Review
Medicine, General & Internal
Ana-Maria Gheorghe, Alexandra-Ioana Trandafir, Mihaela Stanciu, Florina Ligia Popa, Claudiu Nistor, Mara Carsote
Summary: This article provides new insights into the challenges of pituitary apoplexy during pregnancy and the postpartum period. The study includes a review of 35 original studies and highlights the importance of prompt recognition of headache as the main clinical feature. Most patients receive conservative management with corticosteroid substitution and dopamine agonists. Surgical intervention is reserved for cases with neuro-ophthalmological deterioration. This study is clinically significant for obstetricians and neurologists.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Clinical Neurology
Ana Isabel Almeida, Jose Maria Sousa, Luisa Sampaio
Summary: Tension pneumosella is a very rare complication of pituitary transsphenoidal surgery. We report the second case of pituitary adenoma pneumo-apoplexy, characterized by findings consistent with tension pneumosella in the context of apoplexy of a pituitary adenoma. Although it is an extremely rare diagnosis, it should be considered in patients with compatible clinical and radiological findings, particularly with a previous history of transsphenoidal pituitary surgery.
WORLD NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Kaori Takeshita, Ichiro Abe, Wataru Kameda, Kota Ishii, Yuya Fujita, Mai Nagata, Kentaro Ochi, Yuki Senda, Midori Koga, Tadachika Kudo, Yurika Hada, Kaoru Takase, Yusuke Morinaga, Miiko Ito, Makiko Abe, Kenichi Ishizawa, Kunihisa Kobayashi
Summary: Pituitary apoplexy is a rare syndrome that often leads to spontaneous bleeding or infarction in pituitary tumors or glands. This study found that pituitary apoplexy occurs most frequently in patients with nonfunctional pituitary adenomas and is not related to tumor size. However, it is associated with hormonal deficiencies, liver dysfunction, hyponatremia or hypochloremia, and dyslipidemia.
Article
Endocrinology & Metabolism
Jaypalsinh Gohil, Arun Gowda, Tobin George, H. Easwer, Alexander George, Prakash Nair
Summary: This article reports a case of pituitary apoplexy in a patient being treated for leptospirosis, discussing possible mechanisms of apoplexy in this scenario and reviewing other infectious causes that may result in pituitary apoplexy.
Article
Medicine, General & Internal
Betina Biagetti, Silvana Sarria-Estrada, Esteban Cordero Asanza, Anas Chaachou-Charradi, Yiken Karelys Ng-Wong, Marta Cicuendez, Irene Hernandez, Alba Rojano-Toimil, Pilar Costa, Elena Martinez-Saez, Anna Casteras, Rafael Simo
Summary: This study describes the clinical characteristics and evolution of patients with APA compared to SPA. The results show that APA is more frequent in larger NFPAs and this subset of patients has a higher risk of surgery. Hypopituitarism is quite frequent even in patients with SPA, and therefore long-term follow-up is necessary.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Burak Cabuk, Necdet Selim Kaya, Caner Polat, Abidin Murat Geyik, Dilek Icli, Ihsan Anik, Savas Ceylan
Summary: Surgical management of pituitary apoplexy within 21 days of symptom onset (early and delayed groups) can effectively improve headache, neuro-ophthalmic symptoms, and endocrine function, while surgery beyond 21 days (late group) may not be as effective in restoring pituitary function.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Review
Medicine, General & Internal
Valentina Puglisi, Elisabetta Morini, Fiammetta Biasini, Luisa Vinciguerra, Giuseppe Lanza, Placido Bramanti
Summary: This is a case report on giant pituitary tumor apoplexy, presenting a rare case of an 81-year-old female with this condition. The authors highlight the importance of prompt diagnosis and multidisciplinary management in achieving significant improvement in symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Yesim Yildiz, Arno Lauber, Natalia Velez Char, Oliver Bozinov, Marian Christoph Neidert, Isabel Charlotte Hostettler
Summary: Pituitary apoplexy may lead to subarachnoid hemorrhage. Based on a literature review, subarachnoid hemorrhage associated with pituitary apoplexy is more common in middle-aged males and is associated with hypertension, diabetes mellitus, prior trauma, anticoagulant, and/or antiplatelet therapy. Timely surgery can prevent severe neuro-ophthalmological defects and improve clinical outcomes.
