Article
Oncology
Yen-Ling Lai, Jun-Hyeok Kang, Che-Yu Hsu, Jung-Il Lee, Wen-Fang Cheng, Yu-Li Chen, Yoo-Young Lee
Summary: This study found that for EOC patients with CNS metastases, factors such as serous histological type, disease progression, CNS involvement in first disease recurrence, and GKS-based combination treatment significantly impact survival. Patients with CNS involvement not in first tumor recurrence who underwent GKS-based combination treatment showed superior survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Binwei Lin, Dan Huang, Huan Du, Jinjia Fan, Yu Zhang, Gang Feng, Feng Gao, Xiao Bo Du
Summary: This study compared the efficacy of whole-brain radiation therapy (WBRT) with simultaneous integrated boost (SIB) to WBRT followed by stereotactic radiosurgery (SRS) in lung cancer patients with brain metastasis. The results showed that WBRT + SIB provided a longer intracranial progression-free survival and lower incidence of progression outside the radiation field compared to WBRT + SRS, indicating better local control for brain metastasis. However, there was no significant difference in overall survival and toxicity between the two treatment groups.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Angela M. Hong, Cora Waldstein, Brindha Shivalingam, Matteo S. Carlino, Victoria Atkinson, Richard F. Kefford, Grant A. McArthur, Alexander M. Menzies, John F. Thompson, Georgina Long
Summary: The brain is a common site of metastatic disease for patients with advanced melanoma, with treatment approaches including surgery, radiotherapy, and systemic therapy. Management of melanoma brain metastases should involve a multidisciplinary team and consider optimal combinations and sequencing of treatments. It is important to establish appropriate guidelines for the management of melanoma brain metastases and update them regularly as new treatment options become available.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Yasunori Sato, Masaaki Yamamoto, Toru Serizawa, Kei-ichiro Yamada, Yoshinori Higuchi, Hidetoshi Kasuya
Summary: A grading system for brain metastases patients treated with stereotactic radiosurgery and surviving long has been developed in this study. Through analysis of clinical factors, five factors correlated with survival of more than 3 years were identified and used to categorize patients into four grades, with significant differences in mean survival times among the grades. The model was shown to be useful in predicting survival time for patients undergoing aggressive treatment options.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zekun Jiang, Bao Wang, Xiao Han, Peng Zhao, Meng Gao, Yi Zhang, Ping Wei, Chuanjin Lan, Yingchao Liu, Dengwang Li
Summary: Multimodality MRI-based radiomics models can predict the posttreatment response of LCBM to GKRS.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Eric J. Hsu, Yulong Yan, Robert D. Timmerman, Zabi Wardak, Tu D. Dan, Toral R. Patel, Dat T. Vo, Strahinja Stojadinovic
Summary: In this study, tumor surface area (SA) was found to be the most accurate univariate predictor of radiation necrosis risk. A preplan model was developed using a simple power-law model with SA and other variables to estimate and minimize radiosurgical toxicity. This model can facilitate dose prescription and escalation strategies without relying on planning software.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Andras Piffko, Benedikt Asey, Lasse Duehrsen, Inka Ristow, Johannes Salamon, Harriet Wikman, Cecile L. Maire, Katrin Lamszus, Manfred Westphal, Thomas Sauvigny, Malte Mohme
Summary: Non-small cell lung cancer is the leading cause of cancer-related death globally, with an increasing incidence of brain metastases in NSCLC patients. This study identified systemic metastatic load and number of brain metastases as significant factors affecting overall survival in resectable NSCLC patients. Factors such as age, absence of other systemic metastases, and number of brain metastases were found to impact survival outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Joonho Byun, Sang Woo Song, Young-Hoon Kim, Chang Ki Hong, Jeong Hoon Kim, Jong Hyun Kim
Summary: This study investigated the treatment outcomes of Gamma Knife radiosurgery for patients with brain metastasis from thyroid cancer. The results showed that Gamma Knife treatment was effective in achieving local control, but the rate of distant brain metastasis was high and the median survival was only 15 months.
