Article
Clinical Neurology
Alexis L. Pracar, Maria V. Ivanova, Amber Richardson, Nina F. Dronkers
Summary: Apraxia of speech (AOS) is a motor speech disorder affecting the coordination of articulatory movements. The study focused on a case of pure AOS without aphasia and explored speech errors and their underlying neural correlates. The findings supported the dissociability of AOS and aphasia, and highlighted the role of the precentral gyrus and underlying white matter in articulatory coordination.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Samuel W. Centanni, Amy C. Janes, David L. Haggerty, Brady Atwood, Frederic W. Hopf
Summary: Insula function is critical for motivated behaviors and implicated in neuropsychiatric conditions, with distinct subregions encoding different types of information. Precision in describing these subregions is important, as task details can impact recruitment. Continued research on insula contributions is of paramount importance.
Article
Multidisciplinary Sciences
Annalisa Gessani, Francesco Cavallieri, Valentina Fioravanti, Isabella Campanini, Andrea Merlo, Giulia Di Rauso, Benedetta Damiano, Sara Scaltriti, Elisa Bardi, Maria Giulia Corni, Francesca Antonelli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Alessandro Fraternali, Annibale Versari, Giuseppe Biagini, Valerie Fraix, Serge Pinto, Elena Moro, Carla Budriesi, Franco Valzania
Summary: This study evaluated the long-term effects of bilateral STN-DBS on speech in advanced PD patients. The results showed that speech intelligibility remained at the same level as preoperative values in the long-term, and STN-DBS led to a significant improvement in speech intelligibility in the postoperative assessment.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Wenhao Jiang, Kelly Rootes-Murdy, Jiayu Chen, Nora Perrone-Bizzozero, Vince D. Calhoun, Theo G. M. van Erp, Stefan Ehrlich, Ingrid Agartz, Erik G. Jonsson, Ole A. Andreassen, Lei Wang, Godfrey D. Pearlson, David C. Glahn, Elliot Hong, Jingyu Liu, Jessica A. Turner
Summary: The study found that genes in the 12q24 region may partially explain brain alterations in schizophrenia patients, and may also be related to other psychiatric disorders and developmental disorders.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Rui Yan, Ji Ting Geng, Ying Hong Huang, Hao Wen Zou, Xu Miao Wang, Yi Xia, Shuai Zhao, Zhi Lu Chen, Hongliang Zhou, Yu Chen, Zhi Jian Yao, Jia Bo Shi, Qing Lu
Summary: This study found significant differences in functional connectivity between insular subregions and other brain regions in SD patients compared to NSD patients, which may be related to cognitive impairment in SD patients. Additionally, there were no significant differences in functional connectivity between bilateral posterior insula and any brain regions among the SD, NSD, and HC groups.
Article
Rehabilitation
Jie Wang, Gaiyan Li, Shanshan Ding, Long Yu, Yan Wang, Lei Qiao, Qilin Wu, Weidong Ni, Hang Fan, Qianyun Zheng, Ying Zhang, Hongli Li
Summary: The study showed that combining liuzijue qigong with basic articulation training can significantly improve the respiratory control and comprehensive speech ability of stroke patients with dysarthria.