NEUROLOGICAL SCIENCES
(2023)
Article
Emergency Medicine
Abidin Murat GeyiK, Mehmet Ozan Durmaz, Adem Dogan, Berna Kaya Ugur, Sirma Geyik, Ibrahim Erkutlu, Soner Yasar, Alparslan Kirik, Gulsah Kose, Ali Nehir
Summary: Pituitary apoplexy is an important and potentially life-threatening complication of pituitary adenomas. Early surgical intervention is crucial for achieving positive outcomes, with 72% of patients achieving total resection and significant decrease in hormone levels post-surgery.
ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
(2022)
Article
Clinical Neurology
Shinichiro Teramoto, Shigeyuki Tahara, Akihide Kondo, Akio Morita
Summary: The study revealed that age, tumor size, and sphenoid sinus mucosal thickening were strongly associated with the occurrence of ICA stenosis in pituitary apoplexy. Among these factors, age had the potential to be an independent predictor of the condition.
WORLD NEUROSURGERY
(2021)
Review
Clinical Neurology
Rafael Martinez-Perez, Michael W. Kortz, Benjamin W. Carroll, Daniel Duran, James S. Neill, Gustavo D. Luzardo, Marcus A. Zachariah
Summary: This study identified 3 cases of pituitary apoplexy with concomitant COVID-19 infection, with symptoms including headache and vision changes. The patients were successfully treated with surgery and medical management, showing improvement in visual symptoms. The study suggests that COVID-19 infection may be a risk factor for the development of pituitary apoplexy, but further research is needed.
WORLD NEUROSURGERY
(2021)
Article
Veterinary Sciences
Greta Galli, Giovanna Bertolini, Giulia Dalla Serra, Marika Menchetti
Summary: This study describes the abnormal neurological signs, diagnostic imaging findings, and short-term prognosis in dogs with suspected pituitary apoplexy (PA). Dogs with suspected PA showed behavioral abnormalities, obtundation, vestibular signs, and epileptic seizures. The onset of neurological signs was usually acute, and the short-term prognosis was favorable in the majority of cases.
VETERINARY SCIENCES
(2022)
Article
Clinical Neurology
Matthew C. Findlay, Richard Drexler, Majid Khan, Kyril L. Cole, Arian Karbe, Roman Rotermund, Franz L. Ricklefs, Joerg Flitsch, Timothy R. Smith, John L. Kilgallon, Juergen Honegger, Isabella Nasi-Kordhishti, Paul A. Gardner, Zachary C. Gersey, Hussein M. Abdallah, John A. Jane, Alexandria C. Marino, Ulrich J. Knappe, Nesrin Uksul, Jamil A. Rzaev, Evgeniy V. Galushko, Ekaterina V. Gormolysova, Anatoliy V. Bervitskiy, Henry W. S. Schroeder, Marton Eoerdoegh, Marco Losa, Pietro Mortini, Ruediger Gerlach, Apio C. M. Antunes, William T. Couldwell, Karol P. Budohoski, Robert C. Rennert, Mohammed Azab, Michael Karsy
Summary: This international multicenter study compared the clinical outcomes of microsurgical and endoscopic transnasal surgery for resecting pituitary adenomas. The results showed that microsurgery had better gross total resection rates but also had more complications and hospital utilization.
Article
Clinical Neurology
Zhicheng Wang, Xiaorong Yan, Changzhen Jiang, Jianping Song
Summary: The surgical removal of complex pituitary adenomas (PA) is a challenging procedure. This study presents the approach to removing a complex PA using the micro-endoscopic combination strategy. The effectiveness of this technique in managing complicated skull base surgeries is highlighted.
ACTA NEUROCHIRURGICA
(2023)
Article
Endocrinology & Metabolism
Claire Marx, Muriel Rabilloud, Francoise Borson Chazot, Caroline Tilikete, Emmanuel Jouanneau, Gerald Raverot
Summary: The study compared the outcomes of patients with pituitary apoplexy managed by conservative or surgical approaches, finding no significant differences at 1 year in terms of visual field defects and visual acuity impairment. The Pituitary Apoplexy Score (PAS) may be a reliable parameter for guiding therapeutic strategy, with surgery recommended for patients with a PAS score >= 4.