WORLD NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Li-Tsun Shieh, Sung-Wei Lee, Chia-Chun Chen, Yi-Chia Ho, Yu-Wen Wang, Sheng-Yow Ho
Summary: This study retrospectively analyzed 23 brain metastatic cancer patients who underwent HA-WBRT and described the clinical features of intracranial recurrence. Two patients experienced intracranial failure in the perihippocampal region. Perihippocampal failure may be associated with under-dose radiation or the aggressiveness of the cancer.
Article
Oncology
Haomiao Zhang, Hanfeng Wu, Jianjie Lu, Wencheng Shao, Lili Yu
Summary: This study reported a case of recurrent orbital meningioma treated with a hybrid treatment model, including postoperative radiation therapy and gamma knife multifractionated stereotactic radiosurgery (MF-SRS). Through this treatment model, the patient's lesion disappeared completely, and some symptoms after surgery were significantly relieved.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Zhishuo Wei, Diego D. Luy, Shalini Jose, Hansen Deng, Sila Yavan, Stephen Worrell, J. Raouf Belkhir, Lilly W. Tang, Ajay Niranjan, L. Dade Lunsford
Summary: Single-session SRS is a well-tolerated palliative treatment option even in patients with =20 brain metastases, achieving a local control rate >90% with low risks of neurotoxicity while continuing concurrent systemic oncological care.
Article
Oncology
Tian-Qi Du, Xiang Li, Wei-Si Zhong, Jian-Dong Tian, Yu-Xia Zhao, Dan Liu
Summary: For patients with brain metastasis of lung cancer, SIB-IMRT may be associated with a more favorable prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Hung Van Nguyen, Duong Thuy Phung, Trung Thanh Nguyen, Bach Trung Tran, Kim Ngan Thi Mai, Huy Le Trinh
Summary: Brain metastases in colorectal cancer are uncommon, and there is a shortage of data concerning their screening and management. Various treatment modalities, including chemotherapy, chemoradiation, and targeted therapy, have shown promising results. This study describes the case of a 47-year-old male with rectal cancer who achieved a complete clinical response following systemic therapy, but subsequently developed brain metastasis. The patient showed a good response to whole-brain radiation therapy followed by a bevacizumab plus chemotherapy regimen.
Article
Oncology
Yuki Shinya, Hirotaka Hasegawa, Masahiro Shin, Mariko Kawashima, Tomoyuki Koga, Shunya Hanakita, Atsuto Katano, Takehiro Sugiyama, Yuki Nozawa, Nobuhito Saito
Summary: This study examined therapeutic factors and a novel therapeutic approach for skull base chordoma (SBC). The results showed that higher radiation doses improved local control rates, and extended-field SRS improved remote control rates and overall survival without increasing the risk of radiation-induced adverse events.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Yanhua Duan, Hongbin Cao, Boheng Wu, Yinghui Wu, Dong Liu, Lijun Zhou, Aihui Feng, Hao Wang, Hua Chen, Hengle Gu, Yan Shao, Ying Huang, Yang Lin, Kui Ma, Xiaolong Fu, Hong Fu, Qing Kong, Zhiyong Xu
Summary: This study compared the advantages and disadvantages of GK, Cone-VMAT, and MLC-CRT in treating single small brain metastasis, finding that Cone-VMAT has the advantage of shorter treatment time, while MLC-CRT showed superior Conformity Index (CI) with increasing target volume.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Jong-Hyeok Park, Sun-Ho Lee, Eun-Sang Kim, Whan Eoh
BRITISH JOURNAL OF NEUROSURGERY
(2020)
Article
Clinical Neurology
Hyukjun Kwon, Sungjoon Lee, Sun-Ho Lee, Eun-Sang Kim
