microglial activation. Furthermore, these effects were mediated by paracrine factors and reversed when the JAK2/STAT3 signaling pathway was inhibited. This preclinical study provides important insights for the development of stem cell therapeutics for ischemic stroke.
Correction
Cell & Tissue Engineering
Hyun Nam, In-Hee Lee, Jason K. Sa, Sung Soo Kim, Hee-Jang Pyeon, Kee Hang Lee, Kyunghoon Lee, Sun-Ho Lee, Kyeung Min Joo
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Cell & Tissue Engineering
Hyun Nam, In-Hee Lee, Jason K. Sa, Sung Soo Kim, Hee-Jang Pyeon, Kee Hang Lee, Kyunghoon Lee, Sun-Ho Lee, Kyeung Min Joo
Summary: The study found that long-term in vitro expansion of adult human multipotent neural cells (ahMNCs) can induce copy number variations and genetic mutations, but the number did not increase with culture progression and many of them disappeared. Although most of the observed genetic mutations were not shared by all ahMNCs, non-synonymous missense mutations at the MUC4 gene were found in three out of five long-term cultured ahMNC lines. The genetic instability did not confer in vivo tumorigenic potential to ahMNCs.
STEM CELL REVIEWS AND REPORTS
(2022)
Review
Clinical Neurology
Chang-Hyun Lee, Jae Taek Hong, Sun-Ho Lee, Seong Yi, Moon-Jun Sohn, Sung Hwan Kim, Chun Kee Chung
Summary: Spinal metastases can vary in mechanical stability. The Spinal Instability Neoplastic Score (SINS) is used to assess spinal neoplastic-related instability. Studies have conflicting opinions on the accuracy and reliability of SINS, but most agree on its predictive accuracy for vertebral compression fractures (VCFs).
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2021)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)