Article
Clinical Neurology
Shinn-Yn Lin, Chi-Cheng Chuang, Din-Li Tsan, Yu-Shin Hung, Chen-Ju Fu, Yi-Liang Shen, Yin-Yin Chiang, Yin-Cheng Huang, Yu-Jen Lu, Chi-Cheng Yang
Summary: A study on newly-diagnosed PCNSL patients found that neurocognitive functions improved or remained stable after combined chemoradiation therapy. Specifically, there was significant improvement in attention. The multidisciplinary treatment guidelines for newly-diagnosed PCNSL patients are of great importance.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Neurosciences
Hong-Chieh Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Chiung-Yin Huang, Ko-Ting Chen, Ya-Jui Lin, Hsiao-Wei Cheng, Chun-Hao Huang, Hsiang-Tsai Wang
Summary: This study found that higher expression of RIP140 in GBM patients is associated with prolonged survival, and overexpression of RIP140 reduces glioma cell proliferation and migration, increases cellular sensitivity to chemotherapy, contributing to extended patient survival.
NEUROMOLECULAR MEDICINE
(2022)
Review
Otorhinolaryngology
Cheng-Chi Lee, Chien-Chia Huang, Ta-Jen Lee, Yu-Chi Wang, Yu-Tse Liu, Ting-Wei Chang, Abel Po-Hao Huang, Chi-Cheng Chuang
Summary: Based on the updated systematic review and meta-analysis, endoscopic surgery for sellar/parasellar disease may not pose a greater risk of olfactory dysfunction. The evidence also does not support an increased risk of diminished olfaction among patients treated with nasoseptal flap during surgery.
Article
Clinical Neurology
Mun-Chun Yeap, Ching-Chang Chen, Chun-Ting Chen, Zhuo-Hao Liu, Chieh-Tsai Wu, Po-Chuan Hsieh, Hong-Yi Lai, Yu-Chi Wang, Ting -Wei Chang, Cheng-Chi Lee, Yu-Tse Liu, Yin-Cheng Huang, Kuo-Chen Wei, Po-Hsun Tu
Summary: A retrospective study on patients undergoing delayed cranioplasties with cryopreserved autografts found that swab cultures of cryopreserved skull flaps have high specificity but low sensitivity in predicting surgical site infections, leading to the conclusion that they should not be routinely performed during these surgeries.
WORLD NEUROSURGERY
(2022)
Article
Oncology
Shinn-Yn Lin, Din-Li Tsan, Chi-Cheng Chuang, Chi-Cheng Yang, Ping-Ching Pai, Chih-Liang Wang, Yi-Ming Wu, Cheng-Chi Lee, Chia-Hsin Lin, Kuo-Chen Wei, Wen-Chi Chou
Summary: In this study, we examined the oncological outcomes of cancer patients undergoing HS-WBRT, and found distinct patterns of neurologic/non-neurologic death and LMD recurrence between patients with intact brain metastases and those with resection cavities.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhuo-Hao Liu, Yin-Cheng Huang, Chang-Yi Kuo, Chi-Cheng Chuang, Ching-Chang Chen, Nan-Yu Chen, Ping K. Yip, Jyh-Ping Chen
Summary: In the process of repairing spinal cord injury, electrospun membranes containing DHA and BDNF can be used to achieve neurogenesis and guide neurite extension through the controlled release of these two pro-regenerative agents and the topography of aligned fibers. In the rat experiment, it was also demonstrated that drug-loaded fibrous membranes are important for improving neurological function recovery and promoting neuroprotection and neuroplasticity changes.
Article
Clinical Neurology
Shinn-Yn Lin, Chi-Cheng Chuang, Yin-Cheng Huang, Ping-Ching Pai, Cheng-Chi Lee, Kuo-Chen Wei, Chen-Kan Tseng, Chi-Cheng Yang
Summary: This prospective study investigates the impact of adjuvant brain irradiation on neurocognitive performances and relevant oncological outcomes in patients with infiltrative non-GBM gliomas. The results show a marked tendency toward neurocognitive stabilization in almost all cognitive functions, with significant differences in verbal and visual memory functions, as well as stabilization/improvement in psychomotor speed and executive functions.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Medicine, General & Internal
Cheng-Yu Li, Chi-Cheng Chuang, Ching-Chang Chen, Po-Hsun Tu, Yu-Chi Wang, Mun-Chun Yeap, Chun-Ting Chen, Ting-Wei Chang, Zhuo-Hao Liu
Summary: Traumatic intraventricular hemorrhage (tIVH) is associated with increased mortality and disability in traumatic brain injury (TBI). Factors associated with outcomes include age, Glasgow Coma Scale (GCS) severity score, and Graeb score. The Traumatic Graeb Score can be used to predict short-term functional outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Analytical
Chih-Hsien Hsu, Akhilesh Kumar Gupta, Agnes Purwidyantri, Briliant Adhi Prabowo, Ching-Hsiang Chen, Chi-Cheng Chuang, Ya-Chung Tian, Yu-Jen Lu, Chao-Sung Lai
Summary: This paper reports the development of an Alzheimer's disease sensor that can detect amyloid-beta (Aβ) (1-42) through simple nanorestructuring of a gold sheet plate. The sensor achieved rapid, accurate, precise, reproducible, and highly sensitive detection of Aβ (1-42) with a low detection limit and a wide linear range.