Summary: This report describes a case of dural rupture and subsequent spinal cord herniation related to the use of closed suction drains in spinal surgery.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Jeong-Seob Won, Je Young Yeon, Hee-Jang Pyeon, Yu-Jeong Noh, Ji-Yoon Hwang, Chung Kwon Kim, Hyun Nam, Kyung-Hoon Lee, Sun-Ho Lee, Kyeung Min Joo
Summary: Stem cell-based therapeutics, particularly adult human multipotent neural cells (ahMNCs) from patients with hemorrhagic stroke, show potential in promoting significant locomotor recovery in spinal cord injury (SCI) through modulating glial scar formation, neuroprotection, and/or angiogenesis. The optimal transplantation dose of ahMNCs identified in this study could be beneficial in determining the appropriate injection dose for SCI patients in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Sung Soo Kim, Hee-Jang Pyeon, Yoon Kyung Bae, Hyun Nam, Chung Kwon Kim, Sun-Ho Lee, Kyeung Min Joo
Summary: Adult human multipotent neural cells (ahMNCs) derived from adult human temporal lobes exhibit unique characteristics, including distinctive cell marker expression, higher neural differentiation potentials, and increased expression of paracrine factors. These features set ahMNCs apart from other cell types such as pericytes, mesenchymal stem cells (MSCs), and fetal neural stem cells (fNSCs). The distinct properties of ahMNCs make them valuable for potential applications in regenerative medicine research and as comparative references for other cell types.
STEM CELLS INTERNATIONAL
(2021)
Article
Oncology
Haeyoung Kim, Hongryull Pyo, Hee Chul Park, Do Hoon Lim, Jeong Il Yu, Won Park, Yong Chan Ahn, Doo Ho Choi, Dongryul Oh, Jae Myoung Noh, Won kyung Cho, Gyu Sang Yoo, Sang Hoon Jung, Eun-Sang Kim, Sun-Ho Lee, Se-Jun Park, Chong-Suh Lee
Summary: This study aimed to evaluate the incidence of vertebral compression fracture (VCF) in patients undergoing SBRT for spinal bone metastases and determine contributing factors. Results showed that the dosimetric parameter PTV_V15 Gy was the most significant for predicting VCF, while primary tumor site and PTV_V-15 Gy were also associated with VCF incidence.
JOURNAL OF BONE ONCOLOGY
(2021)
Article
Clinical Neurology
Scott L. Zuckerman, Sun-Ho Lee, George J. Chang, Garrett L. Walsh, Reza J. Mehran, Ziya L. Gokaslan, Ganesh Rao, Claudio E. Tatsui, Laurence D. Rhines
Summary: The study revealed that negative margin resection of sacral chordoma was associated with decreased local recurrence, but did not affect patient's survival and functional outcomes. Most patients experienced complications after surgery, but these complications did not significantly impact the patient's survival, recurrence, or function.
GLOBAL SPINE JOURNAL
(2021)
Article
Clinical Neurology
Soo Heon Kim, Sun Ho Lee, Dong Ah Shin
Summary: This study aimed to investigate whether machine learning (ML) can predict postoperative C5 palsy of cervical ossification of the posterior longitudinal ligament (OPLL) patients better than a conventional logistic regression. Four sampling methods were used to balance the data, and six ML algorithms and conventional logistic regression were compared. The results showed that the ML algorithm using adaptive reinforcement learning and downsampling had the highest AUC and outperformed logistic regression. Age, surgical method, and involvement of OPLL at C1-C3 were significantly associated with C5 palsy, and postoperative shoulder pain was closely related to postoperative C5 palsy of OPLL patients.