CLINICAL REHABILITATION
(2021)
Article
Multidisciplinary Sciences
Loreen Tisdall, Kelly H. MacNiven, Claudia B. Padula, Josiah K. Leong, Brian Knutson
Summary: Diffusion tractography can predict relapse in patients with stimulant use disorder, and lowered diffusion metrics in the tract from the anterior insula to the NAcc are associated with subsequent relapse.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Jason A. Avery, Alexander G. Liu, John E. Ingeholm, Stephen J. Gotts, Alex Martin
Summary: Research has shown that viewing pictures of food triggers automatic retrieval of specific taste quality information associated with the depicted foods within the taste cortex, but the patterns of neural activity elicited by pictures and their associated tastes are unrelated.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Hong Li, Alvaro Duque, Pasko Rakic
Summary: New studies in rodents have provided insights into the functions of the claustrum, suggesting its involvement in attention, salience detection, slow-wave generation, and neocortical network synchronization. However, the origin and development of the claustrum, particularly in primates, remain poorly understood. This study demonstrates that the claustrum in rhesus macaque embryos expresses neocortical molecular markers and undergoes two waves of neurogenesis, establishing a core and shell cytoarchitecture. Furthermore, the claustrum is found to be an independent pallial region, indicating its potentially unique role in cognitive control.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, General & Internal
L. Billeri, A. Naro, A. Manuli, R. S. Calabro
Summary: Agraphia, defined as disruption of writing skills due to brain damage, can be an underestimated symptom in stroke patients. This report highlights two cases where agraphia was an early sign of stroke, emphasizing the need for evaluation of acute agraphia to facilitate timely diagnosis and treatment.
JOURNAL OF POSTGRADUATE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Irena Arslanova, Vassilis Kotsaris, Manos Tsakiris
Summary: Perception of time can be distorted by emotional experiences, particularly arousal, which interact with attention and sensory mechanisms. Cardiac fluctuations within the heartbeat distort experienced time and this effect is influenced by subjective arousal.
Article
Medicine, General & Internal
Nilakshi Vaidya, Bharath Holla, Jon Heron, Eesha Sharma, Yuning Zhang, Gwen Fernandes, Udita Iyengar, Alex Spiers, Anupa Yadav, Surajit Das, Sanjit Roy, Chirag K. Ahuja, Gareth J. Barker, Debasish Basu, Rose Dawn Bharath, Matthew Hickman, Sanjeev Jain, Kartik Kalyanram, Kamakshi Kartik, Murali Krishna, Ghattu Krishnaveni, Kalyanaraman Kumaran, Rebecca Kuriyan, Pratima Murthy, Dimitri Papadopoulos Orfanos, Meera Purushottam, Sunita Simon Kurpad, Lenin Singh, Roshan Singh, B. N. Subodh, Mireille Toledano, Henrik Walter, Sylvane Desrivieres, Amit Chakrabarti, Vivek Benegal, Gunter Schumann
Summary: This cohort study shows that low-level arsenic exposure is associated with impairments in executive function and has characterized the underlying brain mechanisms. These impairments are exacerbated by risk factors such as poor nutrition and poverty. The study calls for reexamination of safe levels of arsenic exposure and suggests improvements in nutrition and socioeconomic conditions as potential ways to mitigate the harmful consequences.
Article
Clinical Neurology
Jan Rusz, Tereza Tykalova, Michal Novotny, David Zogala, Karel Sonka, Evzen Ruzicka, Petr Dusek
Summary: This study identified three distinct speech subtypes in treatment-naive patients with PD, including prosodic, phonatory-prosodic, and articulatory-prosodic subtypes. Untreated controls with PD showed deteriorated speech over 1 year, while long-term dopaminergic medication maintained stable speech impairment severity in some subtypes and improved speech performance in others.
Article
Neurosciences
Heather M. Clark, Joseph R. Duffy, Edythe A. Strand, Holly Hanley, Nancy Pearl Solomon
Summary: This study compared orofacial muscle strength between normal and dysarthric speakers and across types of dysarthria and examined correlations between strength and dysarthria severity. The results indicated that orofacial weakness is mainly associated with flaccid and spastic dysarthria, but not with ataxic dysarthria.
Article
Acoustics
Yuqin Lin, Longbiao Wang, Yanbing Yang, Jianwu Dang
Summary: This article proposes a cognition-inspired feature decomposition and recombination network (CFDRN) for dysarthric ASR. CFDRN uses slow- and rapid-varying temporal processors to decompose features into stable and changeable features, and a gated fusion module for selective recombination. The study also utilizes an adaptation approach based on unsupervised pre-training techniques. Experimental results show significant word error rate reductions compared to baseline methods on the TORGO and UASpeech datasets.