Article
Medicine, General & Internal
Yu-Chi Wang, Mei-Yun Cheng, Po-Cheng Hung, Cheng-Yen Kuo, Hsiang-Yao Hsieh, Kuang-Lin Lin, Po-Hsun Tu, Chieh-Tsai Wu, Peng-Wei Hsu, Kuo-Chen Wei, Chi-Cheng Chuang
Summary: In this study, a simulation combined with a robot-assisted radiofrequency ablation (S-RARFA) protocol was used to treat patients with epilepsy. The method showed high accuracy, minimal collateral damage, and good seizure control, making it a helpful alternative for institutions without real-time imaging monitoring or electrophysiologic guidance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Cheng-Chi Lee, Jeng-Fu You, Yu-Chi Wang, Shao-Wei Lan, Kuo-Chen Wei, Ko-Ting Chen, Yin-Cheng Huang, Tai-Wei Erich Wu, Abel Po-Hao Huang
Summary: This study found that NK cell activity is significantly impaired in glioblastoma patients. Gross total resection (GTR) can help restore impaired NK cell activity and increase the CD56(bright) CD16(-) NK subset, resulting in better prognosis.
Article
Biology
Meng-Wu Chung, Chi-Cheng Chuang, Chun-Chieh Wang, Hsien-Chih Chen, Peng-Wei Hsu
Summary: This study evaluated prognostic factors for post-radiosurgical rebleeding and focal edematous changes in patients with CCM. The results showed that higher dose and earlier treatment were associated with a lower rebleeding rate. The study demonstrated the efficacy of LINAC SRS in preventing CCM rebleeding.
Article
Biotechnology & Applied Microbiology
Shin-Yan Chiou, Li-Sheng Liu, Chia-Wei Lee, Dong-Hyun Kim, Mohammed A. Al-masni, Hao-Li Liu, Kuo-Chen Wei, Jiun-Lin Yan, Pin-Yuan Chen
Summary: Most current surgical navigation methods rely on optical navigators with images displayed on an external screen. However, the spatial information displayed in this arrangement is non-intuitive, and previous studies have mainly focused on visual aids with little attention to surgical guidance aids. Therefore, this paper proposed an augmented reality surgical navigation system based on image positioning that achieves low cost, high stability, and high accuracy, while providing intuitive guidance for surgical targets. Clinical trials confirmed the overall benefit of the system, and the recognition accuracy, sensitivity, and specificity were significantly improved compared to previous studies.
BIOENGINEERING-BASEL
(2023)
Article
Health Care Sciences & Services
Shin-Yan Chiou, Zhi-Yue Zhang, Hao-Li Liu, Jiun-Lin Yan, Kuo-Chen Wei, Pin-Yuan Chen
Summary: This paper introduces an augmented reality surgical navigation system that accurately superimposes the surgical target position, scalpel entry point, and scalpel direction on a patient's head and displays this data on a tablet. The designed system meets clinical requirements and provides a visual and intuitive guide for neurosurgeons.
Article
Materials Science, Biomaterials
Chi-Cheng Chuang, Yu-Hsiang Lan, Yu-Jen Lu, Yu-Lun Weng, Jyh-Ping Chen
Summary: In this study, a multifunctional magnetic graphene oxide nanoparticle was prepared for drug and gene targeted delivery in brain glioma treatment. The results demonstrated that the nanocomposite exhibited excellent targeting and antitumor efficacy, effectively slowing down tumor growth and prolonging animal survival time.
BIOMATERIALS SCIENCE
(2022)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)