CLINICAL SPINE SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Chung Kwon Kim, Jeong-Seob Won, Jae Yeol An, Ho Jin Lee, Ah-Jin Nam, Hyun Nam, Ji Yeoun Lee, Kyung-Hoon Lee, Sun-Ho Lee, Kyeung Min Joo
Summary: Adult human neural stem cells (ahNSCs) can improve motor function and provide neuroprotective effects for spinal cord injury (SCI) patients by inhibiting apoptosis of spinal cord neurons. The conditioned medium (CM) of ahNSCs was found to have paracrine effects through the release of various cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Sungjoon Lee, Sunghoon Min, Junghoon Han, Eun Sang Kim, Sun-Ho Lee
Summary: This study aimed to determine the long-term clinical and radiologic outcomes using L-shaped mini-plates for laminoplasty. The results showed that laminoplasty using L-shape Leibinger mini-plates had a fusion rate of 89.3% and no displacement of the re-attached laminae was observed. It is considered a safe and feasible option for surgeries for intraspinal pathologies.
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
Sungjoon Lee, Hyun Nam, Kyeung-Min Joo, Sun-Ho Lee
Summary: Spinal cord injury is a devastating injury that leads to severe disabilities. Stem cell therapy, specifically neural stem cells, has shown promising results in regenerating damaged neural tissues. Preclinical and clinical studies have demonstrated positive outcomes, although there are still challenges to overcome.
Article
Multidisciplinary Sciences
Junghoon Han, Chang-Min Ha, Woon Tak Yuh, Young San Ko, Jun-Hoe Kim, Tae-Shin Kim, Chang-Hyun Lee, Sungjoon Lee, Sun-Ho Lee, Asfandyar Khan, Chun Kee Chung, Chi Heon Kim
Summary: This study compared the reduction of spondylolisthesis and the placement of the cage between the OLIF-one and OLIF-con procedures. The results showed that OLIF-one achieved better reduction of spondylolisthesis and placement of the cage at the desired location.
Article
Cell Biology
Geun-Hyoung Ha, Eun Ji Kim, Jee Soo Park, Ji Eun Kim, Hyun Nam, Je Young Yeon, Sun-Ho Lee, Kyunghoon Lee, Chung Kwon Kim, Kyeung Min Joo
Summary: This study demonstrated the neuroprotective and pro-angiogenic effects of adult human neural stem cells (ahNSCs) in the treatment of ischemic stroke. Tissue analysis showed that ahNSCs reduced brain tissue atrophy and functional loss, and preserved neurons by decreasing reactive astrogliosis and microglial activation. Furthermore, these effects were mediated by paracrine factors and reversed when the JAK2/STAT3 signaling pathway was inhibited. This preclinical study provides important insights for the development of stem cell therapeutics for ischemic stroke.
Correction
Cell & Tissue Engineering
Hyun Nam, In-Hee Lee, Jason K. Sa, Sung Soo Kim, Hee-Jang Pyeon, Kee Hang Lee, Kyunghoon Lee, Sun-Ho Lee, Kyeung Min Joo
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Cell & Tissue Engineering
Hyun Nam, In-Hee Lee, Jason K. Sa, Sung Soo Kim, Hee-Jang Pyeon, Kee Hang Lee, Kyunghoon Lee, Sun-Ho Lee, Kyeung Min Joo
Summary: The study found that long-term in vitro expansion of adult human multipotent neural cells (ahMNCs) can induce copy number variations and genetic mutations, but the number did not increase with culture progression and many of them disappeared. Although most of the observed genetic mutations were not shared by all ahMNCs, non-synonymous missense mutations at the MUC4 gene were found in three out of five long-term cultured ahMNC lines. The genetic instability did not confer in vivo tumorigenic potential to ahMNCs.
STEM CELL REVIEWS AND REPORTS
(2022)
Review
Clinical Neurology
Chang-Hyun Lee, Jae Taek Hong, Sun-Ho Lee, Seong Yi, Moon-Jun Sohn, Sung Hwan Kim, Chun Kee Chung
Summary: Spinal metastases can vary in mechanical stability. The Spinal Instability Neoplastic Score (SINS) is used to assess spinal neoplastic-related instability. Studies have conflicting opinions on the accuracy and reliability of SINS, but most agree on its predictive accuracy for vertebral compression fractures (VCFs).
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2021)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