IEEE-ACM TRANSACTIONS ON AUDIO SPEECH AND LANGUAGE PROCESSING
(2023)
Article
Clinical Neurology
Akiyuki Hiraga, Masahiro Mori, Satoshi Kuwabara
Summary: This case demonstrates that NMOSD associated with dementia and/or Parkinson-like syndrome with basal ganglia lesions could be another clinical presentation in NMOSD, even in sites not enriched with AQP4.
Letter
Clinical Neurology
Akiyuki Hiraga, Kazuho Kojima, Yoshihisa Kitayama, Yuki Kiuchi, Satoshi Kuwabara
ACTA NEUROLOGICA BELGICA
(2022)
Letter
Clinical Neurology
Akiyuki Hiraga, Satoshi Kuwabara
NEUROLOGICAL SCIENCES
(2022)
Letter
Clinical Neurology
Akiyuki Hiraga, Kazuho Kojima, Satoshi Kuwabara
ACTA NEUROLOGICA BELGICA
(2022)
Letter
Clinical Neurology
Minori Watanabe, Akiyuki Hiraga, Satoshi Kuwabara
ACTA NEUROLOGICA BELGICA
(2022)
Letter
Medicine, General & Internal
Akiyuki Hiraga, Satoshi Kuwabara
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Akiyuki Hiraga, Mayumi Muto, Satoshi Kuwabara
Summary: Loss of taste can be a symptom of Guillain-Barre syndrome (GBS) after COVID-19 vaccination. Clinicians should be aware of this possibility and provide timely treatment.
Article
Medicine, General & Internal
Marie Morooka, Akiyuki Hiraga, Keiko Tanaka, Satoko Yoshizaki, Kyosuke Koide, Satoshi Kuwabara
Summary: Two cases of encephalitis with symptoms similar to NMDAR encephalitis but negative for anti-NMDAR antibodies were reported. The patients showed clinical improvement and good prognosis after ovarian teratoma resection and immunotherapy, indicating a close association between encephalitis and ovarian teratoma.
Article
Medicine, General & Internal
Akiyuki Hiraga, Yutaka Watabe, Satoshi Kuwabara
Summary: The early diagnosis of cerebral venous thrombosis in the emergency department is challenging. In this case, a 70-year-old man with new-onset convulsions was misdiagnosed with traumatic subarachnoid hemorrhage based on brain CT scan. However, further examination revealed a filling defect in the anterior superior sagittal sinus, indicating the presence of cerebral venous thrombosis.
Letter
Clinical Neurology
Akiyuki Hiraga, Kazuho Kojima, Masahide Suzuki, Satoshi Kuwabara
ACTA NEUROLOGICA BELGICA
(2023)
Letter
Clinical Neurology
Akiyuki Hiraga
NEUROLOGICAL SCIENCES
(2023)
Letter
Clinical Neurology
Akiyuki Hiraga, Kazuho Kojima, Satoshi Kuwabara
NEUROLOGICAL SCIENCES
(2023)
Editorial Material
Clinical Neurology
Akiyuki Hiraga, Kentaro Kurumada, Kazuho Kojima, Satoshi Kuwabara
Editorial Material
Clinical Neurology
Akiyuki Hiraga, Satoshi Kuwabara
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Akiyuki Hiraga, Kazuho Kojima, Satoshi Kuwabara
Summary: This study analyzed the frequency, etiology, clinical features, and recovery patterns of patients with secondary hypokalaemic paralysis. Lifestyle conditions/disorders such as chronic alcoholism, diarrhea, and imbalanced diet were the common causes. Initial symptoms were often atypical, and rebound hypokalaemia and delayed hyperCKaemia were common despite potassium replacement. Careful serial monitoring is needed for patients with secondary hypokalaemic paralysis.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
